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1.
2021 AIS SIGED International Conference on Information Systems Education and Research ; 2021.
Article in English | Scopus | ID: covidwho-1958155

ABSTRACT

The COVID-19 pandemic has impacted the global economy massively, resulting in a magnitude of transitions and transformations in labor markets worldwide. Along with the need for more upskilling and reskilling, skills-based hiring has become another accelerating trend during the pandemic. Skill-based hiring challenges educators to take an innovative as well as viable approach to prepare students for this evolving workforce landscape. We propose a skills-focused approach emphasizing more on skills-based competencies rather than solely knowledge-based degree qualifications. This study demonstrates how we are reshaping our Information Technology (IT) undergraduate program with major shifts in thinking about how hiring is done today. We map the undergraduate IT curriculum against the skills identified from current job posting websites, aiming to align the course content to competencies and skills sought after by the employers. We are also creating various innovative channels to expand experiential learning opportunities for skills enhancement. © Proceedings of the 2021 AIS SIGED International Conference on Information Systems Education and Research.

2.
Natural Product Communications ; 17(7), 2022.
Article in English | EMBASE | ID: covidwho-1956964

ABSTRACT

Objective: The Chinese herbal formula Huo-Xiang-Zheng-Qi (HXZQ) is effective in preventing and treating coronavirus disease 19 (COVID-19) infection;however, its mechanism remains unclear. This study used network pharmacology and molecular docking techniques to investigate the mechanism of action of HXZQ in preventing and treating COVID-19. Methods: The Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) was used to search for the active ingredients and targets of the 10 traditional Chinese medicines (TCMs) of HXZQ prescription (HXZQP). GeneCards, Online Mendelian Inheritance in Man (OMIM), Pharmacogenomics Knowledge Base (PharmGKB), Therapeutic Target Database (TTD), and DrugBank databases were used to screen COVID-19-related genes and intersect them with the targets of HXZQP to obtain the drug efficacy targets. Cytoscape 3.8 software was used to construct the drug-active ingredient–target interaction network of HXZQP and perform protein–protein interaction (PPI) network construction and topology analysis. R software was used to perform Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Finally, AutoDock Vina was utilized for molecular docking of the active ingredients of TCM and drug target proteins. Results: A total of 151 active ingredients and 250 HXZQP targets were identified. Among these, 136 active ingredients and 67 targets of HXZQP were found to be involved in the prevention and treatment of COVID-19. The core proteins identified in the PPI network were MAPK1, MAPK3, MAPK8, MAPK14, STAT3, and PTGS2. Using GO and KEGG pathway enrichment analysis, HXZQP was found to primarily participate in biological processes such as defense response to a virus, cellular response to biotic stimulus, response to lipopolysaccharide, PI3K-Akt signaling pathway, Th17 cell differentiation, HIF-1 signaling pathway, and other signaling pathways closely related to COVID-19. Molecular docking results reflected that the active ingredients of HXZQP have a reliable affinity toward EGFR, MAPK1, MAPK3, MAPK8, and STAT3 proteins. Conclusion: Our study elucidated the main targets and pathways of HXZQP in the prevention and treatment of COVID-19. The study findings provide a basis for further investigation of the pharmacological effects of HXZQP.

3.
Chinese Journal of Microsurgery ; 45(1):1-4, 2022.
Article in Chinese | Scopus | ID: covidwho-1954153

ABSTRACT

Chinese Journal of Microsurgery, based on the premise of doing well in the prevention and control of COVID-19 pandemics, shall keep on driving on the inheritance and innovation, carry forward the spirit of microsurgery, give full play to the advantages of microsurgery technology and improve the level of surgical repair and reconstruction, as well as try new ways for academic communications and give full play to the roles of an academic platform for a professional magazine;Clinical Orthopaedic Microsurgery (internal communication), the internal journal of editorial office, is the "showcase in China" to highlight and disseminate the achievements in microsurgery, focus on the support for the Chinese young microsurgeons who work in the front-line of medical services, provide a platform effectively for the young microsurgeons in China to actively participate in the Sino-English literary exchange, and truly "publish the papers on the land of our motherland". © 2022 by the authors.

