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1.
Political Psychology ; : 1, 2022.
Article in English | Academic Search Complete | ID: covidwho-2161747

ABSTRACT

We test the hypothesis that COVID‐19 vaccine hesitancy is attributable to distrustful complacency—an interactive combination of low concern and low trust. Across two studies, 9,695 respondents from different parts of Britain reported their level of concern about COVID‐19, trust in the UK government, and intention to accept or refuse the vaccine. Multilevel regression analysis, controlling for geographic area and relevant demographics, confirmed the predicted interactive effect of concern and trust. Across studies, respondents with both low trust and low concern were 10%–22% more vaccine hesitant than respondents with either high trust or high concern, and 26%–29% more hesitant than respondents with both high trust and high concern. Results hold equally among White, Black, and Muslim respondents, consistent with the view that regardless of mean‐level differences, a common process underlies vaccine hesitancy, underlining the importance of tackling distrustful complacency both generally and specifically among unvaccinated individuals and populations. [ FROM AUTHOR]

2.
Elife ; 112022 10 13.
Article in English | MEDLINE | ID: covidwho-2067163

ABSTRACT

Background: The development of vaccines to control the coronavirus disease 2019 (COVID-19) pandemic progression is a worldwide priority. CoronaVac is an inactivated severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine approved for emergency use with robust efficacy and immunogenicity data reported in trials in China, Brazil, Indonesia, Turkey, and Chile. Methods: This study is a randomized, multicenter, and controlled phase 3 trial in healthy Chilean adults aged ≥18 years. Volunteers received two doses of CoronaVac separated by 2 (0-14 schedule) or 4 weeks (0-28 schedule); 2302 volunteers were enrolled, 440 were part of the immunogenicity arm, and blood samples were obtained at different times. Samples from a single center are reported. Humoral immune responses were evaluated by measuring the neutralizing capacities of circulating antibodies. Cellular immune responses were assessed by ELISPOT and flow cytometry. Correlation matrixes were performed to evaluate correlations in the data measured. Results: Both schedules exhibited robust neutralizing capacities with the response induced by the 0-28 schedule being better. No differences were found in the concentration of antibodies against the virus and different variants of concern (VOCs) between schedules. Stimulation of peripheral blood mononuclear cells (PBMCs) with Mega pools of Peptides (MPs) induced the secretion of interferon (IFN)-γ and the expression of activation induced markers in CD4+ T cells for both schedules. Correlation matrixes showed strong correlations between neutralizing antibodies and IFN-γ secretion. Conclusions: Immunization with CoronaVac in Chilean adults promotes robust cellular and humoral immune responses. The 0-28 schedule induced a stronger humoral immune response than the 0-14 schedule. Funding: Ministry of Health, Government of Chile, Confederation of Production and Commerce & Millennium Institute on Immunology and Immunotherapy, Chile. Clinical trial number: NCT04651790.


Subject(s)
COVID-19 Vaccines , COVID-19 , Immunization Schedule , Adult , Humans , Antibodies, Neutralizing , Antibodies, Viral , COVID-19/prevention & control , COVID-19 Vaccines/therapeutic use , Immunity, Humoral , Interferons , Leukocytes, Mononuclear , SARS-CoV-2
3.
Microbiol Spectr ; : e0314322, 2022 Oct 12.
Article in English | MEDLINE | ID: covidwho-2063988

