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1.
Front Psychol ; 13: 818845, 2022.
Article in English | MEDLINE | ID: covidwho-1753409

ABSTRACT

The COVID-19 pandemic has had a profound psychological and behavioral impact on people around the world. Consumer purchase behaviors have thus changed greatly, and consumer services companies need to adjust their business models to adapt to this change. From the perspective of consumer psychology, this paper explores the impact of consumer purchase behavior changes over the course of the pandemic on the business model design of consumer services companies using a representative survey of 1,742 individuals. Our results show that changes in consumer purchase behavior have a significant impact on the design of consumer services firms' business models. Specifically, changes in consumers' purchase object, motive, and timeframe are more likely to spark a novelty-centered business model design, whereas changes in purchase method tend to inspire an efficiency-centered one. Our findings provide a theoretical reference for consumer services companies in designing business models when faced with unexpected crises.

2.
Front Aging Neurosci ; 14: 850743, 2022.
Article in English | MEDLINE | ID: covidwho-1742232

ABSTRACT

Myelin oligodendrocyte glycoprotein-IgG-associated disorder (MOGAD) is a nervous system (NS) demyelination disease and a newly recognized distinct disease complicated with various diseases or symptoms; however, MOGAD was once considered a subset of neuromyelitis optica spectrum disorder (NMOSD). The detection of MOG-IgG has been greatly improved by the cell-based assay test method. In one study, 31% of NMOSD patients with negative aquaporin-4 (AQP-4) antibody were MOG-IgG positive. MOGAD occurs in approximately the fourth decade of a person's life without a markedly female predominance. Usually, optic neuritis (ON), myelitis or acute disseminated encephalomyelitis (ADEM) encephalitis are the typical symptoms of MOGAD. MOG-IgG have been found in patients with peripheral neuropathy, teratoma, COVID-19 pneumonia, etc. Some studies have revealed the presence of brainstem lesions, encephalopathy or cortical encephalitis. Attention should be given to screening patients with atypical symptoms. Compared to NMOSD, MOGAD generally responds well to immunotherapy and has a good functional prognosis. Approximately 44-83% of patients undergo relapsing episodes within 8 months, which mostly involve the optic nerve, and persistently observed MOG-IgG and severe clinical performance may indicate a polyphasic course of illness. Currently, there is a lack of clinical randomized controlled trials on the treatment and prognosis of MOGAD. The purpose of this review is to discuss the clinical manifestations, imaging features, outcomes and prognosis of MOGAD.

3.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-324781

ABSTRACT

Background: The purpose of this study is to understand the influencing factors of Chinese college students’ satisfaction with online teaching and psychological pressure on learning during the novel coronavirus epidemic. Methods: : We assessed the effect of online teaching of 7084 medical students from wannan medical college in March 5 to April 2, 2020 using cluster sampling. The respondents were asked to complete a 7-item self-compiled online teaching satisfaction questionnaire. Chi-square test and multivariate logistic regression analysis are used. Results: : Gender is female ( OR =1.257, 95% CI : 1.132~1.396), grades are second and third grades (second grades: OR =1.228, 95% CI : 1.080~1.397;third grades: OR =1.197, 95% CI : 1.048~1.367), normal/unfamiliar learning platform operation ( OR =3.692, 95% CI : 3.321~4.103) were risk factors for satisfactory teaching effect. In addition, students whose school year system is four-year ( OR =0.870, 95% CI : 0.781~0.969) and grade 4 and above ( OR =0.594, 95% CI : 0.485~0.727) were more satisfied with the teaching effect of teachers. And, during the period of the COVID-19 epidemic, the risk factors for college students to have psychological stress were: female ( OR =1.258, 95% CI : 1.096~1.442), from rural areas ( OR =1.511, 95% CI : 1.312~1.740), and the academic year system is four-year system ( OR =1.191, 95% CI : 1.028~1.380), using mobile phones and other learning tools ( OR =1.388, 95%CI: 1.205~1.600), general/unfamiliar with learning platform operations ( OR =2.273), 95% CI : 1.888~2.735). While the protective factors for college students’ psychological stress included: grade three and four and above ( OR =0.463, 95% CI : 0.387~0.554;OR =0.232, 95% CI : 0.187~0.286), and they think that the teaching effect is satisfactory ( OR =0.314, 95% CI : 0.261~0.379). Conclusion: This survey shows that compared with male college students, female college students were more dissatisfied with the teaching effect of teachers and havd greater psychological pressure on learning. Psychological counseling should be strengthened for students in rural areas and those who were not familiar with the operating platform to relieve their psychological pressure on learning.

