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1.
China CDC Weekly ; 4(22):465-470, 2021.
Article in English | China CDC Weekly | ID: covidwho-1879866

ABSTRACT

< -type=""> <sec> Introduction Current evidence shows that coronavirus disease 2019 (COVID-19) is neither a food safety issue nor a foodborne disease. However, the outbreaks of this disease in workers of meat- or poultry-processing plants and food markets have been reported in many countries. Systematic reports on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contamination in food-related samples worldwide are lacking so far. This study aimed to survey and monitor SARS-CoV-2 contamination in samples of foods or their packaging, storage environment, and employees, as well as explore the possible potential for virus transmission via frozen foods.</sec><sec> Methods Swabs of frozen food-related samples were collected between July 2020 and July 2021 in 31 provincial-level administrative divisions (PLADs) and Xinjiang Construction Corps in China. The SARS-CoV-2 RNAs were extracted and analyzed by real-time quantitative polymerase chain reaction using the commercially available SARS-CoV-2 nucleic acid test kit.</sec><sec> Results More than 55.83 million samples were analyzed, and 1,455 (0.26 per 10,000) were found to be positive for SARS-CoV-2 nucleic acid. Among the virus-positive samples, 96.41% (1,398/1,450) and 3.59% (52/1,450) were food/food packaging materials and environment, respectively. As for 1,398 SARS-CoV-2-positive food and food packaging materials, 99.50%, (1,391/1,398) were imported and 7 were domestic. The outer packaging of food was frequently contaminated by the virus 78.75% ( 1,101/1,398).</sec><sec> Conclusions Our study supported speculation that cold-chain foods might act as the SARS-CoV-2 carrier, and food handlers/operators were at high risk of exposure to the virus. It is necessary to carry out a comprehensive mass testing for SARS-CoV-2 nuclei acid, along with contact tracing and symptom screening in cold-chain food handlers and processors so as to identify high proportions of asymptomatic or pre-symptomatic infections. Meanwhile, research and development of effective self-protection equipment available at a temperature below −18 ℃ is urgent.</sec>

2.
China CDC Weekly ; 4(22):483-487, 2022.
Article in English | China CDC Weekly | ID: covidwho-1879864

ABSTRACT

< -type=""> Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA contamination was reported on China’s imported frozen foods and packaging materials. However, there was no evidence of this disease initiated by environment-to-human transmission until the outbreak of coronavirus disease 2019 (COVID-19) in Beijing in June 2020. This article aimed to analyze and summarize COVID-19 outbreaks related to cold-chain foods to provide a scientific basis for tracing the epidemiological trajectory of the pandemic, providing risk assessments, and mitigation policies. Overall, 37 COVID-19 outbreaks and 5,741 infected cases were reported within the study period. It was found that 7 outbreaks and 689 cases were linked to imported frozen foods. The first index case among the 7 outbreaks was exposed to SARS-CoV-2-contaminated outer packaging of frozen food, triggering the subsequent community transmission. This study supported the speculation that cold-chain foods act as a pathway for SARS-CoV-2 and might present a risk for virus transmission between countries and regions. Handlers and processors exposed to the imported frozen foods should be effectively self-protected, daily monitored for clinical manifestations of COVID-19, and tested for SARS-CoV-2 nucleic acid at regular intervals.

