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1.
Pediatr Surg Int ; 2022 Jun 07.
Article in English | MEDLINE | ID: covidwho-1877828

ABSTRACT

PURPOSE: To investigate the impact of COVID-19 on the treatment of children with congenital diaphragmatic hernia (CDH). METHODS: We retrospectively collected and compared the data of patients with CDH admitted between January 1, 2020 and December 31, 2021(study group) with the CDH patients admitted before the pandemic between January 1, 2018 and December 31, 2019 (control group). RESULTS: During the pandemic, 41 patients with CDH diagnosed prenatally were transferred to our hospital, and 40 underwent surgical repair. The number of patients treated in our hospital increased by 24.2% compared with the 33 patients before the pandemic. During the pandemic, the overall survival rate, postoperative survival rate and recurrence rate were 85.4%, 87.5% and 7.3%, respectively, and there were no significant differences compared with the control group (75.8%, 83.3% and 9.1%, respectively). The average length of hospital stay in patients admitted during the pandemic was longer than that in the control group (31 days vs. 16 days, P < 0.001), and the incidence of nosocomial infection was higher than that in the control group (19.5% vs. 3%, P = 0.037). CONCLUSIONS: CDH patients confirmed to be SARS-CoV-2 infection-free can receive routine treatment. Our data indicate that the implementation of protective measures during the COVID-19 pandemic, along with appropriate screening and case evaluation, do not have a negative impact on the prognosis of children.

2.
Hum Vaccin Immunother ; : 2076523, 2022 May 18.
Article in English | MEDLINE | ID: covidwho-1852829

ABSTRACT

Vaccine uptake rate is crucial for herd immunity. Medical care workers (MCWs) can serve as ambassadors of COVID-19 vaccine acceptance. This study aimed to assess MCWs' willingness to receive the COVID-19 vaccine, and to explore the factors affecting COVID-19 vaccination acceptance. A multicenter study among medical care workers was conducted in seven selected hospitals from seven geographical territories of China, and data were collected on sociodemographic characteristics, vaccine hesitancy, and health beliefs on COVID-19 vaccination among participants. Univariate and multivariate logistic regression models were performed to explore the correlations between individual factors and the acceptance of the COVID-19 vaccine. Among the 2681 subjects, 82.5% of the participants were willing to accept the COVID-19 vaccination. Multivariate regression analyses revealed that individuals with more cues to action about the vaccination, higher level of confidence about the vaccine, and higher level of trust in the recommendations of COVID-19 vaccine from the government and the healthcare system were more likely to get the COVID-19 vaccine. In contrast, subjects with higher level of perceived barriers and complacency were less likely to accept the COVID-19 vaccine. Overall, MCWs in China showed a high willingness to get the COVID-19 vaccine. The governmental recommendation is an important driver and lead of vaccination. Relevant institutions could increase MCWs' willingness to COVID-19 vaccines by increasing MCWs' perception of confidence about COVID-19 vaccines and cues to action through various strategies and channels. Meanwhile, it can also provide evidence in similar circumstances in the future to develop vaccine promotion strategies.

3.
Front Microbiol ; 13: 792532, 2022.
Article in English | MEDLINE | ID: covidwho-1809433

ABSTRACT

A recent study showed that patients with coronavirus disease 2019 (COVID-19) have gastrointestinal symptoms and intestinal flora dysbiosis. Yeast probiotics shape the gut microbiome and improve immune homeostasis. In this study, an oral candidate of yeast-derived spike protein receptor-binding domain (RBD) and fusion peptide displayed on the surface of the yeast cell wall was generated. The toxicity and immune efficacy of oral administration were further performed in Institute of Cancer Research (ICR) mice. No significant difference in body weights, viscera index, and other side effects were detected in the oral-treated group. The detectable RBD-specific immunoglobulin G (IgG) and immunoglobulin A (IgA) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and more complex microbiota were detected from oral administration mice compared with those of the control group. Interestingly, the recombinant yeast was identified in female fetal of the high-dose group. These results revealed that the displaying yeast could fulfill the agent-driven immunoregulation and gut microbiome reconstitution. The findings will shed light on new dimensions against SARS-CoV-2 infection with the synergistic oral agents as promising non-invasive immunization and restoring gut flora.

