Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 2 de 2
Filter
Add filters

Database
Document Type
Language
Year range
2.
J Med Virol ; 92(9): 1684-1689, 2020 09.
Article in English | MEDLINE | ID: covidwho-133577

ABSTRACT

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection causing coronavirus disease 2019 (COVID-19) has spread worldwide. Whether antibodies are important for the adaptive immune responses against SARS-CoV-2 infection needs to be determined. Here, 26 cases of COVID-19 in Jinan, China, were examined and shown to be mild or with common clinical symptoms, and no case of severe symptoms was found among these patients. Strikingly, a subset of these patients had SARS-CoV-2 and virus-specific IgG coexist for an unexpectedly long time, with two cases for up to 50 days. One COVID-19 patient who did not produce any SARS-CoV-2-bound IgG successfully cleared SARS-CoV-2 after 46 days of illness, revealing that without antibody-mediated adaptive immunity, innate immunity alone may still be powerful enough to eliminate SARS-CoV-2. This report may provide a basis for further analysis of both innate and adaptive immunity in SARS-CoV-2 clearance, especially in nonsevere cases.


Subject(s)
Antibodies, Viral/immunology , COVID-19/immunology , COVID-19/virology , Host-Pathogen Interactions/immunology , SARS-CoV-2/immunology , Adolescent , Adult , Antibodies, Viral/blood , Biomarkers , COVID-19/blood , Child , Child, Preschool , Female , Humans , Immunity, Innate , Immunoglobulin G/blood , Immunoglobulin G/immunology , Male , Middle Aged , Viral Load , Young Adult
SELECTION OF CITATIONS
SEARCH DETAIL
...