4.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-313606

ABSTRACT

Background: Immature immunologic function is the primary reason that premature infants are prone to infection after birth. The outbreak of coronavirus infected disease 2019 (COVID-19) has led to an increase in the incidence of preterm birth, representing a new survival risk for preterm infants.Objectives: From February 2020 to May 2020, 57 premature infants of gestational age (GA) less than 37 weeks (28 +3 -36 +5wks ) born to 48 mothers were hospitalized in Zhongnan Hospital of Wuhan University, Wuhan China. Among them, 14 premature infants were delivered by 13 mothers infected with severe acute respiratory syndrome (SARS-CoV-2) in the third trimester.Methods: Due to the epidemic of COVID-19 in Wuhan and the policy of lockdown, all pregnant women underwent examination for SARS-CoV-2 nucleic acid, serum antibody and lung computer tomography (CT) before delivery. After birth, new-borns’ peripheral blood was collected, and immune cells counts and cytokine concentrations were assessed. Subjects’ clinical data were recorded and analysed.Results: Absolute lymphocyte count (ALC) and CD4 cells of preterm infants increased with GA. CD3, CD4, CD8, CD19, CD16-56 cell counts were positively correlated with ALC. Concentrations of IL-2, IL-4, IFN-γ and TNF-α were in the normal reference range and were not correlated with GA and birth weight (BW). Median IL-6 level in preterm infants was 14.71 pg/ml (IQR 6.47-46.14 pg/ml), which was 5.07-fold higher than the reference intervals, 3.9 pg/ml (IQR, 1.79-14.28 pg/ml), and the ratio of IL-6/IL-10 was 3.77. IL-10 was positively correlated with IL-2, IL-4 and IL-6. Immune cell counts, cytokine levels and clinical prognosis of premature infants born to mothers with SARS-CoV-2 were not different from those without maternal SARS-CoV-2 infection.Conclusions: Immune function in preterm infants was characterized by increased CD4 cells with GA and a positive correlation between high levels of IL-6 and IL-10. Maternal infection with SARS-CoV-2 is not an independent perinatal risk factor for premature infants with immature immune function.Trial Registration: The present study was registered as a clinical study in the Chinese Clinical Trial Registry (ChiCTR-ORC-16008872).Funding Statement: This work was supported by a grant from the Chinese National Natural Science Fund 81170005 and 81670007.Declaration of Interests: No conflict of interest.Ethics Approval Statement: The Institutional Review Board of Zhongnan Hospital of Wuhan University approved this study (approval no. 2015019). All guardians signed informed consents.

5.
Nat Med ; 26(6): 845-848, 2020 06.
Article in English | MEDLINE | ID: covidwho-1641979

ABSTRACT

We report acute antibody responses to SARS-CoV-2 in 285 patients with COVID-19. Within 19 days after symptom onset, 100% of patients tested positive for antiviral immunoglobulin-G (IgG). Seroconversion for IgG and IgM occurred simultaneously or sequentially. Both IgG and IgM titers plateaued within 6 days after seroconversion. Serological testing may be helpful for the diagnosis of suspected patients with negative RT-PCR results and for the identification of asymptomatic infections.


