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1.
Gongneng Cailiao/Journal of Functional Materials ; 53(6):6151-6158 and 6158, 2022.
Article in Chinese | Scopus | ID: covidwho-1924372

ABSTRACT

Because of the outbreak of COVID-19 pandemic, the disinfectants have become a daily necessity. The chlorine gas is an important industrial raw material for disinfectants. And the demand of chlorine gas is increasing. As is known to all, chlorine gas is a toxic gas and harmful to health. However, the gas sensors based on common metal oxide semiconductor are not sensitive to low concentrations of chlorine gas. Therefore, it is of great significance to develop the gas sensing materials based on metal oxide semiconductor that are high sensitivity to trace leakage of chlorine gas. In this work, In2O3 microtubules were synthesized by bio-template method with degreasing cotton. In2O3 microtubules was simply treated with NaBH4 reduction and In2O3 microtubules with abundant oxygen vacancies were successfully prepared at room temperature. The effects of the method on the crystal structure, morphology and oxygen vacancies were investigated by means of XRD, SEM, XPS and EPR. The results showed that this method could effectively enhance the concentration of oxygen vacancies in In2O3 materials without the destruction on crystal structure and morphology. In the gas sensing tests, the gas response of In2O3 microtubules with NaBH4 treatment was about 13 times higher than In2O3 microtubules to the same low concentration of chlorine gas. In another word, the In2O3 microtubules were more sensitive to low concentration of chlorine gas after NaBH4 treatment. According to the analysis of gas sensing mechanism, chlorine gas molecule was not only directly adsorbed on the material surface but also oxygen vacancies of material surface. Thus it can be seen that the oxygen vacancies on material surface played an important role in chlorine gas-sensing performance. Because there are more oxygen vacancies in the In2O3 microtubules treated by NaBH4 than the untreated, the In2O3 microtubules with abundant oxygen vacancies exhibited excellent sensitivity to low concentration chlorine gas. © 2022, Editorial Board of Journal of Functional Materials. All right reserved.

2.
HemaSphere ; 6(SUPPL 2):16-17, 2022.
Article in English | EMBASE | ID: covidwho-1915867

ABSTRACT

G protein-coupled receptor family C group 5 member D (GPRC5D) has limited expression in healthy human tissue but is highly expressed in malignant plasma cells, making it a promising target for immunotherapy approaches for MM. Talquetamab (JNJ-64407564) is a first-in-class bispecific antibody that binds to both GPRC5D and CD3 receptors to redirect T cells to kill MM cells. Updated and new results of talquetamab at the recommended phase 2 doses (RP2Ds) are reported (NCT03399799). Eligible patients had RRMM or were intolerant to standard therapies. Patients who were previously treated with B-cell maturation antigen (BCMA)-directed therapies were eligible. This analysis focuses on patients who received talquetamab subcutaneously (SC;range: 5.0-800 μg/kg) weekly (QW) or biweekly (Q2W) with step-up dosing. The primary objectives were to identify the RP2D (part 1) and assess talquetamab safety and tolerability at the RP2Ds (part 2). Adverse events (AEs) were graded by CTCAE v4.03;cytokine release syndrome (CRS) was graded per Lee et al 2014 criteria. Responses were investigator-assessed per IMWG criteria. As of July 19, 2021, 95 patients had received SC talquetamab. The original RP2D was 405 μg/kg SC talquetamab QW with step-up doses, and a second RP2D of 800 μg/kg SC talquetamab Q2W with step-up doses was also identified. 30 patients received 405 μg/kg QW (median 61.5 years [range 46-80];63% male;100% triple-class exposed;80% penta-drug exposed;77% triple-class refractory, 20% penta-drug refractory;30% prior BCMA-directed therapy;median follow-up [mF/U]: 7.5 mo [range 0.9-15.2]). 23 patients received 800 μg/kg Q2W (median 60.0 years [range 47-84];48% male;96% triple-class exposed;70% penta-drug exposed;65% triple-class refractory, 22% penta-drug refractory;17% prior BCMA-directed therapy;mF/U: 3.7 mo [range 0.0-12.0]). No treatment discontinuations due to AEs were reported at either RP2Ds. Most common AEs at the 405 μg/kg QW were CRS (73%;1 grade 3 CRS), neutropenia (67%;grade 3/4: 60%), and dysgeusia (60%;grade 2: 29%). Skin-related AEs occurred in 77% of patients and were all grade 1/2 (nail disorders: 30%). Infections occurred in 37% of patients (1 grade 3 COVID-19 pneumonia). Most common AEs at 800 μg/kg Q2W were CRS (78%;all grade 1/2), dry mouth (44%;all grade 1/2), and neutropenia (44%;grade 3/4: 35%). Skin-related AEs occurred in 65% of patients with grade 3 events in 13% (nail disorders: 17%). Infections occurred in 13% of patients (1 grade 3 pneumococcal sepsis). In 30 response-evaluable patients treated at 405 μg/kg QW, the overall response rate (ORR) was 70% (very good partial response or better [≥VGPR]: 57%). In 17 response-evaluable patients treated at 800 μg/ kg Q2W, the ORR was 71% (≥VGPR: 53%). Responses were durable and deepened over time with both RP2Ds (Figure). Median duration of response (DOR) was not reached at either RP2D;6-month DOR rate was 67% (95% CI: 41-84) at 405 μg/kg QW. Serum trough levels of talquetamab were comparable at both RP2Ds. Pharmacodynamic data at both RP2Ds showed peripheral T cell activation and induction of cytokines. SC talquetamab is well tolerated and highly effective at both RP2Ds. Preliminary data suggest that less frequent, higher doses of SC talquetamab do not negatively impact the safety profile. Further evaluation of talquetamab as monotherapy (phase 2;NCT04634552) and in combination with other therapies in patients with RRMM is underway. (Figure Presented) .

