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1.
Journal of Physics a-Mathematical and Theoretical ; 56(23), 2023.
Article in English | Web of Science | ID: covidwho-20241171

ABSTRACT

Since the outbreak of COVID-19, the severe acute respiratory syndrome coronavirus 2 genome is still mutating. Omicron, a recently emerging virus with a shorter incubation period, faster transmission speed, and stronger immune escape ability, is soaring worldwide and becoming the mainstream virus in the COVID-19 pandemic. It is especially critical for the governments, healthcare systems, and economic sectors to have an accurate estimate of the trend of this disaster. By using different mathematical approaches, including the classical susceptible-infected-recovered (SIR) model and its extensions, many investigators have tried to predict the outbreaks of COVID-19. In this study, we employed a novel model which is based upon the well-known susceptible-infected-removed (SIR) model with the time-delay and time-varying coefficients in our previous works. We aim to predict the evolution of the epidemics effectively in nine cities and provinces of China, including A City, B City, C City, D City, E City, F City, G City, H City and I Province. The results show it is effective to model the spread of the large-scale and sporadic COVID-19 induced by Omicron virus by the novel non-autonomous delayed SIR compartment model. The significance of this study is that it can provide the management department of epidemic control with theoretical references and subsequent evaluation of the prevention, control measures, and effects.

2.
E3S Web of Conferences ; 385, 2023.
Article in English | Scopus | ID: covidwho-20238776

ABSTRACT

A 100 million ton crude oil purchases and sale contract signed between China and Russia, and the crude oil will pass through Kazakhstan and flow along the Alashankou-Dushanzi-Urumchi crude oil pipeline to western Region. As an important crude oil import channel, this paper analyzes the current situation of Alashankou-Dushanzi-Urumchi crude oil pipeline and puts forward some countermeasures. Both Russia and Kazakhstan are major crude oil exporters, with internal demand for exporting crude oil to China. There is a huge gap between domestic crude oil demand, and social and economic development depends on crude oil import. The geographical environment of the crude oil pipeline is conducive to pipeline protection. The security environment of Xinjiang has improved. The situation in Russia and Ukraine and the civil strife in Kazakhstan have limited impact on the pipeline which will have good development opportunities. Thus, this paper proposes the following management strategies. First of all, strengthen communication and coordination between upstream and downstream enterprises. Second, reduce cost and increase efficiency. Third, attach importance of the application of new technologies. Fourth, establish emergency plans and hold emergency drills for emergencies such as COVID-19 outbreak and pipeline leakage. Fifth, strengthen anti-terrorism and riot control. Sixth, strengthen corporate culture and talent team construction. © The Authors, published by EDP Sciences. This is an open access article distributed under the terms of the Creative Commons Attribution License 4.0 (https://creativecommons.org/licenses/by/4.0/).

3.
Atmospheric Environment ; 306 (no pagination), 2023.
Article in English | EMBASE | ID: covidwho-20237416

ABSTRACT

The additional impact of emission-reduction measures in North China (NC) during autumn and winter on the air quality of downwind regions is an interesting but less addressed topic. The mass concentrations of routine air pollutants, the chemical compositions, and sources of fine particles (PM2.5) for January 2018, 2019, and 2020 at a megacity of Central China were identified, and meteorology-isolated by a machine-learning technique. Their variations were classified according to air mass direction. An unexpectedly sharp increase in emission-related PM2.5 by 22.7% (18.0 mug m-3) and 25.7% (19.4 mug m-3) for air masses from local and NC in 2019 was observed compared to those of 2018. Organic materials exhibited the highest increase in PM2.5 compositions by 6.90 mug m-3 and 6.23 mug m-3 for the air masses from local and NC. PM2.5 source contributions related to emission showed an upsurge from 1.39 mug m-3 (biomass burning) to 24.9 mug m-3 (secondary inorganic aerosol) in 2019 except for industrial processes, while all reduced in 2020. From 2018 to 2020, the emission-related contribution of coal combustion to PM2.5 increased from 10.0% to 19.0% for air masses from the local area. To support the priority natural gas quotas in northern China, additional coal in cities of southern China was consumed, raising related emissions from transportation activities and road dust in urban regions, as well as additional biofuel consumption in suburban or rural regions. All these activities could explain the increased primary PM2.5 and related precursor NO2. This study gave substantial evidence of air pollution control measures impacting the downwind regions and promote the necessity of air pollution joint control across the administration.Copyright © 2023 Elsevier Ltd