3.
Signal Transduct Target Ther ; 7(1): 172, 2022 Jun 06.
Article in English | MEDLINE | ID: covidwho-1878517

ABSTRACT

The increased coronavirus disease 2019 (COVID-19) breakthrough cases pose the need of booster vaccination. We conducted a randomised, double-blinded, controlled, phase 2 trial to assess the immunogenicity and safety of the heterologous prime-boost vaccination with an inactivated COVID-19 vaccine (BBIBP-CorV) followed by a recombinant protein-based vaccine (NVSI-06-07), using homologous boost with BBIBP-CorV as control. Three groups of healthy adults (600 individuals per group) who had completed two-dose BBIBP-CorV vaccinations 1-3 months, 4-6 months and ≥6 months earlier, respectively, were randomly assigned in a 1:1 ratio to receive either NVSI-06-07 or BBIBP-CorV boost. Immunogenicity assays showed that in NVSI-06-07 groups, neutralizing antibody geometric mean titers (GMTs) against the prototype SARS-CoV-2 increased by 21.01-63.85 folds on day 28 after vaccination, whereas only 4.20-16.78 folds of increases were observed in control groups. For Omicron variant, the neutralizing antibody GMT elicited by homologous boost was 37.91 on day 14, however, a significantly higher neutralizing GMT of 292.53 was induced by heterologous booster. Similar results were obtained for other SARS-CoV-2 variants of concerns (VOCs), including Alpha, Beta and Delta. Both heterologous and homologous boosters have a good safety profile. Local and systemic adverse reactions were absent, mild or moderate in most participants, and the overall safety was quite similar between two booster schemes. Our findings indicated that NVSI-06-07 is safe and immunogenic as a heterologous booster in BBIBP-CorV recipients and was immunogenically superior to the homologous booster against not only SARS-CoV-2 prototype strain but also VOCs, including Omicron.


Subject(s)
COVID-19 Vaccines , COVID-19 , Immunization, Secondary , Adult , Antibodies, Neutralizing/blood , Antibodies, Viral/blood , COVID-19/prevention & control , COVID-19 Vaccines/immunology , Humans , SARS-CoV-2
4.
Journal of Water Process Engineering ; 48:102834, 2022.
Article in English | ScienceDirect | ID: covidwho-1867447

ABSTRACT

Hospitals generate large volumes of wastewater. Dissolved organic matter (DOM) in wastewater effluent can act as precursors of disinfection by-products, transporter of pollutants, and affect the performance of treatment plants. This study aims to characterize the composition of DOM in medical wastewater and investigate the selectivity of the hospital treatment plant in the removal of DOM. DOM was characterized by Fourier-transform ion-cyclotron resonance mass spectrometry (FT-ICR-MS) and excitation-emission matrix fluorescence spectroscopy (EEMs). DOM of medical wastewater was dominated by aliphatic and highly unsaturated compounds, a feature that is remarkably different from that of natural DOM. In the membrane bioreactor (MBR) unit, more CHNO compounds and highly unsaturated compounds were formed. After disinfection, the highly unsaturated and humic-like compounds were reduced, accompanying a decrease in aromaticity. After reverse osmosis, the highly unsaturated and CHO compounds were concentrated and removed. These steps were complementary in the removal of DOM, suggesting effective transformation and elimination of DOM. This study contributes to a better understanding of the features of DOM in medical wastewater and treatment plant performance in the removal of DOM, which is indispensable for the large-scale design and application of technologies for hospital wastewater treatment, especially in the context of the COVID-19 pandemic.