4.
Chin Med J (Engl) ; 135(6): 691-696, 2022 Mar 20.
Article in English | MEDLINE | ID: covidwho-1806655

ABSTRACT

BACKGROUND: Coronavirus disease 2019 (Covid-19) remains a serious health threat worldwide. We aimed to investigate whether low molecular weight heparin (LMWH) can promote organ function recovery in moderate Covid-19 pneumonia patients. METHODS: We initiated an LMWH protocol in Covid-19 patients with increased D-dimer, body mass index >30 kg/m2 or a history of diabetes from January 18, 2020 at Shanghai Public Health Clinical Center. In this retrospective study, we assigned moderate Covid- 19 pneumonia patients admitted between January 18th and April 18, 2020 receiving the LMWH protocol to the LMWH group. Moderate patients who met the inclusion criteria but did not receive LMWH protocol were included in the control group by 1:2 propensity score matching. General clinical information, indicators for renal function, arterial blood gas analyses, arterial blood lactic acid content (mmol/L), and coagulation indexes at 0 day, 3 days, 7 days, and 11 days after admission were recorded and compared between the two groups. RESULTS: There were 41 patients in the LMWH group and 82 patients in the control group. General information in both groups were similar. Compared to the control group, the arterial blood lactic acid content (mmol/L) at day 11 (1.3 [1.1, 1.7] vs. 1.2 [0.9, 1.3], P = 0.016) was reduced in the LMWH group. The estimated glomerular filtration rate (eGFR) in the LMWH group was higher than that in the control group at day 7 (108.54 [89.11, 128.17] vs. 116.85 [103.39, 133.47], P = 0.039) and day 11 (113.74 [94.49, 126.34] vs. 128.31 [112.75, 144, 12], P  = 0.003). The serum creatinine levels (Scr) in the LMWH group were lower than that in the control group at day 7 (62.13 [51.47, 77.64] vs. 55.49 [49.50, 65.75], P = 0.038) and day 11 (63.35 [50.17, 75.73] vs. 51.62 [44.62, 61.24], P = 0.005). CONCLUSIONS: LMWH treatment can reduce arterial blood lactic acid levels and improve eGFR in moderate Covid-19 pneumonia patients. Randomized controlled trials are warranted to further investigate this issue. TRIAL REGISTRATION: ChiCTR.org.cn, ChiCTR2000034796.


Subject(s)
COVID-19 , Heparin, Low-Molecular-Weight , China , Glomerular Filtration Rate , Heparin, Low-Molecular-Weight/therapeutic use , Humans , Lactic Acid , Retrospective Studies
5.
The New Zealand Medical Journal (Online) ; 135(1552):77, 2022.
Article in English | ProQuest Central | ID: covidwho-1782033

ABSTRACT

AIM: The August 2021 COVID-19 outbreak in Auckland caused the New Zealand Government to transition from an elimination strategy to suppression, which relies heavily on high vaccination rates in the population. As restrictions ease and as COVID-19 spreads throughout New Zealand, there is a need to understand how different levels of vaccination will impact the initial stages of COVID-19 outbreaks that are seeded around the country. METHOD: A stochastic branching process model is used to simulate the initial spread of a COVID-19 outbreak for different vaccination rates. RESULTS: High vaccination rates are effective at minimizing the number of infections and hospitalizations. Increasing vaccination rates from 20% (approximate value at the start of the August 2021 outbreak) to 80% (approximate proposed target) of the total population can reduce the median number of infections that occur within the first four weeks of an outbreak from 1011 to 14 (25th and 75th quantiles of 545-1602 and 2-32 for V=20% and V=80%, respectively). As the vaccination rate increases, the number of breakthrough infections (infections in fully vaccinated individuals) and hospitalisations of vaccinated individuals increases. Unvaccinated individuals, however, are 3.3x more likely to be infected with COVID-19 and 25x more likely to be hospitalised. CONCLUSION: This work demonstrates the importance of vaccination in protecting individuals from COVID-19, preventing high caseloads, and minimising the number of hospitalisations and hence limiting the pressure on the healthcare system.

6.
BenchCouncil Transactions on Benchmarks, Standards and Evaluations ; : 100037, 2022.
Article in English | ScienceDirect | ID: covidwho-1783771