4.
LANCET ; 399(10342):2212-2225, 2022.
Article in English | Web of Science | ID: covidwho-1935221

ABSTRACT

Background Vaccination of children and young people against SARS-CoV-2 is recommended in some countries. Scarce data have been published on immune responses induced by COVID-19 vaccines in people younger than 18 years compared with the same data that are available in adults. Methods COV006 is a phase 2, single-blind, randomised, controlled trial of ChAdOx1 nCoV-19 (AZD1222) in children and adolescents at four trial sites in the UK. Healthy participants aged 6-17 years, who did not have a history of chronic respiratory conditions, laboratory-confirmed COVID-19, or previously received capsular group B meningococcal vaccine (the control), were randomly assigned to four groups (4:1:4:1) to receive two intramuscular doses of 5 x 10(1)degrees viral particles of ChAdOx1 nCoV-19 or control, 28 days or 84 days apart. Participants, clinical investigators, and the laboratory team were masked to treatment allocation. Study groups were stratified by age, and participants aged 12-17 years were enrolled before those aged 6-11 years. Due to the restrictions in the use of ChAdOx1 nCoV-19 in people younger than 30 years that were introduced during the study, only participants aged 12-17 years who were randomly assigned to the 28-day interval group had received their vaccinations at the intended interval (day 28). The remaining participants received their second dose at day 112. The primary outcome was assessment of safety and tolerability in the safety population, which included all participants who received at least one dose of the study drug. The secondary outcome was immunogenicity, which was assessed in participants who were seronegative to the nucleocapsid protein at baseline and received both prime and boost vaccine. This study is registered with ISRCTN (15638344). Findings Between Feb 15 and April 2, 2021, 262 participants (150 [57%] participants aged 12-17 years and 112 [43%] aged 6-11 years;due to the change in the UK vaccination policy, the study terminated recruitment of the younger age group before the planned number of participants had been enrolled) were randomly assigned to receive vaccination with two doses of either ChAdOx1 nCoV-19 (n=211 [n=105 at day 28 and n=106 at day 84]) or control (n=51 [n=26 at day 28 and n=25 at day 84]). One participant in the ChAdOx1 nCoV-19 day 28 group in the younger age bracket withdrew their consent before receiving a first dose. Of the participants who received ChAdOx1 nCoV-19, 169 (80%) of 210 participants reported at least one solicited local or systemic adverse event up to 7 days following the first dose, and 146 (76%) of 193 participants following the second dose. No serious adverse events related to ChAdOx1 nCoV-19 administration were recorded by the data cutoff date on Oct 28, 2021. Of the participants who received at least one dose of ChAdOx1 nCoV-19, there were 128 unsolicited adverse events up to 28 days after vaccination reported by 83 (40%) of 210 participants. One participant aged 6-11 years receiving ChAdOx1 nCoV-19 reported a grade 4 fever of 40.2 degrees C on day 1 following first vaccination, which resolved within 24 h. Pain and tenderness were the most common local solicited adverse events for all the ChAdOx1 nCoV-19 and capsular group B meningococcal groups following both doses. Of the 242 participants with available serostatus data, 14 (6%) were seropositive at baseline. Serostatus data were not available for 20 (8%) of 262 participants. Among seronegative participants who received ChAdOx1 nCoV-19, anti-SARS-CoV-2 IgG and pseudoneutralising antibody titres at day 28 after the second dose were higher in participants aged 12-17 years with a longer interval between doses (geometric means of 73 371 arbitrary units [AU]/mL [95% CI 58 685-91 733] and 299 half-maximal inhibitory concentration [IC 50;95% CI 230-390]) compared with those aged 12-17 years who received their vaccines 28 days apart (43 280 AU/mL [95% CI 35 852-52 246] and 150 IC 50 [95% CI 116-194]). Humoral responses were higher in those aged 6-11 years than in those aged 12-17 years receiving their second dose at the same 112-day interval (geometric mean ratios 1.48 [95% CI 1.07-2.07] for anti-SARS-CoV-2 IgG and 2.96 [1.89-4.62] for pseudoneutralising antibody titres). Cellular responses peaked after a first dose of ChAdOx1 nCoV-19 across all age and interval groups and remained above baseline after a second vaccination. Interpretation ChAdOx1 nCoV-19 is well tolerated and immunogenic in children aged 6-17 years, inducing concentrations of antibody that are similar to those associated with high efficacy in phase 3 studies in adults. No safety concerns were raised in this trial. Copyright (C) 2022 The Author(s). Published by Elsevier Ltd.