4.
Journal of Alloys and Compounds ; 952, 2023.
Article in English | Web of Science | ID: covidwho-2327350

ABSTRACT

In this paper, we reported on the lattice distortion, surface morphologies, vacancy defects and electrochemical performance that had been observed in Na3V2(PO4)2F3 prepared at different annealing temperatures. X-ray diffraction indicated that all the samples were single phase materials with tetragonal structure and exhibited lattice distortion with the increase of annealing temperatures. A possible mechanism causing the strain-induced lattice distortion had been discussed. Moreover, scanning electron microscopy and positron annihilation techniques were used to study the grain size and vacancy defects as a function of annealing temperatures. The superior electrochemical performance of Na3V2(PO4)2F3 electrode was obtained at the annealing temperature of 350 degrees C with 167.73 F center dot g-1 specific capacitance and 85% capacitance retention. The better electrochemical performance was due to the synergistic effects of grain size and vacancy defect regulated by the annealing temperatures. These results could provide experimental basis for enhancing electrochemical performance of Na3V2(PO4)2F3 in sodium-ion battery area applications. (c) 2023 Elsevier B.V. All rights reserved.

5.
Aims Biophysics ; 10(1):50-66, 2023.
Article in English | Web of Science | ID: covidwho-2310032

ABSTRACT

Severe acute respiratory syndrome corona virus2 (SARS-CoV-2) is responsible for the current pandemic that led to so many deaths across the globe and still has no effective medication. One attractive target is Papain-like protease (PLpro), which plays a critical role in viral replication. Several important structural features dictate access to the PLpro narrow active site, which includes a series of loops surrounding the area. As such, it is difficult for chemical compounds to fit the SARS-CoV-2 PLpro active site. This work employed a computational study to discover inhibitors that could bind to the SARS-COV-2 PLpro active site, mainly by virtual screening, molecular dynamic simulation, MMPBSA and ADMET analysis. Eight potential inhibitors were identified: carbonoperoxoic acid, Chrysophanol-9-anthrone, Adrenolutin, 1-Dehydroprogesterone, Cholest-22-ene-21-ol, Cis-13-Octadecenoic acid, Hydroxycarbonate and 1-(4-(4-Methylphenyl)-5-phenyl-1,3-oxazol-2-yl) isoquinoline, with binding scores of -4.4, -6.7, -5.9, -6.7, -7.0, -4.6, -4.5 and -5.6 kcal/mol, respectively. All these compounds interacted with critical PLpro catalytic residues and showed stable conformation in molecular dynamics simulations with significant binding energies of -12.73 kcal/mol, -10.89 kcal/mol, -7.20 kcal/mol, -16.25 kcal/mol, -19.00 kcal/mol, -5.00 kcal/mol, -13.21 kcal/mol and -12.45 kcal/mol, respectively, as revealed by MMPBSA analysis. ADMET analysis also indicated that they are safe for drug development. In this study, we identified novel compounds that interacted with the key catalytic residues of SARS-CoV-2 PLpro with the potential to be utilized for anti-Covid-19 drug development.