ABSTRACT

AI technology has been used in many clinical research fields, but most AI technologies are difficult to land in real-world clinical settings. In most current clinical AI research settings, the diagnosis task is to identify different types of diseases among the given ones. However, the diagnosis in real-world settings needs dynamically developing inspection strategies based on the existing resources of medical institutions and identifying different kinds of diseases out of many possibilities. To promote the development of different clinical AI technologies and the implementation of clinical applications, we propose a benchmark named Clinical AIBench for developing, verifying, and evaluating clinical AI technologies in real-world clinical settings. Specifically, Clinical AIBench can be used for: (1) Model training and testing: Researchers can use the data to train and test their models. (2)Model evaluation: Researchers can use Clinical AIBench to objectively, fairly, and comparably evaluate various models of different researchers. (3) Clinical value evaluation: Researchers can use the clinical indicators provided by Clinical AIBench to evaluate the clinical value of models, which will be applied in real-world clinical settings. For convenience, Clinical AIBench provides three different levels of clinical settings: restricted clinical setting, which is named closed clinical setting, data island clinical setting, and real-world clinical setting, which is called open clinical setting. In addition, Clinical AIBench covers three diseases: Alzheimer’s disease, COVID-19, and dental. Clinical AIBench provides python APIs to researchers. The data and source code are publicly available from the project website https://www.benchcouncil.org/clinical_aibench/.

7.
Front Public Health ; 10: 784668, 2022.
Article in English | MEDLINE | ID: covidwho-1775989

ABSTRACT

Affected by the coronavirus disease 2019 (COVID-19), there were short-term uncertainties in China's live pig industry supply chain. Due to the insufficient supply of pork, the price of pork rose from 33.21 yuan/kg at the end of 2019 to 37.46 yuan/kg in mid-February and fell to 26.41 yuan/kg in mid-May. To restore pig supply and stabilise prices, China issued relevant policies. Given the current effective control of COVID-19 in China, this paper constructed an evolutionary game model of China's pork supply and demand stakeholders under normalisation of COVID-19 prevention and control, analysed the behavioural strategies of consumers, government, and pig farmers, used MATLAB software for data simulation, and expounded on the evolution path and the characteristic rule of tripartite decision-making behaviours. The results showed that government supervision costs, evaluation of government by consumers and pig farmers, government subsidies to pig farmers and consumers, and the proportion of stakeholder behaviours affected the formation of tripartite relationships. The results provide a useful reference for the government to formulate effective policies, increase pig supply, and stabilise pork prices.


Subject(s)
COVID-19 , Pork Meat , Red Meat , Animals , COVID-19/prevention & control , China , Government , Humans , Swine
8.
Front Pediatr ; 9: 801436, 2021.
Article in English | MEDLINE | ID: covidwho-1775736

ABSTRACT

Objective: The study is designed to understand the situation of full-term infants breastfeeding within 6 months of birth in Xi'an before the Covid-19 pandemic and analyze the influencing factors of exclusive breastfeeding. Methods: Five hospitals in Xi'an province have been selected as research centers. Full-term infants who met the inclusion and exclusion criteria were recruited from these centers between January 1 and February 28, 2019. The feeding situation at 10 days, 42 days, 3 months, and 6 months after birth were investigated. A self-designed breastfeeding questionnaire was used for investigation and follow-up. SPSS 22.0 was applied for statistical analysis of the data. Results: The exclusive breastfeeding rate of full-term infants on days 10 and 42 and at months three and six after birth was 61.38%, 54.78%, 48.83%, and 38.78%, respectively, with a decreasing trend over time. During breastfeeding within 48 h after delivery, 1,653 cases (91.83%) of puerpera had different grades of pain, including 1,325 cases (80.16%) of mild discomfort, 321 cases (19.42%) of moderate pain, and seven cases (0.42%) of severe pain. Within 24-48 h postpartum, 1,607 (89.27%) mothers faced problems related to postpartum breastfeeding. Among them, 694 (43,19%) neonates could not be fed effectively; 665 (41.38%) mothers had wound pain and had inconvenience to turn over; 598 (37.21%) neonates were difficult to wake up; 439 (27.32%) mothers had incorrect feeding posture; 181 (11.26%) mothers experienced other problems. The Cox risk regression model showed that weight gain during pregnancy was higher than the recommended standard. Living in suburban counties was a risk factor of exclusive breastfeeding for full-term infants. Participation in breastfeeding courses during pregnancy, feeding more than eight times daily after delivery, were the protective factors of exclusive breastfeeding for full-term infants. Conclusion: The body weight gain of parturients should be controlled within a reasonable range during pregnancy. Parturients were encouraged by medical staff to participate in breastfeeding courses or watch the breastfeeding process during pregnancy to increase their self-confidence and improve the rate of exclusive breastfeeding for full-term infants. In addition, it is necessary to strengthen the publicity of breastfeeding in suburban areas to promote breastfeeding.

