Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 20 de 53
Filter
1.
The Journal of Business & Industrial Marketing ; 37(5):1111-1126, 2022.
Article in English | ProQuest Central | ID: covidwho-1788594

ABSTRACT

Purpose>This study aims to investigate moderators affecting the impact of salesperson acquisition-retention (AR) ambidexterity on sales performance based on the motivation-opportunity-ability (MOA) framework.Design/methodology/approach>The authors collected triadic data through 391 questionnaires from salespeople, 50 questionnaires from sales managers and archival data about each salesperson’s performance. Hierarchical linear modeling was applied to test the hypotheses.Findings>The results indicate that salesperson AR ambidexterity positively affects sales performance. The positive effect is strengthened by capability control but weakened by outcome control and activity control. The authors also find that sales experience and market attractiveness hurt the effectiveness of salesperson AR ambidexterity.Research limitations/implications>First, this study does not examine the mediating mechanism underlying the effect of salesperson AR ambidexterity. Second, sales-service ambidexterity is another ambidextrous variable for salespeople. Future research can consider AR and sales-service ambidexterity together.Practical implications>First, managers should be cautious when encouraging experienced salespeople to conduct AR ambidexterity. Second, managers need to use capability control to motivate salespeople with AR ambidextrous behaviors. Third, AR ambidexterity could be not required in a market with many opportunities.Originality/value>Although some studies have examined the effectiveness of salesperson AR ambidexterity, they reveal inconsistent findings, which suggest contingent conditions on the effectiveness of salesperson AR ambidexterity. However, the attention on the contingent conditions is limited. Therefore, this paper systematically investigates the contingent conditions from the MOA framework. The findings provide some insights into when salesperson AR ambidexterity is effective.

2.
Curr Med Imaging ; 2022 Apr 04.
Article in English | MEDLINE | ID: covidwho-1775541

ABSTRACT

BACKGROUND: Corona virus disease 2019 (COVID-19, previously known as novel coronavirus [2019-nCoV]), first reported in China, has now been declared a global health emergency by World Health Organization. The clinical severity ranges from asymptomatic individuals to death. Here, we report clinical features and radiological changes of a cured family cluster infected with COVID-19. CASE PRESENTATION: In this report, we enrolled a family of 4 members who were admitted to our hospital in January 2020. We performed detailed analysis of each patient's records. All patients underwent chest computed tomography (CT) examination with 120 kilovolts peak and 150 kilovolt-ampere. Real-time polymerase chain reaction (RT-PCR) examinations for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleic acid were done using nasopharyngeal swabs. CONCLUSION: Family members infected with COVID-19 who were accompanied with other diseases or had low immunity, the pneumonia was prone to be aggravated.

3.
Emerg Microbes Infect ; : 1-32, 2022 Mar 28.
Article in English | MEDLINE | ID: covidwho-1764465

ABSTRACT

AbstractAnalysis of large-scale gene expression post vaccination can provide an overview of immune responses. We used transcriptional approaches to comprehensively analyze the innate immune response signatures elicited by protein subunit (PS) vaccine ZF2001 and a mRNA vaccine named RRV. A fine-grained time-dependent dissection of large-scale gene expression post immunization revealed that ZF001 induced MHC class II-related genes, including cd74 and H2-Aa, more expeditiously than RRV. Notably, RRV induced MHC class I-related genes like Tap1/2, B2m and H2-D1/K1. At day 21 post immunization, the titers of binding and neutralization antibody (NAb) induced by both vaccines were comparable, which were accordant with the expression level of genes essential to BCR/TCR signaling transduction and B/T cells activation at day 7. However, compared to ZF2001, the early responses of RRV were more robust, including activation of pattern recognition receptors (PRRs), expression of genes involved in RNA degradation and transcription inhibition, which are directly related to anti-viral signal. This pattern also coincided with the induction of cytokines by RRV. Generally, the transcriptomic patterns of two very different vaccines mapped here provide a framework for establishing correlates between induction of genes and protection, which can be tailored for evoking specific and potent immune responses against SARS-CoV-2.