Subject(s)
Antibodies, Viral/blood , Antibody Formation/drug effects , Betacoronavirus/pathogenicity , Coronavirus Infections/drug therapy , Pneumonia, Viral/drug therapy , Adult , Aged , Antibody Formation/immunology , Antiviral Agents/therapeutic use , Betacoronavirus/genetics , COVID-19 , Coronavirus Infections/blood , Coronavirus Infections/immunology , Coronavirus Infections/virology , Female , Humans , Immunoglobulin G/blood , Immunoglobulin M/blood , Male , Middle Aged , Pandemics/prevention & control , Pneumonia, Viral/blood , Pneumonia, Viral/immunology , Pneumonia, Viral/virology , SARS-CoV-2
6.
Frontiers in psychiatry ; 12, 2021.
Article in English | EuropePMC | ID: covidwho-1609848

ABSTRACT

Background: The purpose of this study was to assess the mental health status of medical students engaged in online learning at home during the pandemic, and explore the potential risk factors of mental health. Methods: A cross-sectional study was conducted via an online survey among 5,100 medical students from Wannan Medical College in China. The Depression, Anxiety and Stress scale (DASS-21) was used to measure self-reported symptoms of depression, anxiety, and stress among medical students during online learning in the pandemic. Results: In total, 4,115 participants were included in the study. The prevalence symptoms of depression, anxiety, and stress were 31.9, 32.9, and 14.6%, respectively. Depression was associated with gender, grade, length of schooling, relationship with father, students' daily online learning time, and students' satisfaction with online learning effects. Anxiety was associated with gender, length of schooling, relationship with father, relationship between parents, students' daily online learning time, and students' satisfaction with online learning effects. Stress was associated with grade, relationship with father, relationship between parents, students' daily online learning time, and students' satisfaction with online learning effects. Conclusions: Nearly one-third of medical students survived with varying degrees of depression, anxiety, and stress symptoms during online learning of the COVID-19 pandemic. Gender, grade, length of schooling, family environment, and online learning environment play vital roles in medical students' mental health. Families and schools should provide targeted psychological counseling to high-risk students (male, second-year and third-year, four-year program). The findings of this study can provide reference for educators to cope with the psychological problems and formulate the mental health curriculum construction among medical students during online learning.

7.
Int J Environ Res Public Health ; 19(1)2021 12 30.
Article in English | MEDLINE | ID: covidwho-1580781

ABSTRACT

Medical wastewater originating from hospitals specializing in infectious diseases pose a major risk to human and environmental health during pandemics. However, there have been few systematic studies on the management of this type of wastewater management. The function of the Huoshenshan Hospital as a designated emergency field hospital for the treatment of COVID-19 has provided lessons for the management measures of medical wastewater, mainly including: (1) Modern information technology, management schemes, and related standard systems provided the legislative foundation for emergency management of medical wastewater. (2) The three-tier prevention and control medical wastewater management system ensured the discharged wastewater met water quality standards, especially for the leak-proof sealed collection system of the first tier, and the biological and chemical treatment technology of the second tier. (3) The establishment of an effective three-tier medical wastewater quality monitoring accountability system. This system was particularly relevant for ensuring continuous data monitoring and dynamic analysis of characteristic indicators. (4) Information disclosure by government and public supervision promoted successful implementation of medical wastewater management and control measures. Public questionnaires (n = 212) further confirmed the effectiveness of information disclosure. The results of this study can act as methodological reference for the emergency management of wastewater in designated infectious disease hospitals under similar situations.


Subject(s)
COVID-19 , Communicable Diseases , China , Communicable Diseases/epidemiology , Hospitals , Humans , SARS-CoV-2 , Waste Water
8.
Biomed J ; 44(6S1): S15-S24, 2021 Dec.
Article in English | MEDLINE | ID: covidwho-1556276

ABSTRACT

BACKGROUND: Coronavirus disease 2019 (COVID-19) is caused by a novel virus that is responsible for the largest pandemic in recent times. Although numerous studies have explored methods to cope with COVID-19 and targeted drugs and vaccines have been developed, the spread of disease remains rapid due to the high infectivity and mutation capability of SARS-CoV-2, the causative virus of COVID-19. Therefore, there is an urgent necessity to seek more efficient treatments and approaches to combat the disease. METHODS: In this study, molecular docking was used to predict the binding of different lipopeptides, which exhibit significant biological functions, to the RNA-dependent RNA polymerase (also known as nsp12) of SARS-CoV-2, the central component of coronaviral replication and transcription machinery. RESULTS: The results showed that seven lipopeptides bound to nsp12 at the same location as the FDA-approved drug remdesivir, with higher affinities. Notably, iron-chelating ferrocin A (ferrocin A-iron complex [FAC]) bound to nsp12 most tightly, releasing up to 9.1 kcal mol-1 of free energy. Protein-ligand interaction analysis revealed that FAC formed four hydrogen bonds, two hydrophobic interactions, and three salt bridges with nsp12. These active amino acids are mainly distributed in the fingers and thumb subdomains of nsp12 and are highly conserved. CONCLUSIONS: Our findings suggest that the abovementioned lipopeptides can tightly bind to nsp12, and thus represent promising drug candidates for anti-coronaviral treatments with the potential to fight SARS-CoV-2.