ABSTRACT

Bats are reservoirs of diverse coronaviruses (CoVs), including progenitors of severe acute respiratory syndrome CoV (SARS-CoV) and SARS-CoV-2. In the Americas, there is a contrast between alphacoronaviruses (alphaCoVs) and betaCoVs: while cospeciation prevails in the latter, alphaCoV evolution is dominated by deep and recent host switches. AlphaCoV lineages are maintained by two different bat family groups, Phyllostomidae and Vespertilionidae plus Molossidae. In this study, we used a Bayesian framework to analyze the process of diversification of the lineages maintained by Molossidae and Vespertilionidae, adding novel CoV sequences from Argentina. We provide evidence that the observed CoV diversity in these two bat families is shaped by their geographic distribution and that CoVs exhibit clustering at the level of bat genera. We discuss the causes of the cocirculation of two independent clades in Molossus and Tadarida as well as the role of Myotis as the ancestral host and a major evolutionary reservoir of alphaCoVs across the continent. Although more CoV sampling efforts are needed, these findings contribute to a better knowledge of the diversity of alphaCoVs and the links between bat host species. IMPORTANCE Bats harbor the largest diversity of coronaviruses among mammals. In the Americas, seven alphacoronavirus lineages circulate among bats. Three of these lineages are shared by members of two bat families: Vespertilionidae and Molossidae. Uncovering the relationships between these coronaviruses can help us to understand patterns of cross-species transmission and, ultimately, which hosts are more likely to be involved in spillover events. We found that two different lineages cocirculate among the bat genera Molossus and Tadarida, which share roosts and have common viral variants. The bat genus Myotis functions as a reservoir of coronavirus diversity and, as such, is a key host. Although there were some spillovers recorded, there is a strong host association, showing that once a successful host jump takes place, it is transmitted onward to members of the same bat genus.

4.
Academy of Marketing Studies Journal ; 26(3), 2022.
Article in English | ProQuest Central | ID: covidwho-2046950

ABSTRACT

Covid 19 pandemic has derailed the progress made by humanity and has caused severe damage to the social and economic life of people. The only solution to prevent the loss of life has been offered in the form of vaccines. However, various countries' vaccination program has received mixed responses from the masses. With the virus refusing to subside and the threat of emergence of a new variant, and government pushing for booster dose, it becomes imperative to study the factors that shape the consumer attitude towards vaccination. The present study attempts in that direction. A detailed questionnaire was floated among five hundred respondents, out of which 404 responses were considered for the study. A theoretical model has been proposed, consisting of nine factors, out of which seven are independent variables, one is mediating variable (attitude), and the other is a dependent variable (Vaccine Intention). In addition to the previously studied factor, the study proposes three new factors: politics and policies, design of vaccination program, and introduction of new vaccines. The results indicate that social media presence, government policies, previous vaccination experience, safety and transparency in the design of vaccination programs, knowledge of vaccines, and health benefits associated with them play a significant role in shaping the consumer intention for vaccination. The mediating role of attitude was also found to be significant for the factors. The study provides significant managerial implications regarding factors that shape the consumer attitude towards vaccination.

5.
Diabetes Metab Syndr Obes ; 15: 2857-2865, 2022.
Article in English | MEDLINE | ID: covidwho-2043235

ABSTRACT

Introduction: In 2020, several countries established a global emergency state. Lockdowns restricted people's lifestyles and daily activities to prevent coronavirus spread. These measures hindered diabetes mellitus control and lifestyle changes. This study aims to evaluate if attending a multidisciplinary program before the pandemic helped maintain a good metabolic state, lifestyle modifications, and mental health in patients with diabetes mellitus during the COVID-19 lockdown. Methods: Patients included in this study attended a multidisciplinary program, with <5 years of diagnosis of type 2 diabetes, without disabling complications, between 18-70 years old. The complete lockdown occurred from February 27, 2020, to May 31, 2020. The first patient (non-COVID) to return to the center for face-to-face consultation was in March 2021. Consultations in 2019 were face-to-face and changed to a virtual modality during 2020. We analyzed metabolic, lifestyle, mental health, and diabetes education parameters. Results: A total of 133 patients with type 2 diabetes mellitus were included with complete information in visits before and during the lockdown. Metabolic parameters and self-care measures (nutrition plan, foot evaluation, and self-glucose monitoring) evaluated on our patients had no change during the lockdown. We found a significant increase in the time patients spent sitting during the day (p<0.05). Barriers to exercise increased during lockdown, being joint pain (3.8% to 12.0%, p<0.01) and lack of time to exercise (4.5% to 7.5%, p=0.33) being the most common. There was no significant difference in symptoms of anxiety and depression, quality of life, and empowerment. Conclusion: A multidisciplinary diabetes mellitus program, including diabetes education for self-care activities, positively impacts patients, maintaining good outcomes despite lockdown difficulties.

