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1.
International Journal of Contemporary Hospitality Management ; 35(7):2289-2321, 2023.
Article in English | ProQuest Central | ID: covidwho-20238618

ABSTRACT

PurposeA proliferation of articles surrounding the COVID-19 pandemic is calling for new insights through review. This paper aims to bibliometrically analyze the current progress of research around hospitality and tourism to define the research directions on herd immunity and the prevention of disease under the "new normal.”Design/methodology/approachThis paper analyzed 326 articles regarding COVID-19 published in SSCI hospitality, leisure and tourism journals in 2020 and 2021 by combining manual analysis and bibliometrics to reveal research topics and to gain insight into research structures.FindingsThe results of this paper summarized topics related to stakeholders' mentality and behavior, responses of travel suppliers to the COVID-19 pandemic, economic impact and demand forecasting, social issues of human rights and racism and reflection on tourism and transformation of the industry. More research is called for in the future to focus on a better response to the crisis, including crisis management education and training and the improving the resilience of small- and medium-sized enterprises.Research limitations/implicationsA three-dimensional consideration was proposed to promote the sustainable development of hospitality and tourism.Originality/valueIn the "new normal” phase of herd immunity and disease prevention, to the best of the authors' knowledge, this is the first paper that provides an up-to-date systematic overview of the evolution of COVID-19 research in tourism and hospitality and encourages more conceptual, practical and futuristic studies.

2.
Arch Psychiatr Nurs ; 41: 341-347, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-2031123

ABSTRACT

AIM: To explore anxiety, sleep quality, and mindfulness of frontline nurses at the initial epicenter of the pandemic, to examine the mediating effects of mindfulness. BACKGROUND: COVID-19 was first identified in Wuhan, China in January 2020. Nurses were at the forefront of care and treatment across hospitals in response to the pandemic. METHODS: Single site cross-sectional survey conducted in Wuhan province (China) between March and April in 2020. Quantitative analysis of survey data from N118 nurses working in the frontline COVID response. Questionnaires included: The general information questionnaire, the Self-Anxiety Scale, the Short Inventory of Mindfulness, and the Pittsburgh Sleep Quality Index. RESULTS: Front-line nurses' anxiety was positively associated with sleep quality and mindfulness was negatively associated with anxiety and sleep quality. Mindfulness had a mediating role on anxiety and sleep quality, with intermediary adjustment effects (ES = 0.136, 95 % CI 0.02 to 0.26), accounting for 21.9 % of the total effect ratio. CONCLUSIONS: Anxiety causes a reduction in sleep quality and mindfulness can help with anxiety. Mindfulness strategies may help during periods of higher anxiety in the workplace; however, other factors must be considered. Further research is required on strategies for assisting nurses during periods of extreme anxiety.


Subject(s)
COVID-19 , Mindfulness , Humans , Sleep Quality , Cross-Sectional Studies , Sleep/physiology , Anxiety/therapy , China
3.
Chinese Veterinary Science / Zhongguo Shouyi Kexue ; 50(7):825-832, 2020.
Article in Chinese | CAB Abstracts | ID: covidwho-1994655

ABSTRACT

In order to establish a method for rapid differential identification of Senecavirus A (SVA) and en-cephalomyocarditis virus (EMCV), two pairs of corresponding specific primers were designed based on the highly conserved 3D genes of SVA and EMCV. And two different fluorescent labeled TaqMan probes were used to establish a dual TaqMan real-time PCR method for simultaneous detection of these two viruses, and we also optimize the reaction conditions. The results showed that the minimum detection of the method was 760 copies/ micro L and 98 copies/ micro L for SVA and EMCV. respectively, and it can specifically detect SVA and EMCV, and there was no cross reaction with CSFV, PRRSV and PEDV. The established standard curves showed good linear relationship. Repeated experimental group and inter-group coefficient of variation were less than 5%. The results indicated that the dual-quantitative PCR established in this study has the advantages of convenience, rapidity, good specificity. high sensitivity and good repeatability .and can be used for simultaneous detection of SVA and EMCV.

