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1.
5th International Conference on Computer Science and Application Engineering, CSAE 2021 ; 2021.
Article in English | Scopus | ID: covidwho-1599479

ABSTRACT

method against the worldwide Coronavirus disease 2019 (COVID- 19). This paper proposes FCOSMask, a fully convolutional one-stage face mask wearing detector based on the lightweight network, for emergency epidemic control and long-term epidemic prevention work. MobileNetV3 is applied as the backbone network to reduce computational overhead. Thus, complex calculation related to anchor boxes is avoided in the anchor-free method, and Complete Intersection over Union (CIoU) loss is selected as the bounding box regression loss function to speed up model convergence. Experiments show that compared to other anchor-based methods, detection speed of FCOSMask is improved around 3 to 4 times on self-established datasets and mean average precision (mAP) achieves 92.4%, which meets the accuracy and real-time requirements of the face mask wearing detection task in most public areas. Finally, a Web-based face mask wearing system is developed that can support public epidemic prevention and control management.. © 2021 Association for Computing Machinery. All rights reserved.

2.
Ieee Internet of Things Journal ; 8(21):15839-15846, 2021.
Article in English | Web of Science | ID: covidwho-1570205

ABSTRACT

The outbreak of Coronavirus Disease-2019 (COVID-19) has posed a threat to world health. With the increasing number of people infected, healthcare systems, especially those in developing countries, are bearing tremendous pressure. There is an urgent need for the diagnosis of COVID-19 and the prognosis of inpatients. To alleviate these problems, a data-driven medical assistance system is put forward in this article. Based on two real-world data sets in Wuhan, China, the proposed system integrates data from different sources with tools of machine learning (ML) to predict COVID-19 infected probability of suspected patients in their first visit, and then predict mortality of confirmed cases. Rather than choosing an interpretable algorithm, this system separates the explanations from ML models. It can do help to patient triaging and provide some useful advice for doctors.

4.
Preprint in English | PUBMED | ID: ppcovidwho-293483

ABSTRACT

The Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has outcompeted previously prevalent variants and become a dominant strain worldwide. We report here structure, function and antigenicity of its full-length spike (S) trimer in comparison with those of other variants, including Gamma, Kappa, and previously characterized Alpha and Beta. Delta S can fuse membranes more efficiently at low levels of cellular receptor ACE2 and its pseudotyped viruses infect target cells substantially faster than all other variants tested, possibly accounting for its heightened transmissibility. Mutations of each variant rearrange the antigenic surface of the N-terminal domain of the S protein in a unique way, but only cause local changes in the receptor-binding domain, consistent with greater resistance particular to neutralizing antibodies. These results advance our molecular understanding of distinct properties of these viruses and may guide intervention strategies.

5.
Preprint in English | PUBMED | ID: ppcovidwho-293189

ABSTRACT

The Delta variant of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has outcompeted previously prevalent variants and become a dominant strain worldwide. We report here structure, function and antigenicity of its full-length spike (S) trimer in comparison with those of other variants, including Gamma, Kappa, and previously characterized Alpha and Beta. Delta S can fuse membranes more efficiently at low levels of cellular receptor ACE2 and its pseudotyped viruses infect target cells substantially faster than all other variants tested, possibly accounting for its heightened transmissibility. Mutations of each variant rearrange the antigenic surface of the N-terminal domain of the S protein in a unique way, but only cause local changes in the receptor-binding domain, consistent with greater resistance particular to neutralizing antibodies. These results advance our molecular understanding of distinct properties of these viruses and may guide intervention strategies.

6.
Preprint in English | PUBMED | ID: ppcovidwho-292872

ABSTRACT

Several fast-spreading variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the dominant circulating strains that continue to fuel the COVID-19 pandemic despite intensive vaccination efforts throughout the world. We report here cryo-EM structures of the full-length spike (S) trimers of the B.1.1.7 and B.1.351 variants, as well as their biochemical and antigenic properties. Mutations in the B.1.1.7 protein increase the accessibility of its receptor binding domain and also the binding affinity for receptor angiotensin-converting enzyme 2 (ACE2). The enhanced receptor engagement can account for the increased transmissibility and risk of mortality as the variant may begin to infect efficiently infect additional cell types expressing low levels of ACE2. The B.1.351 variant has evolved to reshape antigenic surfaces of the major neutralizing sites on the S protein, rendering complete resistance to some potent neutralizing antibodies. These findings provide structural details on how the wide spread of SARS-CoV-2 enables rapid evolution to enhance viral fitness and immune evasion. They may guide intervention strategies to control the pandemic.

