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1.
Frontiers in Environmental Science ; 10, 2022.
Article in English | Web of Science | ID: covidwho-2198778

ABSTRACT

Urine source separation, a kind of new sewage management concept, has made great progress in technology development and application in the past 30 years. However, understanding of the potential microbial risks in reuse of urine derived fertilizer products (UDFPs) in agriculture is still lacking. Outbreak of pandemic of Coronavirus Disease 2019 and more deadly disease caused by Monkeypox strongly sounds the alarm bell to the attention on pathogens in urine and their fate in UDFPs. Therefore, this study presented a comprehensive review on pathogens inactivation in nutrient recovery technologies. The review suggests that technologies using alkaline or heating treatment can effectively reduce pathogens in UDFPs. However, technologies with characteristics such as membrane rejection of nutrients or nutrient adsorption may even concentrate pathogens in their fertilizer products. Based on an overall assessment, connections of technologies and the pathogens inactivation in their UDFPs have been established. This would help to provide a perspective on development of urine treatment technology and management of microbial risks in reusing urine nutrients in agriculture.

2.
PLoS ONE [Electronic Resource] ; 18(1):e0280067, 2023.
Article in English | MEDLINE | ID: covidwho-2197137

ABSTRACT

COVID-19 has brought a great challenge to the medical system. A key scientific question is how to make a balance between home quarantine and staying in the hospital. To this end, we propose a game-based susceptible-exposed-asymptomatic -symptomatic- hospitalized-recovery-dead model to reveal such a situation. In this new framework, time-varying cure rate and mortality are employed and a parameter m is introduced to regulate the probability that individuals are willing to go to the hospital. Through extensive simulations, we find that (1) for low transmission rates (beta < 0.2), the high value of m (the willingness to stay in the hospital) indicates the full use of medical resources, and thus the pandemic can be easily contained;(2) for high transmission rates (beta > 0.2), large values of m lead to breakdown of the healthcare system, which will further increase the cumulative number of confirmed cases and death cases. Finally, we conduct the empirical analysis using the data from Japan and other typical countries to illustrate the proposed model and to test how our model explains reality.

3.
Asian Review of Accounting ; 2022.
Article in English | Scopus | ID: covidwho-2191294

ABSTRACT

Purpose: This paper investigates whether sustainability performance (SP) protects financial performance (FP) for firms in both developed and emerging economies during the COVID-19-induced economic downturn. Design/methodology/approach: Using a recent sample of firms in 34 countries between 2003 and 2021, the authors employ ordinary least squares regressions, moderations and the Heckman two-step method to test the hypotheses. Findings: Firms with strong SP have higher FP in developed and emerging economies in the upcoming year. During the COVID-19 crisis in 2020–2021, the impact of sustainability on FP is pronounced in developed but not in emerging economies. Furthermore, cross-listings expose firms in emerging economies to high-standard institutional mechanisms in developed economies. Thus, sustainable firms in emerging economies cross-listed on European stock exchanges are more profitable. Practical implications: For regulators and standard setters, the global-level comparative analysis helps them find solutions that may assist firms in improving SP globally (e.g. mandatory reporting) and enduring crises resiliently. For institutional investors, the study reveals the relatively different impact of sustainability risk for firms in developed and emerging economies. For practitioners and private sector firms, this study contributes to the dialogue on what makes firms more resilient in COVID-19. Although COVID-19 might be temporary, the lessons learned could protect firms from future crises. Originality/value: The authors contribute to the contingency perspective between sustainability and financial performance by providing recent empirical evidence in a global setting during the COVID-19 pandemic. The authors demonstrate how different external institutional mechanisms (rule-based governance and relation-based governance) and cross-listing affect the SP-FP relationship during a crisis. The authors extend the knowledge in crisis management literature with a comparative study and fill the research gap on how SP affects FP for firms in emerging economies compared to developed economies. © 2022, Emerald Publishing Limited.

