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1.
Clin Pediatr (Phila) ; : 99228211058601, 2021 Nov 09.
Article in English | MEDLINE | ID: covidwho-1511594

ABSTRACT

Background. This case-control study aims to investigate the clinical characteristics in pediatric patients with pneumonia infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), influenza A, and human adenoviruses (HAdVs). Methods. Hospitalized pediatric patients with pneumonia infected with SARS-CoV-2 at Wuhan Children's Hospital and pneumonia infected with influenza A, and HAdVs at Qilu Children's Hospital were compared. Clinical manifestations, laboratory examinations, and imaging characteristics were analyzed. Results. The proportions of hyperpyrexia (54.3%, 33.9%), cough (100%, 99.2%), wheezing (45.7%, 53.7%), diarrhea (31.4%, 14.9%), and fever (100%, 75.2%) in patients with influenza A and HAdVs were higher than those of patients with SARS-CoV-2 (9.4%, P < .001; 48.5%, P < .001; 0%, P < .001; 8.8%, P = .002; 41.5%, P < .001; respectively). Laboratory examinations revealed the proportions of leukocytosis (37.1%, 52.9%), abnormal rates of neutrophils (40%, 40.5%), and lymphocytosis (42.9%, 65.3%) in influenza A and HAdV pneumonia groups were significantly higher than coronavirus disease 2019 (COVID-19) group (0%, P < .001; 0%, P < .001; 0%, P < .001; respectively). The proportion of elevated procalcitonin (5.7%, 14%) in patients with influenza A and HAdVs was significantly lower than those in patients with SARS-CoV-2 (64%, P < .001). In chest computed tomography, ground-glass opacities near the pleura were more common in patients with COVID-19 than those in patients with influenza A and HAdVs (32.7% vs 0% vs 0%, P < .001). Conclusion. Fever, cough, and wheezing are more common in the influenza A and HAdVs groups, whereas procalcitonin and computed tomography findings are likely to be pronounced in COVID-19 pneumonia. It provides a variety of methods except polymerase chain reaction for differentiating COVID-19 pneumonia from influenza A and HAdVs pneumonia.

2.
Chemistry ; 2021 Oct 29.
Article in English | MEDLINE | ID: covidwho-1487453

ABSTRACT

The global spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has called for an urgent need for dedicated antiviral therapeutics. Metal complexes are commonly underrepresented in compound libraries that are used for screening in drug discovery campaigns, however, there is growing evidence for their role in medicinal chemistry. Based on previous results, we have selected more than 100 structurally diverse metal complexes for profiling as inhibitors of two relevant SARS-CoV-2 replication mechanisms, namely the interaction of the spike (S) protein with the ACE2 receptor and the papain-like protease PLpro . In addition to many well-established types of mononuclear experimental metallodrugs, the pool of compounds tested was extended to approved metal-based therapeutics such as silver sulfadiazine and thiomersal, as well as polyoxometalates (POMs). Among the mononuclear metal complexes, only a small number of active inhibitors of the S/ACE2 interaction was identified, with titanocene dichloride as the only strong inhibitor. However, among the gold and silver containing complexes many turned out to be very potent inhibitors of PLpro activity. Highly promising activity against both targets was noted for many POMs. Selected complexes were evaluated in antiviral SARS-CoV-2 assays confirming activity for gold complexes with N-heterocyclic carbene (NHC) or dithiocarbamato ligands, a silver NHC complex, titanocene dichloride as well as a POM compound. These studies might provide starting points for the design of metal-based SARS-CoV-2 antiviral agents.

3.
Innovative Mobile and Internet Services in Ubiquitous Computing : Proceedings of 14th International Conference on Innovative Mobile and Internet Services in Ubiquitous Computing (IMIS-2020) ; 1195:334-343, 2020.
Article in English | PMC | ID: covidwho-828110

ABSTRACT

In the light of problems in online teaching of new coronavirus (2019-nCoV) epidemic period in advanced mathematics curriculum, this paper analyzes the teaching effect of short-term one-way online education mode in the teaching practice of concrete courses by using the real-time data of “rain classroom” teaching management platform. Above that this paper explore and practice the hybrid teaching mode based on “Internet+” big data cloud platform, aiming at promoting the “Internet+Education” information technology and curriculum teaching depth integration, improving the teaching effect, and promoting education and teaching reform.

4.
Preprint | CAplus | ID: ppcovidwho-2039

ABSTRACT

A review on strategy for the clin. diagnosis, treatment and management of gynecol. patients during the prevention and control of new coronavirus pneumonia.

5.
J Asthma ; 58(10): 1337-1339, 2021 10.
Article in English | MEDLINE | ID: covidwho-701958

ABSTRACT

OBJECTIVE: To investigate the relationship between asthma and COVID-19. METHODS: We searched the existing literature and researches to analyze the possible reasons. RESULTS: The possible reasons for the very low COVID-19 infection in asthma patients in China may be as follows: the expression of ACE2 in asthma patients is relatively low; the use of ICS in asthma patients may have protective effect; data bias and ethnic differences are also possible reasons, too. CONCLUSION: The relationship between asthma patients and COVID-19 has not been completely clear, which needs further study.