5.
Journal of Hospitality and Tourism Management ; 52:184-197, 2022.
Article in English | Scopus | ID: covidwho-1930960

ABSTRACT

Using visualizations of danmaku and word cooccurrence analysis, the current research evaluates China's live-streaming travel industry by extracting live streamers' and customers' cocreated content to construct a framework of cocreation patterns on live-streaming platforms. The results indicate that streamers and viewers focus on the themes of “hotel amenities and services”, “live-streaming commerce”, “viewers' evaluations and comments”, “business strategy of Ctrip”, and “price of tourism and hospitality products”. Cocreation behaviors on the Ctrip Live platform include the following: “question only”, “answer only”, and “Q&A”. Six categories of cocreation patterns were also identified. Thus, this paper contributes to the literature on live-streaming travel commerce by providing theoretical insights and practical implications, specifically, for tourism enterprises' recovery following the COVID-19 pandemic. © 2022 The Authors

6.
24th International Conference on Human-Computer Interaction, HCI International, HCII 2022 ; 1581 CCIS:294-301, 2022.
Article in English | Scopus | ID: covidwho-1930341

ABSTRACT

Core muscles play a fundamental role both in exercises and daily routines. Strong core muscles can enhance the Trunk stability and transition of strength. However, due to the weakness, most rookies can hardly feel the recruitment of core muscles and start compensating or using the wrong form. This may lead to cumulative fatigue in the short term and improper postures or spinal injuries in a long time. Thus, monitoring and protecting the unit for early core-muscle training is necessary. The study focuses on fitness rookies and designs an innovative waistband. High-density electromyography (HD-sEMG) can provide real-time monitoring of muscle conditions once it censors fatigue. The band will remind the user to take a break. And the shape memory polymer (SMP) can protect the waist and back from potential injury if necessary. With the continuous impact of the coronavirus, trainers spend more time at home and face the limitation of space and equipment. Nonetheless, isometric and simplified isotonic training will be enough for starters for core-muscle exercise. The study lists core-muscle strength exercises for athletes and core-muscle stability prescriptions for medical care, then reorganize them for rookies at home. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

7.
Chinese Journal of Disease Control and Prevention ; 26(6):696-702, 2022.
Article in Chinese | EMBASE | ID: covidwho-1928935

ABSTRACT

Objective To analyze the work situation of the personnel in Beijing Centers for Disease Prevention and Control during the novel coronavirns disease 2019 (C0VID-19) epidemic,and to provide references for improving the construction of the capital5 s disease control and prevention system. Methods Cross-sectional survey and cluster sanpling methods were used. A total of 422 municipal-level and 664 district-level professional technicians from CDCs who were mainly involved in epidemic prevention and control in Beijing were included in the study. Self-designed questionnaires were used to collect the basic information, work intensity and satisfaction and other data. The statistical description and test analysis were carried out. Results Among professionals, 64. 36% had nornal workload, and 76. 89% had overload during the epidemic prevention and control period. The proportion of disease control personnel expressing dissatisfaction "with the usual salary level "was 54. 51%, and the satisfaction with the professional title promotion w-as mostly at the average level (45. 58%). The proportions of satisfaction with the prevention and control work arrangements and logistical support during the COVID-19 epidemic were 49. 08% and 54. 42%, respectively. Only 21. 73% professionals were satisfied with the temporar w-ork subsidy. From the perspective of population distribution, staffs at the municipal and district levels and in different job positions were mainly dissatisfied with the salar level (all P<0. 05). Most of staffs who undertook different prevention and control responsibilities were satisfied with the work arrangements and logistics support (all P<0. 05), but they w-ere dissatisfied with the temporar work subsidies (H = 27. 076, P = 0. 012). Among the survey respondents, 44.48% had thoughts of resigning. Regardless of the municipal and district levels, different professional titles or positions, the wdllingness to resign was generally high (all P>0. 05). The primar reason for wanting to leave was the low salary level, followed by difficulty in promotion of professional titles and poor development prospects which were also major considerations. Conclusion It is suggested to improve the stability of CDCs staffs and promote the high-quality and sustainable development of the disease control and prevention system by improving the personnel allocation, strengthening the interdisciplinary talent reserve, improving the salary system and optimizing the professional title appointment mechanism.

