Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 4 de 4
Filter
Add filters

Language
Document Type
Year range
1.
Osteoporosis International ; 32(SUPPL 1):S138-S138, 2021.
Article in English | Web of Science | ID: covidwho-1710672
3.
Journal of Immunology ; 206:2, 2021.
Article in English | Web of Science | ID: covidwho-1548310
4.
Science Immunology ; 6(64):10, 2021.
Article in English | Web of Science | ID: covidwho-1535495

ABSTRACT

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 160 million infections and more than 3 million deaths worldwide. Although effective vaccines are currently being deployed, the adaptive immune determinants that promote viral clearance and confer protection remain poorly defined. Using mouse models of SARS-CoV-2, we demonstrate that both humoral and cellular adaptive immunity contribute to viral clearance in the setting of primary infection. Furthermore, we find that either convalescent mice or mice that receive mRNA vaccination are protected from both homologous infection and infection with a variant of concern, B.1.351. In addition, we find that this protection is largely mediated by antibody response and not cellular immunity. These results highlight the in vivo protective capacity of antibodies generated to both vaccine and natural infection.

SELECTION OF CITATIONS
SEARCH DETAIL