Subject(s)
COVID-19 , Antiviral Agents/pharmacology , Humans , Lipopeptides/pharmacology , Molecular Docking Simulation , RNA-Dependent RNA Polymerase , SARS-CoV-2
9.
Ain Shams Engineering Journal ; 2021.
Article in English | ScienceDirect | ID: covidwho-1499628

ABSTRACT

Digital education in schools through artificial intelligence, big data and other technologies is conducive to improving teaching efficiency and promoting teaching progress. Unfortunately, many schools lack a sense of social responsibility when applying digital education.Students are online more than ever before. There are the potential for increased exposure to risks such as exposure to harmful content, cyberbullying, age-inappropriate advertising and data misuse, which affect students’ well-being and undermine their right to privacy.Schools should bear the overall social moral level of social responsibility. This paper focuses on the social responsibility of schools under the new crown epidemic and holds that implanting social responsibility into the value system of the current digital education reform,which can promote the sustainable development of education. This is also a relatively neglected problem in the practice of educational reform. European standard: ISO26000 is adopted as a CEN-standard. 21 October 2020 the stakeholder consultation process in the European Committee for Standardization (CEN) decided that ISO 26000 is approved as a CEN-standard. For businesses and organizations committed to operating in a socially responsible way, there’s ISO 26000. It provides guidance to those who recognize that respect for society and environment is a critical success factor. This paper highlights the school how to take social responsibility by using ISO 26000.Based on the seven subjects of ISO 26000, this paper constructs the social responsibility of digital education frame, focuses on analyzing the main content and core issues of social responsibility of digital education, puts forward some improved strategies and suggestions for the more prominent problems at this stage through the examination and reflection of reality.

10.
FASEB J ; 35(9): e21870, 2021 09.
Article in English | MEDLINE | ID: covidwho-1373669

ABSTRACT

COVID-19 is often characterized by dysregulated inflammatory and immune responses. It has been shown that the Traditional Chinese Medicine formulation Qing-Fei-Pai-Du decoction (QFPDD) is effective in the treatment of the disease, especially for patients in the early stage. Our network pharmacology analyses indicated that many inflammation and immune-related molecules were the targets of the active components of QFPDD, which propelled us to examine the effects of the decoction on inflammation. We found in the present study that QFPDD effectively alleviated dextran sulfate sodium-induced intestinal inflammation in mice. It inhibited the production of pro-inflammatory cytokines IL-6 and TNFα, and promoted the expression of anti-inflammatory cytokine IL-10 by macrophagic cells. Further investigations found that QFPDD and one of its active components wogonoside markedly reduced LPS-stimulated phosphorylation of transcription factor ATF2, an important regulator of multiple cytokines expression. Our data revealed that both QFPDD and wogonoside decreased the half-life of ATF2 and promoted its proteasomal degradation. Of note, QFPDD and wogonoside down-regulated deubiquitinating enzyme USP14 along with inducing ATF2 degradation. Inhibition of USP14 with the small molecular inhibitor IU1 also led to the decrease of ATF2 in the cells, indicating that QFPDD and wogonoside may act through regulating USP14 to promote ATF2 degradation. To further assess the importance of ubiquitination in regulating ATF2, we generated mice that were intestinal-specific KLHL5 deficiency, a CUL3-interacting protein participating in substrate recognition of E3s. In these mice, QFPDD mitigated inflammatory reaction in the spleen, but not intestinal inflammation, suggesting CUL3-KLHL5 may function as an E3 for ATF2 degradation.