6.
International Journal of Care and Caring ; 6(1-2):247-247–251, 2022.
Article in English | ProQuest Central | ID: covidwho-2039176

ABSTRACT

We are a group of social scientists from Austria, Germany and Switzerland who drew attention to the care crisis in a cross-national ‘Care manifesto’ as early as 2013. Since the COVID-19 pandemic, it has become impossible to overlook the crisis of care and we believe this provides an opportunity to correct serious shortcomings in the care sector. That is why we are putting forward a new position paper – ‘Clean up time! Redesigning care after COVID-19’ – aiming at identifying problems in the wake of the pandemic and suggesting goals, as well as the next work packages. We ask you to consider the demands in the position paper, disseminate it and discuss it in your networks and communities. Both the English and German versions are available on our website (see: https://care-macht-mehr.com/).

7.
Права человека и искусственный интеллект в электронных системах здравоохранения ; 15(8):1179-1193, 2022.
Article in English | Academic Search Complete | ID: covidwho-2025863

ABSTRACT

In this paper, we analyze e-Health system from the human-rights based approach, taking into consideration is technical and legal implications;this is important, multidisciplinary approach gives deeper understanding of the problem. Thus an overview of the E-Health legal environment is provided so as to provide a reader with the overall context of electronic healthcare. Technical details of functioning of e-Health systems is also given, with a view to give clear picture of existing risks. As we see the trend of the changing relations between medical professionals (doctors, nurses and other personnel of medical facilities) and patients, we paid specific attention to the issues of data protection, existing advantages and limitations for implementation in E-Health systems. It is shown that COVID-19 led to more extensive application of e-Health system and brought new perspectives to the process. We come to the conclusion that artificial intelligence methods are beneficial for medicine, and from the technical point of view can already provide valuable results. However appropriate legal framework is necessary to ensure the possibilities of control, verification and second opinion by human (doctor). (English) [ FROM AUTHOR] В этой статье мы анализируем систему электронного здравоохранения с точки зрения прав человека, принимая во внимание технические и юридические последствия;это важно, так как мультидисциплинарный подход дает более глубокое понимание проблемы. Таким образом, нами проведен обзор правовой среды электронного здравоохранения, чтобы предоставить читателю общий контекст электронного здравоохранения. Приводятся технические подробности функционирования систем электронного здравоохранения с целью дать четкое представление о существующих рисках. Наблюдая тенденцию изменения отношений между медицинскими работниками (врачами, медсестрами и другим персоналом медицинских учреждений) и пациентами, мы уделили особое внимание вопросам защиты данных, существующим преимуществам и ограничениям для внедрения в системы электронного здравоохранения. Показано, что COVID-19 привел к более широкому применению системы электронного здравоохранения и привнес новые перспективы в этот процесс. Мы приходим к выводу, что методы искусственного интеллекта полезны для медицины, а с технической точки зрения уже могут дать ценные результаты. Однако необходима соответствующая правовая база для обеспечения возможности контроля, проверки и получения второго мнения со стороны человека (врача). (Russian) [ FROM AUTHOR] Copyright of Journal of Siberian Federal University, Humanities & Social Sciences is the property of Siberian Federal University and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