7.
6th International Conference on Data Mining and Big Data, DMBD 2021 ; 1453 CCIS:240-249, 2021.
Article in English | Scopus | ID: covidwho-1530267

ABSTRACT

With the growing demands on civil aviation transportation in post-pandemic of COVID-19, irregular flight has become a headache problem for both airlines and passengers. This paper considers the large-scale irregular flight timetable recovery problem for the airline with temporarily closed airport. First, a mathematical model with the objective of minimizing total delay time of passengers under several realistic constraints is constructed. Second, both improved genetic algorithm for the irregular flight timetable recovery problem and encoding scheme are proposed based on problem characteristics. Finally, a large-scale data set from contest is chosen and both optimal solution and recovery scheme are obtained to illustrate the feasibility of our recovery algorithm for irregular flight timetable recovery problem. © 2021, Springer Nature Singapore Pte Ltd.

8.
Female Pelvic Medicine and Reconstructive Surgery ; 27(10 SUPPL 1):S87, 2021.
Article in English | EMBASE | ID: covidwho-1511124

ABSTRACT

Objective: The COVID-19 pandemic changed the practice of medicine, requiring rapid reorganization and flexibility of healthcare delivery. Guidelines for urogynecologic patient care during the pandemic discuss deferring in-person visits, but little is known about patient satisfaction with telemedicine for a broad range of urogynecologic conditions. Methods: We performed a cross-sectional survey study following a retrospective review of all urogynecologic telemedicine visits from 3/1/2020 to 3/31/2021 at a NewYork City (NYC) tertiary care center inManhattan. Live, two-way synchronous video visits were performed unless there was an inadequate connection necessitating a telephone visit. Patients were then emailed a 19-question survey and electronic consent. The survey queried patient satisfaction with subcategories for scheduling, technology, provider interaction, fulfillment of personal needs, and overall satisfaction (Fig 1). For those who did not complete the survey electronically, phone interviews and consent were conducted. Responses were recorded using the Likert scale and grouped as either satisfied ('strongly agree' and 'agree') versus dissatisfied ('strongly disagree,' 'disagree,' and 'neither agree or disagree'). Visits were categorized by chief complaint, including urinary tract infection (UTI), prolapse, incontinence, overactive bladder/lower urinary tract symptoms/bladder pain syndrome, surgical counseling, vulvovaginal symptoms, or other (e.g., postpartum consult). Chi-square analysis was performed to assess for differences in satisfaction among different demographic groups as well as by visit type. Results: There were 256 telemedicine visits during the study period, and 88 patients completed the survey (34% unadjusted response rate). There were 77 video visits (87.5%) and 11 telephone visits (12.5%), with 65% of participants having prior experience with telemedicine. The average age of study participants was 55 years old (SD 18 yrs;24-84 yrs). The majority of patients were white (69%), lived within the five boroughs of NYC (81%), and had higher levels of education (72% with a bachelor's or professional degree). There was a trend showing Manhattan residents having the greatest number of visits (39%) and higher overall satisfaction scores (98%) compared to other boroughs (P < 0.05). Patients aged 60-79 had lower satisfaction scores compared with other age groups (87% vs 97% for 20-39 yrs, 98% for 40-59 yrs, and 100% for 80+ yrs;P < 0.05). There were no differences in overall satisfaction among racial groups (P = 0.599), though those with advanced educational degrees trended towards higher satisfaction (P < 0.05). The most common reason for visits was for UTIs (31%), with overall satisfaction higher for visits regarding urinary complaints compared to those for prolapse or vulvovaginal complaints (P < 0.05). Altogether, high satisfaction rates were noted among the study population for scheduling (99%), technology (90%), provider interaction (96%), fulfillment of personal needs (91%), and overall satisfaction (94%). Conclusions: We demonstrate high patient satisfaction for telemedicine visits in a tertiary urogynecology clinic during the COVID-19 pandemic for a variety of indications, with greater satisfaction observed for those visits which may not necessitate an in-person exam (e.g., UTI). Patients with a high education level and close proximity to the medical center trended towards higher utilization and satisfaction.