4.
Forests ; 13(8):1282, 2022.
Article in English | MDPI | ID: covidwho-1981425

ABSTRACT

Tree height is an important parameter for calculating forest carbon sink and assessing forest carbon cycle. In order to obtain forest tree height over a large area both efficiently and at a low cost, this study proposed an Interferometric Synthetic Aperture Radar (InSAR) combined with a machine learning method to estimate the tree canopy height. The forest height in the study area was obtained using Unmanned Aerial Vehicle (UAV) photogrammetry, which was considered to be the true canopy height. Two machine learning methods (Random Forest, Multi-layer perceptron) were used to establish the relationship between phase center height calculated by InSAR DEM differential interference method and coherent amplitude method with true canopy height. The topographic factor, backward scattering coefficient and coherence coefficient were introduced into the relationship model. It was found that the accuracy of tree height estimation using random forest and two InSAR methods can reach 0.95 and 0.94. The root-mean-square error was 1.76 m, 1.86 m, respectively. The accuracy of tree height estimation using multi-layer perceptron and two InSAR methods was 0.25 and 0.2. The root-mean-square error was 3.96 m and 4.13 m. The results indicated that the combination of InSAR and machine learning can estimate canopy height efficiently and at a low cost. Moreover, the integrated learning algorithm random forest demonstrated better stability and higher accuracy than the single learning algorithm multi-layer perceptron.

5.
Nat Nanotechnol ; 17(9): 984-992, 2022 09.
Article in English | MEDLINE | ID: covidwho-1960380

ABSTRACT

Quantitative polymerase chain reaction (qPCR) offers the capabilities of real-time monitoring of amplified products, fast detection, and quantitation of infectious units, but poses technical hurdles for point-of-care miniaturization compared with end-point polymerase chain reaction. Here we demonstrate plasmonic thermocycling, in which rapid heating of the solution is achieved via infrared excitation of nanoparticles, successfully performing reverse-transcriptase qPCR (RT-qPCR) in a reaction vessel containing polymerase chain reaction chemistry, fluorescent probes and plasmonic nanoparticles. The method could rapidly detect SARS-CoV-2 RNA from human saliva and nasal specimens with 100% sensitivity and 100% specificity, as well as two distinct SARS-CoV-2 variants. The use of small optical components for both thermocycling and multiplexed fluorescence monitoring renders the instrument amenable to point-of-care use. Overall, this study demonstrates that plasmonic nanoparticles with compact optics can be used to achieve real-time and multiplexed RT-qPCR on clinical specimens, towards the goal of rapid and accurate molecular clinical diagnostics in decentralized settings.


Subject(s)
COVID-19 , Nanoparticles , COVID-19/diagnosis , COVID-19 Testing , DNA-Directed RNA Polymerases , Fluorescent Dyes , Humans , Point-of-Care Systems , RNA, Viral/genetics , Real-Time Polymerase Chain Reaction , Reverse Transcriptase Polymerase Chain Reaction , SARS-CoV-2/genetics , Sensitivity and Specificity
6.
Chemical Engineering Journal ; : 138013, 2022.
Article in English | ScienceDirect | ID: covidwho-1926265

ABSTRACT

Ti3C2Tx (a typical MXene) has been widely used in light-driven actuators due to its outstanding photothermal conversion capability. However, the response speed of these actuators is always slow because the effective irradiated area is limited to their surface. Herein, we propose a wood-based composite material which is made by coating Ti3C2Tx on delignified wood (DW). The high porosity of DW leads to high loading of Ti3C2Tx and provides large irradiated areas, thus enhancing photothermal conversion efficiency. The delignification on wood can expose cellulose with highly hydrophilic surface for rapid diffusion of Ti3C2Tx suspension, and the hydroxy in cellulose can act as binding sites to form stable combination with Ti3C2Tx. Taking advantage of the good compressibility of DW, a simple densification is conducted on TDW (Ti3C2Tx/DW) to greatly shorten the distance between adjacent oxygen-enriched Ti3C2Tx nanosheets, enhancing the conjugation among nanosheets, thus endowing TDW with good flexibility and high heat transfer efficiency. Moreover, we manufacture a light-driven bilayer actuator comprised of TDW as the passive layer and low-density polyethylene (LDPE) as the active layer. Our light-driven actuator exhibits a tremendous angle variation of 160° at a light intensity of 120 mW/cm2. A series of devices based on the TDW/LDPE actuator are demonstrated, including simulated gestures, a four-finger soft gripper, and a bionic flower. Moreover, we propose a light-controlled smart switch which can be used on non-contact (COVID-19) or dangerous (blasting) occasions. Additionally, we present a finite element simulation to predict the bending deformation, which guides the accurate control of the devices.