4.
Cell Discov ; 9(1):3, 2023.
Article in English | PubMed | ID: covidwho-2185789

ABSTRACT

SARS-CoV-2 Omicron subvariants have demonstrated extensive evasion from monoclonal antibodies (mAbs) developed for clinical use, which raises an urgent need to develop new broad-spectrum mAbs. Here, we report the isolation and analysis of two anti-RBD neutralizing antibodies BA7208 and BA7125 from mice engineered to produce human antibodies. While BA7125 showed broadly neutralizing activity against all variants except the Omicron sublineages, BA7208 was potently neutralizing against all tested SARS-CoV-2 variants (including Omicron BA.1-BA.5) except Mu. By combining BA7208 and BA7125 through the knobs-into-holes technology, we generated a biparatopic antibody BA7208/7125 that was able to neutralize all tested circulating SARS-CoV-2 variants. Cryo-electron microscopy structure of these broad-spectrum antibodies in complex with trimeric Delta and Omicron spike indicated that the contact residues are highly conserved and had minimal interactions with mutational residues in RBD of current variants. In addition, we showed that administration of BA7208/7125 via the intraperitoneal, intranasal, or aerosol inhalation route showed potent therapeutic efficacy against Omicron BA.1 and BA.2 in hACE2-transgenic and wild-type mice and, separately, effective prophylaxis. BA7208/7125 thus has the potential to be an effective candidate as an intervention against COVID-19.

5.
Global Mental Health ; 9:37, 2022.
Article in English | MEDLINE | ID: covidwho-2185041

ABSTRACT

[This corrects the article DOI: 10.1017/gmh.2021.23.].

6.
Social Science and Medicine ; 317, 2023.
Article in English | Scopus | ID: covidwho-2183438

ABSTRACT

National health departments across the globe have utilized persuasive strategies to promote COVID-19 vaccines through Twitter. However, the effectiveness of those strategies is unclear. This study thereby examined how national health departments deployed persuasive strategies to promote citizen engagement in COVID-19 vaccine-related tweets in six countries, including the UK, the US, Germany, Japan, South Korea, and India. Guided by the heuristic-systematic model and the health belief model, we found that national health departments differed significantly in the use of systematic-heuristic cues and health belief constructs in COVID-19 vaccine-related tweets. Generally, the provision of scientific information and appeals to anecdotes and fear positively, while appeals to bandwagon negatively, predicted citizen engagement. Messages about overcoming barriers and promoting vaccine benefits and self-efficacy positively affected engagement. Emphases of COVID-19 threats and cues to vaccinate demonstrated negative impacts. Importantly, health departments across countries often used futile or detrimental strategies in tweets. A locally adapted evidence-based approach for COVID-19 vaccination persuasion was discussed. © 2022 Elsevier Ltd

7.
Science China Life sciences ; 30:30, 2022.
Article in English | MEDLINE | ID: covidwho-2174848

ABSTRACT

Multivalent vaccines combining crucial mutations from phylogenetically divergent variants could be an effective approach to defend against existing and future SARS-CoV-2 variants. In this study, we developed a tetravalent COVID-19 vaccine SCTV01E, based on the trimeric Spike protein of SARS-CoV-2 variants Alpha, Beta, Delta, and Omicron BA.1, with a squalene-based oil-in-water adjuvant SCT-VA02B. In the immunogenicity studies in naive BALB/c and C57BL/6J mice, SCTV01E exhibited the most favorable immunogenic characteristics to induce balanced and broad-spectrum neutralizing potencies against pre-Omicron variants (D614G, Alpha, Beta, and Delta) and newly emerging Omicron subvariants (BA.1, BA.1.1, BA.2, BA.3, and BA.4/5). Booster studies in C57BL/6J mice previously immunized with D614G monovalent vaccine demonstrated superior neutralizing capacities of SCTV01E against Omicron subvariants, compared with the D614G booster regimen. Furthermore, SCTV01E vaccination elicited naive and central memory T cell responses to SARS-CoV-2 ancestral strain and Omicron spike peptides. Together, our comprehensive immunogenicity evaluation results indicate that SCTV01E could become an important COVID-19 vaccine platform to combat surging infections caused by the highly immune evasive BA.4/5 variants. SCTV01E is currently being studied in a head-to-head immunogenicity comparison phase 3 clinical study with inactivated and mRNA vaccines (NCT05323461).

