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1.
Genetic Epidemiology ; 46(7):547-547, 2022.
Article in English | Web of Science | ID: covidwho-2030857
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International Journal of Infectious Diseases ; 122:537-542, 2022.
Article in English | Web of Science | ID: covidwho-2015429

ABSTRACT

Objectives: Interferon- gamma release assays (IGRAs) are widely used in public health practice to diagnose latent tuberculosis. During the COVID-19 pandemic and rollout of COVID-19 vaccination, it has remained unclear whether COVID-19 vaccines interfere with IGRA readouts. Methods: We prospectively recruited healthcare workers during their annual occupational health examinations in 2021. Baseline IGRA readouts were compared with follow-up data after the participants had received two doses of COVID-19 vaccination. Results: A total of 134 baseline IGRA-negative cases (92 with ChAdOx1 vaccine, 27 with mRNA-1273 vaccine, and 15 with heterologous vaccination) and seven baseline IGRA-positive cases were analyzed. Among the baseline IGRA-negative cases, there were decreased interferon- gamma concentrations over the Nil ( P = 0.005) and increased Mitogen-Nil ( P < 0.001) values after vaccination. For TB2-Nil value, a similar trend ( P = 0.057) of increase was observed. Compared with the 0.35 IU/ml threshold, the baseline and follow-up readout differences were less than ;+/- 0.10;IU/ml over the TB1-Nil and TB2-Nil values in > 90% baseline IGRA-negative cases. No significant readout difference was observed among baseline IGRApositive cases. Conclusion: COVID-19 vaccination did not change IGRA interpretation in most cases. Cases showing conversion/borderline IGRA readouts should be given special consideration. (c) 2022 The Author(s). Published by Elsevier Ltd on behalf of International Society for Infectious ( http://creativecommons.org/licenses/by-nc-nd/4.0/ )

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International Eye Science ; 22(5):870-874, 2022.
Article in Chinese | Scopus | ID: covidwho-1847437

ABSTRACT

AIM: To analyze the epidemiological characteristics of patients hospitalized for ocular trauma during the novel coronavirus (COVID-19) epidemic. METHODS: A retrospective case analysis. Totally 876 cases (905 eyes) of ocular trauma were analyzed in this study, including 545 cases (565 eyes) from January to June 2019 were enrolled ascontrol group, and 331 cases (340 eyes) from January to June 2020 were enrolled in the research group. Information regarding age, sex, location of injury, cause of injury, place of residence, and type of injury were collected and analyzed. RESULTS: The number of hospitalisation for ocular trauma in the research group decreased by 39.3% compared with the control group. The age distribution of patients showed a double peak, at 0-10 years (20.55%, 21.45%) and 41-50 years (17.98%, 19.03%) in the control group and research group, respectively. There was no statistically significant difference in the age distribution between the two groups (P=0.907). Men were predominantly injured in both the control and the research groups, accounting for 80.37% and 83.69%, respectively (P=0.219). The proportion of home injuries in the research group (28.40%) was higher than the control group (11.38%) (P<0.001). The proportion of mechanical eye injuries in the research group (98.19%) was higher than the control group (95.60%) (P=0.041), and the proportion of open globe injuries (85.54%) was also higher than the control group (76.58%) (P=0.001). The proportion of patients with no light perception in the research group (18.86%) was higher than that of the control group (9.53%) (P<0.001). CONCLUSION: During the COVID-19 epidemic period, the total number of ocular trauma cases was significantly reduced. Mechanical eye injuries are still the main type for hospitalisation of patients with eye injuries. The awareness of eye injury prevention should be strengthened during the period of epidemic. Copyright 2022 by the IJO Press.

5.
Geophysical Research Letters ; 49(2):10, 2022.
Article in English | Web of Science | ID: covidwho-1692656

ABSTRACT

The significant reduction in human activities during COVID-19 lockdown is anticipated to substantially influence urban climates, especially urban heat islands (UHIs). However, the UHI variations during lockdown periods remain to be quantified. Based on the MODIS daily land surface temperature and the in-situ surface air temperature observations, we reveal a substantial decline in both surface and canopy UHIs over 300-plus megacities in China during lockdown periods compared with reference periods. The surface UHI intensity (UHII) is reduced by 0.25 (one S.D. = 0.22) K in the daytime and by 0.23 (0.20) K at night during lockdown periods. The reductions in canopy UHII reach 0.42 (one S.D. = 0.26) K in the daytime and 0.39 (0.29) K at night. These reductions are mainly due to the near-unprecedented drop in human activities induced by strict lockdown measures. Our results provide an improved understanding of the urban climate variations during the global pandemic.

7.
Chinese Automation Congress (CAC) ; : 58-63, 2020.
Article in English | Web of Science | ID: covidwho-1406534

ABSTRACT

In recent days, the outbreak of COVID-19 poses a great threat to global public health. While great efforts have been made to combat the virus by medical workers of various countries, considerable attention has also been paid to forecast the trend of the epidemic by the researchers, which may help the government formulate corresponding policies. In this paper, we proposed an improved SEIR epidemiological model, named SEIQR (susceptible-exposed-infected-quarantined-recovered). Quarantine group and several time-varying parameters were considered to make the model better approximate the real situation. Besides, ABC-SMC algorithm was introduced to tackle parameter inference problem and ABC-SMC model selection framework was employed to demonstrate the superiority of SEIQR over traditional methods. Extensive experiments have shown that the proposed SEIQR model can perform well in identifying epidemic trends and predicting future development.