8.
Neurology ; 98(18 SUPPL), 2022.
Article in English | EMBASE | ID: covidwho-1925285

ABSTRACT

Objective: Determine neuromuscular manifestation incidence in COVID-19 patients from the longitudinal electronic health record database Optum. Background: Both central and peripheral nervous system (PNS) manifestations of COVID-19 have been reported. A Chinese retrospective case series, on 214 hospitalized COVID-19 patients, found that 8.9% presented with peripheral nerve disease and 7% had muscular injuries. Other studies looking at the prevalence of PNS manifestations are limited and have significantly lower numbers. Design/Methods: The COVID-19 data is sourced from more than 700 hospitals and 7000 clinics in the US. Patients with numerous neuromuscular diagnoses were identified based on ICD-10 coding. Examples include carpal tunnel syndrome, radial nerve lesion, sciatic nerve lesion, myasthenia gravis, acute transverse myelitis, Bell's palsy, and trigeminal neuralgia. Results: We reviewed a total of 598,847 patients with positive COVID-19 PCR and/or diagnosis coding. Neuromuscular complications must have been within 45 days of diagnosis to be included. Incidence of similar neuromuscular complaints was evaluated in 3,001,153 controls without COVID-19. Critical illness neuropathy was found in 35,782 COVID-positive patients and 6,281 of those without. Retrospective study limitations include temporal relationship to COVID-19 does not necessarily indicate causality and inability to confirm the coding by record review or EMG/NCS. Conclusions: Incidence of neuromuscular disorders is generally lower or equivalent in COVID19 patients than in the general population, except for critical illness neuropathy and myopathy. This finding may be explained by more COVID-19 patients being in the intensive care unit and bedbound for longer periods. It is worth noting that a small case series of COVID-related critical illness neuropathy and myopathy patients showed no histopathological or clinical differences compared to non-COVID patients. To our knowledge, this report includes an analysis of neuromuscular manifestations in one of the largest cohorts of COVID-19 patients. This can assist with risk-benefit discussions regarding treatment initiation, etiology of diagnoses, and counseling for COVID-19 questions.

9.
Mathematics ; 10(10), 2022.
Article in English | Scopus | ID: covidwho-1924295

ABSTRACT

As COVID-19 continues to threaten public health around the world, research on specific vaccines has been underway. In this paper, we establish an SVI R model on booster vaccination with two time delays. The time delays represent the time of booster vaccination and the time of booster vaccine invalidation, respectively. Second, we investigate the impact of delay on the stability of non-negative equilibria for the model by considering the duration of the vaccine, and the system undergoes Hopf bifurcation when the duration of the vaccine passes through some critical values. We obtain the normal form of Hopf bifurcation by applying the multiple time scales method. Then, we study the model with two delays and show the conditions under which the nontrivial equilibria are locally asymptotically stable. Finally, through analysis of official data, we select two groups of parameters to simulate the actual epidemic situation of countries with low vaccination rates and countries with high vaccination rates. On this basis, we select the third group of parameters to simulate the ideal situation in which the epidemic can be well controlled. Through comparative analysis of the numerical simulations, we concluded that the most appropriate time for vaccination is to vaccinate with the booster shot 6 months after the basic vaccine. The priority for countries with low vaccination rates is to increase vaccination rates;otherwise, outbreaks will continue. Countries with high vaccination rates need to develop more effective vaccines while maintaining their coverage rates. When the vaccine lasts longer and the failure rate is lower, the epidemic can be well controlled within 20 years. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.