Subject(s)
Activating Transcription Factor 2/metabolism , Down-Regulation/drug effects , Drugs, Chinese Herbal/pharmacology , Flavanones/pharmacology , Glucosides/pharmacology , Inflammation/drug therapy , Proteolysis/drug effects , Ubiquitin Thiolesterase/deficiency , Animals , Cell Line , Colitis/chemically induced , Colitis/drug therapy , Cullin Proteins/metabolism , Cytokines/metabolism , Dextran Sulfate/pharmacology , Dextran Sulfate/therapeutic use , Drugs, Chinese Herbal/therapeutic use , Flavanones/therapeutic use , Glucosides/therapeutic use , Inflammation/chemically induced , Macrophages/drug effects , Macrophages/metabolism , Male , Mice , Mice, Inbred C57BL , Phosphorylation/drug effects , Proteasome Endopeptidase Complex/drug effects , Proteasome Endopeptidase Complex/metabolism , Pyrroles/pharmacology , Pyrrolidines/pharmacology , Ubiquitin Thiolesterase/antagonists & inhibitors , Ubiquitination
11.
Front Public Health ; 9: 649157, 2021.
Article in English | MEDLINE | ID: covidwho-1359253

ABSTRACT

Background: Due to the novel coronavirus epidemic, medical workers are under immense psychological pressure. As such, the East Campus of Shanghai Sixth People's Hospital actively adopted the Symptoms Checklist 90 (SCL-90) to evaluate the mental health of hospital staff before and after the psychological intervention from the Employee Assistance Program (EAP). Methods: Medical workers from the East Campus of Shanghai Sixth People's Hospital were recruited for this study. Psychological evaluations were conducted using the SCL-90, with a score of >160 regarded as a positive result, or in other words, an indication of abnormal psychological symptoms. The EAP adopted different forms of psychological interventions for healthcare professionals, and participation in these measures was entirely voluntary. Medical workers completed the SCL-90 again after participating in the psychological intervention, and we analyzed the changes between their two assessments. Results: Of the 1,198 total medical staff present at the hospital, 844 participated in the initial survey, while only 652 completed the survey a second time (i.e., post-psychological intervention). Multivariate logistic regression analysis found that the psychological status of hospital staff was correlated with gender, education background, and fertility status (P < 0.05). The results showed that, compared with women, men's mental health status was better, with an OR value of 0.598 (0.372-0.962). Groups with high school, junior high school, and below education levels were at higher risk of psychological problems, with OR values of 23.655 (2.815-198.784) and 9.09 (2.601-31.801), respectively. Administrative occupations and having two or more children were protective factors for mental health, and the OR values were 0.400 (0.175-0.912) and 0.327 (0.152-0.703), respectively. Following the psychological intervention, we found that the mental health of hospital workers improved, as indicated by their second SCL-90 evaluations, although the proportion of medical staff willing to participate in the second evaluation was lower than the initial assessment. There were differences in the SCL-90 scores among different occupations, and there were also differences in the scores of employees of different occupations who had participated in the two evaluations. The employees of different positions who participated in the two evaluations were matched and analyzed and found that the depression and anxiety of the doctor group were significantly reduced. In the nursing group, the total score, somatization, interpersonal sensitivity, depression, and anxiety were significantly reduced. In the medical technician group, depression, anxiety, and paranoia were reduced considerably. Among office staff, no significant differences were found. Among workers, the total score, depression, and anxiety were significantly reduced. Conclusion: Hospitals have the potential to alleviate and reduce the psychological pressure placed on medical staff members through the EAP, which can actively adopt intervention and guidance measures. The findings of this study have important implications, as reducing abnormal psychological symptoms of healthcare professionals can be helpful in the fight against the coronavirus epidemic.