9.
Iran J Public Health ; 50(2): 271-279, 2021 Feb.
Article in English | MEDLINE | ID: covidwho-1761416

ABSTRACT

BACKGROUND: Coronavirus disease 2019 (COVID-19) has caused massive casualties, severe economic losses, and poses a threat to the world. This study's primary objective was to analyze the hospital's potential hazards of COVID-19 prevention and control. The second objective was to review the disaster plan and make recommendations to minimize the spread of COVID-19 in hospitals. METHODS: An expert group for the prevention and control of COVID-19 in the First People's Hospital of Long-quanyi Dis-trict, Chengdu, China was established. We adopted the hazard vulnerability analysis (HVA) to risk-stratify potential hazards and calculated relative risk values. We used the Delphi expert consultation method to propose and implement targeted improvement measures for the top five potential hazards. Then, the effects before and after the intervention were compared. RESULTS: The top five hazards were: insufficient Personal Protective Equipment (PPE) (25.68%), inadequate diagnosis ability of clinicians (22.55%), and inadequate management strategies of patients and caregivers (22.38%), lack of professional ability of pre-checking and triage staff (16.96%), lack of knowledge of COVID-19 of medical staff (15.59%). After taking targeted improvement measures, the average score of the hospital staff's COVID-19 knowledge test increased from 73.26 points to 90.44 points, the average test score of the outsourcing company employees increased from 68.55 to 89.75 points. The differences were statistically significant (P<0.05). CONCLUSION: HVA can be used to systematically risk-stratify potential threats, measure the probability of those potential hazards, and develop various hospital prevention and control measures for COVID-19 epidemics.

10.
Zhongguo Yi Xue Ke Xue Yuan Xue Bao ; 44(1): 30-39, 2022 Feb.
Article in Chinese | MEDLINE | ID: covidwho-1753709

ABSTRACT

Objective To measure the prevalence of mental health symptoms and identify the associated factors among college students at the beginning of coronavirus disease 2019(COVID-19)outbreak in China. Methods We carried out a multi-center cross-sectional study via snowball sampling and convenience sampling of the college students in different areas of China.The rates of self-reported depression,anxiety,and stress and post-traumatic stress disorder(PTSD)were assessed via the 21-item Depression-Anxiety-Stress Scale(DASS-21)and the 6-item Impact of Event Scale-Revised(IES-6),respectively.Covariates included sociodemographic characteristics,health-related data,and information of the social environment.Data pertaining to mental health service seeking were also collected.Multivariate Logistic regression analyses were performed to identify the risk factors. Results A total of 3641 valid questionnaires were collected from college students.At the beginning of the COVID-19 outbreak,535(14.69%)students had negative emotions,among which 402(11.04%),381(10.49%),and 171(4.90%)students had the symptoms of depression,anxiety,and stress,respectively.Meanwhile,1245(34.19%)college students had PTSD.Among the risk factors identified,male gender was associated with a lower likelihood of reporting depression symptoms(AOR=0.755,P=0.037],and medical students were at higher risk of depression and stress symptoms than liberal arts students(AOR=1.497,P=0.003;AOR=1.494,P=0.045).Family support was associated with lower risks of negative emotions and PTSD in college students(AOR=0.918,P<0.001;AOR=0.913,P<0.001;AOR=0.899,P<0.001;AOR=0.971,P=0.021). Conclusions College students were more sensitive to public health emergencies,and the incidence of negative emotions and PTSD was significantly higher than that before the outbreak of COVID-19.More attention should be paid to female college students who were more likely to develop negative emotions.We should strengthen positive and proper propaganda via mass media and help college students understand the situation and impact of COVID-19.Furthermore,we should enhance family support for college students.The government and relevant agencies need to provide appropriate mental health services to the students under similar circumstances to avoid the deterioration of their mental well-being.


Subject(s)
COVID-19 , COVID-19/epidemiology , Cross-Sectional Studies , Female , Health Status , Humans , Male , Students/psychology , Universities
11.
EuropePMC; 2022.
Preprint in English | EuropePMC | ID: ppcovidwho-330390

ABSTRACT

Purpose: To investigate the impact of COVID-19 on the treatment of children with congenital diaphragmatic hernia (CDH). Methods: We retrospectively collected and compared the data of patients with CDH admitted between January 1, 2020 and December 31, 2021 with the CDH patients admitted before the pandemic between January 1, 2018 and December 31, 2019 (control group). Results: During the pandemic, 41 patients with CDH diagnosed prenatally were transferred to our hospital, and 40 underwent surgical repair. The number of patients treated in our hospital increased by 24.2% compared with that before the pandemic. During the pandemic, the overall survival rate, postoperative survival rate and recurrence rate were 85.4%, 87.5% and 7.3%, respectively, and there were no significant differences compared with the control group. The average length of hospital stay in patients admitted during the pandemic was longer than that in the control group, and the incidence of nosocomial infection was higher than that in the control group. Conclusions: CDH patients confirmed to be SARS-CoV-2 infection-free can receive routine treatment. Our data indicate that the implementation of protective measures during the COVID-19 pandemic, along with appropriate screening and case evaluation, do not have a negative impact on the prognosis of children.