10.
2nd International Conference on Applied Mathematics, Modelling, and Intelligent Computing, CAMMIC 2022 ; 12259, 2022.
Article in English | Scopus | ID: covidwho-1923095

ABSTRACT

The application field of big data technology is very wide. In any industry, data and information can be analyzed through big data, and the results of these analysis are of high practical value. However, with the advent of the Internet era today, various fields are constantly developing, including the education circle. Using network education to carry out a series of teaching activities, can comprehensively improve the effectiveness of education. In the current COVID-19 epidemic, many schools and many industries have adopted computer technology and big data technologies, such as web conferencing, online classroom, remote conferencing, remote video and other teaching and production activities. This paper focuses on the role and value of computer data analysis in applied mathematics. The research shows that cloud data analysis has super high application value in applied mathematics. © 2022 SPIE

11.
2021 International Conference on Electronic Information Engineering and Computer Communication, EIECC 2021 ; 12172, 2022.
Article in English | Scopus | ID: covidwho-1923084

ABSTRACT

In the context of the era of big data, the emergence of e-commerce platforms has brought many opportunities and risks. Due to the COVID-19, e-commerce has achieved unprecedented development, and e-commerce fraud has severely damaged the healthy economic environment. This paper uses the RUSBoost algorithm to build an e-commerce fraud risk prediction model, and verifies the predictive performance of the model through data experiments. The results show that it has a high accuracy rate for identifying e-commerce fraud. If the model is applied to e-commerce, the losses caused by ecommerce fraud could be avoided in time. At present, there are fewer e-commerce fraud risk prediction models and have a wide development prospection. © COPYRIGHT SPIE. Downloading of the is permitted for personal use only.

12.
Global Advances in Health and Medicine ; 11:47, 2022.
Article in English | EMBASE | ID: covidwho-1916546

ABSTRACT

Methods: The survey was designed by an international team, translated and adapted to simplified Chinese, including 132 kinds of traditional Chinese medicine (TCM) preparation recommended by guidelines. It was distributed and collected from February to May 2021, with data analysed by WPS spreadsheet and wjx.cn. Descriptive statistics were used to describe demographics and clinical characteristics, diagnosis, treatments, preventative behaviours and interventions, and their associated outcomes. Results: The survey was accessed 503 times with 341 (67.8%) completions covering 23 provinces and four municipalities in China. Most (282/341, 82.7%) respondents reported no symptoms during the pandemic and the majority (290/341, 85.0%) reported having a SARS-CoV-2 PCR test at some point. Forty-five (13.2%) reported having a respiratory infection, among which 19 (42.2%) took one or more categories of modern medicine, e.g. painkillers, antibiotics;16 (35.6%) used TCM interventions(s);while seven respondents combined TCM with modern medicine. All respondents reported using at least one behavioural or medical approach to prevention, with 22.3% taking TCM and 5.3% taking modern medicines. No respondents reported having a critical condition related to COVID-19. Background: We aimed to investigate use of infection control behaviours, preventative and therapeutic interventions, and outcomes among respondents to an online survey during the COVID-19 pandemic in China. Conclusion: We found evidence of widespread use of infection control behaviours, modern medicines and TCM for treatment and prevention of COVID-19 and other respiratory symptoms. Larger scale studies are warranted, including a more representative sample exploring TCM preparations recommended in clinical guidelines.