4.
Healthcare (Basel) ; 10(3)2022 Mar 04.
Article in English | MEDLINE | ID: covidwho-1731991

ABSTRACT

The use of mobile technology and equipment has been found to be successful in the governance of public health. In the context of the coronavirus disease 2019 (COVID-19) pandemic, mobile health (mhealth) apps are expected to play an important role in the governance of public health. This study establishes a structural equation model based on the digital content value chain framework, identifies the main values created by mhealth apps in the prevention and control of COVID-19, and surveys 500 citizens of China. The data were analyzed using an independent t-test and partial least squares structural equations (PLS-SEM). The results showed that people who use mhealth apps are more satisfied with public health governance than those who do not; the healthcare assurance value of mhealth apps and healthcare confidence positively influence the interaction between users and mhealth app functions, the interaction with information, and the interaction with doctors to improve users' satisfaction with public health governance; and the parasocial relationships between doctors and users of mhealth apps positively affect the interactions between users and doctors to improve users' satisfaction with public health governance. This study confirms the potential of mhealth apps toward improving public health governance during the COVID-19 pandemic from a new perspective and provides a new theoretical basis whereby mobile technology can contribute toward improving public health governance.

5.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-324298

ABSTRACT

Background: The outbreak of Coronavirus Disease 2019(COVID-19) caused psychological stress in Chinese adults population. But we are unaware of whether the pandemic causes psychological stress on children. Methods: : We used the Children’s Impact of Event Scale questionnaire (CRIES-13) to investigate the degree of Post-traumatic Stress (PTSD) symptoms caused by the pandemic in students selected from schools in Sichuan, Jiangsu, Henan, Yunnan, and Chongqing provinces of China. Results: : A total of 7769 students(3692 male and 4077 female), aged 8-18 years, were enrolled in the study, comprising 1214 in primary schools, 2799 in junior high schools and 3756 in senior high schools. A total of 1639 students (21.1%) had severe psychological stress reactions. A large proportion of senior high school students (23.3%) experienced severe psychological stress, and they had the highest median total CRIES-13 score. Female students were more likely to experience severe psychological stress and had higher median CRIES-13 total scores than males. Conclusion: COVID-19 has placed psychological stresses on primary and secondary school students in China. These stresses are more likely to reach severe levels among female students and senior high school students.

6.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-315685

ABSTRACT

Background: The novel coronavirus pneumonia (COVID-19) was entered into the critical period of epidemic prevention. Our hospital was designated as a hospital for severe pneumonia in Wuhan. Timely and effective pharmaceutical emergency support system is of great significance for the epidemic prevention and control of COVID-19. Method: In order to ensure COVID-19 patients' medication needs and ensure the safety treatment, we focus on the key points and difficult problems in the practice of pharmaceutical management during the period of COVID-19, and then formulate appropriate pharmaceutical emergency support system combined with clinical practice. Results: The pharmaceutical department quickly launched the emergency mechanism, formulated the key drug catalog for COVID-19, purchased some treatment drugs, reformed the emergency pharmacy process, established the donated drug management system, established the pharmacist consultation team, set up the "cloud pharmacy" for patients with chronic diseases other than COVID-19, and strengthened pharmacist protection management. Conclusion: During the period of COVID-19, the pharmaceutical administration is a professional, comprehensive, complex and systematic emergency project to ensure the drug supply and safety administration.

7.
Prev Med Rep ; 26: 101705, 2022 Apr.
Article in English | MEDLINE | ID: covidwho-1634770

ABSTRACT

The three-generational household was a focal point of concern for school and community the Coronavirus Disease 2019 (COVID-19) transmission. The current study, using small area data and household variables, reported an approach to neighborhood-level COVID-19 mitigation for school reopening and communities returning to normalcy. The study started with an age-stratified Poisson regression to examine the association between the proportion of three-generational households and COVID-19 infection rates based on data from 74 census tracts in Lancaster County, Nebraska, U.S. from March 5, 2020 to August 22, 2020, followed by mapping the model-based risk score by census tract in the study area. We explored the feasibility of using COVID-19 infection rates and vaccination rates to inform decision-making on school opening from March 5, 2020 to February 3, 2021. The overall infection rate increased by 3% for every unit increased in the percentage of three-generational households after controlling for other covariates in the model. The census tracts were classified into low-, medium-, and high-priority neighborhoods for potential community-based interventions, such as targeted messages for household hygiene and isolation strategies.