8.
ChemMedChem ; 17(20): e202200382, 2022 10 19.
Article in English | MEDLINE | ID: covidwho-2013440

ABSTRACT

Nucleic acid-based detection of RNA viruses requires an annealing procedure to obtain RNA/probe or RNA/primer complexes for unwinding stable structures of folded viral RNA. In this study, we designed a protein-enzyme-free nano-construction, named four-armed DNA machine (4DNM), that requires neither an amplification stage nor a high-temperature annealing step for SARS-CoV-2 detection. It uses a binary deoxyribozyme (BiDz) sensor incorporated in a DNA nanostructure equipped with a total of four RNA-binding arms. Additional arms were found to improve the limit of detection at least 10-fold. The sensor distinguished SARS-CoV-2 from other respiratory viruses and correctly identified five positive and six negative clinical samples verified by quantitative polymerase chain reaction (RT-qPCR). The strategy reported here can be used for the detection of long natural RNA and can become a basis for a point-of-care or home diagnostic test.


Subject(s)
COVID-19 , DNA, Catalytic , Humans , SARS-CoV-2 , COVID-19/diagnosis , RNA, Viral/genetics , Real-Time Polymerase Chain Reaction
9.
5th International Conference on Quality Engineering and Management: A Better World with Quality! Quality in the Digital Transformation, ICQEM 2022 ; : 881-906, 2022.
Article in English | Scopus | ID: covidwho-2011599

ABSTRACT

Purpose - This paper investigates the resonant effect of risks on supply chain performance under COVID-19. Design/methodology/approach - Eleven managers attended and applied the Q-sort method to evaluate the unidimensionality, reliability and validity of research concepts. Afterwards, a comparative model containing the single effects of risks on supply chain performance was developed as a basis for comparison with the theoretical model. The impacts of each risk on supply chain performance were demonstrated in both models. When the parameters of the theoretical model are greater than those in the competitive model, the resonant effect mechanism is proven and vice versa. Findings - 63% variance of supply chain performance was explained by our risk model, which includes positive and negative resonant effects between risks. It is a remarkable rate compared with the comparative model and previous studies. Whilst a positive relationship (α ≥ 0) increases the effect of the impacted risk on the output, a negative relationship (α ≤ 0) decreases this effect, bringing benefits for companies which “see” these opportunities. Thus, practitioners should treat risk as an opportunity rather than a threat. Research limitations/implications - A positive optimal resonant model is necessary to maximize the impact of risks on supply chain performance. Hence, companies can predict the worst-case scenario when six risks occur simultaneously. However, companies can devise mitigating techniques if a negative optimal resonant model is detected. Although risks can not be eliminated, their impact is likely to be abated by using a new paradigm. Originality/value - The data used in this research is from a large-scale survey supported by Japanese Government to promote ASEAN sustainable socio-economic development. This dataset collected during the Covid-19 pandemic to validate our models is an interesting and topical point of this study. © 2022 Universidade do Minho. All rights reserved.

10.
Journal de Chirurgie Viscérale ; 159(4, Supplement):S91, 2022.
Article in French | ScienceDirect | ID: covidwho-2007818

ABSTRACT

La prise en charge des tumeurs hépatiques est multidisciplinaire parce qu’elle fait appel à l’oncologie, les exérèses chirurgicales et les destructions locales (radiofréquence, micro-ondes). Chez les patients cirrhotiques et pour les petites tumeurs (≤3cm), les destructions locales sont considérées comme aussi efficaces que l’exérèse chirurgicale. But du travail : vérifier si la destruction percutanée des tumeurs hépatiques est faisable en ambulatoire. Étude monocentrique, rétrospective et observationnelle qui incluait tous les patients ayant eu au sein de l’unité de chirurgie ambulatoire une destruction percutanée de tumeurs hépatiques, entre septembre 2019 et décembre 2020. Le critère de jugement principal est la destruction complète sur l’imagerie après 1 mois. Dix-neuf destructions percutanées ont été réalisées sans échec du processus ambulatoire, chez 19 patients (H/F=16/3), âgés de 66±12 ans. Les tumeurs étaient réparties : 14 carcinomes hépatocellulaires (86 % de cirrhose, 11 Child A, 1 Child B) et 5 métastases. Le taux de destruction complète sur l’imagerie à 1 mois était de 100 %. Durant la même période, 30 patients ont eu une destruction percutanée et n’ont pas été pris en charge en ambulatoire pour les raisons suivantes : geste chirurgical associé (hépatectomie : 2, cœlioscopie : 14, cure d’éventration : 2), comorbidités (âge : 6, anticoagulant : 1, Child B : 3, autre : 18) et organisationnelle (COVID : 1, fermeture annuelle : 2, absence d’entourage : 2). Les destructions locales de tumeurs hépatiques sont faisables en ambulatoire, avec des résultats immédiats très satisfaisants, y compris chez les patients cirrhotiques.