Subject(s)
COVID-19 , Epidemics , Child , China/epidemiology , Female , Humans , Male , Mental Health , Psychosocial Intervention , SARS-CoV-2
12.
BMC Med Educ ; 21(1): 397, 2021 Jul 23.
Article in English | MEDLINE | ID: covidwho-1322933

ABSTRACT

BACKGROUND: The purpose of this study is to understand the influencing factors of Chinese college students' satisfaction with online teaching and psychological pressure on learning during the novel coronavirus epidemic. METHODS: We assessed the effect of online teaching of 7084 medical students from wannan medical college in March 5 to April 2, 2020 using cluster sampling. The respondents were asked to complete a 7-item self-compiled online teaching satisfaction questionnaire. Chi-square test and multivariate logistic regression analysis are used. RESULTS: Sex is female (OR = 1.257, 95%CI: 1.132 ~ 1.396), grades are second and third grades (second grades: OR = 1.228, 95%CI: 1.080 ~ 1.397; third grades: OR = 1.197, 95%CI: 1.048 ~ 1.367), normal/unfamiliar learning platform operation (OR = 3.692, 95%CI: 3.321 ~ 4.103) were risk factors for satisfactory teaching effect. In addition, students whose school year system is four-year (OR = 0.870, 95%CI: 0.781 ~ 0.969) and grade 4 and above (OR = 0.594, 95%CI: 0.485 ~ 0.727) were more satisfied with the teaching effect of teachers. And, during the period of the COVID-19 epidemic, the risk factors for college students to have psychological stress were: female (OR = 1.258, 95%CI: 1.096 ~ 1.442), from rural areas (OR = 1.511, 95%CI: 1.312 ~ 1.740), and the academic year system is four-year system (OR = 1.191, 95%CI: 1.028 ~ 1.380), using mobile phones and other learning tools (OR = 1.388, 95%CI: 1.205 ~ 1.600), general/unfamiliar with learning platform operations (OR = 2.273), 95%CI: 1.888 ~ 2.735). While the protective factors for college students' psychological stress included: grade three and four and above (OR = 0.463, 95%CI: 0.387 ~ 0.554; OR = 0.232, 95%CI: 0.187 ~ 0.286), and they think that the teaching effect is satisfactory (OR = 0.314, 95%CI: 0.261 ~ 0.379). CONCLUSION: This survey shows that compared with male college students, female college students were more dissatisfied with the teaching effect of teachers and havd greater psychological pressure on learning. Psychological counseling should be strengthened for students in rural areas and those who were not familiar with the operating platform to relieve their psychological pressure on learning.


Subject(s)
COVID-19 , Epidemics , Students, Medical , Female , Humans , Male , SARS-CoV-2 , Schools, Medical
13.
Glob Heart ; 16(1): 43, 2021 06 10.
Article in English | MEDLINE | ID: covidwho-1285506

ABSTRACT

Background: We investigated impacts of COVID-19 on cardiac rehabilitation (CR) delivery around the globe, including virtual delivery, as well as effects on providers and patients. Methods: In this cross-sectional study, a piloted survey was administered to CR programs globally via REDCap from April to June 2020. The 50 members of the International Council of Cardiovascular Prevention and Rehabilitation (ICCPR) and personal contacts facilitated program identification. Results: Overall, 1062 (18.3% program response rate) responses were received from 70/111 (63.1% country response rate) countries in the world with existent CR programs. Of these, 367 (49.1%) programs reported they had stopped CR delivery, and 203 (27.1%) stopped temporarily (mean = 8.3 ± 2.8 weeks). Alternative models were delivered in 322 (39.7%) programs, primarily through low-tech modes (n = 226,19.3%). Furthermore, 353 (30.2%) respondents were re-deployed, and 276 (37.3%) felt the need to work due to fear of losing their job, despite the perceived risk of contracting COVID-19 (mean = 30.0% ± 27.4/100). Also, 266 (22.5%) reported anxiety, 241(20.4%) were concerned about exposing their family, 113 (9.7%) reported increased workload to transition to remote delivery, and 105 (9.0%) were juggling caregiving responsibilities during business hours. Patients were often contacting staff regarding grocery shopping for heart-healthy foods (n = 333, 28.4%), how to use technology to interact with the program (n = 329, 27.9%), having to stop their exercise because they have no place to exercise (n = 303, 25.7%), and their risk of death from COVID-19 due to pre-existing cardiovascular disease (n = 249, 21.2%). Respondents perceived staff (n = 488, 41.3%) and patient (n = 453, 38.6%) personal protective equipment, as well as COVID-19 screening (n = 414, 35.2%), and testing (n = 411, 35.0%) as paramount to in-person service resumption. Conclusion: Given the estimated number of CR programs globally, these results suggest approximately 4400 CR programs globally have ceased or temporarily stopped service delivery. Those that remain open are implementing new technologies to ensure their patients receive CR safely, despite the challenges. Highlights: - COVID-19 has impacted cardiac rehabilitation (CR) delivery around the globe.- In this cross-sectional study, a survey was completed by 1062 (18.3%) CR programs from 70 (63.1%) countries.- The pandemic has resulted in at least temporary cessation of ~75% of CR programs, with others ceasing initiation of new patients, reducing components delivered, and/or changing of mode delivery with little opportunity for planning and training.- There is also significant psychosocial and economic impact on CR providers.- Alternative CR model (e.g., home-based, virtual) reimbursement advocacy is needed, to ensure safe, accessible secondary prevention delivery.