3.
Journal of Complex Networks ; 10(3):14, 2022.
Article in English | Web of Science | ID: covidwho-1915544

ABSTRACT

One of the most effective strategies to mitigate the global spreading of a pandemic (e.g. coronavirus disease 2019) is to shut down international airports. From a network theory perspective, this is since international airports and flights, essentially playing the roles of bridge nodes and bridge links between countries as individual communities, dominate the epidemic spreading characteristics in the whole multi-community system. Among all epidemic characteristics, the peak fraction of infected, I-ma(x), is a decisive factor in evaluating an epidemic strategy given limited capacity of medical resources but is seldom considered in multi-community models. In this article, we study a general two-community system interconnected by a fraction r of bridge nodes and its dynamic properties, especially I-max, under the evolution of the susceptibleinfected-recovered model. Comparing the characteristic time scales of different parts of the system allows us to analytically derive the asymptotic behaviour of I-max with r, as r -> 0, which follows different power-law relations in each regime of the phase diagram. We also detect crossovers when I-max changes from one power law to another, crossing different power-law regimes as driven by r. Our results enable a better prediction of the effectiveness of strategies acting on bridge nodes, denoted by the power-law exponent epsilon(I) as in I-max proportional to r(1/epsilon I).

4.
Vestnik of Saint Petersburg University-Law-Vestnik Sankt-Peterburgskogo Universiteta-Pravo ; 13(1):181-205, 2022.
Article in English | Web of Science | ID: covidwho-1897262

ABSTRACT

On the eve of the 2020 Spring Festival, the new coronavirus pneumonia broke out, normal social order was affected, and crimes involving the epidemic increased. On February 6, 2020, the Supreme People's Court, the Supreme People's Procuratorate, the Ministry of Public Security, and the Ministry of Justice jointly issued "Opinions on Punishment of Crimes Obstructing the Prevention and Control of the Novel Coronavirus Infection Pneumonia Epidemic According to Law", which clearly stipulates nine types of crimes that hinder the prevention and control of the epidemic. In order to clarify and solve some outstanding problems of inconsistent understanding of the application of laws in the practice of epidemic prevention and control, the Supreme People's Procuratorate selected cases that accounted for a large portion of cases, reflected many problems, and urgently required practical practices;they then issued ten batches of "Typical Cases of Crimes Obstructing the Prevention and Control of the New Coronary Pneumonia Epidemic by Procuratorial Organs across the Country". This article is mainly based on the "Prosecutors across the country handle typical cases of crimes obstructing the prevention and control of the new crown pneumonia epidemic in accordance with the law", analyzing economic and property crimes, crimes that disrupt the order of social management, and crimes that endanger public safety.