9.
3rd International Conference on Electrical, Communication and Computer Engineering, ICECCE 2021 ; 2033, 2021.
Article in English | Scopus | ID: covidwho-1493590

ABSTRACT

Object: Evaluation of various new type of coronavirus pneumonia (COVID-19) normalization prevention measures and methods: Based on the actual data and transmission characteristics of the COVID-19 epidemic, this paper constructs an SEIR model for the transmission of new coronary pneumonia, which focuses on parameters such as asymptomatic infection. Result: Simulate the implementation of different types of public health preventive policies, and explore normalized preventive countermeasures. © 2021 Institute of Physics Publishing. All rights reserved.

10.
Organization Science ; : 21, 2021.
Article in English | Web of Science | ID: covidwho-1486638

ABSTRACT

In an era of globalization, it is commonly assumed that multicultural experiences foster leadership effectiveness. However, little research has systematically tested this assumption. We develop a theoretical perspective that articulates how and when multicultural experiences increase leadership effectiveness. We hypothesize that broad multicultural experiences increase individuals' leadership effectiveness by developing their communication competence. Because communication competence is particularly important for leading teams that are more multinational, we further hypothesize that individuals with broader multicultural experiences are particularly effective when leading more versus less multinational teams. Four studies test our theory using mixed methods (field survey, archival panel, field experiments) and diverse populations (corporate managers, soccer managers, hackathon leaders) in different countries (Australia, Britain, China, America). In Study 1, corporate managers with broader multicultural experiences were rated as more effective leaders, an effect mediated by communication competence. Analyzing a 25-year archival panel of English Premier League soccer managers, Study 2 replicates the positive effect of broad multicultural experiences using a team performance measure of leadership effectiveness. Importantly, this effect was moderated by team national diversity: soccer managers with broader multicultural experiences were particularly effective when leading teams with greater national diversity. Study 3 (digital health hackathon) and Study 4 (COVID-19 policy hackathon) replicate these effects in two field experiments, in which individuals with varying levels of multicultural experiences were randomly assigned to lead hackathon teams that naturally varied in national diversity. Overall, our research suggests that broad multicultural experiences help leaders communicate more competently and lead more effectively, especially when leading multinational teams.

11.
9th International Symposium on Project Management, ISPM 2021 ; : 1432-1437, 2021.
Article in English | Scopus | ID: covidwho-1481756

ABSTRACT

The COVID-19 in 2020 precipitating global economy makes the problems of geopolitics and protectionism more significant, economy development among host countries is imbalance, and the investment enterprises in the post epidemic era face various risks. The paper based on text analysis adopts factor analysis method to construct finance risk assessment index system and gives an assessment on finance risk of overseas investment countries as well as reasonable advices after analysis. © ISPM 2021.All right reserved.

12.
Gut ; 70(SUPPL 2):A13, 2021.
Article in English | EMBASE | ID: covidwho-1467716

ABSTRACT

Background SARS-CoV-2 has caused the COVID-19 pandemic, 14-53% with COVID-19 developed hepatic dysfunction. More data is required to ascertain the pattern of liver injury in patients with COVID-19. Here we report the use of human liver and biliary organoids as a tool to investigate the SARSCoV- 2 infection and virus-induced tissue damage ex vivo at the cellular and molecular levels. Methods Immunofluorescence staining and RT-qPCR was performed to examine the susceptibility and replication of human liver and biliary organoids to SARS-CoV-2. Transmission electron microscopy was performed to investigate the ultrastructure of SARS-CoV-2 infected biliary organoid. The mRNA sequence analysis was performed to determine gene expression changes induced by SARS-CoV-2-infection of biliary organoids. Results Immunofluorescence staining showed that SARS-CoV-2 spike (S) glycoprotein protein was readily detected in patchy areas of the human liver and biliary organoids, whereas no signal was found in uninfected control. RT-qPCR showed that the SARS-CoV-2 genomic RNAs revealed a dramatic increase of viral load in organoids at 24 h post-infection (MOI=1) and it can remain stable 96 hours in the liver organoids and 48 hours in biliary organoids. Unsupervised transmission electron microscopy (TEM) showed that viral particles occurred in the lumen of the organoid, at the basolateral and apical side of the organoid, even in membrane-bound vesicles. Additionally, RNA-seq revealed early cell response to virus infection, including the well-known upregulation of chemokines and inflammatory cytokines. Conclusions Therefore, the hepatocytes and bile duct cells have effectively been infected by COVID-19, and human liver and biliary organoids can serve as a pathophysiological model to investigate the underlying mechanism of SARS-CoV-2 infection.