7.
Front Public Health ; 10: 851714, 2022.
Article in English | MEDLINE | ID: covidwho-1887151

ABSTRACT

Reducing neonatal mortality is an important goal in the Sustainable Development Goals (SDGs), and with the outbreak of the new crown epidemic and severe global inflation, it is extremely important to explore the relationship between inflation and infant mortality. This paper investigates the causal relationship between inflation and infant mortality using a mixed frequency vector autoregressive model (MF-VAR) without any filtering procedure, along with impulse response analysis and forecast misspecification variance decomposition, and compares it with a low frequency vector autoregressive model (LF-VAR). We find that there is a causal relationship between inflation and infant mortality, specifically, that is inflation increases infant mortality. Moreover, the contribution of CPI to IMR is greater in the forecast error variance decomposition in the MF-VAR model compared to the LF-VAR model, indicating that CPI has stronger explanatory power for IMR in mixed-frequency data. The results of the study have important implications for China and other developing countries in reducing infant mortality and achieving the Sustainable Development Goals (SDGs). Policymakers should focus on inflation as a macroeconomic variable that reduces the potential negative impact of inflation on infant mortality. The results of the analysis further emphasize the importance of price stability in the context of global inflation caused by the outbreak of the coronavirus pandemic outbreak.


Subject(s)
Coronavirus Infections , Infant Mortality , China/epidemiology , Coronavirus Infections/epidemiology , Disease Outbreaks , Humans , Infant , Infant, Newborn , Pandemics
8.
Tourism Review of AIEST - International Association of Scientific Experts in Tourism ; 77(2):484-502, 2022.
Article in French | ProQuest Central | ID: covidwho-1722844

ABSTRACT

Purpose>COVID-19 is currently the most serious crisis facing the world, and scholars in the medical and social sciences are working to save lives and mitigate the societal effects of the pandemic. This global public health emergency requires interdisciplinary work to provide comprehensive insight into a rapidly changing situation. However, attempts to integrate the medical and social sciences have met several barriers. This paper aims to identify feasible research opportunities for interdisciplinary studies across tourism and public health regarding COVID-19.Design/methodology/approach>This paper presents a critical review of the literature and generates corresponding conceptual and theoretical frameworks to provide an in-depth discussion.Findings>Tourism-related issues of destination management policies and capital are addressed from an interdisciplinary perspective. The conclusions encourage interdisciplinary research into global health problems, which will promote tourism’s renaissance and sustainable development while enhancing social welfare.Practical implications>This study focuses on integrating tourism and public health to offer stakeholders recommendations regarding destination management and tourism industry recovery amid COVID-19.Originality/value>This paper represents a frontier study, critically uncovering a host of innovative interdisciplinary research directions and tourism-focused collaboration opportunities related to COVID-19.

9.
Front Microbiol ; 12: 820698, 2021.
Article in English | MEDLINE | ID: covidwho-1686502

ABSTRACT

Rapid and sensitive nucleic acid detection of SARS-CoV-2 has contributed to the clinical diagnosis and control of COVID-19. Although detection of virus genomic RNA (gRNA) has been commonly used in clinical diagnosis, SARS-CoV-2 gRNA detection could not discriminate between active infectious virus with remnant viral RNA. In contrast to genomic RNA, subgenomic RNAs (sgRNAs) are only produced when the virus is actively replicating and transcription, detection of sgRNA could be an indication to evaluate infectivity. CRISPR/Cas-based nucleic acid detection methods have been considered potential diagnostic tools due to their intrinsic sensitivity, specificity and simplicity. In this study, to specifically detect active virus replication, we developed a CRISPR-based active SARS-CoV-2 (CRISPR-actCoV) detection strategy by detecting sgRNAs of SARS-CoV-2. CRISPR-actCoV with CRISPR Cas12a-assisted fluorescence reporter system enables detection of sgRNAs at 10 copies in 35 min with high specificity and can be read out with naked eyes. Further, we performed CRISPR-actCoV mediated sgRNA detection in 30 SARS-CoV-2 potentially infected clinical samples, and 21 samples were SARS-CoV-2 sgRNA positive. A quantitative RT-PCR assay was also performed to detect gRNA of SARS-CoV-2 in parallel. Among the 30 clinical samples, 27 samples were gRNA positive. Taken together, CRISPR-actCoV provides an alternative for rapid and accurate detection of active SARS-CoV-2 and has great significance in better response of coronavirus causing epidemic disease.