Subject(s)
Asthma/epidemiology , COVID-19/epidemiology , SARS-CoV-2/pathogenicity , Administration, Inhalation , Angiotensin-Converting Enzyme 2/metabolism , Anti-Inflammatory Agents/administration & dosage , Asthma/drug therapy , Asthma/immunology , Asthma/pathology , COVID-19/immunology , COVID-19/prevention & control , COVID-19/virology , China/epidemiology , Comorbidity , Disease Susceptibility/immunology , Glucocorticoids/administration & dosage , Humans , Incidence , Lung/immunology , Lung/pathology , Lung/virology , Risk Assessment/statistics & numerical data , Risk Factors , SARS-CoV-2/immunology , Serine Endopeptidases/metabolism
6.
Nan Fang Yi Ke Da Xue Xue Bao ; 40(2): 147-151, 2020 Feb 29.
Article in Chinese | MEDLINE | ID: covidwho-250195

ABSTRACT

The SARS-CoV-2 epidemic starting in Wuhan in December, 2019 has spread rapidly throughout the nation. The control measures to contain the epidemic also produced influences on the transport and treatment process of patients with acute myocardial infarction (AMI), and adjustments in the management of the patients need to be made at this particular time. AMI is characterized by an acute onset with potentially fatal consequence, a short optimal treatment window, and frequent complications including respiratory infections and respiratory and circulatory failure, for which active on-site treatment is essential. To standardize the management and facilitate the diagnosis and treatment, we formulated the guidelines for the procedures and strategies for the diagnosis and treatment of AMI, which highlight 5 Key Principles, namely Nearby treatment, Safety protection, Priority of thrombolysis, Transport to designated hospitals, and Remote consultation. For AMI patients, different treatment strategies are selected based on the screening results of SARS-CoV-2, the time window of STEMI onset, and the vital signs of the patients. During this special period, the cardiologists, including the interventional physicians, should be fully aware of the indications and contraindications of thrombolysis. In the transport and treatment of AMI patients, the physicians should strictly observe the indications for patient transport with appropriate protective measurements of the medical staff.


Subject(s)
Coronavirus Infections , Myocardial Infarction , Pandemics , Pneumonia, Viral , Betacoronavirus , COVID-19 , Consensus , Coronavirus Infections/complications , Coronavirus Infections/epidemiology , Coronavirus Infections/prevention & control , Humans , Myocardial Infarction/diagnosis , Myocardial Infarction/therapy , Pandemics/prevention & control , Pneumonia, Viral/complications , Pneumonia, Viral/epidemiology , Pneumonia, Viral/prevention & control , Practice Guidelines as Topic , Remote Consultation , SARS-CoV-2 , Thrombolytic Therapy , Transportation of Patients
8.
Emerg Microbes Infect ; 9(1): 707-713, 2020 Dec.
Article in English | MEDLINE | ID: covidwho-18586

ABSTRACT

This study aims to analyze the different clinical characteristics between children and their families infected with severe acute respiratory syndrome coronavirus 2. Clinical data from nine children and their 14 families were collected, including general status, clinical, laboratory test, and imaging characteristics. All the children were detected positive result after their families onset. Three children had fever (22.2%) or cough (11.2%) symptoms and six (66.7%) children had no symptom. Among the 14 adult patients, the major symptoms included fever (57.1%), cough (35.7%), chest tightness/pain (21.4%), fatigue (21.4%) and sore throat (7.1%). Nearly 70% of the patients had normal (71.4%) or decreased (28.6%) white blood cell counts, and 50% (7/14) had lymphocytopenia. There were 10 adults (71.4%) showed abnormal imaging. The main manifestations were pulmonary consolidation (70%), nodular shadow (50%), and ground glass opacity (50%). Five discharged children were admitted again because their stool showed positive result in SARS-CoV-2 PCR. COVID-19 in children is mainly caused by family transmission, and their symptoms are mild and prognosis is better than adult. However, their PCR result in stool showed longer time than their families. Because of the mild or asymptomatic clinical process, it is difficult to recognize early for pediatrician and public health staff.


Subject(s)
Betacoronavirus , Coronavirus Infections , Pandemics , Pneumonia, Viral , Adult , COVID-19 , COVID-19 Testing , Chest Pain , Child , Child, Preschool , China , Clinical Laboratory Techniques , Coronavirus Infections/diagnosis , Coronavirus Infections/diagnostic imaging , Coronavirus Infections/physiopathology , Cough , Family Health , Feces/virology , Female , Fever , Humans , Infant , Lung/diagnostic imaging , Male , Pneumonia, Viral/diagnosis , Pneumonia, Viral/diagnostic imaging , Pneumonia, Viral/physiopathology , Polymerase Chain Reaction , Prognosis , Retrospective Studies , SARS-CoV-2
9.
J Microbiol Immunol Infect ; 53(3): 373-376, 2020 Jun.
Article in English | MEDLINE | ID: covidwho-9661

ABSTRACT

SARS-CoV-2 can be shed in the stool of patients in the recovery phase. Children show a longer shedding time than adults. We analyzed the possible causes of this finding and recommend that a negative stool sample be included in a patient's discharge criteria.


Subject(s)
Betacoronavirus/isolation & purification , Feces/virology , Adult , COVID-19 , Child , Child, Preschool , Coronavirus Infections/diagnosis , Coronavirus Infections/pathology , Female , Humans , Infant , Male , Pandemics , Pneumonia, Viral/diagnosis , Pneumonia, Viral/pathology , Real-Time Polymerase Chain Reaction/methods , SARS-CoV-2 , Time Factors
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