9.
Cell Discov ; 8(1):131, 2022.
Article in English | PubMed | ID: covidwho-2160195

ABSTRACT

The immunity of patients who recover from coronavirus disease 2019 (COVID-19) could be long lasting but persist at a lower level. Thus, recovered patients still need to be vaccinated to prevent reinfection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or its mutated variants. Here, we report that the inactivated COVID-19 vaccine can stimulate immunity in recovered patients to maintain high levels of anti-receptor-binding domain (RBD) and anti-nucleocapsid protein (NP) antibody titers within 9 months, and high neutralizing activity against the prototype, Delta, and Omicron strains was observed. Nevertheless, the antibody response decreased over time, and the Omicron variant exhibited more pronounced resistance to neutralization than the prototype and Delta strains. Moreover, the intensity of the SARS-CoV-2-specific CD4(+) T cell response was also increased in recovered patients who received COVID-19 vaccines. Overall, the repeated antigen exposure provided by inactivated COVID-19 vaccination greatly boosted both the potency and breadth of the humoral and cellular immune responses against SARS-CoV-2, effectively protecting recovered individuals from reinfection by circulating SARS-CoV-2 and its variants.

10.
ACS Applied Nano Materials ; 2022.
Article in English | Scopus | ID: covidwho-2150981

ABSTRACT

Page 5452. In the "2.1. Preparation of CCM-CDs" section in the Experimental Section, "Curcumin (CCM;0.30 g) and citric acid (0.60 g) were ground uniformly, sealed, and hydrothermally treated in a 25 mL Teflon-lined autoclave at 180 C for 1 h." was incorrectly written. It should be "Curcumin (CCM;0.30 g) and citric acid (0.60 g) were ground uniformly, sealed, and hydrothermally treated in a 25 mL Teflon-lined autoclave at 180 C for 1.5 h.". This change does not affect the conclusion of this paper. Page 5455. In the caption of Figure 6c, "Virus titers calculated in the presence and absence of EDA-CDs or CCMCDs. The pictures were taken at 12 hpi." was incorrectly written. It should be "Virus titers calculated in the presence and absence of EDA-CDs or CCM-CDs. The pictures were taken at 9 hpi.". In addition, the fluorescence images of the DAPI and Merge in the EDA-CDs (125 g/mL) group (Figure 6a) were chosen by mistake when the artwork was submitted. These changes do not affect the conclusion of this paper. The revised Figure 6a, which now shows the correct images from the original data source, is as follows: (Figure Present). © 2022 American Chemical Society. All rights reserved.

11.
Journal of Endourology ; 36(Supplement 1):A170-A171, 2022.
Article in English | EMBASE | ID: covidwho-2114765

ABSTRACT

Introduction &Objective: The COVID-19 pandemic and subsequent world-wide quarantine resulted in a major change in individual lifestyles. In New York State, March 16, 2020 marked the end of any in-restaurant dining and the general population reported a shift to more cooking at home. Reducing dietary sodium intake, such as less dining out, is often considered first line dietary therapy for calcium stone formers due to known risk factors of hypernatriuria and hypercalciuria. We investigated the 24-hour urine of our patients with known history of nephrolithiasis to see if these dietary changes during COVID-19 pandemic may have also changed the risk of stone disease. Method(s): Retrospectively, patients with a history of nephrolithiasis seen for an outpatient visit from April 1, 2020-December 31, 2020 were studied. All patients included had a 24-hour urine study pre-COVID, defined as before March 16, 2020 as well as a study during-COVID, March 16, 2020-December 31, 2020;a post-COVID study including January 1, 2021-December 31, 2021 was also included. Mean pre-COVID, during-COVID and post-COVID values were compared using paired, 2-tailed t-tests. Result(s): 94 patients (M = 54, F = 40) with a mean age of 60 years were evaluated. Stone analysis revealed calcium oxalate (61%), calcium phosphate (15%), uric acid (15%), other (9%). The 24-hour urine revealed a significant reduction in urinary sodium (uNa) levels from pre-COVID (165.64 +/- 7.5 mEq/L) compared to during-COVID (149.16 +/- 7.6 mEq/L) (p = 0.018). There was also a significant reduction in urinary calcium (uCa) from pre-COVID (214.18 +/- 13.05mEq/L) compared to during-COVID levels (191.48 +/- 13.03 mEq/L) (p = 0.010). Post-COVID 24-hour urine (N = 59) levels for both post-COVID uNa (137.43 +/- 8.03mEq/L, p = 0.02) and post-COVID uCa (193.07 +/- 13.23, p = 0.035) remained significantly reduced compared to the pre-COVID values, but with no difference compared to during-COVID values. There were no significant differences in 24 hour urine total volume, magnesium, or citrate levels. Conclusion(s): During the COVID-19 lockdown, dietary choices limited to home cooked meals allowed patients to better identify their food choices. This study demonstrates that home cooked meals improved urinary parameters to minimize the lithogenic risk factors for stone formation including hypernatriuria and hypercalciuria. Persistently improved urinary factors during the post-COVID period may be secondary to improved dietary practices combined with continued lockdown as a result of new virus variants.