13.
Latin American Journal of Pharmacy ; 40(10):2527-2531, 2021.
Article in English | EMBASE | ID: covidwho-1464464

ABSTRACT

In the present study, a new Co(II)-Schiff base complex, [Co(HL)2Cl2] (1), [Schiff base (HL) = 2-(2-methoxybenzylideneamino)phenol] has been successfully prepared by reaction of Co(II) chloride hexahydrate with the Schiff base ligand HL in a mixed solvent of aqueous-methanolic solution via a slow evaporation synthesis method. For the treatment of SARS-COV-2 induced acute lung injury, the ELISA detection kit was performed in the research to measure the content of inflammatory cytokines TNF-α and IFN-γ released into the alveolar lavage fluid. In addition to this, the activation levels of the prolyl carboxypeptidase in the alveolar epithelial cells were determined with real time RT-PCR.

14.
Epidemiology and Infection ; 2021.
Article in English | EMBASE | ID: covidwho-1447272

ABSTRACT

Hebei Province was affected by the two COVID-19 outbreak wavesduring the period 22 January 2020 through 27 February 2020 (wave 1) and 2 January 2021 through 14 February 2021 (wave 2). To evaluate and compare the epidemiological characteristics, containment delay, cluster events and social activity, as well as non-pharmaceutical interventions of the two COVID-19 outbreak waves, we examined real-time update information on all COVID-19 confirmed cases from publicly available database. Wave 1 was closely linked with the COVID-19 pandemic in Wuhan, whereas wave 2 was triggered, to a certain extent, by the increasing social activities such as weddings, multi-household gatherings and church events during the slack agricultural period. In wave 2, the epidemic spread undetected in the rural areas, and people living in the rural areas had a higher incidence rate than those living in the urban areas(5.3 vs. 22.0 per 1000000).Further, Rt was greater than 1 in the early stage of the two outbreak waves, and decreased substantially after massive non-pharmaceutical interventions were implemented. In China's 'new-normal' situation, development of targeted and effective intervention remains key for COVID-19 control in consideration of the potential threat of new coronavirus strains.

15.
2nd International Conference on Neural Computing for Advanced Applications, NCAA 2021 ; 1449:154-165, 2021.
Article in English | Scopus | ID: covidwho-1437240

ABSTRACT

The 2019 Coronavirus Disease (COVID-19), with the characteristics of rapid onset, strong infectivity, fast transmission and wide susceptibility, has quickly swept China since its appearance in Wuhan, Hubei province. COVID-19 spreads among people mainly by movement and close contact. Railway plays an important role in transport people national-wide as its essential role in public transportation, which conduced to the spreading of COVID-19 from Hubei province to other provinces in some sense. Inspired by this, this paper collected the data of Trains with Infectors (TwI) reported by the national health commission of the People’s Republic of China. Then the spreading of COVID-19 via railway network with the concept of complex network is analyzed. Results show that nodes with higher centrality tends to provide more TwI, and the closure of Wuhan railway station significantly prevents the spreading of COVID-19. © 2021, Springer Nature Singapore Pte Ltd.

