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1.
International Journal of Advertising ; 2022.
Article in English | Web of Science | ID: covidwho-2004863

ABSTRACT

Many brands have launched pandemic-themed advertising campaigns, aiming to build rapport with their customers in this unprecedented moment. Yet it is challenging for brands to know how to communicate efficiently. To fill this gap, the current research aims to provide a systematic framework that could guide advertisers in designing pandemic-themed advertisements to stimulate consumer engagement on social media by examining the role of values in context-specific brand communications. In particular, we analyze a large corpus of 286 brand YouTube videos posted between the onset of the COVID-19 and the fall of 2020 through a combination of qualitative induction, coding, and big data analytics. The results demonstrate that brands can incorporate various values in their brand communications when the world is combating a victim crisis like the current pandemic. Our findings reveal that hedonism, universalism, conformity, security, and tradition values positively predict consumer engagement (i.e., commenting), whereas stimulation value negatively predicts consumer commenting. We develop a new type of victim crisis - omnipresent victim crisis - and offer a theorization of this sub-type of victim crisis to delineate the pandemic or crises alike (e.g., environmental issues) for future research. We further highlight the role of value embodiment in crisis communication and advertising literature and offer rich theoretical and practical implications.

2.
Applied Sciences-Basel ; 10(18), 2020.
Article in English | Web of Science | ID: covidwho-902468

ABSTRACT

Emodin, a widespread natural anthraquinone, has many biological activities including health-protective and adverse effects. Amongst beneficial effects, potential antiviral activity against coronavirus responsible for the severe acute respiratory syndrome outbreak in 2002-2003 has been described associated with the inhibition of the host cells target receptors recognition by the viral Spike protein. However, the inhibition mechanisms have not been fully characterized, hindering the rational use of emodin as a model compound to develop more effective analogues. This work investigates emodin interaction with the Spike protein to provide a mechanistic explanation of such inhibition. A 3D molecular modeling approach consisting of docking simulations, pharmacophoric analysis and molecular dynamics was used. The plausible mechanism is described as an interaction of emodin at the protein-protein interface which destabilizes the viral protein-target receptor complex. This analysis has been extended to the Spike protein of the coronavirus responsible for the current pandemic hypothesizing emodin's functional conservation. This solid knowledge-based foothold provides a possible mechanistic rationale of the antiviral activity of emodin as a future basis for the potential development of efficient antiviral cognate compounds. Data gaps and future work on emodin-related adverse effects in parallel to its antiviral pharmacology are explored.

3.
Applied Sciences ; 10(18):6358, 2020.
Article | MDPI | ID: covidwho-770340

ABSTRACT

Emodin, a widespread natural anthraquinone, has many biological activities including health-protective and adverse effects. Amongst beneficial effects, potential antiviral activity against coronavirus responsible for the severe acute respiratory syndrome outbreak in 2002-2003 has been described associated with the inhibition of the host cells target receptors recognition by the viral Spike protein. However, the inhibition mechanisms have not been fully characterized, hindering the rational use of emodin as a model compound to develop more effective analogues. This work investigates emodin interaction with the Spike protein to provide a mechanistic explanation of such inhibition. A 3D molecular modeling approach consisting of docking simulations, pharmacophoric analysis and molecular dynamics was used. The plausible mechanism is described as an interaction of emodin at the protein-protein interface which destabilizes the viral protein-target receptor complex. This analysis has been extended to the Spike protein of the coronavirus responsible for the current pandemic hypothesizing emodin"s functional conservation. This solid knowledge-based foothold provides a possible mechanistic rationale of the antiviral activity of emodin as a future basis for the potential development of efficient antiviral cognate compounds. Data gaps and future work on emodin-related adverse effects in parallel to its antiviral pharmacology are explored.

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