5.
Clin Cosmet Investig Dermatol ; 15: 947-954, 2022.
Article in English | MEDLINE | ID: covidwho-1866436

ABSTRACT

Background: Coronavirus disease 2019 (COVID-19) has developed into a worldwide pandemic, which presents several challenges for frontline health-care workers (HCWs). HCWs are highly prone to various skin diseases due to prolonged use of personal protective equipment (PPE). The most frequently used type of PPE is facemasks. To effectively control adverse skin reactions, there is an urgent need for a range of preventive practices. Methods: This cross-sectional study was conducted at 12 hospitals in Zhejiang province, China. HCWs were invited to participate in the web survey. Data were extracted by two independent reviewers using a predesigned data collection form and analyzed with SPSS 20.0. Results: A total of 1147 questionnaires were collected, and of these, 1090 (95.03%) were valid and returned. The incidence of chest tightness and shortness of breath and face eczema was significantly higher in HCWs wearing N95 facemasks (41.91%; 31.62%) than in the HCWs wearing medical facemasks (38.05%, P = 0.010; 21.91%, P = 0.012). The incidence of ear pain and indentation was significantly higher in HCWs wearing hang-facemasks (83.81%) than in HCWs wearing strains-facemasks (61.19%, P < 0.001). The incidence of ear pain and indentation was significantly higher in HCWs wearing undiscriminating size code facemasks (79.88%) than in the HCWs wearing discriminating size code facemasks (67.86%, P = 0.031). There was a significant reduction (P < 0.001) in the incidence of HCWs without adverse reactions (ADRs) with increasing time wearing facemasks. Conclusion: Incidence of ADRs does not significantly increase with the durations of mask wear where wearing mask time exceeded 4 hours per day. The medical staff generally wore masks for more than 4 hours per day; therefore, we recommend taking 15 min of rest after 2 hours of mask-wearing. Results in this study support the conclusion that the type of strain-facemasks and discriminating size code facemasks has a lower incidence of ADRs than other type of medical facemasks.

6.
Exp Ther Med ; 23(5): 321, 2022 May.
Article in English | MEDLINE | ID: covidwho-1818257

ABSTRACT

Non-traumatic osteonecrosis of the femoral head is the main cause of disability in young individuals and incurs major health care expenditure. The lifestyle changes in recent years, especially increased use of hormones and alcohol consumption, has greatly increased the incidence of femoral head necrosis. The underlying causes and risk factors of osteonecrosis of the femoral head are increasingly being elucidated, which has led to the development of novel surgical and non-surgical treatment options. Although the main goal of any treatment method is prevention and delaying the progression of disease, there is no common consensus on the most suitable method of treatment. The present review discussed the latest developments in the etiology and treatment methods for femoral head necrosis.

7.
China CDC Weekly ; 4(14):302-305, 2022.
Article in English | China CDC Weekly | ID: covidwho-1786624

ABSTRACT

< -type=""> <sec>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RNA contamination was reported on China’s imported frozen foods and packaging materials. However, there was no evidence of this disease initiated by environment-to-human transmission until the outbreak of coronavirus disease 2019 (COVID-19) in Beijing in June 2020. This article aims to analyze and summarize COVID-19 outbreaks related to cold-chain foods to provide a scientific basis for tracing the epidemiological trajectory of the pandemic, providing risk assessments, and mitigation policies.</sec><sec>Overall, 37 COVID-19 outbreaks and 5,741 infected cases were reported within the study period. It was found that 7 outbreaks and 689 cases were linked to imported frozen foods. The first index case among the 7 outbreaks was exposed to SARS-CoV-2-contaminated outer packaging of frozen food, triggering the subsequent community transmission.</sec><sec>This study supported the speculation that cold-chain foods act as a pathway for SARS-CoV-2 and might present a risk for virus transmission between countries and regions. Handlers and processors exposed to the imported frozen foods should be effectively self-protected, daily monitored for clinical manifestations of COVID-19, and tested for SARS-CoV-2 nucleic acid at regular intervals.</sec>

8.
J Obstet Gynaecol Can ; 2022 Apr 05.
Article in English | MEDLINE | ID: covidwho-1773526

ABSTRACT

OBJECTIVE: Significant changes to the delivery of obstetrical care that occurred with the onset of the COVID-19 pandemic may be associated with higher risks of adverse maternal outcomes. We evaluated preeclampsia/HELLP (hemolysis, elevated liver enzymes and low platelets) syndrome and composite severe maternal morbidity (SMM) among pregnant people who gave birth during the COVID-19 pandemic and compared these data with those of people who gave birth before the pandemic in Ontario, Canada. METHODS: This was a population-based, retrospective cohort study using linked administrative data sets from ICES. Data on pregnant people at ≥20 weeks gestation who gave birth between March 15, 2020, and September 30, 2021, were compared with those of pregnant people who gave birth within the same date range for the years 2015-2019. We used multivariable logistic regression to assess the effect of the pandemic period on the odds of preeclampsia/HELLP syndrome and composite SMM, adjusting for maternal baseline characteristics and comorbidities. RESULTS: There were no differences between the study periods in the adjusted odds ratios (aORs) for preeclampsia/HELLP syndrome among primiparous (aOR 1.00; 95% CI 0.91-1.11) and multiparous (aOR 0.94; 95% CI 0.81-1.09) patients and no differences for composite SMM (primiparous, aOR 1.00; 95% CI 0.95-1.05; multiparous, aOR 1.01; 95% CI 0.95-1.08). CONCLUSION: Adverse maternal outcomes were not higher among pregnant people who gave birth during the first 18 months of the COVID-19 pandemic in Ontario, Canada, when compared with those who gave birth before the pandemic.

