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1.
Critical Reviews in Environmental Science and Technology ; 2022.
Article in English | EMBASE | ID: covidwho-1895682

ABSTRACT

Far UV-C, informally defined as electromagnetic radiation with wavelengths between 200 and 230 nm, has characteristics that are well-suited to control of airborne pathogens. Specifically, Far UV-C has been shown to be highly effective for inactivation of airborne pathogens;yet this same radiation has minimal potential to cause damage to human skin and eye tissues. Critically, unlike UV-B, Far UV-C radiation does not substantially penetrate the dead cell layer of skin (stratum corneum) and does not reach germinative cells in the basal layer. Similarly, Far UV-C radiation does not substantially penetrate through corneal epithelium of the eye, thereby preventing exposure of germinative cells within the eye. The most common source of Far UV-C radiation is the krypton chloride excimer (KrCl*) lamp, which has a primary emission centered at 222 nm. Ozone production from KrCl* lamps is modest, such that control of indoor ozone from these systems can be accomplished easily using conventional ventilation systems. This set of characteristics offers the potential for Far UV-C devices to be used in occupied spaces, thereby allowing for improved effectiveness for inactivation of airborne pathogens, including those that are responsible for COVID-19.

2.
Osteoporosis International ; 32(SUPPL 1):S138-S138, 2021.
Article in English | Web of Science | ID: covidwho-1710672
3.
Shanghai Chest ; 6, 2022.
Article in English | Scopus | ID: covidwho-1699823

ABSTRACT

Background: The thoracic surgery team of the Shanghai Chest Hospital has been publishing its annual report since 2018, summarizing the services and major progress over the last year. Methods: All patients receiving thoracic surgery services at the Department of Thoracic Surgery and the Department of Oncological Surgery at the Shanghai Chest Hospital in 2020 were enrolled. The number of surgical resections, types of surgical procedures, disease histological types, and perioperative outcomes were collected and compared with the results from previous years. Results: In the year 2020, the thoracic team of the Shanghai Chest Hospital faced the unprecedented challenge of the coronavirus disease 2019 (COVID-19) epidemic. A total of 15,664 patients received thoracic surgeries at the Shanghai Chest Hospital, only an 8.0% decrease compared with the previous year of 2019. These included 13,493 pulmonary procedures, 1,075 esophageal procedures, 969 mediastinal procedures, 66 tracheal procedures, 2 lung transplantations, and 59 other procedures. The rate of minimally invasive surgeries among all procedures was 91.1%, including 721 robotic-assisted thoracic surgeries, both of which increased from the year before. In addition, the average length of hospital stay continuously decreased, being only 3.82 days after pulmonary surgery and 10.96 days after esophageal surgery. Meanwhile, the quality of thoracic surgery has improved, with continuously lower rates of perioperative complications and an in-hospital mortality rate of only 0.14%. Conclusions: The services provided and progress made in 2020 by the thoracic surgery team of the Shanghai Chest Hospital were reviewed in this annual report, reflecting a consistent effort to help our patients with high-standard services and state-of-the-art surgical techniques. © 2022 Shanghai Chest. All rights reserved.

6.
Journal of Immunology ; 206:2, 2021.
Article in English | Web of Science | ID: covidwho-1548310
7.
Science Immunology ; 6(64):10, 2021.
Article in English | Web of Science | ID: covidwho-1535495

ABSTRACT

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused more than 160 million infections and more than 3 million deaths worldwide. Although effective vaccines are currently being deployed, the adaptive immune determinants that promote viral clearance and confer protection remain poorly defined. Using mouse models of SARS-CoV-2, we demonstrate that both humoral and cellular adaptive immunity contribute to viral clearance in the setting of primary infection. Furthermore, we find that either convalescent mice or mice that receive mRNA vaccination are protected from both homologous infection and infection with a variant of concern, B.1.351. In addition, we find that this protection is largely mediated by antibody response and not cellular immunity. These results highlight the in vivo protective capacity of antibodies generated to both vaccine and natural infection.

8.
Xitong Fangzhen Xuebao / Journal of System Simulation ; 33(1):24-36, 2021.
Article in Chinese | Scopus | ID: covidwho-1061631

ABSTRACT

The construction of a large-scale online public opinion evolution simulation model has guidance value for differentiated emergency management and public opinion guidance in the worst-hit areas in Wuhan and the other areas in China during the outbreak of the COVID-19. In order to realize the fine-grained simulation of the public sentiment evolution of the topic, the LDA topic model is deeply integrated with BERT word vector to optimize the topic vector and power the text topic clustering. At the same time, on the basis of improving BERT pre-training task, the deep pre-training task is superimposed to improve the accuracy of the model in emotion classification. The results show that the NPMI value of the improved BERT-LDA model is 0.357 higher than that of the original LDA model during the topic vector training. In terms of the emotional classification task of epidemic events, the AUC value exceeds 99.6%, which proves that the improved BERT-LDA model can be effectively applied to large-scale internet public opinion evolution simulation. © 2021, The Editorial Board of Journal of System Simulation. All right reserved.

9.
Zhonghua Gan Zang Bing Za Zhi ; 28(2): 100-106, 2020 Feb 20.
Article in Chinese | MEDLINE | ID: covidwho-686167

ABSTRACT

Objective: To explore and analyze the possible mechanism of liver injury in patients with coronavirus disease 2019 (novel coronavirus pneumonia, NCP). Methods: The correlation between ALT, AST and other liver enzyme changes condition and NCP patients' disease status reported in the literature was comprehensively analyzed. ACE2 expression in liver tissue for novel coronavirus was analyzed based on single cell sequencing (GSE115469) data. RNA-Seq method was used to analyze Ace2 expression and transcription factors related to its expression in liver tissues at various time-points after hepatectomy in mouse model of acute liver injury with partial hepatectomy. t-test or Spearman rank correlation analysis was used for statistical analysis. Results: ALT and AST were abnormally elevated in some patients with novel coronavirus infection, and the rate and extent of ALT and AST elevation in severe NCP patients were higher than those in non-severe patients. Liver tissue results of single cell sequencing and immunohistochemistry showed that ACE2 was only expressed in bile duct epithelial cells of normal liver tissues, and very low in hepatocytes. In a mouse model of acute liver injury with partial hepatectomy, Ace2 expression was down-regulated on the first day, but it was elevated up to twice of the normal level on the third day, and returned to normal level on seventh day when the liver recovered and hepatocyte proliferation stopped. Whether this phenomenon suggests that the bile duct epithelial cells with positive expression of Ace2 participate in the process of liver regeneration after partial hepatectomy deserves further study. In RNA-Seq data, 77 transcription factors were positively correlated with the expression of Ace2 (r > 0.2, FDR < 0.05), which were mainly enriched in the development, differentiation, morphogenesis and cell proliferation of glandular epithelial cells. Conclusion: We assumed that in addition to the over activated inflammatory response in patients with NCP, the up-regulation of ACE2 expression in liver tissue caused by compensatory proliferation of hepatocytes derived from bile duct epithelial cells may also be the possible mechanism of liver tissue injury caused by 2019 novel coronavirus infection.


Subject(s)
Betacoronavirus , Coronavirus Infections , Pandemics , Pneumonia, Viral , Animals , COVID-19 , Humans , Liver , Mice , Peptidyl-Dipeptidase A , SARS-CoV-2
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