Subject(s)
Attitude of Health Personnel , COVID-19 , Cardiac Rehabilitation/methods , Delivery of Health Care/methods , Cross-Sectional Studies , Duration of Therapy , Global Health , Humans , Reimbursement Mechanisms , SARS-CoV-2 , Surveys and Questionnaires , Telerehabilitation/methods
14.
Front Public Health ; 9: 662166, 2021.
Article in English | MEDLINE | ID: covidwho-1207797

ABSTRACT

The slow-down of the Chinese economy and the depression in the global economy during the COVID-19 show that governments should provide stimulus packages. These policies should be inclusive in terms of financial gains. Using the panel data of 30 regions in China from 2006 to 2016, this paper uses the Poisson Pseudo-Maximum Likelihood (PPML) estimator to analyze the impact of inclusive finance on public health. The results show that inclusive finance has a significant positive effect on public health. The performance of the eastern region is significantly better than that of the central and western regions. When we consider the combined effect of environmental regulation, the improvement effect of inclusive finance on public health is still significant, and the coefficient increases in the eastern region. Similarly, there is also a significant improvement effect in the central and western regions. Our findings reveal that environmental regulation promotes the beneficial effect of inclusive finance. Therefore, it is important to improve the inclusive financial development mechanism and enhance environmental regulation intensity for solving public health issues. Lessons related to the COVID-19 pandemic are also discussed.


Subject(s)
COVID-19 , Public Health , China/epidemiology , Humans , Pandemics , SARS-CoV-2
15.
Ann Transl Med ; 9(5): 395, 2021 Mar.
Article in English | MEDLINE | ID: covidwho-1176211

ABSTRACT

BACKGROUND: Hand hygiene is one of the ways to prevent the spread of diseases. Our aim was to explore the relationship between hand washing frequency and the impact on disease, and give recommendations on the number of times to wash hands. METHODS: We searched seven electronic databases from their inception to April 11, 2020, and reference lists of related reviews for all studies on hand washing frequency and disease prevention. The Review Manager 5.3. software was used to conduct a meta-analysis. We assessed the risk of bias of included studies, and quality of evidence of the main findings. RESULTS: A total of eight studies were included. The results of the meta-analysis showed that there was no statistical significance between the effect of disease prevention and washing more than 4 times/day compared to not [odds ratio (OR) =0.61, 95% confidence interval (CI): 0.37 to 1.01]. The results of a case-control study showed that compared with hand washing ≤4 times/day, hand washing 5-10 times/day (OR =0.75, 95% CI: 0.63 to 0.91) and hand washing >10 times/day (OR =0.65, 95% CI 0.53 to 0.80) could reduce the risk of disease infection. There was no statistical significance advantage to hand washing more than 10 times/day compared to 5-10 times/day (OR =0.86, 95% CI: 0.70 to 1.06). Comparing hand washing ≤10 times/day with hand washing >10 times/day, increased hand washing was a protective factor against infection (OR =0.59, 95% CI: 0.36 to 0.97). CONCLUSIONS: The more frequently hands were washed, the lower risk of disease. So far however, there is no high-quality evidence indicating the best range of hand washing frequency for disease prevention.