9.
EuropePMC; 2022.
Preprint in English | EuropePMC | ID: ppcovidwho-331897

ABSTRACT

Large-scale populations in the world have been vaccinated with COVID-19 vaccines, however, breakthrough infections of SARS-CoV-2 are still growing rapidly due to the emergence of immune-evasive variants, especially Omicron. It is urgent to develop effective broad-spectrum vaccines to better control the pandemic of these variants. Here, we present a mosaic-type trimeric form of spike receptor-binding domain (mos-tri-RBD) as a broad-spectrum vaccine candidate, which carries the key mutations from Omicron and other circulating variants. Tests in rats showed that the designed mos-tri-RBD, whether used alone or as a booster shot, elicited potent cross-neutralizing antibodies against not only Omicron but also other immune-evasive variants. Neutralizing antibody titers induced by mos-tri-RBD were substantially higher than those elicited by homo-tri-RBD (containing homologous RBDs from prototype strain) or the inactivated vaccine BBIBP-CorV. Our study indicates that mos-tri-RBD is highly immunogenic, which may serve as a broad-spectrum vaccine candidate in combating SARS-CoV-2 variants including Omicron.

10.
J Affect Disord ; 307: 62-68, 2022 06 15.
Article in English | MEDLINE | ID: covidwho-1747863

ABSTRACT

BACKGROUND: COVID-19 pandemic may impact the prevalence and incidence of depression in college students. However, there is no longitudinal study focusing on major depressive disorder (MDD) before and during COVID-19 pandemic. METHODS: A cohort study was carried out among 8079 Chinese college freshmen. The baseline survey was conducted in 2018 (T0) and annual follow-ups were in 2019 (T1, before COVID-19) and in 2020 (T2, during COVID-19). CIDI-3.0 was used to diagnose MDD. Random effects logistic models of panel data analysis were used for the risk of MDD incidence. STATA 15.1 was used for all analysis. RESULTS: The weighted 12-month prevalence of MDD at T2 (2.10%) was significantly lower than that at T1 (2.67%) (p < 0.001). However, among students who reported exposure to the COVID-19 events, the annual prevalence of MDD at T2 was higher than that at T1 (4.21% vs. 2.79%, p < 0.001). The incidence from T0 to T1, incidence from T1 to T2, and the 2-year incidence was 2.23%, 1.34% and 3.75%, respectively. Only 8.93% of MDD students had chosen to seek professional help during the COVID-19 pandemic period. LIMITATIONS: The computer assisted CIDI may not be as sensitive and specific as the diagnosis made by a psychiatrist and may have caused report bias. CONCLUSIONS: Although the MDD incidence of college students was decreasing over time, the impact of the pandemic on student mental health may depend on exposure to COVID-19 events. Not seeking professional help in the Chinese college students is still an important issue.