8.
Sci Rep ; 11(1): 23874, 2021 12 13.
Article in English | MEDLINE | ID: covidwho-1569277

ABSTRACT

The worsening progress of coronavirus disease 2019 (COVID-19) is attributed to the proinflammatory state, leading to increased mortality. Statin works with its anti-inflammatory effects and may attenuate the worsening of COVID-19. COVID-19 patients were retrospectively enrolled from two academic hospitals in Wuhan, China, from 01/26/2020 to 03/26/2020. Adjusted in-hospital mortality was compared between the statin and the non-statin group by CHD status using multivariable Cox regression model after propensity score matching. Our study included 3133 COVID-19 patients (median age: 62y, female: 49.8%), and 404 (12.9%) received statin. Compared with the non-statin group, the statin group was older, more likely to have comorbidities but with a lower level of inflammatory markers. The Statin group also had a lower adjusted mortality risk (6.44% vs. 10.88%; adjusted hazard ratio [HR] 0.47; 95% CI, 0.29-0.77). Subgroup analysis of CHD patients showed a similar result. Propensity score matching showed an overall 87% (HR, 0.13; 95% CI, 0.05-0.36) lower risk of in-hospital mortality for statin users than nonusers. Such survival benefit of statin was obvious both among CHD and non-CHD patients (HR = 0.30 [0.09-0.98]; HR = 0.23 [0.1-0.49], respectively). Statin use was associated with reduced in-hospital mortality in COVID-19. The benefit of statin was both prominent among CHD and non-CHD patients. These findings may further reemphasize the continuation of statins in patients with CHD during the COVID-19 era.


Subject(s)
COVID-19/drug therapy , Coronary Disease/drug therapy , Hydroxymethylglutaryl-CoA Reductase Inhibitors/administration & dosage , Inpatients/statistics & numerical data , Adult , Aged , Aged, 80 and over , COVID-19/mortality , China/epidemiology , Comorbidity , Coronary Disease/mortality , Female , Hospital Mortality/trends , Humans , Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use , Male , Middle Aged , Retrospective Studies , Treatment Outcome
9.
Zhongguo Yaolixue yu Dulixue Zazhi = Chinese Journal of Pharmacology and Toxicology ; - (8):561, 2021.
Article in English | ProQuest Central | ID: covidwho-1564979

ABSTRACT

Since the outbreak of the novel coronavirus (SARS-CoV-2), the number of people infected worldwide has been increasing, and the medical situation is very severe. In emergency situations, the development of innovative drugs and the treatment of new coronavirus pneumonia (COVID-19) new adaptations on the market The development of the certificate has become the only way to find specific therapeutic drugs and the best treatment plan for COVID-19. The mechanism of angiotensin-converting enzyme 2 (ACE2) that mediates the invasion of host cells by SARS-CoV-2 has been discovered and is based on SARS-CoV- 2. Potential therapeutic targets of host and host, mainly including RNA-dependent RNA polymerase, 3CL protease, papain-like protease, Janus kinase, interleukin 6 and immunomodulators, etc. According to the above-mentioned pharmacological mechanism of action, the treatment of marketed drugs Great progress has been made in the development of new indications for COVID-19 and the clinical research and development of innovative drugs, but no specific drugs have been found. Some traditional Chinese medicines in China can block the SARS-CoV-2 replication cycle, regulate the body's immune response, and treat COVID-19. Biopharmaceuticals are currently undergoing phase I clinical studies in the world for the treatment of COVID-19. Biopharmaceuticals are progressing rapidly, accounting for 67%. At present, the research and development of drugs for the treatment of COVID-19 in China is facing severe challenges and biosafety The number of protection laboratories is small, the research on the mechanism of SARS-CoV-2 infection and the body's response mechanism is not in-depth, the resources of non-clinical cells and animal models are scarce, and the professional quantitative pharmacology research platform and professional talent training system are not perfect to treat COVID-19 The informatization of drug clinical trials and sample testing capabilities are in urgent need of improvement. If China can use this to improve its ability to develop new drugs in emergency situations, it will be able to better protect people's health.

11.
Int J Biol Macromol ; 193(Pt B): 1124-1129, 2021 Dec 15.
Article in English | MEDLINE | ID: covidwho-1487744

ABSTRACT

Thrombotic complication has been an important symptom in critically ill patients with COVID-19. It has not been clear whether the virus spike (S) protein can directly induce blood coagulation in addition to inflammation. Heparan sulfate (HS)/heparin, a key factor in coagulation process, was found to bind SARS-CoV-2 S protein with high affinity. Herein, we found that the S protein can competitively inhibit the bindings of antithrombin and heparin cofactor II to heparin/HS, causing abnormal increase in thrombin activity. SARS-CoV-2 S protein at a similar concentration (~10 µg/mL) as the viral load in critically ill patients can cause directly blood coagulation and thrombosis in zebrafish model. Furthermore, exogenous heparin/HS can significantly reduce coagulation caused by S protein, pointing to a potential new direction to elucidate the etiology of the virus and provide fundamental support for anticoagulant therapy especially for the COVID-19 critically ill patients.