12.
Chinese Journal of Biologicals ; 35(3):299-303, 2022.
Article in Chinese | EMBASE | ID: covidwho-2102861

ABSTRACT

Objective To analyze the antibody against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) of recovered patients with confirmed or suspected Coronavirus Disease 2019 (COVID-19) in Dawu County, Hubei Province, China 6 months after discharge from hospital. Methods A total of 166 serum samples were collected from the recovered patients with COVID-19 6 months after discharge from hospital and determined for neutralizing antibody by plaque reduction neutralization test (PRNT), and the neutralizing antibody titer (EC50) was calculated. The specific IgG antibody against SARS-CoV-2 was determined by ELISA, of which the relationship to the neutralizing antibody titer was analyzed by Pearson method. Results The positive rates of neutralizing antibody and specific IgG in the 166 samples were 68. 7% and 77. 7%, while those in samples from patients with typical symptoms were 82. 2%, and 90. 1%, those from confirmed patients without symptoms were 66. 7% and 88. 9%, and those from suspected patients were 44. 6% and 53. 6%, respectively. The Pearson relationship between neutralizing antibody titer and IgG titer was 93. 0%. Conclusion The antibody against SARS-CoV-2 still exists in patients with confirmed or suspected COVID-19 6 months after discharge from hospital, and the titer of neutralizing antibody is significandy related to that of specific IgG against SARS-CoV-2. Copyright © 2022 Changchun Institute of Biological Products. All rights reserved.

13.
24th International Conference on Human-Computer Interaction, HCII 2022 ; 13519 LNCS:57-66, 2022.
Article in English | Scopus | ID: covidwho-2094455

ABSTRACT

During COVID-19, people often wear masks in daily activities or communication. To solve the problem of generating faces with expressions under masks, we propose a framework of methods, including detecting the shape or locations of masked faces, generating the facial expressions under masks. Further, due to synthesizing quality facial expressions, we propose to optimize the merging of sub-results with useful face information such as key points of face. Further, we propose a framework for customization or personalization of user-preferring AI-generation results. We showed the system capable of running real-time and discussed the development in multiple aspects of research, interface, and applications. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.

14.
Xitong Gongcheng Lilun yu Shijian/System Engineering Theory and Practice ; 42(9):2426-2446, 2022.
Article in Chinese | Scopus | ID: covidwho-2090893

ABSTRACT

Because of double pressures from “twelve consecutive declines” in monthly sales year-on-year and the novel coronavirus outbreak, purchase subsidy decrease for new energy vehicle had to be postponed from the end of 2020 to 2022. However, carmakers concentrating on intelligentization were outstanding and became the center of attention. Therefore, when purchase subsidy decrease should apply for and whether intelligentization can hedge the negative effect should be answered immediately. This paper builds a computable general equilibrium (CGE) model by adding productive intelligentization factors to production function and using procedure intelligentization factors to utility function, using different macro-closure to simulate the period of insufficient supply or demand and Chinese statistical data in 2018 to calibrate parameters, to analyze the suitable situation for purchase subsidy decrease and the difference and function border of hedging between productive intelligentization and using procedure intelligentization. The results show that purchase subsidy decrease for new energy vehicle should apply for the period of insufficient supply, because it will promote the low correlation industries and decrease the income inequality, while using procedure intelligentization developed moderately can hedge the negative effects to social farewell and new energy industry caused by purchase subsidy decrease and will not over hedge the above positive effects at the same time. But in the period of insufficient demand, the above positive effects will be altered to negative and hardly be hedged by intelligentization. Therefore, the policy decision of purchase subsidy decrease for new energy vehicle should depend on the degree of economic recovery from the novel coronavirus outbreak. If economic recovery is rapid, we can develop using procedure intelligentization moderately, namely, self driving, to hedge the subsidy decrease. Otherwise, we should postpone the subsidy decrease. © 2022 Systems Engineering Society of China. All rights reserved.