13.
Value in Health ; 25(7):S467, 2022.
Article in English | EMBASE | ID: covidwho-1914756

ABSTRACT

Objectives: Price and volume changing trends of medicines has become a focus of attention from a global perspective. This is especially true in China because of a series of drug reforms initiated in recent years, such as nationwide bulk procurement of medicines. This study aims to compile the drug purchase price index and volume index, which is applied to present their dynamic changes of prices and volumes and to reflect overall supply of medicines in Shanghai. Methods: Based on the database of Shanghai Sunshine Medical Procurement All-In-One, Laspeyres price index and Pascal purchase volume index was calculated monthly and annually by using Western medicines purchase records during 2018 and 2020, which were uploaded from all the medical institutions in Shanghai. Results: Compared with the previous year, the price index of medicines and those covered by the basic medical insurance schemes were 93.3 and 93.1 respectively in 2019, while they were 95.8 and 95.6 in 2020. Monthly price index declined significantly in March 2019, April 2020 and November 2020, for the new purchase prices were implemented in these months. Meanwhile, annual procurement volume had limited changes with monthly fluctuations. Prices of those drugs not covered by the medical insurance fell slightly, and their volumes dropped sharply after the COVID-19 outbreak. Conclusions: Prices of medicines maintained a downward trend in stability with limited procurement volume changes in Shanghai. The empirical case of price index and volume index of medicines in Shanghai has verified the feasibility of its application in drug price monitoring and management. It has also provided strong evidence for policy decision-making and evaluation.

15.
Journal of Environmental and Occupational Medicine ; 38(6):624-630, 2021.
Article in Chinese | Scopus | ID: covidwho-1912212

ABSTRACT

[Background] The epidemic of coronavirus disease 2019 (COVID-19) seriously affects the psychological status of medical staff who directly face the risk of the disease. [Objective] This study investigates the prevalence and related factors of depression, anxiety, and insomnia among medical staff during the COVID-19 pandemic. [Methods] From February 13 to March 1, 2020, a network questionnaire survey was conducted among 482 medical staff selected by convenience sampling. A self-designed questionnaire was used to investigate the basic demographic information and COVID-19-related questions. The Patient Health Questionnaire-9 (PHQ-9), Generalized Anxiety Disorder-7 (GAD-7), and Insomnia Severity Index (ISI) were used to estimate the prevalence of depression, anxiety, and insomnia among the medical staff. Stepwise multiple linear regression analysis was performed with PHQ-9 score, GAD-7 score, and ISI score as dependent variables. Multivariate logistic regression analysis (forward-conditional method) on depression, anxiety, and insomnia as dependent variables was performed with basic demographic information and COVID-19-related questions as independent variables. [Results] Among the surveyed medical staff, the prevalence rates of depression, anxiety, and insomnia were 14.3%, 11.2%, and 23.2%, respectively. There were no significant differences in the prevalence rates among different age, gender, local risk level, and occupation groups and those aiding Hubei Province or not. The medical staff who directly contacted fever or diagnosed patients had more serious depression (b=1.73, 95%CI: 0.79-2.66) and insomnia (b=2.43, 95%CI: 1.48-3.39) and a higher risk of insomnia (OR=1.89, 95%CI: 1.21-2.96). The medical staff whose current protective measures cannot prevent infection had more serious depression (b=1.72, 95% CI: 0.65-2.80), anxiety (b=1.75, 95% CI: 0.76-2.75), and insomnia (b=1.73, 95% CI: 0.63-2.82), and had a higher risk of depression (OR=1.97, 95% CI: 1.11-3.49), anxiety (OR=3.00, 95%CI: 1.64-5.46), and insomnia (OR=1.79, 95%CI: 1.08-2.96). [Conclusion] During the COVID-19 epidemic, the risks of depression, anxiety, and insomnia among selected medical staff are increased compared with the non-epidemic period. Occupational exposure to high-risk groups and protective measures would significantly affect mental health of medical staff. © 2021, Shanghai Municipal Center for Disease Control and Prevention. All rights reserved.