12.
Iranian Journal of Public Health ; 49(6):1169-1172, 2020.
Article in English | CAB Abstracts | ID: covidwho-1717219

ABSTRACT

The objective of the article was to outline the practical nursing management strategies successfully followed in a general tertiary hospital involved in the of pre-screening 195458 patients, treatment of 316 suspected cases, and 4 confirmed COVID-19 cases from December 2019 to Mar 29, 2020, with no infection of medical staff. During the outbreak, the orderly management and distribution of personal protective equipment (PPE) were essential for COVID-19 prevention and control. A two-level warehouse management system for PPE was established. The hospital-level warehouse of the isolation hospital stored medical supplies. Input/output forms were used to record the usage of PPE. The wardlevel warehouse was equipped with daily requirements of protective supplies. Medical staff followed the policies and procedures of isolation precautions to use PPE. The nurse in charge reported the quantity of PPE used so that replenishment could be provided in time. Reasonable distribution and usage of PPE could be obtained through the two-level warehouse management system.

13.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-321484

ABSTRACT

Background: College students are a uniquely vulnerable group and may experience high stress levels due to COVID-19. This study aims to identify the the psychological state and related factors on Chinese college students during the initial phases of the COVID-19 pandemic. Methods: From February 23 to March 5, 2020, a cross-sectional online survey was conducted among 3606 college students from seven provinces in China using standard questionnaires measuring adverse psychological outcomes and related factors including Impact of Event Scale-6 (IES-6), Depression, Anxiety and Stress Scale (DASS), Perceived Social Support Scale (PSSS) and Simplified Coping Style Questionnaire (SCSQ). Exploratory factor analysis (EFA) were used to determine underlying constructs of the perceived threat items. Multivariate regression was used to explore the determinants of adverse psychological impact. Results: Posttraumatic stress (PTS) were prevalent in this sample of college students, and 34.22% met the cut-off for posttraumatic stress disorder (PTSD). The proportion of having mild to extremely severe symptoms of depression, anxiety and stress were 15.70%, 13.31% and 7.10%, respectively. The impact of closed-off management on life, perceived threat and passive coping strategies were positively correlated to PTS and DASS scores, while knowledge score, perceived social support and active coping strategies were negatively correlated to DASS scores. Conclusions: In summary, adverse psychological symptoms were prevalent among college students in China during the COVID-19 epidemic. Identifying vulnerable populations and formulating correspondingly psychological interventions would be beneficial to improve the mental health during the COVID-19 epidemic.

14.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-321483

ABSTRACT

Background: College students are a uniquely vulnerable group and may experience high stress levels due to COVID-19, especially for girls. This study aims to identify the post-traumatic stress disorder (PTSD) symptoms and related factors among the target population during the initial phases of the COVID-19 pandemic. Methods: A cross-sectional online survey was conducted during the initial phases of the COVID-19 pandemic in China. A total of 2205 college female students from six provinces enrolled in this study and completed the questions about cognitive status of COVID-19, the Impact of Event Scale-6 (IES-6), the Multidimensional Perceived Social Support Scale (MPSSS) and a self-developed 10-item Perceived threat scale. Univariate and multivariate logistic regression were performed by SPSS software to explore the determinants of PTSD symptoms. Results: PTSD symptoms were prevalent in this sample of college female students, and 34.20% met the cut-off for PTSD. Self-reported fair or poor health (AOR=1.78, 95%CI: 1.22-2.59), high concern about COVID-19 (AOR=1.66, 95%CI: 1.35-2.03), beliefs that 'COVID-19 can cause a global outbreak' (AOR=1.26, 95%CI: 1.02-1.56), the perception of ‘risk of infection’ (AOR=2.46, 95%CI: 2.16-2.81), beliefs that ‘closed management’ and ‘COVID-19 as a public health emergency of international concern’ would have an impact, and the fear of ‘impact on life planning’ were all positively associated with PTSD (AOR=1.37, 1.22 and 1.29, respectively), whereas perceived social support from family (AOR=0.81, 95%CI: 0.70-0.93) was negatively associated with PTSD. Among the significant variables at the bivariate level, multivariate logistic regression revealed that the greatest protector for PTSD was the high knowledge score (AOR=0.73, 95%CI: 0.60-0.90), while had confirmed cases among relatives and friends (AOR=7.70, 95%CI: 1.28-46.25) was the strongest predictor of PTSD. Conclusions: In summary, PTSD symptoms were prevalent among college female students in China during the COVID-19 epidemic. Targeting vulnerable populations to improve their knowledge of COVID-19 and create an atmosphere of social support would be beneficial to improve the mental health of the female students during the COVID-19 epidemic.