5.
Asian Pacific Journal of Tropical Medicine ; 15(5):213-219, 2022.
Article in English | EMBASE | ID: covidwho-1896976

ABSTRACT

Objective: To determine the degree of knowledge in the usage of pulse oximeter as a home assessment tool among the community in Malaysia. Methods: A cross-sectional survey was conducted in November 2021. The questionnaire assessed the knowledge in using pulse oximeters, user experience and opinions in using pulse oximeter as a home assessment tool during the pandemic. Results: A total of 504 respondents were included in the study, and the mean score in knowledge related to application of pulse oximetry was 73.00%, while the mean score in knowledge related to factors affecting pulse oximetry readings was only 38.51%. A total of 90.5% of the respondents recognised normal pulse rate and 88.5% knew the blood oxygen saturation levels of a healthy adult, while 69.4% recognised the definition of silent hypoxia. In addition, the majority of the respondents agreed that factors such as poor blood circulation (71.2%), excessive movements (69.8%), and hand position (60.7%) affected oximetry readings. However, 61.7%, 81.7%, 77.2% and 76.8% of the respondents could not identify nail polish, skin colour, skin thickness and tattoos as factors that may affect oximetry readings respectively. Conclusions: The respondents showed a satisfactory level of knowledge related to application of pulse oximetry, but a poor level of knowledge related to factors affecting pulse oximetry readings among the community in Malaysia. Continuous efforts in educating the community on the correct use of pulse oximeters are crucial for appropriate home assessment and avoiding unnecessary stress.

6.
Australasian Journal of Dermatology ; 63(SUPPL 1):73, 2022.
Article in English | EMBASE | ID: covidwho-1883168

ABSTRACT

We report a case of eruptive xanthomas in a 31 year old Caucasian man with a background history of poorly controlled Type 2 diabetes mellitus, obstructive sleep apnoea and fatty liver disease. He developed a widespread pruritic rash which started on his left arm 9 h after his first dose of the Pfizer covid vaccination which progressed to involve bilateral upper limbs, lower limbs and abdomen. However, he presented a week later with acute abdominal pain and was later admitted to ICU with pancreatitis resulting in diabetic ketoacidosis. Dermatology were consulted for management of his pruritic eruption and possible covid vaccination adverse reaction. Physical examination revealed multiple excoriated yellow to pink papules. His bloods showed a total cholesterol of 31 and triglycerides of 157. A biopsy was taken which demonstrated perivascular and periadnexal foam cells in the superficial to mid dermis consistent with eruptive xanthoma. He was commenced on fenofibrate to manage his hypertriglyceridemia and insulin to manage his diabetes. This case highlights the rarity of eruptive xanthomas and that it can go unrecognised or misdiagnosed if not considered. Clinicians should consider a biopsy to confirm the diagnosis and consider differentials of Non-Langerhans cell and Langerhans cell histiocytosis, disseminated granuloma annulare and sarcoidosis. Eruptive xanthomas are lipid deposits in the skin in the context of high triglycerides >20 mmol/L. They are characterised by firm 2-5 mm papules that commonly involve the extensor surfaces. The papules can be pruritic or tender. The xanthomas usually resolve within two weeks of normalisation of triglyceride levels, as observed in this patient. Effective treatment options include dietary modification and lipid lowering medication such as fenofibrate. In refractory cases, surgical excisions, cryotherapy and ablative lasers such as Er-YAG and CO2 have been reported . Clinical photos and histology will be presented for discussion.