Subject(s)
COVID-19 , Depressive Disorder, Major , COVID-19/epidemiology , China/epidemiology , Cohort Studies , Depressive Disorder, Major/diagnosis , Depressive Disorder, Major/epidemiology , Humans , Incidence , Pandemics , Prevalence , Universities
11.
Current psychology (New Brunswick, N.J.) ; : 1-10, 2022.
Article in English | EuropePMC | ID: covidwho-1728565

ABSTRACT

This study explores the relationship between adolescents’ perceptions of epidemic risk and their emotions through three follow-up surveys during the early stages of the COVID-19 pandemic on February 11th (T1), 18th (T2), and 25th (T3), 2020. Three hundred and four adolescents in different academic stages (junior high middle school, senior high middle school, and university) participated in the online survey, and cross-lag analysis was used to examine the causal relationship between epidemic risk perceptions and positive and negative emotions. The results found that the individual’s positive emotions were significantly higher than the negative emotions in T1, T2 and T3. Cross-lag analysis found that for positive emotions, T2 positive emotions could negatively predict T3 epidemic risk perceptions, and T2 epidemic risk perceptions could negatively predict the individual’s T3 positive emotions. For negative emotions, risk perceptions at T1 could positively predict negative emotions at T2, and at the same time, negative emotions at T1 could also positively predict epidemic risk perceptions at T2. This indicates that during the early stages of the COVID-19 pandemic, there was a causal relationship between the perceptions of epidemic risk and the emotions of adolescents, and this relationship had high stability among groups of different genders and academic stages.

12.
Cell Discov ; 8(1): 17, 2022 Feb 15.
Article in English | MEDLINE | ID: covidwho-1692628

ABSTRACT

The continuous emergence of SARS-CoV-2 variants highlights the need of developing vaccines with broad protection. Here, according to the immune-escape capability and evolutionary convergence, the representative SARS-CoV-2 strains carrying the hotspot mutations were selected. Then, guided by structural and computational analyses, we present a mutation-integrated trimeric form of spike receptor-binding domain (mutI-tri-RBD) as a broadly protective vaccine candidate, which combined heterologous RBDs from different representative strains into a hybrid immunogen and integrated immune-escape hotspots into a single antigen. When compared with a homo-tri-RBD vaccine candidate in the stage of phase II trial, of which all three RBDs are derived from the SARS-CoV-2 prototype strain, mutI-tri-RBD induced significantly higher neutralizing antibody titers against the Delta and Beta variants, and maintained a similar immune response against the prototype strain. Pseudo-virus neutralization assay demonstrated that mutI-tri-RBD also induced broadly strong neutralizing activities against all tested 23 SARS-CoV-2 variants. The in vivo protective capability of mutI-tri-RBD was further validated in hACE2-transgenic mice challenged by the live virus, and the results showed that mutI-tri-RBD provided potent protection not only against the SARS-CoV-2 prototype strain but also against the Delta and Beta variants.

13.
Int J Environ Res Public Health ; 19(2)2022 01 13.
Article in English | MEDLINE | ID: covidwho-1625145

ABSTRACT

The COVID-19 pandemic outbreak in December 2019 has spread globally. The ongoing psychological and behavioral effects of the COVID-19 pandemic, which poses a major challenge to humanity, are of concern to researchers. To understand the academic community's attention, focus and research collaboration on psychological and behavioral research during the COVID-19 pandemic, we conducted a macro analysis using a bibliometric approach. Using the topic selection strategy of TS = ("COVID-19" OR "coronavirus disease 2019" OR "SARS-CoV-2" OR "2019-nCoV") AND TS = ("behavio*") AND TS = ("psycholog*"), 2096 high-quality research articles and reviews were downloaded as data from the Web of Science core collection on 16 November 2021. Through analysis and visualization, the following conclusions are drawn in this study: (1) The popularity and importance of psychological and behavioral research under COVID-19 has increased significantly and needs further attention; (2). Related research focuses on eight hotspots, with quarantine, health care workers, the elderly, students, pregnant women, family, consumers, social media and emergency preparedness knowledge as the focus of the research object; and (3) Research collaboration is relatively high at the author, organizational and national levels. However, low-income countries need to get more attention. Furthermore, this article would help researchers make decisions for the research of psychological and behavioral issues under COVID-19 and planning for future prospects to contribute to academic development and applied methodology.


