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1.
J Mater Sci ; 57(20): 9104-9117, 2022.
Article in English | MEDLINE | ID: covidwho-1866648

ABSTRACT

With the continuous spread of COVID-19, the water pollution problems caused by the abuse of chloroquine phosphate (CQP) as an antiviral drug have attracted wide attention. The cubic Fm-3m spinel high entropy oxide (HEO)-(MgCuMnCoFe)O x was prepared by coprecipitation method as the catalytic wet air oxidation (CWAO) catalyst to treat CQP simulated wastewater. Through electron spin resonance (ESR) analysis, HEO will stimulate the production of superoxide radical (·O2 -) and hydroxyl radical (·OH) in the wet air oxidation (WAO) process, which accelerates the degradation and mineralization of CQP. Through response surface method (RSM) optimization, the optimal degradation conditions of CQP in CWAO were proposed: initial oxygen pressure of 15 bar, catalyst dosage of 1.4 g/L and temperature of 230 °C. The advantages of HEO in CWAO were analyzed by principal component analysis (PCA). The degradation mechanism of CQP in CWAO by (MgCuMnCoFe)O x were explored. This work provides a new idea for the rapid development of HEO in the field of environmental catalysis. Supplementary Information: The online version contains supplementary material available at 10.1007/s10853-022-07271-z.

2.
Sci Total Environ ; 825: 153880, 2022 Jun 15.
Article in English | MEDLINE | ID: covidwho-1692895

ABSTRACT

Since the COVID-19 outbreak in early 2020, face mask (FM) has been recognized as an effective measure to reduce the infection, increasing its consumption across the world. However, the large amount of at-home FM usage changed traditional medical waste management practices, lack of improper management. Currently, few studies estimate FM consumption at a global scale, not to say a comprehensive investigation on the environmental risks of FM from a life cycle perspective. Therefore, global FM consumption and its associated environmental risks are clarified in the present study. Our result shows that 449.5 billion FMs were consumed from January 2020 to March 2021, with an average of 59.4 FMs per person worldwide. This review also provides a basis to understand the environmental risk of randomly disposed of FM and highlights the urgent requirement for the attention of FMs waste management to prevent pollution in the near future.


Subject(s)
COVID-19 , COVID-19/epidemiology , Humans , Masks , Pandemics , Plastics , SARS-CoV-2
3.
Biomed Pharmacother ; 137: 111313, 2021 May.
Article in English | MEDLINE | ID: covidwho-1062248

ABSTRACT

The SARS-CoV-2 outbreak and pandemic that began near the end of 2019 has posed a challenge to global health. At present, many candidate small-molecule therapeutics have been developed that can inhibit both the infection and replication of SARS-CoV-2 and even potentially relieve cytokine storms and other related complications. Meanwhile, host-targeted drugs that inhibit cellular transmembrane serine protease (TMPRSS2) can prevent SARS-CoV-2 from entering cells, and its combination with chloroquine and dihydroorotate dehydrogenase (DHODH) inhibitors can limit the spread of SARS-CoV-2 and reduce the morbidity and mortality of patients with COVID-19. The present article provides an overview of these small-molecule therapeutics based on insights from medicinal chemistry research and focuses on RNA-dependent RNA polymerase (RdRp) inhibitors, such as the nucleoside analogues remdesivir, favipiravir and ribavirin. This review also covers inhibitors of 3C-like protease (3CLpro), papain-like protease (PLpro) and other potentially innovative active ingredient molecules, describing their potential targets, activities, clinical status and side effects.


Subject(s)
Antiviral Agents , COVID-19 , Molecular Targeted Therapy/methods , SARS-CoV-2 , Antiviral Agents/classification , Antiviral Agents/pharmacology , COVID-19/drug therapy , COVID-19/metabolism , Enzyme Inhibitors/pharmacology , Humans , SARS-CoV-2/drug effects , SARS-CoV-2/enzymology , Therapies, Investigational
4.
Phytomed Plus ; 1(2): 100027, 2021 May.
Article in English | MEDLINE | ID: covidwho-1032443