16.
Zhonghua Liu Xing Bing Xue Za Zhi ; 43(6): 835-840, 2022 Jun 10.
Article in Chinese | MEDLINE | ID: covidwho-1903513

ABSTRACT

Objective: To analyze the epidemiological characteristics of COVID-19 caused by 2019-nCoV Delta variant (B.1.617.2) in Gansu province, and provide evidence for the prevention and control of COVID-19. Methods: The information of COVID-19 cases, including demographic characteristics, epidemiological history, onset date, diagnosis date, exposure place, detection way and infection source, in Gansu from 17 October to 25 November, 2021 were collected. Software Excel 2016,SPSS 22 and ArcGIS 10.7 were used for data process and analysis. Results: As of November 25, 2021, a total of 146 COVID-19 cases had been reported in Gansu and the epidemic affected 10 counties (districts) in 5 cities. The epidemic of COVID-19 in Gansu had three stages: imported case stage,imported-local case stage and local case stage. The age of cases ranged from 1 to 87 years,and the cases in age group 18-59 years accounted for 59.59% (87/146). The male to female ratio of the cases was 1∶1.12 (69∶77). The cases were mainly people engaged in business services (17.12%, 25/146),retirees (15.75%, 23/146),students (13.70%, 20/146),the jobless and unemployed (12.33%, 18/146). In 3 epidemic stages, the cases aged 18-59 years accounted for 44.44%,54.41% and 70.00% respectively,showing an upward trend,and there were differences among different populations (trend χ2=23.24, P<0.001). Also, the incubation period of the cases tended to decrease, and severe cases accounted for 33.33% (6/18), 19.12% (13/68) and 3.33% (2/60) respectively, showing a downward trend. Community screening (25.34%, 37/146) and close contact screening were the main ways to detect cases,the cases detected by close contact screening in 3 epidemic stages accounted for 50.00% (9/18), 66.18% (45/68) and 86.67% (52/60) respectively. The epidemic had obvious case clustering in confined places,and the main exposure modes were living together (24.66%), working/studying together (11.64%), taking same transportation (9.59%) and dining together (9.59%). Conclusions: The COVID-19 epidemic in Gansu was caused by 2019-nCoV Delta variant from imported cases. The virus was mainly transmitted through travel, sharing transportation, dining together and home contact. The characteristics of COVID-19 epidemic in Gansu changed with time, the case's clinical symptoms were not obvious and the incubation period became shorter. The infections mainly occurred in group aged 18 years and above.


Subject(s)
COVID-19 , SARS-CoV-2 , COVID-19/epidemiology , China/epidemiology , Cities , Cluster Analysis , Female , Humans , Male
17.
Chinese Journal of New Drugs ; 31(10):972-977, 2022.
Article in Chinese | EMBASE | ID: covidwho-1894105

ABSTRACT

Objective: To explore the implementation and management measures of drug clinical trials during the period of COVID-19 epidemic, protect the safety and rights of subjects, ensure the smooth implementation of clinical trials, and provide reference and suggestions for the management work of clinical trial institutions. Methods: According to the requirements of COVID-19 epidemic prevention and control policies and the national guiding principles for drug clinical trial management, combining the experience of our hospital, we optimized the working process and proposed management measures in four aspects including project and personnel management, subject follow-up management, drug distribution management, and communication between all parties involved in clinical trials. Results and conclusions: During the period of COVID-19 epidemic, our hospital has taken a series of measures which ensured the smooth implementation of more than 200 drug clinical trials and protected the safety and rights of subjects and researchers.

18.
Beijing Da Xue Xue Bao Yi Xue Ban ; 54(3):520-525, 2022.
Article in Chinese | PubMed | ID: covidwho-1887663

ABSTRACT

OBJECTIVE: To explore potential categories of parental social support for young parents under the coronavirus disease 2019 (COVID-19) epidemic, and to examine correlations of different types of parents' social support with parental burnout. METHODS: In April 2020, we conducted an online voluntary survey among young parents across China with scales and a self-designed questionnaire. The latent profile analysis method was used to analyze parents' received social support and perceived social support. The social support categories were taken as independent variables and parental burnout as dependent variables, and multiple regression analysis was carried out to explore the relationship between received social support, perceived social support and parental burnout. Finally, the moderating effect of resilience between social support groups and parental burnout was discussed. RESULTS: The results of latent profile analysis revealed three potential types of received social support, namely isolate, normal, and multi-support and the proportions of the respondents with the three profiles were 14.1%, 78.0%, and 7.9%. Four potential types of perceived social support, namely, indigent, medium, affluent and divergent and the proportions of the respondents with the four profiles were 13.7%, 29.6%, 25.3%, and 31.3%. Among them, the parents with divergent perceived social support had more perception of social support from the couple, family and relatives, but less perception of social support from net-friend, social organizations and the government. Regression analysis showed that there was no statistically significant correlation between different profiles of received social support and parental burnout, and among the groups of perceived social support, there was a statistically significant correlation between indigent and divergent types of social support and parental burnout. The divergent parents had lower levels of parental burnout compared with indigent (β=-0.120, P=0.003). Also, resilience moderated the effect of divergent perceived social support and parental burnout. Compared with the parents with low resilience, the parents with high resilience perceived divergent social support with lower parenting burnout. CONCLUSION: There are prominent latent types of received social support and perceived social support under epidemic. People with divergent perceived social support (more perceived supports from partner, family and friends) are prone to have a relatively lower risk of parental burnout. Parents with higher resilience will be more sensitive to the support of close acquaintances, and can better resist parental burnout.

