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1.
Frontiers in Pediatrics ; 10, 2022.
Article in English | Web of Science | ID: covidwho-2199081

ABSTRACT

The COVID-19 pandemic represents a valuable opportunity to carry out cohort studies that allow us to advance our knowledge on pathophysiological mechanisms of neuropsychiatric diseases. One of these opportunities is the study of the relationships between inflammation, brain development and an increased risk of suffering neuropsychiatric disorders. Based on the hypothesis that neuroinflammation during early stages of life is associated with neurodevelopmental disorders and confers a greater risk of developing neuropsychiatric disorders, we propose a cohort study of SARS-CoV-2-infected pregnant women and their newborns. The main objective of SIGNATURE project is to explore how the presence of prenatal SARS-CoV-2 infection and other non-infectious stressors generates an abnormal inflammatory activity in the newborn. The cohort of women during the COVID-19 pandemic will be psychological and biological monitored during their pregnancy, delivery, childbirth and postpartum. The biological information of the umbilical cord (foetus blood) and peripheral blood from the mother will be obtained after childbirth. These samples and the clinical characterisation of the cohort of mothers and newborns, are tremendously valuable at this time. This is a protocol report and no analyses have been conducted yet, being currently at, our study is in the recruitment process step. At the time of this publication, we have identified 1,060 SARS-CoV-2 infected mothers and all have already given birth. From the total of identified mothers, we have recruited 537 SARS-COV-2 infected women and all of them have completed the mental health assessment during pregnancy. We have collected biological samples from 119 mothers and babies. Additionally, we have recruited 390 non-infected pregnant women.

2.
Circulation Conference: American Heart Association's ; 146(Supplement 1), 2022.
Article in English | EMBASE | ID: covidwho-2194381

ABSTRACT

Introduction: With more people working from home after the COVID pandemic, it is of utmost importance to further understand the impact of social isolation on outcomes of patients with coronary atherosclerosis. Our preliminary studies have shown that the novel diet-inducible, fatal mouse model of coronary atherosclerosis, SR-BIDELTACT/LDLR KO, tend to die on average around 4-6 weeks after starting a high-fat Paigan diet (HFD). This mouse model can be used to further understand the effect of social isolation on cardiovascular disease. We hypothesize that social isolation will decrease survival and worsen cardiac function. Method(s): Male and female SR-BIDELTACT/LDLR KO mice were put into social isolation (n=11), in a group of 2-3 (n=13), or in a group of 4-5 (n=22). At six-weeks-old, mice were started on a HFD to induce pathology. Echocardiography was performed to assess cardiac function. Analysis was performed using one-way Analysis of Variance tests and hoc-Tukey's Honest Significant Difference tests. A log-rank test was used to calculate the difference in survival distributions. Result(s): Mice living in groups of 1, 2-3, and 4-5 lived for an average of 34.9, 35.6, and 41.5 days, respectively, after starting the HFD (Fig. 1A). The survival distribution is significantly different between the mice in isolation versus the mice in groups of 4-5 (p<;0.01). Mice in social isolation have significantly lower ejection fractions than mice living in groups of 4-5 after two weeks of being on the HFD (Fig. 1B, p=0.028). Conclusion(s): Mice in social isolation exhibited decreased survival and reduced ejection fractions compared to mice in groups of 4-5. More mice would be needed to determine whether single isolation is different from mice in groups of 2-3. Further studies should be performed to understand the mechanism underlying the effect of social isolation on heart function. Such studies may influence future prevention strategies to positively affect outcomes of patients with atherosclerosis. (Figure Presented).

