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1.
The International Journal of Electrical Engineering & Education ; : 0020720920985048, 2021.
Article | WHO COVID | ID: covidwho-1093905

ABSTRACT

The new crown pneumonia (COVID-19) epidemic in 2020 has spread globally, causing schools around the world to stop routine teaching Educational institutions in various countries have adopted online teaching methods in response to this crisis This research, carried out in Human Institute of Information Technology with a number of teachers and students as its subjects, sets out to give statistical analysis upon the students' selections of online teaching platforms as well as their evaluations of online teaching At the same time, based on the online teaching practice of ?Building Structure?, a certain quantity of research upon the online teaching practice is completed among the students who began their college studies in engineering cost in the year of 2018 According to all these studies, it is evident that multiple factors such as teachers' ages, professions, and the features of various online teaching platforms, can determine which one is used by different individuals The evaluation results suggest that online teaching is necessary under the impact of the epidemic despite the fact that students may face a series of problems for lack of self-control and other possible reasons Through practice, an innovative teaching and evaluation method can partially solve the problems found in online teaching and provide useful ideas for creating higher quality teaching on the Internet

2.
Chance ; 33(3):49, 2020.
Article | WHO COVID | ID: covidwho-1089386

ABSTRACT

A variety of types of information has been collected during the COVID-19 pandemic that can lead to privacy concerns Depending on data type, the approaches and measures taken to mitigate privacy concerns can be different The privacy issues incurred by collecting and sharing location and contact tracing data have their own importance While contact tracing has proved useful in tracking and slowing down the spread of COVID-19 and plays an important role in fighting the pandemic, major newspapers such as the Washington Post and Forbes;the Reuters news agency;and government agencies have raised red flags about the high privacy risk associated with this process The information collected during contact tracing often includes detailed and frequent location data that lead to inferences about the private social life and health status of individuals

3.
International Core Journal of Engineering ; 7(1):108-115, 2021.
Article | WHO COVID | ID: covidwho-1034038

ABSTRACT

The prevention and control of the new coronavirus pneumonia outbreak poses an unprecedented and urgent need and challenge to the construction industry The development of on-site rapid assembly steel buildings for epidemic prevention and disaster relief that can promptly resolve post-disaster risks and enhance the safety and security of people's lives is the inevitable choice, or even its only choice, in the event of a public health emergency The development and application of assembled buildings is of strategic importance to enhance China's independent innovation and core competitiveness in the construction industry and to achieve sustainable economic and social development in the future This paper analyzes the application and development of assembled buildings under public health emergencies by combing the history of the development of assembled buildings, combined with the current market situation research, to provide some reference for the practical application of assembled buildings under emergency events

6.
Ann Intensive Care ; 11(1): 5, 2021 Jan 09.
Article in English | MEDLINE | ID: covidwho-1015901

ABSTRACT

BACKGROUND: Few specific medications have been proven effective for the treatment of patients with severe coronavirus disease 2019 (COVID-19). Here, we tested whether high-dose vitamin C infusion was effective for severe COVID-19. METHODS: This randomized, controlled, clinical trial was performed at 3 hospitals in Hubei, China. Patients with confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in the ICU were randomly assigned in as 1:1 ratio to either the high-dose intravenous vitamin C (HDIVC) or the placebo. HDIVC group received 12 g of vitamin C/50 ml every 12 h for 7 days at a rate of 12 ml/hour, and the placebo group received bacteriostatic water for injection in the same way within 48 h of arrival to ICU. The primary outcome was invasive mechanical ventilation-free days in 28 days (IMVFD28). Secondary outcomes were 28-day mortality, organ failure (Sequential Organ Failure Assessment (SOFA) score), and inflammation progression (interleukin-6). RESULTS: Only 56 critical COVID-19 patients were ultimately recruited due to the early control of the outbreak. There was no difference in IMVFD28 between two groups (26.0 [9.0-28.0] in HDIVC vs 22.0 [8.50-28.0] in control, p = 0.57). HDIVC failed to reduce 28-day mortality (P = 0.27). During the 7-day treatment period, patients in the HDIVC group had a steady rise in the PaO2/FiO2 (day 7: 229 vs. 151 mmHg, 95% CI 33 to 122, P = 0.01), which was not observed in the control group. IL-6 in the HDIVC group was lower than that in the control group (19.42 vs. 158.00; 95% CI -301.72 to -29.79; P = 0.04) on day 7. CONCLUSION: This pilot trial showed that HDIVC failed to improve IMVFD28, but might show a potential signal of benefit in oxygenation for critically ill patients with COVID-19 improving PaO2/FiO2 even though.