16.
Pediatric Medicine ; 4, 2021.
Article in English | Scopus | ID: covidwho-1399731

ABSTRACT

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic with major concerns on finding effective ways for clinical management. In this review, we searched available publications on the pharmacological treatment options for children with COVID-19. In total, 104 case reports and 15 cohort studies were included for analysis. For children, commonly applied medications were categorized into five main types: antivirals, antibacterials and antifungals, anti-inflammatories, anticoagulants, and vasopressors. Inhaled interferon was the most used antiviral in cohort studies, while hydroxychloroquine (HCQ) or chloroquine (CQ) was the most in case reports. Different from adult patients, special consideration should be given to COVID-19 children diagnosed with multisystem inflammatory syndrome (MIS-C). Besides direct antiviral treatment, pharmacological care managing the inflammatory process comprises a great part of the treatment protocol. In addition to commonly used glucocorticoids, intravenous immunoglobulin (IVIG), and aspirin, some biologics could be considered as potential treatment. Anakinra, an interleukin-1 (IL-1) receptor antagonist, is highly recommended by the American College of Rheumatology as a safe treatment for children with MIS-C. The IL-6 receptor antagonist, tocilizumab, is also a potential treatment option. This review offers a comprehensive overview of the common medications used in clinical settings all over the world, but should be referred to with caution and flexibility depending on the actual condition of a specific patient. © Pediatric Medicine. All rights reserved.

17.
7th International Conference of the Immersive Learning Research Network, iLRN 2021 ; 2021.
Article in English | Scopus | ID: covidwho-1395649

ABSTRACT

This panel provides an overview of how immersive learning technologies can be used for higher education in several non-Westernized contexts in the middle of the COVID-19 pandemic. Through the outline of pluriversal design combined with design transitions, we aim to explore how a world within which many worlds coexist can resurge from the present educational challenges and become a fairer, sustainable place for all. © 2021 Immersive Learning Research Network.

18.
European Urology ; 79:S1386-S1386, 2021.
Article in English | Web of Science | ID: covidwho-1357896
19.
Blood ; 136:25-26, 2020.
Article in English | EMBASE | ID: covidwho-1344053