3.
Crit Rev Biotechnol ; : 1-18, 2023.
Article in English | PubMed | ID: covidwho-2186995

ABSTRACT

Phloroglucinol and derived compounds comprise a huge class of secondary metabolites widely distributed in plants and brown algae. A vast array of biological activities, including antioxidant, anti-inflammatory, antimicrobial, and anticancer has been associated to this class of compounds. In this review, the available data on the antiviral and antibacterial capacity of phloroglucinols have been analyzed. Some of these compounds and derivatives show important antimicrobial properties in vitro. Phloroglucinols have been shown to be effective against viruses, such as human immunodeficiency virus (HIV), herpes or enterovirus, and preliminary data through docking analysis suggest that they can be effective against SARS-CoV-19. Also, some phloroglucinols derivatives have shown antibacterial effects against diverse bacteria strains, including Bacillus subtilis and Staphylococcus aureus, and (semi)synthetic development of novel compounds have led to phloroglucinols with a significantly increased biological activity. However, therapeutic use of these compounds is hindered by the absence of in vivo studies and scarcity of information on their mechanisms of action, and hence further research efforts are required. On the basis of this consideration, our work aims to gather data regarding the efficacy of natural-occurring and synthetic phloroglucinol derivatives as antiviral and antibacterial agents against human pathogens, which have been published during the last three decades. The recollection of results reported in this review represents a valuable source of updated information that will potentially help researchers in the development of novel antimicrobial agents.

5.
Revista Universidad Y Sociedad ; 14(5):178-197, 2022.
Article in English | Web of Science | ID: covidwho-2169519

ABSTRACT

The research proposes a social support program for rhythmic gymnastics athletes of the School of Sports Initiation of Cienfuegos for the reincorporation to sports practice post-COVID-19. The program is psychosocially based on 1) reading of needs in terms of social support to rhythmic gymnastics athletes for the reincorporation to post-COVID-19 sports activity;2) social support as a resource of psychosocial strengthening for the reincorporation of rhythmic gymnastics athletes to postCOVID-19 sports activity;and 3) integral, processual and systemic character of the program of social support to rhythmic gymnastics athletes for the reincorporation to post-COVID-19 sports activity. It is structurally organized into three projects: mental health services, psychosocial accompaniment in the sports context and social support to the family. Main strategies It contains the planning of the evaluation and monitoring of the implementation and results.

6.
Revista Medica del Instituto Mexicano del Seguro Social ; 61(1):1-3, 2023.
Article in Spanish | MEDLINE | ID: covidwho-2169321

ABSTRACT

Nowadays, mental health has acquired greater relevance and attention as a consequence mainly of the COVID-19 pandemic, to which is attributed a negative impact on the development of life, work and social coexistence of people, along with the magnitude derived from non-communicable diseases. This is why the Instituto Mexicano del Seguro Social (IMSS, Mexican Institute for Social Security) developed the Mental Health Comprehensive Program 2021-2024, whose main purpose was to establish strategies and lines of action for the prevention, early detection and timely management regarding mental health and addictions. Based on this, different actions have been carried out, for example, the identification of the material and human resources available at IMSS to meet the mental health issue;the training of healthcare professionals at the three levels of care;the integration of a census that has reported a prevalence of anxiety and depressive episodes in the users of 39.9 and 3%, respectively, as well as the evaluation of instruments for screening mental disorders. Therefore, this document describes what has been done in the IMSS in relation to the user's mental health in the context of the COVID-19 pandemic.

7.
Human Review International Humanities Review / Revista Internacional de Humanidades ; 11(Monografico), 2022.
Article in Spanish | Scopus | ID: covidwho-2206396

ABSTRACT

The objective of this research is to investigate, from an interdisciplinary perspective between sociology, psychology, law and history, the management of the coronavirus crisis, which in the Spanish case is based on authoritarian lounge dure logics rooted in the XIX and absolutism. With the use of measures imposed by the authorities and assumed by a terrified citizenry, governments and the media have generated a turning point that has dismantled the associative fabric and the social movements that emerged in response to the bursting of the real estate bubble that occurred in Spain. © GKA Ediciones, authors.

8.
Innovar ; 33(87):93-108, 2022.
Article in English | Scopus | ID: covidwho-2204131

ABSTRACT

This study sought to understand the factors behind the intention towards buying organic products mentioned in the existing literature and provide conceptual and theoretical guidelines for future research on the subject. A systematic revision of original research papers included in Scopus and Web of Science databases during the period 2011-2021 was conducted, resulting in a sample of 162 articles. The results show that the attitude, values, and confidence of the consumer were the main factors in the intention to buy organic foods. Moreover, it was found that the theory of planned behavior was the most used theoretical framework in the analysis of organic foods purchasing. The changes brought by the covid-19 pandemic are manifested in consumers' values and their implications to the sale of this type of foods. We propose to consider consumers' values as variables that intertwine the rational and motivational approaches to consumption analysis. It is also proposed to understand the purchase intention underlying the stimulation of attitudes and the confidence of consumers due to their values. Finally, it is suggested to consider the analysis of the mediating effect of attitudes and trust in the relationship between values and purchase intention. © 2022, Universidad Nacional de Colombia. All rights reserved.