15.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-316025

ABSTRACT

Background: Coronavirus disease 2019 (Covid-19) remains a serious health threat worldwide. It is crucial to explore effective treatment measures that reduce mortality. Our aim was to investigate whether low molecular weight heparin (LMWH) can reduce organ injury in patients with Covid-19 pneumonia. Methods: A retrospective study was conducted at the Shanghai Public Health Clinical Center. We initiated a LMWH protocol from January 18th 2020. LMWH was injected subcutaneously at 4100U per day until the D-dimer(DD) level returned to normal, or 5-7 days after admission, whichever occurred first. Admitted patients who received LMWH between January 18th and February 17th 2020 were assigned to the LMWH group. Patients admitted between January 18th and February 17th who did not receive LMWH anticoagulant therapy were the control group. All patients in both groups were aged >18 years, were not pregnant, had no tumors and were in accordance with the following inclusion criteria: 1) DD increased on admission;2) Body mass index(BMI) >30;3) History of diabetes. The exclusion criteria were: 1) Platelets <30x10 9 /L or fibrinogen <150 mg/dL;2) Pregnancy and lactation;3) Presence of blood system diseases;4) Immunosuppression;5) Diseases with a potential risk of bleeding;6) Receiving anticoagulant drugs or antiplatelet drugs during treatment. General clinical information, indicators for renal function, arterial blood gas analyses and blood lactic acid content were recorded in the two groups 0 (Day 0), 3 (Day 3), 7 (Day 7), and 11 (Day 11) and 15 (Day 15) days after admission. Results: There were 48 patients in the LMWH group and 74 patients in the control group. General information, including age, gender, co-existing diseases and onset-to-admission time in both groups was similar. Compared to the control group, LMWH treatment improved the estimated glomerular filtration rate (eGFR) reduced the serum creatinine level (Scr), blood urea nitrogen (BUN),arterial blood carbon dioxide partial pressure (PaCO2) and arterial blood lactic acid content. However, LMWH treatment reduced arterial oxygen partial pressure (PaO2) and arterial oxygen saturation (SaO2). Conclusion: LMWH might be beneficial to improve renal function, CO2 discharge and microcirculation during the early phase of Covid-19 patients . Further randomized controlled trials(RCTs) are warranted in order to further investigate this issue. Trial registration ChiCTR, ChiCTR2000034796. Registered 19 July 2020 - Retrospectively registered, http:// www. chictr.org.cn/listbycreater.aspx.

16.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-312746

ABSTRACT

Background: COVID-19 vaccine has been available in China since the beginning of the 2021, however, certain numbers of people are reluctant for some reasons to vaccinate. The high vaccine coverage is crucial for controlling disease transmission. Meanwhile, the vaccine hesitancy might be a barrier to the establishment of sufficient herd immunization. This study aims to investigate the prevalence of vaccine hesitancy towards the COVID-19 vaccine among different population groups, and explores the characteristics of different groups about vaccine hesitancy and common barriers and facilitators to vaccination decisions. Methods: : The current survey was performed among students, public health professionals, medical workers and general population from January to March 2021 among Chinese from seven cities located in seven geographical territories of China. The questionnaire contained sociodemographic information, concerns about COVID-19 epidemic, general vaccination behavior and attitudes, the General Vaccine Hesitancy Scale, the COVID-19 Vaccine Hesitancy Scale and other potential factors of vaccine hesitancy. Univariate analysis was conducted by chi-squared test, and variables were significant at P < 0.10 were then included in a multivariable regression model. Results: : The prevalence of COVID-19 vaccine hesitancy was 64.1% in our study, and a higher prevalence (73.7%) was in public health professionals compared to students (58.3%), medical workers (64.9%) and general population (61.1%). The results of multivariate analysis indicated that public health professionals were more likely to be hesitant against COVID-19 vaccine than general population (OR: 1.469, 95% CI: 1.069-2.019. And participants who needed transparent information about COVID-19 vaccine development, efficacy and safety (OR: 1.609, 95% CI: 1.343-1.928) and who have received negative information of COVID-19 vaccine (OR: 1.300, 95% CI: 1.130-1.496) were more likely to have vaccine hesitancy. Conclusions: : Appropriate training in knowledge and communication skills about vaccines are necessary for public health professionals to help themselves and the public to increase their willingness of vaccination. Reducing the spread of misinformation and disseminating facts in a timely and accurate way will likely reduce vaccine hesitancy. Also, to establish suitable communication strategies between the government and the public and a warning system on infodemic would be helpful to improve public’s confidence in vaccination.