Subject(s)
Blood Coagulation , Heparitin Sulfate , SARS-CoV-2 , Spike Glycoprotein, Coronavirus , Thrombosis/metabolism , Animals , Heparitin Sulfate/chemistry , Heparitin Sulfate/metabolism , Humans , Mice , Protein Binding , SARS-CoV-2/chemistry , SARS-CoV-2/metabolism , Spike Glycoprotein, Coronavirus/chemistry , Spike Glycoprotein, Coronavirus/metabolism
12.
Front Aging Neurosci ; 13: 722836, 2021.
Article in English | MEDLINE | ID: covidwho-1477840

ABSTRACT

Background: This study investigated the impact of metabolic syndrome on the progression from mild parkinsonian signs (MPS) to Parkinson's disease (PD). Methods: A total of 1,563 participants with MPS completed 6 years of follow-up. The diagnosis of metabolic syndrome was made according to Adult Treatment Panel III of the National Cholesterol Education Program. The evaluations of MPS and PD were based on the motor portion of the Unified Parkinson's Disease Rating Scale. Cox proportional hazard models were used to identify the association between metabolic syndrome and PD conversion. Results: Of the 1,563 participants, 482 (30.8%) with MPS developed PD at the end of the follow-up. Metabolic syndrome (HR: 1.69, 95% CI: 1.29-2.03) was associated with the risk of PD conversion. Metabolic syndrome was associated with the progression of bradykinesia (HR: 1.85, 95% CI: 1.43-2.34), rigidity (HR: 1.36, 95% CI: 1.19-1.57), tremor (HR: 1.98, 95% CI: 1.73-2.32), and gait/balance impairment (HR: 1.66, 95% CI: 1.25-2.11). The effect of metabolic syndrome on the progression of bradykinesia and tremor was nearly two fold. Participants treated for two or three to four components of metabolic syndrome, including high blood pressure, high fasting plasma glucose, hypertriglyceridemia, and low HDL-C, had a lower risk of PD conversion. Conclusion: Metabolic syndrome increased the risk of progression from MPS to PD. Participants treated for two or more components of metabolic syndrome had a lower risk of PD conversion.

13.
Sci Total Environ ; 802: 149585, 2022 Jan 01.
Article in English | MEDLINE | ID: covidwho-1351831

ABSTRACT

The impacts of COVID-19 lockdowns on air quality around the world have received wide attention. In comparison, assessments of the implications for water quality are relatively rare. As the first country impacted by COVID-19, China implemented local and national lockdowns that shut down industries and businesses between January and May 2020. Based on monthly field measurements (N = 1693) and daily automonitoring (N = 65), this study analyzed the influence of the COVID-19 lockdown on river water quality in China. The results showed significant improvements in river water quality during the lockdown period but out-of-step improvements for different indicators. Reductions in ammonia nitrogen (NH4+-N) began relatively soon after the lockdown; chemical oxygen demand (COD) and dissolved oxygen (DO) showed improvements beginning in late January/early February and mid-March, respectively, while increases in pH were more temporally concentrated in the period from mid-March to early May. Compared to April 2019, the Water Quality Index increased at 67.4% of the stations in April 2020, with 75.9% of increases being significant. Changes in water quality parameters also varied spatially for different sites and were mainly determined by the locations and levels of economic development. After the lifting of the lockdown in June, all water quality parameters returned to pre-COVID-19 lockdown conditions. Our results clearly demonstrate the impacts of human activities on water quality and the potential for reversing ecosystem degradation by better management of wastewater discharges to replicate the beneficial impacts of the COVID-19 lockdown. CAPSULE SUMMARY: River water quality improved during China's COVID-19 lockdown, but returned to normal conditions after the lockdown.