10.
Int J Environ Res Public Health ; 19(3)2022 Jan 29.
Article in English | MEDLINE | ID: covidwho-1667150

ABSTRACT

The Delta variant (B.1.617.2) has dominated in many countries over the world. Its sudden outbreak in China has led the government to quickly carry out large-scale nucleic acid testing to curb its spread. This qualitative study aims to find the challenges based on empirical evidence from the perspectives of the different groups of people involved in the testing, and further explore possible strategies to improve the efficiency of large-scale nucleic acid testing. Using a phenomenological approach, we selected 35 participants (seven managers, eight health professionals, six community volunteers and 14 residents) by purposive sampling. The interviews were conducted by in-depth semi-structured interviews and the data were analyzed by Colaizzi's seven-step method. Qualitative analysis revealed three main themes: unreasonable and unsafe testing points layout settings, human and medical resources challenges, and potential infection risk. From the different angles, participants all experienced challenges during large-scale nucleic acid testing, making positive planning and adequate preparation important parts of the smooth development of testing. Large-scale nucleic acid testing relies on the cooperation and efforts of all to support containment of the spread of the virus. Local governments should improve their ability to respond to and deal with public health emergencies.


Subject(s)
COVID-19 , Nucleic Acids , Disease Outbreaks , Health Personnel , Humans , Qualitative Research
11.
Current Issues in Tourism ; : 1-20, 2022.
Article in English | Taylor & Francis | ID: covidwho-1625446
12.
Nurs Open ; 9(1): 320-328, 2022 01.
Article in English | MEDLINE | ID: covidwho-1599319

ABSTRACT

AIM: This study aims to develop a reliable and validate Chinese version of Oldenburg Burnout Inventory (OLBI). DESIGN: A cross-sectional validation design was adopted in this study. METHODS: After obtaining the copyright by contacting with the author, the original English OLBI was developed to Chinese by forward translation, back-translation, cultural adaptation and a pre-test (20 nurses). The Chinese OLBI and Maslach Burnout Inventory (MBI) were administered to 641 clinical nurses during July and August, 2020. Internal consistency (Cronbach's α coefficient), split reliability (split half coefficient), construct validity (confirmatory factor analysis) and criterion validity (comparison with MBI, using Pearson correlation analysis) were assessed. RESULTS: The Chinese OLBI included 16 items. Exploratory factor analysis extracted two factors with a cumulative contribution of 62.245%. Two-dimensional structure (exhaustion and disengagement) was confirmed. It has good internal consistency (Cronbach's α coefficient values of 0.905, 0.933 and 0.876 for the total questionnaire, exhaustion dimension and disengagement dimension, respectively), split half reliability (split half coefficient = 0.883, p < .01) and criterion validity (r = 0.873, p < .01). Pearson coefficients between 16 items and the scale varied from 0.479-0.765. An acceptable model fit (χ2 /df = 2.49, RMSEA = 0.068, TLI = 0.906, CFI = 0.922, SRMR = 0.061) was achieved.


Subject(s)
Burnout, Psychological , China , Cross-Sectional Studies , Humans , Psychometrics/methods , Reproducibility of Results
13.
Tour Manag Perspect ; 40: 100895, 2021 Oct.
Article in English | MEDLINE | ID: covidwho-1466929

ABSTRACT

This paper examines the impacts of COVID-19 on Chinese nationals' tourism preferences. Employing a mixed-method research design, two rounds of nation-wide online surveys were conducted, one in February 2020 when COVID-19 cases started to peak in China and another one in June 2020 when COVID-19 was a global pandemic; both survey studies were accompanied with semi-structured in-depth interviews and altogether 37 interviews were conducted in two stages. Based on both quantitative survey data and qualitative interview data, the research identified that: 1) COVID-19 significantly reduced Chinese nationals' preferences to travel to countries with high infection numbers, and geographically faraway, administratively and culturally distant outbound destinations; 2) Chinese nationals reduced their preferences in all travel modes and most of the tourism forms, but most of them would prefer nature-based, rural, and cultural destinations after COVID-19; and 3) shortened trips in short travel distance are preferred after COVID-19. The findings offer rich insights and practical implications for governments, industry organisations, and tourism operators to formulate tourism recovery strategies toward Chinese tourists.