7.
Huanjing yu Zhiye Yixue = Journal of Environmental & Occupational Medicine ; 37(10):1017, 2020.
Article | WHO COVID | ID: covidwho-1005125

ABSTRACT

The global pandemic of coronavirus disease 2019 (COVID-19) remains challenging as it shows no signs of abating in key countries, but resurgence in European and East Asian regions On July 23, the cumulative number of confirmed cases worldwide exceeded 15 million The coronavirus pandemic has rebounded in some parts of China In particular, there many outbreaks of cluster infections at home and abroad recently and SARS-CoV-2 have been detected positive in multiple environment samples The role of environmental factors in the transmission of COVID-19 has attracted widespread attention This article summarized the research progress of various environmental factors[such as meteorological factors (temperature, humidity, and wind speed), contaminated water and drinking water, air, surfaces, food, food packages, and food processors, and insects] affecting the transmission of COVID-19, emphasizing that environmental sanitation is one of the keys to controlling rebound and large-scale transmission of the pandemic, and proposed corresponding prevention and control recommendations

9.
Liver Int ; 2020 Dec 22.
Article in English | MEDLINE | ID: covidwho-991633

ABSTRACT

BACKGROUND & AIMS: The outbreak of coronavirus disease 2019 (COVID-19) has been declared a pandemic. Although COVID-19 is caused by infection in the respiratory tract, extrapulmonary manifestations including dysregulation of the immune system and hepatic injury have been observed. Given the high prevalence of hepatitis B virus (HBV) infection in China, we sought to study the impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and HBV coinfection in patients. METHODS: Blood samples of 50 SARS-CoV-2 and HBV coinfected patients, 56 SARS-CoV-2 mono-infected patients, 57 HBeAg-negative chronic HBV patient controls and 57 healthy controls admitted to Renmin Hospital of Wuhan University were collected in this study. Complete blood count and serum biochemistry panels including markers indicative of liver functions were performed. Cytokines including IFN-γ, TNF-α, IL-2, IL-4, IL-6 and IL-10 were evaluated. T cell, B cell and NK cell counts were measured using flow cytometry. RESULTS: SARS-CoV-2 and HBV coinfection did not significantly affect the outcome of the COVID-19. However, at the onset of COVID-19, SARS-CoV-2 and HBV coinfected patients showed more severe monocytopenia and thrombocytopenia as well as more disturbed hepatic function in albumin production and lipid metabolism. Most of the disarrangement could be reversed after recovery from COVID-19. CONCLUSIONS: While chronic HBV infection did not predispose COVID-19 patients to more severe outcomes, our data suggest SARS-CoV-2 and HBV coinfection poses a higher extent of dysregulation of host functions at the onset of COVID-19. Thus, caution needs to be taken with the management of SARS-CoV-2 and HBV coinfected patients.

13.
J Clin Transl Hepatol ; 8(3): 246-254, 2020 Sep 28.
Article in English | MEDLINE | ID: covidwho-854699

ABSTRACT

Background and Aims: Coronavirus disease 2019 (COVID-19) is a new respiratory infectious disease caused by severe acute respiratory syndrome coronavirus-2 (commonly known as SARS-CoV-2) with multiple organ injuries. The aim of this study was to analyze COVID-19-associated liver dysfunction (LD), its association with the risk of death and prognosis after discharge. Methods: Three-hundred and fifty-five COVID-19 patients were recruited. Clinical data were collected from electronic medical records. LD was evaluated and its prognosis was tracked. The association between LD and the risk of death was analyzed. Results: Of the 355 COVID-19 patients, 211 had mild disease, 88 had severe disease, and 51 had critically ill disease. On admission, 223 (62.8%) patients presented with hypoproteinemia, 151(42.5%) with cholestasis, and 101 (28.5%) with hepatocellular injury. As expected, LD was more common in critically ill patients. By multivariate logistic regression, male sex, older age and lymphopenia were three important independent risk factors predicting LD among COVID-19 patients. Risk of death analysis showed that the fatality rate was higher in patients with hypoproteinemia than in those without hypoproteinemia (relative risk=9.471, p<0.01). Moreover, the fatality rate was higher in patients with cholestasis than those without cholestasis (relative risk=2.182, p<0.05). Follow-up observation found that more than one hepatic functional index of two-third patients remained abnormal at 14 days after discharge. Conclusions: LD at early disease stage elevates the risk of death of COVID-19 patients. COVID-19-associated LD does not recover completely by 14 days after discharge.