11.
Banks and Bank Systems ; 17(2):124-137, 2022.
Article in English | Scopus | ID: covidwho-1994766

ABSTRACT

During the COVID-19 pandemic, bank stability became a priority for the Indonesian Financial Services Authority and the government. Economic activity is expected to be restored by muffling the shocks caused by the COVID-19 outbreak. This paper investigates the influence of COVID-19 on banking stability by differentiating bank core capital size and ownership. Using data from 108 commercial banks in Indonesia for the period March 2020 and March 2021, the paper analyzes data using fixed effects regression. The results show that COVID-19 has a detrimental and significant effect on bank stability in Indonesia. Regardless of the size and ownership of a bank’s core capital, it was found that no bank is immune for a year to the severe implications of COVID-19. This condition was experienced by both state banks and private banks, large and small. To assist in the absorption of COVID-19 shocks, this paper proposes policies for regulators that include stimulus packages and countercyclical roles in the banking system via government-owned banks. © Siti Maria, Rizky Yudaruddin, Yanzil Azizil Yudaruddin, 2022.

12.
mBio ; 13(4): e0142322, 2022 08 30.
Article in English | MEDLINE | ID: covidwho-1986332

ABSTRACT

CoronaVac is an inactivated SARS-CoV-2 vaccine approved by the World Health Organization (WHO). Previous studies reported increased levels of neutralizing antibodies and specific T cells 2 and 4 weeks after two doses of CoronaVac; these levels were significantly reduced at 6 to 8 months after the two doses. Here, we report the effect of a booster dose of CoronaVac on the anti-SARS-CoV-2 immune response generated against the variants of concern (VOCs), Delta and Omicron, in adults participating in a phase III clinical trial in Chile. Volunteers immunized with two doses of CoronaVac in a 4-week interval received a booster dose of the same vaccine between 24 and 30 weeks after the second dose. Neutralization capacities and T cell activation against VOCs Delta and Omicron were assessed 4 weeks after the booster dose. We observed a significant increase in neutralizing antibodies 4 weeks after the booster dose. We also observed a rise in anti-SARS-CoV-2-specific CD4+ T cells over time, and these cells reached a peak 4 weeks after the booster dose. Furthermore, neutralizing antibodies and SARS-CoV-2-specific T cells induced by the booster showed activity against VOCs Delta and Omicron. Our results show that a booster dose of CoronaVac increases adults' humoral and cellular anti-SARS-CoV-2 immune responses. In addition, immunity induced by a booster dose of CoronaVac is active against VOCs, suggesting adequate protection. IMPORTANCE CoronaVac is an inactivated vaccine against SARS-CoV-2 that has been approved by WHO for emergency use. Phase III clinical trials are in progress in several countries, including China, Brazil, Turkey, and Chile, and have shown safety and immunogenicity after two doses of the vaccine. This report characterizes immune responses induced by two doses of CoronaVac followed by a booster dose 5 months after the second dose in healthy Chilean adults. The data reported here show that a booster dose increased the immune responses against SARS-CoV-2, enhancing levels of neutralizing antibodies against the ancestral strain and VOCs. Similarly, anti-SARS-CoV-2 CD4+ T cell responses were increased following the booster dose. In contrast, levels of gamma interferon secretion and T cell activation against the VOCs Delta and Omicron were not significantly different from those for the ancestral strain. Therefore, a third dose of CoronaVac in a homologous vaccination schedule improves its immunogenicity in healthy volunteers.