ABSTRACT

Introduction To further improve efficacy and duration of response of CAR-T therapy for Relapsed/Refractory Multiple Myeloma (R/R MM), we have designed a dual FasT CAR-T targeting both B cell maturation antigen (BCMA), a well-established MM target, and CD19, which is expressed on MM cells and their progenitors. Here we report early results from the first-in-human multicenter clinical study (NCT04236011;NCT04182581) to determine safety, pharmacokinetics (PK) and efficacy of BCMA-CD19-directed FasT CAR-T (GC012F) in patients with R/R MM. Methods The BCMA-CD19 dual CAR was constructed by linking BCMA and CD19 scFv, joined by a CD8 hinge, transmembrane domain, co-stimulatory domain and CD3z. Peripheral blood (PB) mononuclear cells were obtained by leukapheresis, T cells were isolated and CAR-T cells were manufactured (FasT CAR platform). From September 2019 to April 2020, we enrolled 16 heavily pretreated R/R MM patients (Age range 27-71), with a median of 5 prior lines of therapies (range 2-7), 93.8% (15/16) of these patients were high risk as defined by mSMART criteria, 5 had extramedullary disease. 4 out of 16 patients had received prior anti CD38 therapy, 93.8% (15/16) patients had received prior IMiD, all patients received at least 1 prior PI and corticosteroids with 3 patients being primary refractory to last therapy. Prior to CAR-T infusion patients received a conditioning regimen over 3 days of 30 mg/m2/d fludarabine and 300 mg/m2/d cyclophosphamide. CAR-T cells were administered in a single infusion at 3 dose levels 1x105/Kg (DL1) (1 patients), 2x105/Kg (DL2) (9 patients) and 3x105/Kg (DL3) (6 patients). Results As of July 17th 2020, all 16 patients were evaluable for response assessment, 15 out of 16 patients responded to treatment (ORR 93.8%) in all dose levels with the earliest response observed at day 28. Best response to date is MRD- CR/sCR in 9/16 patients (56.3%). In DL3 100% (6/6) of patients achieved sCR, 3 at data cut off had been confirmed by PET-CT. In all response evaluable patients, 78.6% (11/14) were MRD- by flow at month 1, and 100% at month 3 (11/11) and 6 (10/10) (sensitivity by flow cytometry measured at 10-4 in 7 patients, and at 10-6 in 9 patients tested by EuroFlow with at least 1.08x107 cells analyzed). At data cut off, the median follow up time was 7.3 months, the longest follow up was 10 months post infusion. CAR-T PK in PB was monitored by qPCR and flow cytometry. The CAR-T median proliferation peak was reached on Day10 (Day8-Day14), and the median peak copy number was 140,982 (16,011-374,346) copies /ug DNA. GC012F showed an acceptable safety profile with 14 out of 16 patients experiencing a cytokine release syndrome (CRS) grade 1-2 (n=14, 87.5%) and 2 grade 3 (n=2, 12.5%). The median duration of CRS was 4 days (1-8 days). No neurotoxicity of any grade was observed. One patient (DL2) presented with fever and died shortly after Day 78 of unknown cause during the COVID-19 Pandemic. Two patients had progression of extramedullary disease while achieving MRD negativity at month 1 and 3, respectively. At landmark analysis at 6 months, all patients in DL3 had achieved and maintained MRD- sCR including patients heavily pretreated including Daratumumab - among them 83.3% (5/6) patients in DL3 had high risk features according to mSMART criteria, and 5 out of 6 patients in DL3 were assessed by 10-6 Euroflow for MRD. The study is still enrolling patients and we will continue to be monitoring safety and efficacy including duration of response. Conclusion The data of BCMA-CD19 dual FasT CAR-T showed an early and high response rate with 93.8% ORR to date with a promising early high MRD-sCR rate in the highest dose level DL3 (100%) which was sustained with a median duration of follow up of 7.3 months at cut off. The data shows very promising activity of the BCMA-CD19 dual FasT CAR-T with a favorable safety profile in R/R MM patients. 93.8% (15/16) of the treated patients exhibited high risk features - a specifically difficult to treat patient population which remains a high unmet medical need in Mul iple Myeloma. This data indicates that BCMA-CD19 dual FasT CAR-T (GC012F) may present an effective new treatment option for patients with R/R MM including those with high-risk features who failed multiple prior therapies including anti-CD38. The study is still ongoing and enrolling patients, we will update the results as they become available. Disclosures: Zhao: Gracell Biotechnologies Ltd: Current Employment. Han: Gracell Biotechnologies Co., Ltd.: Current Employment. Chen: Gracell Biotechnologies Ltd: Current Employment. Xu: Gracell Biotechnologies Ltd: Current Employment. Zhang: Gracell Biotechnologies Ltd: Current Employment. He: Gracell Biotechnologies Co., Ltd.: Current Employment. Shi: Gracell Biotechnologies Ltd: Current Employment. Han: Gracell Biotechnologies Co., Ltd.: Current Employment. Ye: Gracell Biotechnologies Co., Ltd.: Current Employment. Wang: Gracell Biotechnologies Ltd: Current Employment. Liu: Gracell Biotechnologies Co., Ltd.: Current Employment. Shen: Gracell Biotechnologies Ltd: Current Employment. Cao: Gracell Biotechnologies Ltd: Current Employment. Sersch: Gracell Biotechnologies Co., Ltd.: Current Employment.

20.
Environmental Science and Technology Letters ; 2021.
Article in English | Scopus | ID: covidwho-1340970

ABSTRACT

The application of wastewater-based epidemiology (WBE) to support the global response to the COVID-19 pandemic has shown encouraging outcomes. The accurate, sensitive, and high-throughput detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in municipal wastewater is critical for WBE. Here, we present a novel approach based on multiplexed amplicon-based sequencing, namely the ATOPlex platform, for detecting SARS-CoV-2. The ATOPlex platform is capable of quantifying SARS-CoV-2 RNA at concentrations that are at least 1 order of magnitude lower than the detection limit of reverse transcription quantitative polymerase chain reaction (RT-qPCR). Robust and accurate phylogenetic placement can be done at viral concentrations 4 times lower than the detection limit of RT-qPCR. We further found that the solid fraction in wastewater harbors a considerable amount of viral RNA, highlighting the need to extract viral RNA from the solid and liquid fractions of wastewater. This study delivers a highly sensitive, phylogenetically informative, and high-throughput analytical workflow that facilitates the application of WBE. ©

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