9.
Acta Colombiana de Cuidado Intensivo ; 2022.
Article in English, Spanish | Scopus | ID: covidwho-2158309

ABSTRACT

Guillain-Barré syndrome and its variants are among the neurological complications induced by SARS-CoV-2. A 49-year-old woman with COVID-19. After 14 days of presenting respiratory symptoms, she started with paresthesias, facial and limb weakness, dysphagia, ataxia, and respiratory failure. An unusual picture of overlapping Guillain-Barré and Miller Fisher syndromes was diagnosed. Nerve conduction study showed myelin damage. IgEV was used, recovery started one week after starting treatment. Guillain-Barré syndrome and its variants are a complication of COVID-19 whose diagnosis can become more complex in cases of unusual presentation where different clinical subtypes overlap. © 2022 Asociación Colombiana de Medicina Crítica y Cuidado lntensivo

10.
Medicine & Science in Sports & Exercise ; 54(9):151-151, 2022.
Article in English | Web of Science | ID: covidwho-2156911
11.
Patient Experience Journal ; 9(2):36-45, 2022.
Article in English | Scopus | ID: covidwho-2156211

ABSTRACT

The objective of this study is to examine the incidence of reported stress due to mistreatment by patients toward clinicians and the role of mistreatment from patients along with organizational factors in clinician distress. A survey of clinicians was conducted at a large academic medical center, resulting in a final analytic sample of 1,682 physicians, nurses, advanced practice providers and clinical support staff. Nurses reported the greatest incidence of mistreatment by patients as a major stressor (18.69%), followed by Advanced Practice Providers (11.26%), Clinical Support Staff (10.36%), and Physicians (7.69%). Logistic regression analysis was conducted to determine the relationship of individual- and organization-level characteristics with the odds of reporting mistreatment from patients as a major stressor. Overall findings indicate that nurses and those who work in the ER and ambulatory or outpatient clinics were more likely to be stressed from mistreatment by patients than other clinicians. Stress due to mistreatment by patients was also associated with higher Well-Being Index (WBI) distress scores, rapid changes in workflows or policies, ongoing care of COVID-19 patients, under-staffing, and low perceived organizational support. Gender or sexual minorities (not identifying as male or female) and younger (18-34 years of age) healthcare workers were also more likely to experience stress from mistreatment by patients. Individual resilience was not statistically significantly associated with reported stress from mistreatment by patients. Organizations must examine expectations for patient and visitor behavior in tandem with service standards for clinicians toward patients. © The Author(s), 2022.

12.
J Am Board Fam Med ; 2022.
Article in English | PubMed | ID: covidwho-2154584

ABSTRACT

BACKGROUND: Primary care level close monitoring of mild COVID-19 patients has shown to provide a risk reduction in hospitalization and death. We aimed to compare the risk of all-cause death among COVID-19 ambulatory patients who received and did not receive telephonic follow-up in primary health care settings. METHODS: A secondary database analysis, 2-group comparative study, was conducted with data from the medical information systems of the Mexican Institute of Social Security. A total of 1,498,808 ambulatory patients aged 20 years old and over and with laboratory confirmed SARS-CoV-2 by PCR or rapid antigen test were analyzed. Of them, 535,898 (35.8%) where followed by telephonic calls. The cases were attended from October 14, 2020, to April 10, 2022. Death incidence was evaluated. To assess the association between death and telephonic follow-up we calculated risk ratio using a multivariate logistic model. RESULTS: Case fatality rate was 1.29% in the patients who received telephonic follow-up and 2.95% in the cases who did not receive phone calls. Medical history of chronic kidney disease, COPD, cardiovascular disease, tobacco consumption and diabetes were associated with increased risk of death. In the multivariate model, telephonic follow-up was associated with lower risk of all-cause death, with an adjusted risk ratio of 0.61 (95% confidence interval from 0.59, 0.64). CONCLUSION: Our data suggest that telephonic follow-up is associated with a risk of death reduction in adult outpatients with mild COVID-19, in the context of a multimodal strategy in the primary health care settings.