6.
Adverse Drug Reactions Journal ; 22(3):180-187, 2020.
Article in Chinese | EMBASE | ID: covidwho-2293262

ABSTRACT

Objective: To explore the clinical safety of lopinavir/ritonavir (LPV/r) by mining the risk signals of adverse events (AEs) related to LPV/r for the safe application of the drug in the treatment of novel coronavirus pneumonia (COVID-19). Method(s): The risk signals related to LPV/r in AE reports of US FDA Adverse Event Reporting System (FAERS) from the first quarter of 2010 to the third quarter of 2019 were mined by reporting odds ratio (ROR). An AE with reports more than 3 and 95% confidence interval (CI) lower limit of ROR greater than 1 was defined as a positive signal. AEs were counted and classified using the preferred system organ class (SOC) and preferred term (PT) of Medical Dictionary for Regulatory Activities (MedDRA). The PTs of top 50 adverse event reports and signal strength were selected and analyzed. Result(s): From the first quarter of 2010 to the third quarter of 2019, a total of 13 335 AE reports with LPV/r as the primary suspicious drug were reported in the FAERS database. Four hundred and fifty-five AE risk signals with reports more than 3 and the 95%CI lower limit of ROR greater than 1 were detected, involving 7 718 AE reports. The top 2 system organs involved in AE reports were "injury, poisoning and procedural complications" [13.6% (1 051/7 718)] and "pregnancy, puerperium and perinatal conditions" [11.7% (899/7 718)]. However, 998 (95.0%) of 1051 AE reports involved in "injury, poisoning and procedural complications" were related to drug exposure during pregnancy. The system organ with the highest signals was "congenital, familial and genetic disorders" [16.3% (74/455)]. In addition, 144 AEs caused by drug interactions were detected, which ranked the 7th in the AE reports. Conclusion(s): The risk signals of fetal, neonatal and infant abnormalities related to LPV/r during pregnancy were detected, suggesting that attention should be paid to the risk of using LPV/r in pregnant women and infants. The interaction between LPV/r and other drugs was also worthy of attention.Copyright © 2020 by the Chinese Medical Association.

7.
Eur Rev Med Pharmacol Sci ; 27(7): 3191-3200, 2023 04.
Article in English | MEDLINE | ID: covidwho-2296648

ABSTRACT

A few patients who have recovered from COVID-19 develop persistent or new symptoms that last for weeks or months; this is called "long COVID" or "post-COVID-19 syndrome." Over time, awareness of the short- and long-term consequences of COVID-19 has increased. The pulmonary consequences are now fairly well established, but little is known about the extrapulmonary system of COVID-19, particularly its effects on bones. Current evidence and reports indicate a direct relationship between SARS-CoV-2 infection and bone health, with SARS-CoV-2 having a significant negative effect on bone health. In this review, we analyzed the impact of SARS-CoV-2 infection on bone health and assessed the impact of COVID-19 on the diagnosis and treatment of osteoporosis.


Subject(s)
COVID-19 , Osteoporosis , Humans , Post-Acute COVID-19 Syndrome , SARS-CoV-2 , Bone Density
8.
Computer Applications in Engineering Education ; 2023.
Article in English | Scopus | ID: covidwho-2246641

ABSTRACT

Building practical programming competency requires a long-lasting journey of discovery, trial and error, learning and improvement. This article presents essential findings of a case study of a Python programming contest with an automatic judgement system for Competitive Programming training extending the learning experiences for students in an introductory course, computational thinking and problem-solving. The benefits and challenges are discussed. Due to the coronavirus disease 2019 (COVID-19) epidemic, a hybrid model of the contest was adopted, that is, some students participated in the contest on-site, while others participated remotely. To alleviate human effort in judging the submissions, the DOMjudge platform, a web-based automatic judgement system, has been deployed as an online automatic judgement system and contest management in competitive programming. The implementation roadmap and framework were provided. The contest problems and contestants' performances were discussed. Not many junior contestants could solve at least one problem(s), and competitive computing training should be offered if the students are keen on open competitions. An empirical study was conducted to evaluate the student feedback after the contest. Preliminary results revealed that the contest offering the chance to stimulate student learning interests could enhance their independent learning, innovative thinking and problem-solving skills, and could thus lead to the overall benefits of the learning experiences, which further encourage them to participate in future contests to improve their learning and therefore enhance their employability. Employers often treasure student experiences in competitive programming events, like association for computing machinery programming contests, Google Code Jam or Microsoft Imagine Cup. Sharp vision requiring skills to tackle unseen problems within a short period is also instrumental to students planning for graduate school. © 2023 Wiley Periodicals LLC.