Subject(s)
COVID-19 , Viral Vaccines , Adult , Antibodies, Neutralizing , Antibodies, Viral , COVID-19/prevention & control , COVID-19 Vaccines , Humans , SARS-CoV-2 , T-Lymphocytes
13.
medrxiv; 2022.
Preprint in English | medRxiv | ID: ppzbmed-10.1101.2022.08.22.22279080

ABSTRACT

The SARS-CoV-2 Omicron variant has challenged the control of the COVID-19 pandemic even in highly vaccinated countries. While a second booster of mRNA vaccines improved the immunity against SARS-CoV-2, the humoral and cellular responses induced by a second booster of an inactivated SARS-CoV-2 vaccine have not been studied. In the context of a phase 3 clinical study, we report that a second booster of CoronaVac increased the neutralizing response against the ancestral virus yet showed poor neutralization against the Omicron variant. Additionally, isolated PBMCs displayed equivalent activation of specific CD4+ T lymphocytes and IFN-{gamma} production when stimulated with a mega-pool of peptides derived from the spike protein of the ancestral virus or the Omicron variant. In conclusion, a second booster dose of CoronaVac does not improve the neutralizing response against the Omicron variant compared with the first booster dose, yet it helps maintain a robust spike-specific CD4+ T cell response.


Subject(s)
COVID-19
14.
International Journal of Pharmaceutical Sciences Review and Research ; 74(2):65-78, 2022.
Article in English | EMBASE | ID: covidwho-1970065

ABSTRACT

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an emerging infection causing a widely spread pandemic of Coronavirus disease 2019 (COVID-19). The COVID-19 pandemic has a significant impact on public mental health. Therefore, monitoring and oversight of the population mental health is crucial during pandemic. Various psychological problems and important consequences in terms of mental health including stress, anxiety, depression, insomnia, fear, frustration, uncertainty during COVID 19 outbreak emerged progressively. Isolation and quarantine to reduce disease transmission have a negative impact on one’s mental health. The lockdown led to the closure of educational institutions and workplaces, loss of jobs, economic loss, lack of physical activity, restrictions on travel and gatherings. All these factors cumulatively affected the mental stamina of millions worldwide.

15.
Laryngo- Rhino- Otologie ; 101:S198-S199, 2022.
Article in English | EMBASE | ID: covidwho-1967673

ABSTRACT

Objective The objective of this study was to determine if patients with Neurofibromatosis Type 1 (NF1) have an impaired sense of smell or taste. Neurofibromin, the NF1gene protein product is ubiquitous in the body and is especially associated with the development of neurogenetic structures. Lately enlarged olfactory bulbs have been described in patients with NF1. Until now, there is no study to evaluate the sense of smell and taste in patients with NF1. Method This study has been approved by the Hamburg Ethics committee. An evaluation of the sense of smell and taste was undertaken in 26 patients with NF1 using the Burghart Sniffin' Sticks. Three patients were excluded due to a prior infection with the Corona virus. As a control group the same examination was performed in healthy individuals (same sex/ same age as the NF1 patients) by the same examiner. Results Preliminary results show a normal sense of smell in patients with NF1. The morphologic finding of enlarged olfactory bulbs seem to have no functional equivalent. However, 8 out of 23 patients with NF1 had difficulties identifying at least one taste flavor. The data collection of the control group is still ongoing, thus far none of the study participants misidentified a taste flavor. A statistical significance is aimed at by increasing the case numbers.