16.
Front Immunol ; 11: 595342, 2020.
Article in English | MEDLINE | ID: covidwho-1106024

ABSTRACT

The outbreak of coronavirus disease 2019 (COVID-19) underlined the urgent need for alleviating cytokine storm. We propose here that activating the cholinergic anti-inflammatory pathway (CAP) is a potential therapeutic strategy. However, there is currently no approved drugs targeting the regulatory pathway. It is evident that nicotine, anisodamine and some herb medicine, activate the CAP and exert anti-inflammation action in vitro and in vivo. As the vagus nerve affects both inflammation and specific immune response, we propose that vagus nerve stimulation by invasive or non-invasive devices and acupuncture at ST36, PC6, or GV20, are also feasible approaches to activate the CAP and control COVID-19. It is worth to investigate the efficacy and safety of the strategy in patients with COVID-19.


Subject(s)
COVID-19/therapy , Cytokine Release Syndrome/therapy , Neuroimmunomodulation/immunology , Vagus Nerve Stimulation/methods , Vagus Nerve/immunology , Acupuncture , Anti-Inflammatory Agents/pharmacology , Cytokines/blood , Drugs, Chinese Herbal/pharmacology , Humans , Inflammation/therapy , Nicotine/pharmacology , SARS-CoV-2 , Solanaceous Alkaloids/pharmacology
17.
Chinese Journal of Viral Diseases ; 10(4):249-254, 2020.
Article in Chinese | GIM | ID: covidwho-976631

ABSTRACT

Coronavirus disease 2019 (COVID-19) pandemic has become an important public health issue in the whole world and poses a serious threat to individual health. Vaccination is one of the most effective and economical approaches to prevent and control infectious diseases. SARS-CoV-2 belongs to betacoronavirus. With the research experience of SARS-CoV and MERS-CoV, researchers at home and abroad have made considerable progress in the selection of SARS-CoV-2 vaccine targets, animal models and immune protection indicators. On this basis, the research and development of the vaccines is also in rapid development. As of June, 2020, 136 vaccine development projects are under way, covering all the five types, inactivated, attenuated, re-combinant protein, nucleic acid and viral vector vaccines, 10 of which are in clinical trials. However, the development of SARS-CoV-2 vaccines is still faced with many challenges, including anti-body-dependent enhancement (ADE) effect, safety problem, unknown long-term protection, possible mutation of virus and the issue of mass production and delivery. There is still a long way to go in the research and development of SARS-CoV-2 vaccines, and researchers at home and abroad should work together to develop a successful vaccine and curb the pandemic as soon as possible.

18.
Chin J Acad Radiol ; : 1-6, 2020 Nov 16.
Article in English | MEDLINE | ID: covidwho-938653

ABSTRACT

The COVID-19 epidemic has swept across China and spread to other countries. The rapid spreading of COVID-19 and panic combined with the lack of a hierarchical medical system in China have resulted in a huge number of hospital visiting which are overwhelming local medical system and increasing the incidence of cross infection. To meliorate this situation, we adopted the management concept of the system of Tiered Diagnosis and Treatment and developed an online tool for self-triage based on the mostly used multi-purpose smartphone app Wechat in China. This online tool helps people perform self-triage so that they can decide whether to quarantine at home or visit hospital. This tool further provides instructions for home quarantine and help patients make an appointment online if hospital visiting suggested. This smartphone application can reduce the burden on hospitals without losing the truly COVID-19 patients and protect people from the danger of cross infection.

20.
Progress in Biochemistry and Biophysics ; 47(4):275-285, 2020.
Article | WHO COVID | ID: covidwho-707699

ABSTRACT

The new coronavirus SARS-CoV-2 has a strong transmission ability and has been confirmed to be transmissible from person to person. Asymptomatic carriers can also be a source of transmission. Rapid and accurate diagnosis of the new coronavirus is particularly important to control the outbreak. Based on the relevant research progress at home and abroad, this paper analyzes and combs the four major detection technologies of new coronaviruses such as fluorescent PCR, isothermal amplification, Cas enzyme technology and immunoassay, in order to provide references and ideas for the diagnosis, prevention and control of new coronaviruses and other epidemic viruses.

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