9.
Alexandria Engineering Journal ; 64:297-308, 2023.
Article in English | Web of Science | ID: covidwho-2232601

ABSTRACT

Since the outbreak of the COVID-19 pandemic, fires occurred frequently in hospitals managing COVID-19, and caused over 279 deaths. Fire safety in hospitals should be identified clearly and taken seriously. Fire probability and fire service coverage for hospitals from a national perspective in China were analyzed in this study. Calculated with the generalized Barrois model, the annual fire frequency of hospital building exceeds 0.5, when its floor area reaches approximately 180,000 m2. Based on the number of hospital fires in Changsha and that of hospitals in China from 2014 to 2017, the average annual fire probability of a hospital in China was calculated to be 0.017. The total effective coverage rate (TECR) of fire service for hospitals in Changsha, China was esti-mated to be between 11.82 % and 25.74 %, based on real-time travel times extracted from the Baidu Map. The TECR of national fire service for hospitals was estimated to be between 14.18 % and 30.89 %, according to the ratio of the number of hospitals and the number of fire stations in China to that in Changsha. Currently, recruiting medical staff as fire volunteers can quickly improve fire safety in hospitals for a low cost.(c) 2022 THE AUTHORS. Published by Elsevier BV on behalf of Faculty of Engineering, Alexandria University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/ licenses/by-nc-nd/4.0/).

10.
19th IEEE International Conference on Networking, Sensing and Control, ICNSC 2022 ; 2022.
Article in English | Scopus | ID: covidwho-2230750

ABSTRACT

In 2020, COVID-19 swept the world. To prevent the spread of the outbreak, it is crucial to ensure that everyone wears a mask during daily travel and in public places. However, relying on human inspection alone is inevitably negligent and there is a potential risk of cross-contamination between people. Automated detection by means of cameras and artificial intelligence becomes a technical solution. By training convolutional neural networks, image recognition can be implemented and image classification can be performed as a solution to the target mask-wearing detection problem. To this end, in this thesis, three typical convolutional neural network architectures, VGG-16, Inception V3, and DenseNet-121, are used as models based on deep learning to investigate the mask-wearing detection problem by using transfer learning ideas. By building six different models and comparing the performance of different typical network architectures on the same dataset using two transfer learning methods, feature extraction and fine-tuning, we can conclude that DenseNet-121 is the typical architecture with the best performance among the three networks, and fine-tuning has better transfer ability than feature extraction in solving the target mask wearing detection problem. © 2022 IEEE.

11.
Comparative Education Review ; 2023.
Article in English | Web of Science | ID: covidwho-2212665

ABSTRACT

In response to the COVID-19 epidemic, many education systems have relied on distance learning and educational technologies to an unprecedented degree. However, rigorous empirical research on the impacts on learning under these conditions is still scarce. We present the first large-scale, quantitative evidence detailing how school closures affected education in China. The data set includes households and teachers of 4,360 rural and urban primary school students. We find that although the majority of students engaged in distance education, many households encountered difficulties including barriers to learning (such as access to appropriate digital devices and study spaces), curricular delays, and costs to parents equivalent to between 3.5 and 6 months of income. We also find significant disparities across rural and urban households.

