ABSTRACT
Background: Coronavirus disease 2019 (COVID-19) pandemic imposed enormous burdens of morbidity and mortality while severely disrupting people, especially frontline healthcare working in hospitals.The vaccine discovery gives hope to the world population, but it was received with skepticism and fear stressed by the great media coverage. Materials and Methods: We conducted an anonymous survey of the quality of life during pandemic era and the likelihood of COVID- 19 vaccine acceptance on a sample of healthcare at the Italian Hospital more involved by COVID-19 pandemic. Results: 3134 survey respondents represented a random sample in which was represented different health workers.Of these survey participants, 644 contracted SARS-CoV-2.Healthcare workers could be psychologically stressed by covid-19 pandemic.A considerable proportion of participants reported symptoms of depression and sadness (52%), anxiety (40.9%), insomnia (33.02%) and distress (55.4%).Most healthcare workers have documented vaccination through scientific articles 1423 (45.4%) by social media news 348 (11.1%) while 152 (4.8%) haven't documented at all.They would take a vaccine if it were proven safe and effective. Conclusions: Health workers who have to be on the front line during an epidemic are more exposed to psychological distress as, in addition to guaranteeing the necessary care and assistance, they are constantly in the condition of being affected by the epidemic itself.Specific projects aimed at the prevention of burn-out and distress of health workers will be carried out to improve the entire care process.