Subject(s)
Air Pollutants , Air Pollution , COVID-19 , Air Pollutants/analysis , Air Pollution/analysis , China , Communicable Disease Control , Ecosystem , Environmental Monitoring , Humans , Particulate Matter/analysis , Rivers , SARS-CoV-2 , Water Quality
14.
Eur Respir J ; 59(2)2022 02.
Article in English | MEDLINE | ID: covidwho-1320527

ABSTRACT

The current pandemic of coronavirus disease 2019 (COVID-19) has affected >160 million individuals to date, and has caused millions of deaths worldwide, at least in part due to the unclarified pathophysiology of this disease. Identifying the underlying molecular mechanisms of COVID-19 is critical to overcome this pandemic. Metabolites mirror the disease progression of an individual and can provide extensive insights into their pathophysiological significance at each stage of disease. We provide a comprehensive view of metabolic characterisation of sera from COVID-19 patients at all stages using untargeted and targeted metabolomic analysis. As compared with the healthy controls, we observed different alteration patterns of circulating metabolites from the mild, severe and recovery stages, in both the discovery cohort and the validation cohort, which suggests that metabolic reprogramming of glucose metabolism and the urea cycle are potential pathological mechanisms for COVID-19 progression. Our findings suggest that targeting glucose metabolism and the urea cycle may be a viable approach to fight COVID-19 at various stages along the disease course.


Subject(s)
COVID-19 , Cohort Studies , Humans , Metabolomics , Pandemics , SARS-CoV-2
15.
Front Psychol ; 12: 628707, 2021.
Article in English | MEDLINE | ID: covidwho-1315957
16.
J Affect Disord ; 294: 707-713, 2021 Nov 01.
Article in English | MEDLINE | ID: covidwho-1313192

ABSTRACT

In the current study, we aimed to investigate the network structure of COVID-19 symptoms and its related psychiatric symptoms, using a network approach. Specifically, we examined how COVID-19 symptoms relate to psychiatric symptoms and highlighted potential pathways between COVID-19 severity and psychiatric symptoms. With a sample of six hundred seventy-five recovered COVID-19 patients recruited 1 month after hospital discharge, we respectively integrated COVID-19 symptoms with PTSD, depression, and anxiety symptoms and analyzed the three network structures. In all three networks, COVID-19 severity and ICU admission are not linked directly to COVID-19 symptoms after hospitalization, while COVID-19 severity (but not ICU admission) is linked directly to one or more psychiatric symptoms. Specific pathways between COVID-19 symptoms and psychiatric symptoms were discussed. Finally, we used directed acyclic graph estimation to show potential causal effects between COVID-19 related variables and demographic characteristics.


Subject(s)
COVID-19 , Stress Disorders, Post-Traumatic , Anxiety/epidemiology , Depression , Hospitals , Humans , Patient Discharge , SARS-CoV-2
17.
Trans GIS ; 2021 Jul 12.
Article in English | MEDLINE | ID: covidwho-1307868

ABSTRACT

This study compares the space-time patterns and characteristics of high-risk areas of COVID-19 transmission in Hong Kong between January 23 and April 14 (the first and second waves) and between July 6 and August 29 (the third wave). Using space-time scan statistics and the contact tracing data of individual confirmed cases, we detect the clusters of residences of, and places visited by, both imported and local cases. We also identify the built-environment and demographic characteristics of the high-risk areas during different waves of COVID-19. We find considerable differences in the space-time patterns and characteristics of high-risk residential areas between waves. However, venues and buildings visited by the confirmed cases in different waves have similar characteristics. The results can inform policymakers to target mitigation measures in high-risk areas and at vulnerable groups, and provide guidance to the public to avoid visiting and conducting activities at high-risk places.

18.
BMC Psychiatry ; 21(1): 330, 2021 07 03.
Article in English | MEDLINE | ID: covidwho-1295451

ABSTRACT

BACKGROUND: The outbreak of Coronavirus Disease 2019(COVID-19) caused psychological stress in Chinese adults population. But we are unaware of whether the pandemic causes psychological stress on children. METHODS: We used the Children's Impact of Event Scale questionnaire (CRIES-13) to investigate the degree of Post-traumatic Stress (PTSD) symptoms caused by the pandemic in students selected from schools in Sichuan, Jiangsu, Henan, Yunnan, and Chongqing provinces of China. RESULTS: A total of 7769 students(3692 male and 4077 female), aged 8-18 years, were enrolled in the study, comprising 1214 in primary schools, 2799 in junior high schools and 3756 in senior high schools. A total of 1639 students (21.1%) had severe psychological stress reactions. A large proportion of senior high school students (23.3%) experienced severe psychological stress, and they had the highest median total CRIES-13 score. Female students were more likely to experience severe psychological stress and had higher median CRIES-13 total scores than males. CONCLUSION: COVID-19 has placed psychological stresses on primary and secondary school students in China. These stresses are more likely to reach severe levels among female students and senior high school students.