12.
Innov Aging ; 6(Suppl 1):458-9, 2022.
Article in English | PubMed Central | ID: covidwho-2188954

ABSTRACT

The post-acute and long-term care (PALTC) sector has, in some respects, served as the epicenter in the U.S. during the COVID-19 pandemic. Many decisions were carried out by administrative and/or clinical leaders during this pandemic. The decisions were made based on their professional experiences, and recommendations by the Centers for Medicare & Medicaid Services (CMS). However, little research has reported on the perspective of those administrators who took the lead during this most difficult time. This study aims to understand how responses and decisions were formed during COVID-19 to ensure resources were available protect staff and residents. Accordingly, this study tried to answer two key questions: 1) What did the PALTC administrative and clinical leaderships learn? 2) What can we do better not if, but when COVID ever "…hits again?” We interviewed nursing home and/or assisted living administrators in two conveniently selected states: Pennsylvania and North Carolina. These interviews (each of which took about 30 minutes) were conducted over Zoom using structured and open-ended questions. The transcripts were entered and analyzed using NVivo – a qualitative data analysis software. The results revealed several themes including communications, relationship building, experience as an administrator, fears and resilience, as well as successful activities to support their staffs such as recognition, bonuses, and food bags prepared for their family. The findings highlight some important administrators' thoughts which recommend key future strategies. These include whether preparedness assets, knowledge, resources, and policies were adequate and where the future efforts should focus.

13.
2022 ASABE Annual International Meeting ; 2022.
Article in English | Scopus | ID: covidwho-2040428

ABSTRACT

Since COVID-19 became a global pandemic, improving air quality has been increasingly important to mitigate the transmission of pathogenic aerosols. Air filters such as MERV filters have been widely used in heating, ventilation, and air conditioning (HVAC) systems to clean inlet air. In recent years, ultraviolet (UV) light has been used for decontamination and disinfection in various applications, including indoor air cleaning, e.g., upper-room ultraviolet germicidal irradiation (UVGI). There are a variety of air purification devices available in the market, with some incorporating UV technology. However, many of them are not formally tested and certified for their effectiveness in mitigating airborne pathogens and particulate matter. The research's objectives are to (1) evaluate, design, and upgrade an existing air filtration device (~2,200 CFM) with the addition of UV-C lamps;(2) test the effectiveness of the upgraded device in mitigating airborne pathogens (bacteria) and particulate matter (PM) in real scenario (poultry farm). The testing results of air quality are expressed in particular matter (PM) levels and colony-forming units (CFUs). The preliminary data showed that both MERV-8 & MERV 13 and UV-C lamps can inactivate up to 100% of airborne bacteria, and the device can remove over 95% of total PM after treatment in a ~150-layer room. © 2022 ASABE. All Rights Reserved.

14.
Journal of Social Computing ; 3(2):139-157, 2022.
Article in English | Scopus | ID: covidwho-2026288

ABSTRACT

Building on our previous work, we assess how social solidarity towards migrants and refugees has changed before and after the onset of the COVID-19 pandemic, by collecting and analyzing a large, novel, and longitudinal dataset of migration-related tweets. To this end, we first annotate above 2000 tweets for (anti-) solidarity expressions towards immigrants, utilizing two annotation approaches (experts vs. crowds). On these annotations, we train a BERT model with multiple data augmentation strategies, which performs close to the human upper bound. We use this high-quality model to automatically label over 240 000 tweets between September 2019 and June 2021. We then assess the automatically labeled data for how statements related to migrant (anti-)solidarity developed over time, before and during the COVID-19 crisis. Our findings show that migrant solidarity became increasingly salient and contested during the early stages of the pandemic but declined in importance since late 2020, with tweet numbers falling slightly below pre- pandemic levels in summer 2021. During the same period, the share of anti-solidarity tweets increased in a sub- sample of COVID-19-related tweets. These findings highlight the importance of long-term observation, pre- and post-crisis comparison, and sampling in research interested in crisis related effects. As one of our main contributions, we outline potential pitfalls of an analysis of social solidarity trends: for example, the ratio of solidarity and anti-solidarity statements depends on the sampling design, i.e., tweet language, Twitter-user accounts' national identification (country known or unknown) and selection of relevant tweets. In our sample, the share of anti-solidarity tweets is higher in native (German) language tweets and among 'anonymous' Twitter users writing in German compared to English-language tweets of users located in Germany. © 2020 Tsinghua University Press.