15.
Sustainability ; 14(3), 2022.
Article in English | Web of Science | ID: covidwho-2071729

ABSTRACT

The Boeing 737 MAX crisis and COVID-19 pandemic have seriously influenced the development of China's aircraft leasing industry in the past two years. This paper applies system dynamics theory to explore the sustainable development of China's aircraft leasing industry. It analyses the dynamic mechanism and constructs a system dynamics model. Based on China's macroeconomic data and historical data from the financial, aviation, and leasing industries, it aims to stimulate the development of China's aircraft leasing industry in the next five years. Through sensitivity analysis, this research finds that changes in GDP growth have the most obvious impact on the sustainable development of China's aircraft leasing industry. Reducing the average financing cost and the income tax rate of aircraft leasing companies, increasing their investment in talent, and controlling risk will increase the market share of China's aircraft leasing companies and promote the development of the industry. However, increasing the number of aircraft leasing companies has little effect on market share. On this basis, this paper proposes policy recommendations to promote the sustainable development of China's aircraft leasing industry.

16.
Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology ; 60(Suppl 1):16-16, 2022.
Article in English | EuropePMC | ID: covidwho-2058160
17.
Ultrasound in Obstetrics & Gynecology ; 60(S1):16, 2022.
Article in English | ProQuest Central | ID: covidwho-2027409
18.
Frontiers in Environmental Science ; 10, 2022.
Article in English | Web of Science | ID: covidwho-2022689

ABSTRACT

Between 2018 and 2022, a total of 231 PM2.5 samples were collected in Nantong, China, and analyzed online for 16 US EPA PAHs utilizing a variety of analytical methodologies, including high-performance liquid chromatography data analysis, principal component analysis, and characteristic ratio analysis. The seasonal variation and pollution characteristics of 16 PAHs in PM2.5 over a long period in Nantong, China, were analyzed, and correlations and traceability changes with a variety of emission sources were established. Additionally, health assessment models for BaP equivalent concentration, daily exposure dose, lifetime excess risk of cancer, and life expectancy loss were constructed for various ages and genders. The results indicated that the total number of days with BaP concentrations less than the national limit standard of 1.0 ng/m(3) was 60.17% (139/231), with rates of 25.40%, 35.71%, and 94.05% from 2019 to 2021, respectively;the total concentration range of 16 PAHs demonstrated a downward trend, but pollution was relatively severe in winter. The seasonal variation showed winter > autumn > spring > summer. The detection rates of 4 and 5 rings were generally high and fluctuated between dropping and increasing. Principal factor analysis and characteristic ratio traceability analysis indicated that PAH pollution is primarily caused by local coal-fired sources and traffic emissions, with a new trend of biomass combustion. Furthermore, BaP remains the primary contributor to carcinogenic factors, and the health risk is higher in females than in males, and in adults than in children. A low level of PAHs in the air may have health benefits. Traffic control and flow restrictions, as well as production restrictions, are all part of Nantong's COVID-19 pandemic prevention and control policies. These policies contributed to PAH risk prevention and control, as well as pollution reduction.