ABSTRACT

Background: In December 2019, a novel coronavirus, SARS-CoV-2 caused a series of acute atypical respiratory diseases worldwide. However, there is still a lack of drugs with clear curative effects, and the clinical trial research of vaccines has not been completely finished. Purpose: LH capsules are approved TCM patent medicine that are widely used for the treatment of respiratory tract infectious diseases caused by colds and flu. On April 12, 2020, LH capsules and granules were officially repurposed by the China Food and Drug Administration (CFDA) for patients with mild COVID-19 based on their safety and efficacy demonstrated through multicentre, randomized, controlled clinical trials. We hope to conduct a comprehensive review of it through modern pharmacy methods, and try to explain its possible mechanism. Methods: Using the full names of LH capsules Lianhuaqingwen, Lianhua Qingwen andSARS-COV-2, COVID-19 as the keywords of the search terms, systemically search for existing related papers in various databases such as Web of Science and PubMed. And completed the collection of clinical data in ClinicalTrials.gov and Chinese Clinical Trial Registry. Last but not least, we have sorted out the anti-inflammatory and antiviral mechanisms of LH capsules through literature and Selleck. Results: This review systematically sorted out the active ingredients in LH capsules. Furthermore, the related pharmacological and clinical trials of LH capsule on SARS-CoV-2, IAV and IBV were discussed in detail. Moreover, the present review provides the first summary of the potential molecular mechanism of specific substances in LH capsules involved in resistance to SARS-COV-2 infection and the inhibition of cytokine storm syndrome (CSS) caused by IL-6. Conclusion: This review summarizes the available reports and evidence that support the use of LH capsules as potential drug candidates for the prevention and treatment of COVID-19. However, TCM exerts its effects through multiple targets and multiple pathways, and LH capsules are not an exception. Therefore, the relevant mechanisms need to be further improved and experimentally verified.

5.
Eur J Med Chem ; 206: 112711, 2020 Nov 15.
Article in English | MEDLINE | ID: covidwho-879739

ABSTRACT

This review fully describes the coronavirus 3CLpro peptidomimetic inhibitors and nonpeptidic small molecule inhibitors developed from 2010 to 2020. Specifically, the structural characteristics, binding modes and SARs of these 3CLpro inhibitors are expounded in detail by division into two categories: peptidomimetic inhibitors mainly utilize electrophilic warhead groups to covalently bind the 3CLpro Cys145 residue and thereby achieve irreversible inhibition effects, whereas nonpeptidic small molecule inhibitors mainly interact with residues in the S1', S1, S2 and S4 pockets via hydrogen bonds, hydrophobic bonds and van der Waals forces. Based on the emerging PROTAC technology and the existing 3CLpro inhibitors, 3CLpro PROTAC degraders are hypothesised to be next-generation anti-coronavirus drugs.


Subject(s)
Antiviral Agents/pharmacology , Protease Inhibitors/pharmacology , Viral Nonstructural Proteins/antagonists & inhibitors , Antiviral Agents/therapeutic use , Coronavirus 3C Proteases , Cysteine Endopeptidases , Humans , Peptidomimetics , Protease Inhibitors/therapeutic use
6.
Eur J Med Chem ; 201: 112527, 2020 Sep 01.
Article in English | MEDLINE | ID: covidwho-548763

ABSTRACT

Remdesivir (GS-5734), a viral RNA-dependent RNA polymerase (RdRP) inhibitor that can be used to treat a variety of RNA virus infections, is expected to be an effective treatment for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. On May 1, 2020, The U.S. Food and Drug Administration (FDA) has granted Emergency Use Authorization (EUA) for remdesivir to treat COVID-19 patients. In light of the COVID-19 pandemic, this review presents comprehensive information on remdesivir, including information regarding the milestones, intellectual properties, anti-coronavirus mechanisms, preclinical research and clinical trials, and in particular, the chemical synthesis, pharmacology, toxicology, pharmacodynamics and pharmacokinetics of remdesivir. Furthermore, perspectives regarding the use of remdesivir for the treatment of COVID-19 are also discussed.


Subject(s)
Adenosine Monophosphate/analogs & derivatives , Alanine/analogs & derivatives , Antiviral Agents/therapeutic use , Betacoronavirus/drug effects , Coronavirus Infections/drug therapy , Pneumonia, Viral/drug therapy , Adenosine Monophosphate/therapeutic use , Alanine/therapeutic use , COVID-19 , Clinical Trials as Topic , Coronavirus Infections/virology , Humans , Pandemics , Pneumonia, Viral/virology , SARS-CoV-2
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