14.
Int J Environ Res Public Health ; 18(19)2021 09 29.
Article in English | MEDLINE | ID: covidwho-1444202

ABSTRACT

There has long been a gender bias in medicine. This qualitative study aims to identify the experience of sexism among frontline female nurses and further explore their expectations and possible strategies to get rid of gender bias. This is a descriptive phenomenological study of 23 female nurses with 11 ± 3.98 years of experience who spent 36 ± 6.50 days at the frontline during the initial COVID-19 outbreak. We employed Colaizzi's phenomenological analysis method to understand the subjective experiences, revealing the following themes: (a) materialization of gender identity; (b) incoordinate relationships; (c) future voice of female nurses. The gender bias experienced by female frontline nurses further challenges their emotional identity and self-identity. Therefore, it is important to require extensive consciousness-raising and policy support to defend female nurses' rights.


Subject(s)
COVID-19 , Nursing Staff, Hospital , China , Female , Gender Identity , Humans , Male , Pandemics , Qualitative Research , SARS-CoV-2 , Sexism
15.
Cell Discov ; 7(1): 76, 2021 Aug 31.
Article in English | MEDLINE | ID: covidwho-1380898

ABSTRACT

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causes a broad clinical spectrum of coronavirus disease 2019 (COVID-19). The development of COVID-19 may be the result of a complex interaction between the microbial, environmental, and host genetic components. To reveal genetic determinants of susceptibility to COVID-19 severity in the Chinese population, we performed a genome-wide association study on 885 severe or critical COVID-19 patients (cases) and 546 mild or moderate patients (controls) from two hospitals, Huoshenshan and Union hospitals at Wuhan city in China. We identified two loci on chromosome 11q23.3 and 11q14.2, which are significantly associated with the COVID-19 severity in the meta-analyses of the two cohorts (index rs1712779: odds ratio [OR] = 0.49; 95% confidence interval [CI], 0.38-0.63 for T allele; P = 1.38 × 10-8; and index rs10831496: OR = 1.66; 95% CI, 1.38-1.98 for A allele; P = 4.04 × 10-8, respectively). The results for rs1712779 were validated in other two small COVID-19 cohorts in the Asian populations (P = 0.029 and 0.031, respectively). Furthermore, we identified significant eQTL associations for REXO2, C11orf71, NNMT, and CADM1 at 11q23.3, and CTSC at 11q14.2, respectively. In conclusion, our findings highlight two loci at 11q23.3 and 11q14.2 conferring susceptibility to the severity of COVID-19, which might provide novel insights into the pathogenesis and clinical treatment of this disease.

16.
Int J Environ Res Public Health ; 18(16)2021 08 19.
Article in English | MEDLINE | ID: covidwho-1367821

ABSTRACT

The outbreak of coronavirus disease in 2019 (COVID-19) in Wuhan has led Chinese health authorities to recruit healthcare providers from the least-affected areas to provide care to the infected patients in Wuhan. We took further steps to explain some plausible reasons for their experiences. We used interpretative phenomenological analysis (IPA) to understand the subjective experiences, as well as the reasons for these experiences among the healthcare providers who had traveled from the least-affected parts of China to render aid during Wuhan's COVID-19 outbreak. Using purposive and snowball sampling, healthcare professionals were recruited from three major hospitals in Jiangsu province. Semi-structured interviews were conducted from 1 September to 14 November 2020 in face-to-face contexts. Ten nurses and four doctors provided their informed consent for the study. The primary superordinate theme from the responses highlighted how social identity and individual needs were challenged by each individual's professional ethics. COVID-19 not only presents significant risks to the health of nurses and medical doctors; it further challenges their emotional and psychosocial wellbeing. Care should be taken in allocating support and help, with the careful deployment of professional values and beliefs, so that any human resource as precious as medical doctors and nurses can be protected.


Subject(s)
COVID-19 , China/epidemiology , Delivery of Health Care , Health Personnel , Humans , Qualitative Research , SARS-CoV-2
17.
Nurs Ethics ; 29(1): 7-18, 2022 Feb.
Article in English | MEDLINE | ID: covidwho-1308065