7.
Ieee Journal of Selected Topics in Signal Processing ; 16(2):276-288, 2022.
Article in English | English Web of Science | ID: covidwho-1883131

ABSTRACT

The Coronavirus disease 2019 (COVID-19) is a respiratory illness that can spread from person to person. Since the COVID-19 pandemic is spreading rapidly over the world and its outbreak has affected different people in different ways, it is significant to study or predict the evolution of its epidemic trend. However, most of the studies focused solely on either classical epidemiological models or machine learning models for COVID-19 pandemic forecasting, which either suffer from the limitation of the generalization ability and scalability or the lack of surveillance data. In this work, we propose T-SIRGAN that integrates the strengths of the epidemiological theories and deep learning models to be able to represent complex epidemic processes and model the non-linear relationship for more accurate prediction of the growth of COVID-19. T-SIRGAN first adopts the Susceptible-Infectious-Recovered (SIR) model to generate epidemiological-based simulation data, which are then fed into a generative adversarial network (GAN) as adversarial examples for data augmentation. Then, Transformers are used to predict the future trends of COVID-19 based on the generated synthetic data. Extensive experiments on real-world datasets demonstrate the superiority of our method. We also discuss the effectiveness of vaccine based on the difference between the predicted and the reported number of COVID-19 cases.

8.
American Journal of Respiratory and Critical Care Medicine ; 205:1, 2022.
Article in English | English Web of Science | ID: covidwho-1880762
9.
British Columbia Medical Journal ; 64(4):182-184, 2022.
Article in English | Scopus | ID: covidwho-1870746

ABSTRACT

The COVID-19 pandemic reignited the long-standing issue of global racism against Asian populations. Specifically, Asian health care workers face discrimination due to a unique combination of their racial background and their roles interacting with COVID-19-exposed patients. Sources of violence and prejudice may arise from within and outside the health care system. If left unaddressed, the emotional stress of racial discrimination faced by health care workers can accelerate staff burnout, perpetuate feelings of isolation, and compromise patient care. In this article, we review factors involved in experiences of anti-Asian racism during the COVID-19 pandemic. Proposed areas of action to mitigate incidence of discrimination in the health care system may include policies addressing country-based nomenclature for global issues, funding for Asian community-based medical resources, and early anti-Asian racism education for health care students. © 2022, British Columbia Medical Association. All rights reserved.

10.
Embase; 2022.
Preprint in English | EMBASE | ID: ppcovidwho-337473

ABSTRACT

DNA methylation commonly occurs at cytosine-phosphate-guanine sites (CpGs) that can serve as biomarkers for many diseases. We analyzed whole genome sequencing data to identify DNA methylation quantitative trait loci (mQTLs) in 4,126 Framingham Heart Study participants. Our mQTL mapping identified 94,362,817 cis-mQTLvariant-CpG pairs (for 210,156 unique autosomal CpGs) at P<1e-7 and 33,572,145 trans-mQTL variant-CpG pairs (for 213,606 unique autosomal CpGs) at P<1e-14. Using cismQTL variants for 1,258 CpGs associated with seven cardiovascular disease risk factors, we found 104 unique CpGs that colocalized with at least one cardiovascular disease trait. For example, cg11554650 (PPP1R18) colocalized with type 2 diabetes, driven by a single nucleotide polymorphism (rs2516396). We performed Mendelian randomization (MR) analysis and demonstrated 58 putatively causal relations of CVD risk factor-associated CpGs to one or more risk factors (e.g., cg05337441 [APOB] with LDL;MR P=1.2e-99, and 17 causal associations with coronary artery disease (e.g. cg08129017 [SREBF1] with coronary artery disease;MR P=5e-13). We also showed that three CpGs, e.g., cg14893161 (PM20D1), are putatively causally associated with COVID-19 severity. To assist in future analyses of the role of DNA methylation in disease pathogenesis, we have created a browsable and downloadable resource of mQTLs through the NCBI Molecular QTL Browser.