15.
Natural Gas Industry ; 42(7):1-6, 2022.
Article in Chinese | Scopus | ID: covidwho-2024390

ABSTRACT

Natural gas will play more and more important role in the sustainable low-carbon development mode characterized by low energy consumption, low pollution and low emission. It has been and will continue to be the focus of attention. The 28th World Gas Conference (WGC2022) was held on May 23-27, 2022 in Daegu, South Korea. The conference summarized the progress of world natural gas in the past four years, analyzed and judged the future development trend, and reached seven consensuses: (1) Natural gas is not only a transitional fuel, but also a basic fuel for future development. (2) Supply and demand value chain of natural gas has high flexibility and adaptability, and supply diversification has become a development advantage. (3) With the effect of the rapid increase of oil and gas price, the reversal of natural gas to coal has intensified the rapid growth of global carbon emissions. (4) Structural tension is emerging in the global LNG market, and the number of long-term agreement contracts will show an increasing trend. (5) The coordinated development of natural gas and hydrogen will accelerate the arrival of the low-carbon era. (6) Methane monitoring and leakage measurement technology in the natural gas industry will become the next important innovation. (7) Governments of various countries have continuously raised the minimum level of underground gas storage, and successively issued incentive policies to increase gas reserves and production. Based on the experience, the following suggestions are put forward for the development of China's natural gas: (1) Continue to highlight the important position of the natural gas industry, increase exploration and development, and improve supply capacity and voice;(2) To adapt to the new setup of international natural gas supply caused by the COVID-19 and the conflict between Russia and Ukraine, and to formulate overall strategies for natural gas import and export trade;(3) Attach importance to LNG business, scientifically arrange the construction of LNG import supporting facilities, and take the initiative to cooperate with natural gas resource countries;(4) The whole industrial chain of natural gas and hydrogen business should be planned and deployed together, and hydrogen and natural gas infrastructure construction should be linked up effectively;(5) Increase policy support, strengthen infrastructure construction such as underground gas storage and LNG terminal, reserve more energy to develop confidence, and build a strong defense line for energy security. © 2022 Natural Gas Industry Journal Agency. All rights reserved.

17.
Australian and New Zealand Journal of Psychiatry ; 56(SUPPL 1):71, 2022.
Article in English | EMBASE | ID: covidwho-1916641

ABSTRACT

Background: In 2017 with a University of Sydney grant we designed, developed and delivered a positive psychiatry and Mental Health Massive Open Online Course (MOOC), offering a 5-week course to fill a gap in global mental health (MH) education. We included a research arm to evaluate the MOOC, which has since delivered online education to consumers, carers, clinicians and the interested public internationally with more than 185,000 registered learners, over 95,000 active learners, and over 10,000 course completers by mid-October 2021. We noted a large upswing in users with the onset of the COVID-19 pandemic and the platform host recommended our MOOC as a pandemic resource. Objectives: To examine the impact of the pandemic on participants and outcomes by comparing cohorts before and during the pandemic. Methods: We compared the quantitative outcomes between groups at baseline and after substantial course completion (n = 4734), before (n = 2340) and during (n = 2394) the pandemic. We examined online measures of mental health (MH) knowledge (an in-house test), the Depression, Anxiety and Stress Scale-21 items (DASS-21), the Flourishing Scale and stigma. Findings: The MOOC demonstrated significant improvements across measures (p < 0.05) in both cohorts, and demonstrably larger improvements in flourishing (p < 0.01) and stigma (p < 0.05) in the pandemic cohort. Conclusion: A MOOC can provide significant improvements in MH, knowledge, flourishing and stigma in non-pandemic and pandemic participants.