14.
mSphere ; 5(5)2020 10 07.
Article in English | MEDLINE | ID: covidwho-841943

ABSTRACT

Since the outbreak of coronavirus disease 2019 (COVID-19) in Wuhan, China, it has rapidly spread around the world. Persons with asymptomatic disease exhibit viral shedding, resulting in transmission, which presents disease control challenges. However, the clinical characteristics of these asymptomatic individuals remain elusive. We collected samples of 25 asymptomatic and 27 symptomatic COVID-19 patients. Viral titers of throat swabs were determined by quantitative reverse transcription-PCR (qRT-PCR). COVID-19 IgG and IgM were examined. Complete blood counts were determined, and serum biochemistry panels were performed. Cytokines, including gamma interferon (IFN-γ), tumor necrosis factor alpha (TNF-α), interleukin 2 (IL-2), IL-4, IL-6, and IL-10 were evaluated. T cell, B cell, and NK cell counts were measured using flow cytometry. Although similar viral loads were detected, asymptomatic patients had significantly faster virus turnover than symptomatic patients. Additionally, asymptomatic patients had higher counts of lymphocytes, T cells, B cells, and NK cells. While liver damage was observed in symptomatic patients, as indicated by elevated liver enzymes and decreased liver-synthesized proteins in the blood, asymptomatic patients showed normal liver measurements. Lactate dehydrogenase, a COVID-19 risk factor, was significantly lower in asymptomatic patients. These results suggest that asymptomatic COVID-19 patients had normal clinical indicators and faster viral clearance than symptomatic patients. Lymphocytes may play a role in their asymptomatic phenotype. Since asymptomatic patients may be a greater risk of virus transmission than symptomatic patients, public health interventions and a broader range of testing may be necessary for the control of COVID-19.IMPORTANCE Asymptomatic transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a potential problem for pandemic control through public health strategies. Our results demonstrate that asymptomatic COVID-19 patients have better outcomes than symptomatic patients. This may have been due to more active cellular immune responses and normal liver function. Since asymptomatic patients have no clinical symptoms which can easily prevent timely diagnosis and treatment, they may cause a greater risk of virus transmission than symptomatic patients, which poses a major challenge to infection control. Evidence suggests that nonpharmaceutical public health interventions, like social distancing and face mask ordinances, play important roles in the control of COVID-19. Looking forward, it may be necessary to proceed cautiously while reopening businesses in areas of epidemicity to prevent potential waves of COVID-19 in the future.


Subject(s)
Asymptomatic Infections , Betacoronavirus , Coronavirus Infections/diagnosis , Pneumonia, Viral/diagnosis , Adult , Betacoronavirus/isolation & purification , Biomarkers/blood , Case-Control Studies , China , Clinical Laboratory Techniques , Coronavirus Infections/blood , Coronavirus Infections/prevention & control , Coronavirus Infections/transmission , Female , Humans , Male , Middle Aged , Pandemics/prevention & control , Pneumonia, Viral/blood , Pneumonia, Viral/prevention & control , Pneumonia, Viral/transmission , Retrospective Studies , Virus Shedding
17.
Preprint | SSRN | ID: ppcovidwho-781

ABSTRACT

Background: WHO recently characterized Coronavirus disease 2019 (COVID-19) as a pandemic We aimed to evaluate and compare the efficacy of a National Early Warni

18.
Preprint | SSRN | ID: ppcovidwho-708

ABSTRACT

Background: Limited data were available for profiling the COVID-19 in pregnant women and their neonates This study aimed to investigate the clinico-radiologica

19.
Preprint | SSRN | ID: ppcovidwho-643

ABSTRACT

Background: Coronavirus disease 2019 (COVID-19) triggered by infection with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has been widely epidemi

20.
Nat. Pro. Comm. ; 9(15)2020.
Article in English | ELSEVIER | ID: covidwho-776807

ABSTRACT

At present, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread all over the world, and the best way to effectively carry out drug diagnosis and treatment presents difficulties for all medical staff. In China, some traditional Chinese medicines (TCMs) have been successfully applied to the treatment of SARS-CoV-2 and have achieved good clinical results, including the Reyanning mixture. In this study, we systematically analyzed the mechanism of the Reyanning mixture and its effects against SARS-CoV-2 based on the method of network pharmacology. Here, we used the TCM Systems Pharmacology database and employed a similarity algorithm to screen and identify the bioactive ingredients and potential targets of the Reyanning mixture. The GeneCards database was used to predict and screen the disease targets and build the active ingredient target network diagram. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to construct the target signal pathway associations. The STRING tool was used to reconstruct the protein-protein interaction network. As a result, 27 candidate targets, such as tumor necrosis factor, interferon gamma, tumor protein P53, C-reactive protein, and peroxisome proliferator-activated receptor gamma, were identified among the 33 bioactive ingredients of the 4 TCMs in the Reyanning mixture with effects on treating SARS-CoV-2. These targets were significantly enriched in 20 KEGG pathways and associated with 48 diverse GO terms. All of these targets may play a role in inhibiting inflammatory reactions, regulating immune function, and reducing lung injury to achieve the purpose of treating SARS-CoV-2.

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