11.
31st ACM World Wide Web Conference, WWW 2022 ; : 2678-2686, 2022.
Article in English | Scopus | ID: covidwho-1861668

ABSTRACT

Analyzing the causal impact of different policies in reducing the spread of COVID-19 is of critical importance. The main challenge here is the existence of unobserved confounders (e.g., vigilance of residents) which influence both the presence of policies and the spread of COVID-19. Besides, as the confounders may be time-varying, it is even more difficult to capture them. Fortunately, the increasing prevalence of web data from various online applications provides an important resource of time-varying observational data, and enhances the opportunity to capture the confounders from them, e.g., the vigilance of residents over time can be reflected by the popularity of Google searches about COVID-19 at different time periods. In this paper, we study the problem of assessing the causal effects of different COVID-19 related policies on the outbreak dynamics in different counties at any given time period. To this end, we integrate COVID-19 related observational data covering different U.S. counties over time, and then develop a neural network based causal effect estimation framework which learns the representations of time-varying (unobserved) confounders from the observational data. Experimental results indicate the effectiveness of our proposed framework in quantifying the causal impact of policies at different granularities, ranging from a category of policies with a certain goal to a specific policy type. Compared with baseline methods, our assessment of policies is more consistent with existing epidemiological studies of COVID-19. Besides, our assessment also provides insights for future policy-making. © 2022 ACM.

12.
Isprs International Journal of Geo-Information ; 11(4):15, 2022.
Article in English | Web of Science | ID: covidwho-1820289

ABSTRACT

Currently, coronavirus disease 2019 (COVID-19) remains a global pandemic, but the prevention and control of the disease in various countries have also entered the normalization stage. To achieve economic recovery and avoid a waste of resources, different regions have developed prevention and control strategies according to their social, economic, and medical conditions and culture. COVID-19 disparities under the interaction of various factors, including interventions, need to be analyzed in advance for effective and precise prevention and control. Considering the United States as the study case, we investigated statistical and spatial disparities based on the impact of the county-level social vulnerability index (SVI) on the COVID-19 infection rate. The county-level COVID-19 infection rate showed very significant heterogeneity between states, where 67% of county-level disparities in COVID-19 infection rates come from differences between states. A hierarchical linear model (HLM) was adopted to examine the moderating effects of state-level social distancing policies on the influence of the county-level SVI on COVID-19 infection rates, considering the variation in data at a unified level and the interaction of various data at different levels. Although previous studies have shown that various social distancing policies inhibit COVID-19 transmission to varying degrees, this study explored the reasons for the disparities in COVID-19 transmission under various policies. For example, we revealed that the state-level restrictions on the internal movement policy significantly attenuate the positive effect of county-level economic vulnerability indicators on COVID-19 infection rates, indirectly inhibiting COVID-19 transmission. We also found that not all regions are suitable for the strictest social distancing policies. We considered the moderating effect of multilevel covariates on the results, allowing us to identify the causes of significant group differences across regions and to tailor measures of varying intensity more easily. This study is also necessary to accomplish targeted preventative measures and to allocate resources.

13.
PubMed; 2021.
Preprint in English | PubMed | ID: ppcovidwho-333533

ABSTRACT

Immune dysregulation is characteristic of the more severe stages of SARS-CoV-2 infection. Understanding the mechanisms by which the immune system contributes to COVID-19 severity may open new avenues to treatment. Here we report that elevated interleukin-13 (IL-13) was associated with the need for mechanical ventilation in two independent patient cohorts. In addition, patients who acquired COVID-19 while prescribed Dupilumab had less severe disease. In SARS-CoV-2 infected mice, IL-13 neutralization reduced death and disease severity without affecting viral load, demonstrating an immunopathogenic role for this cytokine. Following anti-IL-13 treatment in infected mice, in the lung, hyaluronan synthase 1 ( Has1 ) was the most downregulated gene and hyaluronan accumulation was decreased. Blockade of the hyaluronan receptor, CD44, reduced mortality in infected mice, supporting the importance of hyaluronan as a pathogenic mediator, and indicating a new role for IL-13 in lung disease. Understanding the role of IL-13 and hyaluronan has important implications for therapy of COVID-19 and potentially other pulmonary diseases. SUMMARY: L-13 levels are elevated in patients with severe COVID-19. In a mouse model of disease, IL-13 neutralization results in reduced disease and lung hyaluronan deposition. Similarly, blockade of hyaluronan's receptor, CD44, reduces disease, highlighting a novel mechanism for IL-13-mediated pathology.