Subject(s)
COVID-19 , Stress Disorders, Post-Traumatic , Adult , Child , China/epidemiology , Depression , Disease Outbreaks , Female , Humans , Male , SARS-CoV-2 , Schools , Stress Disorders, Post-Traumatic/epidemiology , Students , Surveys and Questionnaires
19.
J Med Virol ; 93(3): 1573-1580, 2021 03.
Article in English | MEDLINE | ID: covidwho-1196478

ABSTRACT

To explore the role of thymosin drugs in the prevention of novel coronavirus disease (COVID-19), we analyzed the preventive effects of different medication timings on health medical staff, and then provided recommendations for pharmaceutical monitoring of thymus drugs. The hospital-based retrospective study analyzed 435 medical staffers, treated with or without thymosin drugs as preventive medicines in our hospital of Wuhan City, from January 25 to March 25, 2020. For the prophylactics, the medical staff was prevented from pre-exposure prophylaxis (risk prevention of exposure to COVID-19 patients before using thymosin drugs) and postexposure prophylaxis (risk prevention of exposure to COVID-19 patients after using thymosin drugs). The effectiveness and safety of thymosin drugs were studied in the prevention and control of COVID-19 application, in real-world data research for the application of the drug for COVID- 19. In a similar exposure environment, compared to medical staffers who did not take preventive medicine, the use of thymosin drugs, before exposure and after exposure had an insignificant effect, and the adverse drug reaction (ADR) was increased, especially when thymosin drugs were used together with α-interferon.


Subject(s)
COVID-19/prevention & control , SARS-CoV-2/drug effects , Thymosin/therapeutic use , Adolescent , Adult , Antiviral Agents/therapeutic use , Female , Hospitals , Humans , Male , Medical Staff , Middle Aged , Pre-Exposure Prophylaxis/methods , Retrospective Studies , Young Adult
20.
J Med Virol ; 93(2): 854-862, 2021 02.
Article in English | MEDLINE | ID: covidwho-1196405

ABSTRACT

To evaluate the efficacy of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) vs calcium channel blockers (CCBs) on the progression of Corona Virus Disease 2019 (COVID-19) patients with hypertension in Wuhan. This retrospective single-center case series analyzed COVID-19 patients with hypertension, treated with ACEIs/ARBs or CCBs at the Tongji Hospital of Wuhan City, China from 25th January to 15th March 2020. After propensity score matching analysis, 76 patients were selected into two groups. Univariate and multivariable analyses were conducted to determine factors related to improvement measures and outcome measures by Cox proportional hazard regression models. Among 157 patients with confirmed COVID-19 combined hypertension, including 73 males and 84 females, a median age of 67.28 ± 9.11 vs 65.39 ± 10.85 years. A univariable analysis indicated that clinical classification, lymphocyte count, and interleukin-2 receptor were associated with a lengthened negative time of nucleic acid, with a significant difference between two groups (P = .036). Furthermore, we found no obvious difference in nucleic acid conversion time between ACEIs/ARBs and CCBs groups (hazard ratio [HR]: 0.70; 95% confidence interval [CI]: [0.97, 3.38]; P = .18) in the multivariable analysis as well as chest computed tomography improved time (HR: 0.73; 95% CI [0.45, 1.2]; P = .87), and hospitalization time between ACEIs/ARBs and CCBs groups (HR: 1.06; 95% CI [0.44, 1.1]; P = .83). Our study provided additional evidence of no obvious difference in progress and prognosis between ACEIs/ACEIs and CCBs group, which may suggest ACEIs/ARBs may have scarcely influence on increasing the clinical severe situations of COVID-19 patients with hypertension.


Subject(s)
Angiotensin Receptor Antagonists/therapeutic use , Angiotensin-Converting Enzyme Inhibitors/therapeutic use , COVID-19/drug therapy , Calcium Channel Blockers/therapeutic use , Hypertension/epidemiology , Aged , COVID-19/epidemiology , China , Disease Progression , Female , Hospitalization/statistics & numerical data , Humans , Hypertension/virology , Male , Middle Aged , Propensity Score , Proportional Hazards Models , Retrospective Studies
SELECTION OF CITATIONS
SEARCH DETAIL