13.
21st Mexican International Conference on Artificial Intelligence, MICAI 2022 ; 13613 LNAI:339-347, 2022.
Article in English | Scopus | ID: covidwho-2148604

ABSTRACT

The Default Rate is related to the period of the economic cycle in which they are observed, during expansion periods of the economy the default rate tends to be lower. But in contraction periods, the default rate tends to increase and this could be a risk for the stability of a country’s economy. Therefore, it is important to monitor the perspective of the economy in case it is expected to decrease or have abrupt movements. This work aims to identify the economic variables that determine the default rate of the Mexican Financial System and to find a machine learning model that forecasts the default rate. For this, we aggregate a dataset based on three official Mexican sources that compile data from 2013 to 2022, including the COVID-19 pandemic time frame. Then, we propose the analysis using two machine learning models. After the analysis, the results confirm that the artificial neural networks model shows better predictive power for the default rate values. We also implement an easy to use web application to estimate the default rate based on three simple variables. We anticipate this work might help on estimating the default rate and might impact on the strategic policies in the Mexican economy. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

14.
J Rheumatol ; 2022.
Article in English | PubMed | ID: covidwho-2143927

ABSTRACT

"As the publishing sector continues to grow, the need to measure the quality of the produced science grows in parallel...." This assertion is extracted from a study that assessed the increment in the value of scientometric indexes when they were calculated using citations and open access publications in rheumatology journals.(1).

15.
PLoS ONE [Electronic Resource] ; 17(12):e0278394, 2022.
Article in English | MEDLINE | ID: covidwho-2140704

ABSTRACT

BACKGROUND: While Covid-19 monoclonal antibody therapies (Mab) have been available in the outpatient setting for over a year and a half, little is known about the impact of emerging variants and vaccinations on the effectiveness of Mab therapies. We sought to determine the effectiveness of Covid-19 Mab therapies during the first two waves of the pandemic in Los Angeles County and assess the impact of vaccines, variants, and other confounding factors.

16.
Multiple Sclerosis Journal ; 28(3 Supplement):842-843, 2022.
Article in English | EMBASE | ID: covidwho-2138807

ABSTRACT

Background: Patients on OCR have attenuated antibody, but largely intact T-cell responses to COVID-19 vaccination. Little is known about durability of post-vaccine responses in OCR-treated patients. Objective(s): To examine antibody and cellular responses to mRNA COVID-19 vaccines (Pfizer, BioNTech/Moderna) in Ocrelizumab (OCR)-treated MS patients over 24-week period. Method(s): MS patients on OCR were recruited from NYU (New York City) and Rocky Mountain at CU (Denver) MS Centers. Antibody responses to SARS-CoV-2 spike proteins were assessed with multiplex bead-based (MBI) immunoassays, and cellular responses to SARS-CoV-2 Spike protein with ELISpot and activation induced marker (AIM) panel in a Cytek Aurora full-spectrum flow cytometry platform. Data on samples collected pre-vaccine and 4-, 12-, 24-weeks post 2-doses and 4-, 12-weeks post-third dose will be presented. Result(s): 40/61 enrollees (age 38.3+/-10.9;77.5% female;57.5% non-white) had 24-week post-vaccination data and 9 patients had 4-week post 3rd dose data. Antibody response increased from prevaccine level of 972.0 U/mL to 6307.4 U/mL at week-4 (p=0.0002), then decreased to 4633.8 u/mL at week-12 (26% decrease from week-4, p=0.1377), and further to 2878.4 u/mL at week-24 (37% decrease from week-12, p value=0.109). Spikespecific IFNgamma T-cell responses by ELIspot were 125.7 SFU/106 cells pre-vaccine, increased to 362.9 SFU/106 cells at week-4 (p=0.009), then to 511.5 SFU/106 cells at week-12 (40.9% increase relative to 4-week time-point, p=0.8474), and remained elevated at 501.7 SFU/106 cells at week-24 (p=0.7393, 1.9% compared to week 12). 4-week post 3rd dose, Ab level increased to 5094.8 U/mL (189.9% compared to pre-3rd dose, p =0.076) and IFNgamma responses to 1253.3 SFU/106 cells (484.5% increase, p=0.037). Conclusion(s): Antibody responses to 2-series vaccine peaked at 4 weeks and trended downward thereafter, while cellular responses were sustained at 24 weeks. Third-dose resulted in marked increases in both antibody and T-cell responses 4-weeks. Expanded analyses, including in-depth immunophenotyping and 12-week post 3rd vaccination responses will be presented.