16.
Maturitas ; 165: 33-37, 2022 Nov.
Article in English | MEDLINE | ID: covidwho-1956262

ABSTRACT

OBJECTIVE: To evaluate the association between factors, especially those linked to the climacteric, and a history of COVID-19 infection. METHODS: This was an observational, cross-sectional, and analytical study in which women from ten Latin American countries, aged 40-64, who attended a routine health check-up were invited to participate. A positive history for COVID-19 was based on reverse transcription-polymerase chain reaction reports. We evaluated sociodemographic, clinical, lifestyle, anthropometric variables, and menopausal symptoms using the Menopause Rating Scale (MRS). RESULTS: A total of 1238 women were included for analysis, of whom 304 (24.6 %) had a positive history for COVID-19. The median [interquartile range: IQR] age of participants was 53 [IQR 12] years, duration of formal education was 16 [6] years, body mass index 25.6 [5.1] kg/m2, and total MRS score 10 [13]. In a logistic regression model, factors positively associated with COVID-19 included postmenopausal status and having a family history of dementia (OR: 1.53; 95 % CI: 1.13-2.07, and 2.40; 1.65-3.48, respectively), whereas negatively associated were use of menopausal hormone therapy (current or past), being a housewife, and being nulliparous (OR: 0.47; 95 % CI: 0.30-0.73; 0.72; 0.53-0.97 and 0.56; 0.34-0.92, respectively). Smoking, being sexually active, and use of hypnotics were also factors positively associated with COVID-19. CONCLUSION: Postmenopausal status and a family history of dementia were more frequent among women who had had COVID-19, and the infection was less frequent among current or past menopause hormone therapy users and in those with less physical contact.


Subject(s)
COVID-19 , Climacteric , Dementia , COVID-19/epidemiology , Cross-Sectional Studies , Female , Humans , Hypnotics and Sedatives , Latin America/epidemiology , Menopause , Quality of Life , SARS-CoV-2
17.
medrxiv; 2022.
Preprint in English | medRxiv | ID: ppzbmed-10.1101.2022.08.05.22278464

ABSTRACT

BackgroundThe development of vaccines to control the COVID-19 pandemic progression is a worldwide priority. CoronaVac(R) is an inactivated SARS-CoV-2 vaccine approved for emergency use with robust efficacy and immunogenicity data reported in trials in China, Brazil, Indonesia, Turkey, and Chile. MethodsThis study is a randomized, multicenter, and controlled phase 3 trial in healthy Chilean adults aged [≥]18 years. Volunteers received two doses of CoronaVac(R) separated by two (0-14 schedule) or four weeks (0-28 schedule). 2,302 volunteers were enrolled, 440 were part of the immunogenicity arm, and blood samples were obtained at different times. Samples from a single center are reported. Humoral immune responses were evaluated by measuring the neutralizing capacities of circulating antibodies. Cellular immune responses were assessed by ELISPOT and flow cytometry. Correlation matrixes were performed to evaluate correlations in the data measured. ResultsBoth schedules exhibited robust neutralizing capacities with the response induced by the 0-28 schedule being better. No differences were found in the concentration of antibodies against the virus and different variants of concern between schedules. Stimulation of PBMCs with MPs induced the secretion of IFN-{gamma} and the expression of activation induced markers for both schedules. Correlation matrixes showed strong correlations between neutralizing antibodies and IFN-{gamma} secretion. ConclusionsImmunization with CoronaVac(R) in Chilean adults promotes robust cellular and humoral immune responses. The 0-28 schedule induced a stronger humoral immune response than the 0-14 schedule. FundingMinistry of Health, Government of Chile, Confederation of Production and Commerce & Millennium Institute on Immunology and Immunotherapy, Chile. Clinical trial numberNCT04651790. summaryTwo immunization schedules were evaluated for the inactivated SARS-CoV-2 vaccine, Coronavac(R), with two doses of the vaccine separated by two or four weeks. We compared humoral and cellular immune responses, showing they are mostly similar, with differences in neutralization capacities.