14.
9th Academic Conference of Geology Resource Management and Sustainable Development ; : 1624-1628, 2022.
Article in English | Scopus | ID: covidwho-1787286

ABSTRACT

The COVID-19 pandemic has had a profound impact on international economic and energy development, Until now, the epidemic has not completely retreated, and prevention and control of the epidemic has become a new normal. Starting from the analysis of the impact of COVID-19 on the upper, middle and lower reaches of the energy industry chain, this paper explores the dilemma faced by China's energy development under the situation of normalized epidemic prevention and control, and puts forward effective countermeasures, which have important strategic significance for ensuring the sustainable development of China's energy and the coordination and stability of economic society. © 2022 by Aussino Academic Publishing House.

15.
Open Forum Infectious Diseases ; 8(SUPPL 1):S293, 2021.
Article in English | EMBASE | ID: covidwho-1746611

ABSTRACT

Background. While pediatric cases of COVID-19 are at low risk for adverse events, schoolchildren should be considered for surveillance as they can become infected at school and serve as sources of household or community transmission. Our team assessed the feasibility of young children self-collecting SARS-CoV-2 samples for surveillance testing in an educational setting. Methods. Students at a K-8 school were tested weekly for SARS-CoV-2 from September 2020 - June 2021. Error rates were collected from September 2020 -January 2021. Clinical staff provided all students with instructions for anterior nares specimen self-collection and then observed them to ensure proper technique. Instructions included holding the sterile swab while making sure not to touch the tip, inserting the swab into their nostril until they start to feel resistance, and rubbing the swab in four circles before repeating the process in their other nostril. An independent observer timed random sample self-collections from April - June 2021. Results. 2,590 samples were collected from 209 students during the study period when data on error rates were collected. Errors occurred in 3.3% of all student encounters (n=87). Error rates over time are shown in Figure 1, with the highest rate occurring on the first day of testing (n=20/197, 10.2%) and the lowest in January 2021 (n=1/202, 0.5%). 2,574 visits for sample self-collection occurred during the study period when independent timing data was collected (April - June 2021). Of those visits, 7.5% (n=193) were timed. The average duration of each visit was 70 seconds. Conclusion. Pediatric self-collected lower nasal swabs are a viable and easily tolerated specimen collection method for SARS-CoV-2 surveillance in school settings, as evidenced by the low error rate and short time window of sample self-collection during testing. School administrators should expect errors to drop quickly after implementing testing.

16.
Open Forum Infectious Diseases ; 8(SUPPL 1):S361, 2021.
Article in English | EMBASE | ID: covidwho-1746477

ABSTRACT

Background. BRII-196 and BRII-198 are human monoclonal antibodies (mAb) with an extended half-life targeting distinct epitopes of the spike protein on SARSCoV-2. Mutations in these epitope regions are continuously emerging, potentially conferring resistance to COVID-19 therapeutics in development. Individual phase I studies showed that BRII-196 or BRII-198 alone were safe and well tolerated in healthy subjects. The BRII-196 and BRII-198 cocktail is currently under evaluation in Phase 2/3 studies for the treatment of COVID-19. Methods. Preclinical study: BRII-196 and BRII-198 were evaluated in the microneutralization assay using pseudo-viruses encoding mutations identified in the spike protein of a panel of SARS-CoV-2 variants of concerns, including strains originating in UK, SA, BR, CA, and India. The fold-change in neutralization IC50 titers relative to wild-type virus was calculated. Phase 1 study: healthy adults received sequential IV BRII-196 and BRII-198 (n=9) or placebo (n=3);and were followed for 180 days. Two dose levels (750mg/750mg and 1500mg/1500mg) were evaluated for safety, pharmacokinetics and immunogenicity. Interim analysis results are presented. Results. Preclinical: BRII-196 and BRII-198 exhibited neutralizing activity against pseudo-virus variants that contained spike mutations of a panel of variants including B.1.1.7 (UK), B.1.351(SA), P.1(BR), B.1.427/429 (CA), B.1.526 (NY), and B.1.617 (IN), comparable to that against wild-type virus. Phase I study: BRII-196 plus BRII-198 was well tolerated with no dose-limiting adverse events (AEs), deaths, serious adverse events, or infusion reactions. The majority of AEs were isolated asymptomatic grade 1-2 laboratory abnormalities. (Table 1). Each mAb displayed pharmacokinetic characteristics expected of extended half-life YTE-antibodies. Conclusion. The BRII-196 and BRII-198 cocktail was well-tolerated, and maintains neutralization against currently reported circulating variants of concern. These preclinical and clinical results support further development of BRII-196 and BRII-198 as a therapeutic or prophylactic option for SARS-CoV-2.