19.
Clinical Laboratory ; : 11, 2022.
Article in English | Web of Science | ID: covidwho-1887317

ABSTRACT

Background: The outbreak of SARS-CoV-2 lead to a worldwide pandemic which poses substantial challenges to public health. Methods: We enrolled 102 consecutive recovered patients with laboratory-confirmed SARS-CoV-2 infection. Epidemiological and demographic characteristics, temporal dynamic profiles of laboratory tests and findings on chest CT radiography, and clinical outcomes were collected and analyzed. Results: Independent risk factors for prolonged fever, viral RNA shedding or radiologic recovery included age of more than 44 years, female gender, having symptoms of cough and fever, a delay from the symptom onset to hospitalization of more than 3 days, a lower CD4 count of less than 500/mu L on admission, and severe or critical illness in hospitalization. The estimated median time from symptom onset was 6.4 (5.5 -7.4) days to peak viral load, 9.1 (7.9 -10.4) days to afebrile, 8 (6.7 -9.4) days to worst radiologic finding, 12.7 (11.2 -14.3) days to viral RNA negativity, and 26.7 (23.8 -29.9) days to radiologic resolution. This study included the entire cross-section of patients seen in our clinical practice and reflected the real-world situation. Conclusions: These findings provide the rationale for strategies of active symptom monitoring, timing of quarantine and antiviral interventions, and duration of radiologic follow-up in patients with COVID-19.

20.
Journal of Environmental Sciences ; 125:553-567, 2023.
Article in English | English Web of Science | ID: covidwho-1882187

ABSTRACT

Based on the online and membrane sampling data of Yuncheng from January 1st to February 12th, 2020, the formation mechanism of haze under the dual influence of Spring Festival and COVID-19 (Corona Virus Disease) was analyzed. Atmospheric capacity, chemical composition, secondary transformation, source apportionment, backward trajectory, pollution space and enterprise distribution were studied. Low wind speed, high humidity and small atmospheric capacity inhibited the diffusion of air pollutants. Four severe pollution processes occurred during the period, and the pollution degree was the highest around the Spring Festival. In light, medium and heavy pollution periods, the proportion of SNA (SO 4 2 ???, NO 3 ??? and NH 4 + ) was 59.6%, 56.0% and 54.9%, respectively, which was the largest components of PM 2.5 ;the [NO 3 ???]/[SO 4 2 ???] ratio was 2.1, 1.5 and 1.7, respectively, indicating that coal source had a great influence;the changes of NOR (nitrogen oxidation ratio, 0.44, 0.45, 0.61) and SOR (sulphur oxidation ratio, 0.40, 0.49, 0.65) indicated the accumulation of secondary aerosols with increasing pollution. The coal combustion, motor vehicle, secondary inorganic sources and industrial sources contributed 36.8%, 26.59%, 11.84% and 8.02% to PM 2.5 masses, respectively. Backward trajectory showed that the influence from the east was greater during the Spring Festival, and the pollutants from the eastern air mass were higher, which would aggravate the pollution. Meteorological and Spring Festival had a great impact on heavy pollution weather. Although some work could not operate due to the impact of the COVID-19 epidemic, the emission of pollutants did not reduce much. ?? 2022 The Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences. Published by Elsevier B.V.

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