Subject(s)
COVID-19 , Aged , Behavioral Research , Bibliometrics , Female , Humans , Pandemics , Pregnancy , SARS-CoV-2
14.
Environments ; 8(12):137, 2021.
Article in English | ProQuest Central | ID: covidwho-1591933

ABSTRACT

Busy street canyons can have a large flow of vehicles and reduced air exchange and wind speeds at street level, exposing pedestrians to high pollutant concentrations. The airflow tended to move with vehicles along the canyon and the 1-s concentrations of NO, NO2 and CO were highly skewed close to the road and more normally distributed at sensors some metres above the road. The pollutants were more autocorrelated at these elevated sensors, suggesting a less variable concentration away from traffic in the areas of low turbulence. The kerbside concentrations also showed cyclic changes approximating nearby traffic signal timing. The cross-correlation between the concentration measurements suggested that the variation moved at vehicle speed along the canyon, but slower vertically. The concentrations of NOx and CO were slightly higher at wind speeds of under a metre per second. The local ozone concentrations had little effect on the proportion of NOx present as NO2. Pedestrians on the roadside would be unlikely to exceed the USEPA hourly guideline value for NO2 of 100 ppb. Across the campaign period, 100 individual minutes exceeded the guidelines, though the effect of short-term, high-concentration exposures is not well understood. Tram stops at the carriageway divider are places where longer exposures to higher levels of traffic-associated pollutants are possible.

15.
Pregnancy Hypertens ; 26: 17-23, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1364411

ABSTRACT

AIMS: The aim of this study was to apply the Mendelian randomization (MR) design to explore the potential causal association between COVID-19 and the risk of hypertension disorders in pregnancy. METHODS: Our primary genetic instrument comprised 8 single-nucleotide polymorphisms (SNPs) associated with COVID-19 at genome-wide significance. Data on the associations between the SNPs and the risk of hypertension disorders in pregnancy were obtained from study based on a very large cohort of European population. The random-effects inverse-variance weighted method was conducted for the main analyses, with a complementary analysis of the weighted median and MR-Egger approaches. RESULTS: Using IVW, we found that genetically predicted COVID-19 was significantly positively associated with hypertension disorders in pregnancy, with an odds ratio (OR) of 1.111 [95% confidence interval (CI) 1.042-1.184; P = 0.001]. Weighted median regression also showed directionally similar estimates [OR 1.098 (95% CI, 1.013-1.190), P = 0.023]. Both funnel plots and MR-Egger intercepts suggest no directional pleiotropic effects observed. CONCLUSIONS: Our findings provide direct evidence that there is a shared genetic predisposition so that patients infected with COVID-19 may be causally associated with increased risk of hypertension disorders in pregnancy.


Subject(s)
COVID-19/genetics , Genetic Predisposition to Disease , Hypertension/etiology , Mendelian Randomization Analysis/methods , Polymorphism, Single Nucleotide , Risk Assessment/methods , SARS-CoV-2 , COVID-19/complications , COVID-19/epidemiology , Female , Global Health , Humans , Hypertension/epidemiology , Hypertension/genetics , Incidence , Pregnancy , Risk Factors
16.
Intervirology ; 65(1): 29-36, 2022.
Article in English | MEDLINE | ID: covidwho-1299259

