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1.
Rev. Assoc. Med. Bras. (1992) ; 66(9):1169-1171, 2020.
Article in English | LILACS (Americas), Grey literature | ID: grc-742501
2.
Rev. Assoc. Med. Bras. (1992) ; 66(9): 1169-1171, Sept. 2020. tab, graf
Article in English | WHO COVID, LILACS (Americas) | ID: covidwho-836012
3.
Drug Discov Today ; 25(6): 956-958, 2020 06.
Article in English | MEDLINE | ID: covidwho-88528

ABSTRACT

This article examines three aspects of antivirals, such as hydroxychloroquine, chloroquine, and remdesvir, as they might relate to the treatment of a viral infection such as COVID-19: (i) the use of vaporization for the delivery of antivirals, with the bulk constituents having mild antiviral efficacy; (ii) the application of a marine natural product extract as opposed to a single molecule as an antiviral agent; and (iii) a counter intuitive approach to formulation that is, in part, based on delivering multiple species that fall into three categories: building blocks for the virus to accelerate replication; an energy source for the infected cell to boost its immune response; and the species that antagonize or provide toxicity to the virus.


Subject(s)
Antiviral Agents/administration & dosage , Antiviral Agents/chemistry , Aquatic Organisms/chemistry , Biological Products/administration & dosage , Biological Products/chemistry , Adenosine Monophosphate/administration & dosage , Adenosine Monophosphate/analogs & derivatives , Adenosine Monophosphate/chemistry , Alanine/administration & dosage , Alanine/analogs & derivatives , Alanine/chemistry , COVID-19 , Chloroquine/administration & dosage , Chloroquine/chemistry , Coronavirus Infections/drug therapy , Drug Compounding , Humans , Hydroxychloroquine/administration & dosage , Hydroxychloroquine/chemistry , Models, Molecular , Pandemics , Pneumonia, Viral/drug therapy , Volatilization
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