18.
Chinese Journal of Pharmacology and Toxicology ; 35(8):561-574, 2021.
Article in Chinese | EMBASE | ID: covidwho-1896941

ABSTRACT

Since the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the number of SARS-CoV-2 infections has been increasing and health care is facing huge challenges. Innovative drug development in emergency and the development of new indications for the treatment of Coronavirus disease 2019 (COVID-19) on the market have become critical to finding effective drugs and optimal treatment options for COVID-19. The angiotensin converting enzyme 2 (ACE2) -inducing mechanism of SARS-CoV-2 invasion into host cells and the potential therapeutic targets based on SARS-CoV-2 and (or) host include RNA-dependent RNA polymerase, 3-chymotrypsin-like protease, papain like protease, Janus kinase, interleukine-6 and immune modulators etc. Based on the pharmacological mechanism mentioned above the clinical research and development of new indications and innovative drugs for the treatment of COVID-19 have achieved great progress, but no specific drugs have been found. Some traditional Chinese medicines can block the SARS-CoV-2 replication cycle, regulate human immune response and play an important role in the treatment of COVID-19. The new drugs for COVID-19 are undergoing Phase I clinical studies worldwide, and biologic drugs are gaining momentum, accounting for 67% of the total. The problems with the research and development of drugs for COVID-19 treatment in China include inadequate of biological safety laboratories, less research on SARS-CoV-2 reacting mechanisms, shortages of non-clinical cells and animal models, imperfect research platforms for quantitative pharmacological research and training systems of professionals and poor levels of informatization of drug clinical trials and sample detection. It is hoped that China can take this opportunity to improve the ability to develop new drugs in emergency and better protect human health.

19.
Diabetes Technology and Therapeutics ; 24(SUPPL 2):A9, 2022.
Article in English | EMBASE | ID: covidwho-1895749

ABSTRACT

Background and Aims: Mobile health management platform is a potential way to achieving effective glycemic control in type 2 diabetesmellitus (T2DM) patients, especially during the Covid-19 pandemic. Lilly Connected Care Program (LCCP) is a smartphone-based app providing blood glucose monitoring and diabetes education services to improve diabetes management. This study aimed to evaluate the real-world effectiveness of LCCP platform in glycemic control among Chinese T2DM patients. Methods: This retrospective study included Chinese T2DM patients (age ≥18 years) from January 1, 2015, to January 31, 2020. Data was drawn from mobile app and electronic medical records. Propensity score matching (PSM) was used to match LCCP group and non-LCCP group to reduce confounding, with covariates including age, sex, duration of diabetes, baseline HbA1c, and number of oral diabetes medication classes. We analyzed HbA1c reduction within an average of 4 months and compared the proportions of patients achieving HbA1c reduction ≥0.5% or ≥1% between LCCP and non-LCCP groups. Comparisons were made using independent t-test and Chi-square test. Results: A total of 923 patients were included, among whom 303 pairs of patients were well-matched after PSM (Standardized Mean Difference of covariates <15%). The HbA1c reduction during 4-month follow-up was significantly larger in LCCP group than non-LCCP group (Mean±SD: 2.21 ± 2.37% vs. 1.65 ± 2.29%, P = 0.003). LCCP group had higher proportions of patients with HbA1c reduction ≥1% (69.0% vs. 57.4%, P = 0.003) and ≥0.5% (75.6% vs. 68.0%, P = 0.038). Conclusions: LCCP mobile platform was effective in glycemic control among Chinese T2DM patients in the real world.

20.
Canadian Journal of Ophthalmology-Journal Canadien D Ophtalmologie ; 57(3):E69-E70, 2022.
Article in English | Web of Science | ID: covidwho-1894094
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