ABSTRACT

OBJECTIVE: The aim of the study was to analyze the relationship between serum antibody and neutralizing antibody titers in convalescent coronavirus disease 2019 (COVID-19) patients with different disease severities, and the seropositive reaction rates of 9 reported B-cell epitopes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). METHODS: Serum IgG and total antibody titers of 165 convalescent COVID-19 patients were determined by chemiluminescence, the serum neutralization antibody titers were determined by microneutralization assay, and the S/CO values of 9 peptides were detected by indirect enzyme-linked immunosorbent assay. Correlations between the aforementioned indexes were statistically analyzed, and differences in patients with different diseases severities were evaluated. RESULTS: IgG, total antibody, and neutralizing antibody titers increased with disease severity. The positive rate of the receptor-binding region (RBD) was 100%, and the average positive rate for all the 9 peptides was above 50% in 165 patients. IDf showed the highest rate of positivity (86.06%), with a rate of 95% for the (IDf + IDa) pattern. Moreover, S/CO values of RBD and mix (IDh) were significantly correlated with IgG, total antibody titers, and neutralizing antibody titers (p < 0.001), whereas the S/CO values for other 8 peptides showed no obvious correlation. CONCLUSION: In this study, a large sample was used to confirm that the peptide IDf had a high positive reaction rate for all patients (86.06%) and also had the highest detection rate in asymptomatic patients (86.67%). Only long peptide and mixed peptide showed correlation with neutralizing antibody titers, suggesting that the ability of SARS-CoV-2 antibody to neutralize virus infectivity may require the interaction of multiple sites.


Subject(s)
Antibodies, Neutralizing/immunology , Antibodies, Viral/immunology , Epitopes, B-Lymphocyte , Spike Glycoprotein, Coronavirus/immunology , COVID-19/immunology , Epitopes, B-Lymphocyte/immunology , Humans , Immunoglobulin G/immunology , SARS-CoV-2
18.
Animal Model Exp Med ; 4(1): 2-15, 2021 03.
Article in English | MEDLINE | ID: covidwho-1122088

ABSTRACT

Background: Cardiovascular diseases (CVDs) and diabetes mellitus (DM) are top two chronic comorbidities that increase the severity and mortality of COVID-19. However, how SARS-CoV-2 alters the progression of chronic diseases remain unclear. Methods: We used adenovirus to deliver h-ACE2 to lung to enable SARS-CoV-2 infection in mice. SARS-CoV-2's impacts on pathogenesis of chronic diseases were studied through histopathological, virologic and molecular biology analysis. Results: Pre-existing CVDs resulted in viral invasion, ROS elevation and activation of apoptosis pathways contribute myocardial injury during SARS-CoV-2 infection. Viral infection increased fasting blood glucose and reduced insulin response in DM model. Bone mineral density decreased shortly after infection, which associated with impaired PI3K/AKT/mTOR signaling. Conclusion: We established mouse models mimicked the complex pathological symptoms of COVID-19 patients with chronic diseases. Pre-existing diseases could impair the inflammatory responses to SARS-CoV-2 infection, which further aggravated the pre-existing diseases. This work provided valuable information to better understand the interplay between the primary diseases and SARS-CoV-2 infection.


Subject(s)
COVID-19/complications , COVID-19/physiopathology , Cardiovascular Diseases/complications , Cardiovascular Diseases/physiopathology , Diabetes Complications/physiopathology , Animals , Comorbidity , Diabetes Mellitus , Disease Models, Animal , Male , Mice , SARS-CoV-2
19.
SciFinder; 2020.
Preprint | SciFinder | ID: ppcovidwho-3865

ABSTRACT

the prevention and treatment of New Coronavirus Pneumonia epidemic is reviewed from perspective of Chinese traditional medicine. Also an outlook for future development for prevention of epidemic using Chinese medicine is provided.

20.
Technol Forecast Soc Change ; 163: 120435, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-894238

ABSTRACT

This paper evaluates the impact of COVID-19 media coverage in mitigating its spread in China during the early phase of the pandemic. We construct a provincial-level dataset on COVID-19 and link it with population mobility data, among other control variables, to estimate how media coverage mitigates the spread of COVID-19. Seemingly unrelated regressions are used to examine the simultaneous impact of media coverage on the number of new cases and close contacts. The results show that the effect of media coverage on COVID-19 transmission in China had an inverse-U curvature and was mediated by within- and across-province population mobility. Our simulation results indicate that COVID-19 media coverage in China was associated with a potential reduction of 394,000 cases and 1.4 million close contacts during January 19 and February 29, 2020. Our results also provide strong support for the use of contact tracing in mitigating COVID-19 transmission.

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