ABSTRACT

BACKGROUND: In 2019, an outbreak of COVID-19 broke out in Hubei, China. Medical workers from all over the country rushed to Hubei and participated in the treatment and care of COVID-19 patients. These nurses, dedicated to their professional practice, volunteered to provide compassion and expert clinical care during the pandemic. As with other acts of heroism, the ethical dilemmas associated with working on the front line must be considered for future practice. PURPOSE: To explore the ethical dilemmas of frontline nurses of Jiangsu Province in China during deployment to Wuhan to fight the novel coronavirus pneumonia, and to provide a basis for developing strategies to help nursing staff address personal and practice concerns in order to work more effectively during this pandemic and other disasters in the future. RESEARCH DESIGN AND METHOD: Using the phenomenological research method and the purpose sampling method, semi-structured interviews were conducted with 10 nurses, post-deployment to Wuhan, who had worked on the front line to fight the novel coronavirus. ETHICAL CONSIDERATIONS: The research proposal was approved by the Research Ethic Committee of Yangzhou University, China. FINDINGS: From the analysis of the interviews of the 10 participants, three main themes were identified: ethical dilemmas in clinical nursing, ethical dilemmas in interpersonal relationships, and ethical dilemmas in nursing management. CONCLUSION: During a quick response to public health emergencies, where nurses are deployed immediately as a call to action, the issues surrounding ethical dilemmas from several perspectives must be considered. This research suggests that a team approach to proactive planning and open communication during the emergency is an efficient and productive strategy to improve the nurses' experience and sense of well-being.


Subject(s)
COVID-19 , Ethics, Nursing , Nurses , Humans , Pandemics , Qualitative Research , SARS-CoV-2
18.
Biotechnol J ; 16(6): e2100040, 2021 Jun.
Article in English | MEDLINE | ID: covidwho-1086281

ABSTRACT

Detection of pathogens with single-nucleotide variations is indispensable for the disease tracing, but remains technically challenging. The D614G mutation in the SARS-CoV-2 spike protein is known to markedly enhance viral infectivity but is difficult to detect. Here, we report an effective approach called "synthetic mismatch integrated crRNA guided Cas12a detection" (symRNA-Cas12a) to detect the D614 and G614 variants effectively. Using this method, we systemically screened a pool of crRNAs that contain all the possible nucleotide substitutions covering the -2 to +2 positions around the mutation and identify one crRNA that can efficiently increase the detection specificity by 13-fold over the ancestral crRNA. With this selected crRNA, the symRNA-Cas12a assay can detect as low as 10 copies of synthetic mutant RNA and the results are confirmed to be accurate by Sanger sequencing. Overall, we have developed the symRNA-Cas12a method to specifically, sensitively and rapidly detect the SARS-CoV-2 D614G mutation.


Subject(s)
COVID-19 , RNA, Guide, Kinetoplastida , CRISPR-Cas Systems , Humans , Mutation , SARS-CoV-2 , Spike Glycoprotein, Coronavirus
19.
Journal of Destination Marketing & Management ; 18:100502, 2020.
Article in English | ScienceDirect | ID: covidwho-885338

ABSTRACT

Given growing attention toward the effects on COVID-19 on tourism, a number of institutions have made macro-level predictions related to the disease. More micro-level research are, however, needed. This study seeks to advance the understanding of tourists' potential behavioral transformation by reviewing psychological distance and construal level theory, as well as the relationship between psychological distance and perceived risk. Multiple dimensions of psychological distance and perceived risk are summarized with respect to COVID-19. The discussion suggests that global health emergencies evoke three types of tourism pattern: from general to elaborate, from open-hearted to closed, and from radical to conservative. These categories provide a conceptual foundation for empirical research considering contextual and individual stimuli. Practically, this paper highlights strategies to reduce individuals’ risk perceptions, encourage specific types of tourism, and regulate unethical consumption. The recommendations also encourage the analysis of crisis recovery and relevant market analysis by tourism professionals and marketers.

20.
Front Public Health ; 8: 267, 2020.
Article in English | MEDLINE | ID: covidwho-615606

ABSTRACT

Asymptomatic individuals with coronavirus disease (COVID-19) have been identified via nucleic acid testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, the epidemiologic characteristics and viral shedding pattern of asymptomatic patients remain largely unknown. In this study, serological testing was applied when identifying nine asymptomatic cases of COVID-19 who showed persistent negative RT-PCR test results for SARS-CoV-2 nucleic acid and no symptoms of COVID-19. Two asymptomatic cases were presumed to be index patients who had cleared the virus when their close contacts developed symptoms of COVID-19. Three of the asymptomatic cases were local individuals who spontaneously recovered before their presumed index patients developed symptoms of COVID-19. This report presents the epidemiologic and clinical characteristics of asymptomatic individuals with SARS-CoV-2 infection that were undetected on RT-PCR tests in previous epidemiologic investigations probably due to the transient viral shedding duration.


Subject(s)
Asymptomatic Diseases , COVID-19 Serological Testing , COVID-19 , Reverse Transcriptase Polymerase Chain Reaction , COVID-19/diagnosis , COVID-19/transmission , Female , Humans , Male , Middle Aged , SARS-CoV-2/isolation & purification
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