17.
Aerosol and Air Quality Research ; 22(2), 2022.
Article in English | Scopus | ID: covidwho-1732359

ABSTRACT

Airborne transmission of COVID-19 plays an important role for the pandemic. However, nucleic acid based evidence of direct association of COVID-19 with environmental contamination is lacking. Here, we investigated a COVID-19 outbreak with two fast food employees infected, in which a traveler despite of a 14-day quarantine turned positive after check in with a hotel, using environmental SARS-CoV-2 sampling, epidemiological tracing, viral RNA sequence as well as surveillance method. Out of 25 positive environmental air and surface swab samples (N = 237) collected, SARS-CoV-2 was found to have remained airborne (5640–7840 RNA copies m–3 ) for more than 4 days in a female washroom. After aging for 5 days in the air, no viable virus was detected. The traveler did not have any contacts with the two employees;however, genome sequencing showed that SARS-CoV-2 variants from three patients and two environmental surface samples belonged to 20B viral clade, sharing a nucleic acid identity of more than 99.9%. We concluded that the outbreak was triggered by SARS-CoV-2 contaminated environments, where the employees inhaled the virus from the air or touching facility surfaces where the traveler did not have any physical contacts with. © The Author(s).

18.
International Journal of Modern Physics C ; 2022.
Article in English | Scopus | ID: covidwho-1731301

ABSTRACT

As COVID-19 spread globally in 2020, the interaction between the traffic dynamics and the spread of the epidemic has attracted much attention. However, controlling the spread of the epidemic remains a challenging issue. In this paper, we have investigated the relationships between link-closure strategies and the traffic-driven epidemic spreading. It is found that the epidemic spreading can be suppressed by the targeted closing of links between small-degree nodes. In contrast, closing links between large-degree nodes can accelerate the outbreak of the epidemic. These findings have significance for controlling the spread of the epidemic. © 2022 World Scientific Publishing Company.

19.
21st IEEE International Conference on Data Mining Workshops, ICDMW 2021 ; 2021-December:859-862, 2021.
Article in English | Scopus | ID: covidwho-1730933

ABSTRACT

The COVID-19 pandemic poses a great threat to global public health. Meanwhile, there is massive misinformation associated with the pandemic which advocates unfounded or unscientific claims. Even major social media and news outlets have made an extra effort in debunking COVID-19 misinformation, most of the fact-checking information is in English, whereas some unmoderated COVID-19 misinformation is still circulating in other languages, threatening the health of less-informed people in immigrant communities and developing countries. In this paper, we make the first attempt to detect COVID-19 misinformation in a low-resource language (Chinese) only using the fact-checked news in a high-resource language (English). We start by curating a Chinese realfake news dataset according to existing fact-checking information. Then, we propose a deep learning framework named CrossFake to jointly encode the cross-lingual news body texts and capture the news content as much as possible. Empirical results on our dataset demonstrate the effectiveness of CorssFake under the cross-lingual setting and it also outperforms several monolingual and cross-lingual fake news detectors. The dataset is available at https://github.com/YingtongDou/CrossFake. © 2021 IEEE.

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