8.
Physical Review Research ; 3(1):12, 2021.
Article in English | Web of Science | ID: covidwho-1138040

ABSTRACT

According to the official report, the first case of COVID-19 and the first death in the United States occurred on January 20 and February 29, 2020, respectively. On April 21, California reported that the first death in the state occurred on February 6, implying that community spreading of COVID-19 might have started earlier than previously thought. Exactly what is time zero, i.e., when did COVID-19 emerge and begin to spread in the U.S. and other countries? We develop a comprehensive predictive modeling framework to address this question. Using available data of confirmed infections to obtain the optimal values of the key parameters, we validate the model and demonstrate its predictive power. We then carry out an inverse inference analysis to determine time zero for 10 representative states in the U.S., plus New York City, United Kingdom, Italy, and Spain. The main finding is that, in both the U.S. and Europe, COVID-19 started around the new year day.

9.
Academic Journal of Second Military Medical University ; 41(10):1142-1147, 2020.
Article in Chinese | Scopus | ID: covidwho-971176

ABSTRACT

Epidemic infectious diseases have become a major threat to public health safety. This paper reviews the previous researches and analyzes the psychological impact of infectious disease outbreak on medical staff, patients and the public, exploring the risk and protective factors of adverse psychological reactions, so as to provide references for future research and counseling after coronavirus disease 2019 outbreak. It is suggested that multi-center and large-scale follow-up investigation is needed, and more attention needs to be paid on influences of stigma and public opinion on internet and the change of positive psychological quality after the epidemic outbreak. Moreover, the research results of risk and protective factors should be fully used in psychological intervention. © 2020 Second Military Medical University Press. All rights reserved.

10.
Zhonghua Yu Fang Yi Xue Za Zhi ; 54(9): 963-967, 2020 Sep 06.
Article in Chinese | MEDLINE | ID: covidwho-750613

ABSTRACT

Objective: To evaluate and share the novel method for recruiting participants in clinical trials of vaccines in emergency situations. Methods: To publish recruitment notice in local areas of Wuhan through websites and medium, and guide interested persons to log in to the"Clinical Trials of SARS-CoV-2 Vaccine Reservation and Health Declaration System"to appoint and register their health information. The "Health Declaration System" provides each volunteer evaluation and risk levels to preliminarily exclude those who do not meet the inclusion criteria. Researchers review the qualified volunteers by telephone, organize them to go to the vaccination site, and finally conduct a strict medical screening to determine the final subjects. Results: A total of 4 819 people and 5 132 people registered in the Phase Ⅰ and Phase Ⅱ recruitment system respectively, with men 2 912 (60.43%) and 2 887 (56.25%) more than women 1 907 (39.57%) and 2 245 (43.75%), mostly in the 20-39 age group, with 3 211 (66.63%) and 3 966 (77.28%). All 13 districts in Wuhan have interested residents to participate clinical research.The initial qualified rate of the Phase Ⅱ recruitment system was higher than that of Phase Ⅰ, with men 2 047 (70.28%) and 2 135(73.95%), higher than women 1 083 (56.80%) and 1 472 (65.57%); 440 and 689 people were reviewed by telephone in Phase Ⅰ and Phase Ⅱ respectively, and the number of verified volunteers was about 440 (35.00%) and 689 (67.20%); Of the 201 603 people who arrived at the vaccination site, 12 and 26 of them were positive for the SARS-CoV-2 antibody with an antibody positive rate of 6.00% and 4.31% respectively. Conclusion: The novel method for recruiting subjects in this clinical study is efficient and reliable, and the recruitment situation of Phase Ⅰ had set a good example for Phase Ⅱ but the medium-and long-term compliance of subjects and the separation of willingness and behaviors still need to be further studied.


Subject(s)
Clinical Trials as Topic/organization & administration , Patient Selection , Viral Vaccines , Adult , COVID-19 , COVID-19 Vaccines , China/epidemiology , Coronavirus Infections/epidemiology , Coronavirus Infections/prevention & control , Emergencies , Female , Humans , Male , Pandemics/prevention & control , Pneumonia, Viral/epidemiology , Pneumonia, Viral/prevention & control , Volunteers/statistics & numerical data , Young Adult
11.
Chinese Traditional and Herbal Drugs ; 51(4):873-877, 2020.
Article | WHO COVID | ID: covidwho-46944

ABSTRACT

There are an increasing number of patients suffering from coronavirus disease 2019 (COVID-19) in our country and overseas. After the outbreak, the state health administrative sections have updated steadily several editions of Diagnosis and Treatment of Novel Coronavirus Pneumonia. According to the change of exposition of traditional Chinese medicine (TCM) treatment in these editions and the characteristics of cases in clinic, COVID-19 corresponds to pestilence category of TCM, which also based on the ancient literatures from the seasonal-febrile-disease subject of TCM. The disease contributes to pestilential pathogen caused by specifically regional climate characteristics of Wuhan city. It is important for COVID-19 patients to eliminate pathogens as soon as possible, which should apply defense-qi-nutrient-blood diagnosis to different courses of disease. The TCM therapy should be established according to the different organs where the virus lives and characters. In order to control the epidemic at an early date, it is necessary to consider the local conditions and use the combination of traditional Chinese and western medicine to treat COVID -19 patients.

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