17.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-308295

ABSTRACT

Background: An epidemic of COVID-19 outbroke in Wuhan, China, since December 2019. The ordinary medical services were hindered. However, the emergency cases, including aneurysmal subarachnoid hemorrhage (aSAH), still required timely intervention. Thus, it provoked challenges to the routine management protocol. In this study, we summarized our experience in the emergency management of aSAH (Beijing Tiantan Protocol, BTP) in Beijing, China. Methods: : Demographic, clinical, and imaging data of consecutive emergency aSAH patients who underwent craniotomy clipping during the COVID-19 epidemic season were reviewed and compared with the retrospective period last year. Subgroup analysis was further performed to assess the outcomes of different screening results and several detailed protocols. Neurological outcomes were evaluated by the modified Rankin Scale (mRS). Results: : A total of 127 aSAH referred to our emergency department, and 42 (33.1%) underwent craniotomy clipping between January 20, 2020, and March 25, 2020. The incidence of preoperative hospitalized adverse events, and the perioperative outcomes were similar (-0.1, 95% CI -1.0 to 0.8, P =0.779) to the retrospective period last year (2019.01-2019.03). After the propensity score matching (PSM), there were still no statistical differences in prognostic parameters between the two groups. 8 (19.0%) of the 42 individuals were initially screened as preliminary undetermined COVID-19 cases, in which 2 of them underwent craniotomy clipping in the negative pressure operating room (OR). The prognosis of patients with varied COVID-19 screening results was similar (F(2, 39)=0.393, P =0.678). Since February 28, 12 cases (28.6%) received COVID-19 nucleic acid testing (NAT) upon admission, and all showed negative. The false-negative rate was 0.0%. The preoperative hospitalized adverse events and postoperative prognosis were still similar between patients with and without COVID-19 NAT (-0.3, 95% CI -1.4 to 0.9, P =0.653). Conclusions: : Our emergency surgery management protocol (BTP) is reliable for scheduling emergency aneurysm craniotomy clipping in non-major epidemic areas.

18.
Front Bioeng Biotechnol ; 9: 744659, 2021.
Article in English | MEDLINE | ID: covidwho-1686450

ABSTRACT

Kidney renal clear cell carcinoma (KIRC) is a common aggressive malignancy of the urinary system. COVID-19, a highly infectious and severe disease caused by SARS-CoV-2, has become a significant challenge for global public health. Cancer patients have been reported to be more vulnerable to SARS-CoV-2 infection and have a higher risk for serious complications than the general population. However, the correlation between KIRC and COVID-19 remains incompletely elucidated. In this study, we comprehensively investigated the expression and prognostic significance of 333 SARS-CoV-2 infection-related genes in KIRC using the TCGA dataset and identified 31 SARS-CoV-2-related differently expressed genes between KIRC and normal renal tissues. Based on these genes, we constructed and validated a 5-gene prognostic signature (including ACADM, CENPF, KDELC1, PLOD2, and TRMT1) to distinguish low- and high-risk KIRC patients of poor survival in TCGA and E-MTAB-1980 cohorts. Gene set enrichment analysis (GSEA) showed that some inflammatory/immune-related pathways were significantly enriched in the high-risk group. The ESTIMATE analysis indicated that patients in the high-risk group had higher stromal and immune cell scores, therefore lower tumor purity. Moreover, they presented higher proportions of macrophages M0, regulatory T cells (Tregs), and T follicular helper cells and higher expression of immune checkpoints CTLA-4, LAG-3, TIGIT, and PDCD1 than low-risk patients. Besides, we also developed a nomogram to expand clinical applicability, which exhibits excellent predictive accuracy for survival. In conclusion, we identified a novel prognostic signature and nomogram based on SARS-CoV-2-related genes as reliable prognostic predictors for KIRC patients and provided potential therapeutic targets for KIRC and COVID-19.

