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Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology ; 134(3):e84, 2022.
Article in English | ScienceDirect | ID: covidwho-1983748


We present a case of a patient who died of complications of COVID-19. A 29-year-old woman presented multiple bleeding ulcerous lesions involving lips and inner lip mucosa. The patient was pregnant (29th week) and presented fever, diarrhea, dyspnea, nausea, dysgeusia, and anosmia in a 27-day evolution until death. The patient was admitted to the intensive care unit, submitted to mechanical ventilation and extracorporeal membrane oxygenation, developed fetal distress, and was submitted to an emergency C-section. Cause of death was a cardiogenic shock. During minimally invasive autopsy, oral lesions were identified and postmortem biopsy was performed. Clinical hypotheses were SARS-CoV-2 vs herpes virus. The histopathologic analyses revealed mononuclear inflammatory infiltrate, and keratinocytes showed no viral inclusion or cytopathic alterations. A large amount of a cuboid shaped gram-positive coccus in a tetrad packet arrangement was observed, compatible with Sarcina ventriculi. An abundant amount of Candida spp. was also observed. Samples were negative for immunohistochemistry to anti-SARS-CoV-2, herpes simplex virus, and cytomegalovirus.

Geriatrics (Basel) ; 5(3)2020 Sep 18.
Article in English | MEDLINE | ID: covidwho-789344


It is not established whether SARS-CoV-2 (COVID-19) patients with movement disorders, are at greater risk for more serious outcomes than the larger COVID-19 population beyond the susceptibility associated with greater age. We reviewed electronic health records and conducted telephone interviews to collect the demographics and clinical outcomes of patients seen at our Movement Disorders Center who tested positive for COVID-19 from 8 March 2020 through 6 June 2020. Thirty-six patients were identified, 23 men and 13 women, median age of 74.5 years. They primarily carried diagnoses of idiopathic Parkinson disease (n = 22; 61%) and atypical parkinsonism (n = 7; 19%) with the balance having other diagnoses. Twenty-seven patients (75%) exhibited alteration in mental status and fifteen (42%) had abnormalities of movement as common manifestations of COVID-19; in 61% and 31%, respectively, these were the presenting symptoms of the disease. Sixty-seven percent of patients in our cohort required hospitalization, and the mortality rate was 36%. These data demonstrate that in patients with movement disorders, the likelihood of hospitalization and death after contracting COVID-19 was greater than in the general population. Patients with movement disorders frequently presented with altered mental status, generalized weakness, or worsening mobility but not anosmia.