19.
7th International Conference on Distance Education and Learning, ICDEL 2022 ; : 20-28, 2022.
Article in English | Scopus | ID: covidwho-2020430

ABSTRACT

Object: this research aims to organize, evaluate, improve and supervise college students' comprehensive English ability and learning autonomy through mobile and digital learning activities and management. Method: this research applied Task-based English Teaching and Itest System to improve students' learning autonomy and English ability by launching exercise tasks of 4 different English skills every weekday, such as writing, translation, reading and listening. Various learning data was recorded by Itest System everyday as an accordance for guiding and supervising students learning activity, and a means of the mobilization and digitization of the task, feedback and incentive mechanisms. Result:the pass rate of the exercises launched by Itest system is high at the beginning and ending of a semester and every Monday, while it's pretty low in the mid-term of a semester and every Friday. Moreover, the improvement effect of the 4 different English skills is different, and the progress of the 952 students' listening and translation is more obvious. Conclusion: the educational mechanism in this research is effective in improving the English translation and listening skills of the freshmen in college. Digitized management can clarify blind areas in students' learning activities, and locate students' problems and problematic students. Mobile English teaching can minimize close contact, but its disciplinary constriction to a few students needs the assistance of college counselor. Students' learning autonomy is low at the mid-term of a semester and on every Friday, which requires more management force. © 2022 ACM.

20.
Journal of Clinical Oncology ; 40(16), 2022.
Article in English | EMBASE | ID: covidwho-2005664

ABSTRACT

Background: GC012F is a B cell maturation antigen (BCMA)/CD19 dual-targeting CAR-T developed on the novel FasT CAR-T platform with overnight manufacturing and designed to improve depth of response and efficacy. Data was presented at ASCO and EHA 2021 for initial 19 pts. We present updated data for study (NCT04236011;NCT04182581) with longer follow up and 9 additional pts treated (n = 28) in 3 different dose levels. Methods: From October 2019 to November 2021, 28 heavily pretreated RRMM pts (age 27-76) median of 5 prior lines (range 2-9) were treated on a single-arm, open label, multicenter Investigator Initiated Trial receiving a single infusion of GC012F. 89.3% (25/ 28) were high risk (HR- mSMART), 8 pts had EM disease, 3 had never achieved a CR including after transplant, 1 pts presented with plasma cell leukemia, 24/28 pts were refractory to last therapy, 3 pts primary refractory. 9/28 pts had received prior anti-CD38, 27/28 pts prior IMiDs. 26/28 pts were refractory to PI, 26/28 pts to IMiDs. After lymphodepletion over 2-3 days (30 mg/m2/d, 300mg/ m2/d Flu/Cy) GC012F was administered as single infusion at 3 dose levels: 1x105/kg (DL1) n = 2, 2x105/kg (DL2) n = 10 and 3x105/kg (DL3) n = 16. Results: As of Jan 26th 2022, 28 pts - median follow-up (f/ u) 6.3 mths (1.8-29.9) - had been evaluated for response. Overall response rate (ORR) in DL1 was 100% (2/2)- DL 2 -80% (8/10) DL 3 -93.8% (15/16) with 27 pts MRD negative by flow cytometry (sensitivity 10-4-10-6). 100% of MRD assessable pts (27/27) achieved MRD negativity. One patient out of 28 could not get assessed. At d28, 21/24 assessable patients were MRD negative (81.5%), 4/ 28 pts could not get d28 MRD assessment f/u due to COVID-19 restrictions however were assessed at a later timepoint. To date best response is MRD- sCR in 21/28 patients(75.0%) across all dose levels. Some pts after short f/u show responses that are still deepening. Cytokine Release Syndrome (CRS) was mostly low grade: gr 0 n = 3 (10.7%), gr 1-2 n = 23 (82.1%), gr 3 n = 2 (7.1%) - no gr 4/5 CRS and no ICANs were observed (Graded by ASBMT criteria). Median duration of CRS was 3 d (1-8 d). PK results showed no difference amongst dose levels DL1 to DL3. Overall, CAR-T median Tmax was 10 d (range 8-14 d), median peak copy number (Cmax) was 97009 (16,011-374,346) copies /μg DNA with long duration of persistence of up to d793 (data cut-off). CAR-T geometric mean AUC0-28 for DL1, DL2 and DL3 were 468863, 631540 and 581620 copies/μg DNA×day, respectively. Pts continue to be monitored for safety and efficacy including DOR. Conclusions: BCMA-CD19 dual FasT CAR-T GC012F continues to provide deep and durable responses with a favorable safety profile in additional RRMM pts across all dose levels demonstrating a very high MRD negativity rate including in pts refractory to anti-CD38, PI and IMIDs. GC012F is currently being studied in earlier lines of therapy as well as additional indications.

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