17.
19th International Conference on Remote Engineering and Virtual Instrumentation, REV 2022 ; 524 LNNS:222-230, 2023.
Article in English | Scopus | ID: covidwho-2128457

ABSTRACT

The worldwide confinement due to Covid19 has boosted the development of creative learning activities in academia, including role-playing games and multidisciplinary workshops brought to students’ homes. Tecnologico de Monterrey, like most universities in the world, is delivering classes remotely using internally developed and external platforms designed to continue the practices that were done every day in laboratories, facilities, and partner companies and institutions. One of the biggest challenges of distance education is creating fun and practical learning. Integrating innovative technologies into the learning process is necessary to achieve this challenge. One of these technologies is Augmented Reality (AR), which allows virtual objects to be superimposed in the real world to “coexist” with the objects in real-world surroundings. In this research, we generated an ERP (Enterprise Resource Planning) simulator based on the educational platform “Tec21 Car Assembler”. Using Virtual Reality (VR), the students applied the virtual classroom’s theoretical learning to practice, guided by an academician collaborating with training partners from companies and institutions partnering with Tecnologico de Monterrey to transfer knowledge to students. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

19.
Educatio Siglo Xxi ; 40(3):179-198, 2022.
Article in English | Web of Science | ID: covidwho-2110730

ABSTRACT

The lockdown caused by COVID-19 led to the adoption of new virtual methodo-logies using digital tools. The aim of this study was to design and validate a ques-tionnaire on the use of digital media in the virtual teaching of STEM subjects in Foundation Courses. For this purpose, a descriptive non-experimental quantitative design was used and, with the administra-tion of the designed questionnaire, data were collected from 61 students enrolled in these courses during the academic year 2021/2022 at Northumbria University (United Kingdom). The results showed that the reliability and internal consistency of the implemented questionnaire were good (Cronbach's Alpha = .78;Composite Reliability = .79;Mean Extracted Varian-ce = .48;Omega = .95;KMO = .64) and that in general the student body stated that they had good access to and use of digital media and smooth communication with lecturers during the placement. In addition, they stated that they had adap-ted favourably to virtual teaching and that they had successfully acquired subject competences. The pandemic has brought about the implementation of these new methodologies and has meant a renewal and implementation of new resources, with the consequent acquisition of digital competences by both teaching staff and students.

20.
Clinica e Investigacion en Ginecologia y Obstetricia ; : 100822, 2022.
Article in Spanish | MEDLINE | ID: covidwho-2104970

ABSTRACT

A number of factors can affect a woman's menstrual cycle, including diseases or drugs, such as COVID-19 disease and vaccinations. The aim of this review is to explore the studies published to date that have studied the presence of alterations that may be related to COVID-19 or vaccination against the SARS-CoV-2 virus. We conducted a review in the PubMed database, selecting 10 articles in which the menstrual cycle of adult women of childbearing age was studied, 3 of them in which the participants had been diagnosed with COVID-19 and 7 in which the participants had been vaccinated against the SARS-CoV-2 virus.Regarding COVID-19-related disturbances, 16%-47.2% of the participants presented a prolongation of their cycle, which was more frequent in those who reported more COVID-19 symptoms, and which normalised after 1-2 cycles.Regarding the alterations described after SARS-CoV-2 vaccination, 45%-78% of participants reported menstrual cycle alterations, with disparate results for the different parameters analysed, except that the alterations resolved in about 2 months. Both COVID-19 disease and vaccination appear to be associated with the occurrence of menstrual disturbances, which are limited in time and not severe. However, studies are scarce to date, and it is important to continue to develop studies that provide scientific evidence.

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