19.
BMC Infect Dis ; 22(1): 153, 2022 Feb 14.
Article in English | MEDLINE | ID: covidwho-1686007

ABSTRACT

BACKGROUND: COVID-19 vaccine has been available in China since the beginning of the 2021, however, certain numbers of people are reluctant for some reasons to vaccinate. The high vaccine coverage is crucial for controlling disease transmission, however, the vaccine hesitancy might be a barrier to the establishment of sufficient herd immunization. This study aims to investigate the prevalence of the COVID-19 vaccine hesitancy among different population groups, and explore common barriers and facilitators to vaccination decisions. METHODS: The current survey was performed among Chinese students, public health professionals, medical workers and general population from January to March 2021 from seven cities in China. The questionnaire contained sociodemographic information, concerns about infection with COVID-19, general vaccination behaviors and attitudes, the General Vaccine Hesitancy Scale, the COVID-19 Vaccine Hesitancy Scale and other potential factors. Univariate analysis was conducted by chi-squared test, and variables significant at P < 0.10 were then included in a multivariable regression model. RESULTS: The prevalence of COVID-19 vaccine hesitancy was 15.6% in our study, and 23.9% of students, 21.2% of the general population, 13.1% of medical workers, and 10.4% of public health professionals had vaccine hesitancy. The results of multivariate analysis indicated that participants who had received negative information of COVID-19 vaccine (OR: 1.563, 95% CI: 1.229-1.986) and who had doubts about the information source (OR: 2.157, 95% CI: 1.697-2.742) were more likely to have vaccine hesitancy. While those who needed transparent information about COVID-19 vaccine (OR: 0.722, 95% CI: 0.535-0.973) and who would get COVID-19 vaccine if doctors recommended (OR: 0.176, 95% CI: 0.132-0.234) were less likely to have COVID-19 vaccine hesitancy. CONCLUSIONS: Given recommendations from medical workers about vaccination can motivate people to accept COVID-19 vaccination, appropriate training in knowledge about vaccines and communication skills are necessary for them to increase public's willingness of vaccination. Reducing the spread of misinformation and disseminating facts in a timely and accurate way will likely reduce vaccine hesitancy. Moreover, to establish suitable communication strategies and information exchange platforms between the government and the public and a warning system on infodemic would be helpful to improve public's confidence in vaccination.


Subject(s)
COVID-19 Vaccines , COVID-19 , China/epidemiology , Cross-Sectional Studies , Humans , Population Groups , SARS-CoV-2 , Vaccination
20.
BMC Psychiatry ; 21(1): 530, 2021 10 27.
Article in English | MEDLINE | ID: covidwho-1594206

ABSTRACT

BACKGROUND: An increasing number of undergraduate students in China have been reported to have psychological problems. In response to the COVID-19 pandemic, a series of preventive and control measures were implemented, which undoubtedly worsened their psychological health. Coping style and social support were probably important factors that affected the psychological well-being of undergraduate students during the pandemic. This study aimed to explore the effects of coping style and perceived social support on the psychological well-being of college students and relevant risk factors. METHODS: This cross-sectional study was performed in February and March of 2020 by distributing an online questionnaire among undergraduate students from seven geographical regions across China. The questionnaire included sociodemographic information; the 21-item Depression, Anxiety and Stress Scale (DASS-21); the Perceived Social Support Scale (PSSS); and the Simplified Coping Style Questionnaire (SCSQ). For the analyses, t-tests, one-way analysis of variance (ANOVA), the Kruskal-Wallis test and multiple linear regression were utilized. The level of significance was set at P < 0.05. RESULTS: Among 3113 college students, the rates of anxiety, depression and stress symptoms were 13.3, 15.4 and 6.8%, respectively. Increased rates of current smoking and drinking (5.5 and 25.2%, respectively) among undergraduates were identified. The results indicated that the PSSS subscales and SCSQ subscales were significantly associated with DASS-21 scores (P < 0.001). Multiple linear regression analysis showed that active coping style and family support were protective factors while passive coping style could aggravate psychological problems among participants (P < 0.001). CONCLUSIONS: A remarkable number of college students adopted passive coping strategies to cope with negative feelings, such as smoking and drinking, which were detrimental to their mental health. In contrast, active coping strategies helped improve their psychological well-being. Moreover, family support was particularly important for maintaining their mental health and ameliorating mental health challenges in this major health crisis. Consequently, suitable psychointervention, routine screening for risk behaviors, and provision of further social support are needed for undergraduate students in the COVID-19 pandemic or other emergency public health events.


Subject(s)
COVID-19 , Pandemics , Adaptation, Psychological , Anxiety/epidemiology , China/epidemiology , Cross-Sectional Studies , Depression/epidemiology , Humans , Mental Health , SARS-CoV-2 , Social Support , Students , Surveys and Questionnaires
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