Subject(s)
COVID-19
18.
BMJ Open ; 12(5): e061345, 2022 05 19.
Article in English | MEDLINE | ID: covidwho-1950195

ABSTRACT

INTRODUCTION: The COmmunity Cohort Study aims to determine, after natural exposure to SARS-CoV-2 or anti-SARS-CoV-2 vaccines deployed in Chile to prevent COVID-19 in the context of the current pandemic, the strength and duration of detectable neutralising antibodies in adult ambulatory primary care patients with cardiovascular risk factors. METHODS AND ANALYSIS: We will set up a community-based longitudinal, prospective cohort study. The study will be conducted in two public outpatient clinics located in the southern district of Santiago, Chile. We expect to begin recruitment in the second quarter of 2022. Each patient will be followed up for at least 1 year after inclusion in the cohort. The eligible population will be adult patients registered in the Cardiovascular Health Programme. Exposure in this study is defined as any event where participants have contact with SARS-CoV-2 antigens from natural exposure or vaccination. The primary outcomes are seroconversion and strength and duration of the neutralising IgG antibodies to SARS-CoV-2. Secondary outcomes are any COVID-19-related event or intercurrent morbidities or death. Data will be collected by extracting serial blood samples and administering a questionnaire at the first face-to-face contact and monthly follow-up time points. The sample size estimated for this study is 1060. We will characterise the cohort, determine the seroprevalence rate of neutralising antibodies at baseline and determine the rates of antibody decline using a longitudinal mixed-effects model. ETHICS AND DISSEMINATION: The Scientific Ethics Committee of the South Metropolitan Health Care Service approved the study protocol (Memorandum No 191/2021). We will present the results in two peer-reviewed publications and national and international professional and academic meetings. We will organise seminars with relevant stakeholders and hold town hall meetings with the local community. We will set up a COmmunity Cohort Study website at www.communitystudy.cl to disseminate the study purpose, research team and milestones.


Subject(s)
COVID-19 , SARS-CoV-2 , Adult , Antibodies, Neutralizing , COVID-19/epidemiology , Cohort Studies , Humans , Immunity, Humoral , Prospective Studies , Seroepidemiologic Studies
19.
Curr Dermatol Rep ; 11(3): 146-157, 2022.
Article in English | MEDLINE | ID: covidwho-1935385

ABSTRACT

Purpose of Review: Neutrophilic dermatoses are a heterogeneous group of disorders with significant overlap in associated conditions, clinical presentation, and histopathologic features. This review provides a structural overview of neutrophilic dermatoses that may present in the inpatient setting along with diagnostic work-up and management strategies. Recent Findings: Sweet's syndrome has been found in patients with coronavirus disease 2019 (COVID-19). Pyoderma gangrenosum (PG) has been shown to be equally associated with ulcerative colitis and Crohn's disease. A clinical trial shows that cyclosporine is equally effective as prednisone in treating PG. Neutrophilic eccrine hidradenitis has been found in the setting of newer antineoplastic medications, such as BRAF inhibitors, as well as in the setting of malignancy without chemotherapy exposure. Summary: Neutrophilic dermatoses are a rare and complex group of dermatoses with varying and overlapping clinical presentations. Physicians should be aware of the growing list of associated diseases in order to build a better differential diagnosis or to potentially investigate for co-existing disease.

20.
Hosp Pharm ; 57(6): 744-751, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-1938145

ABSTRACT

Aim: Implementation of a web-form based pharmacovigilance plan for the spontaneous notification of adverse events to the Comirnaty® COVID-19 vaccine during its administration to hospital healthcare professionals. Methods: An electronic pharmacovigilance form was developed containing 8 pre-defined event options, an open answer option for the description of other events and/or symptoms, and a question about the overall intensity of symptoms. The adverse events reports were standardized according to physiological and pathological condition. Results: A total of 4119 adverse events notifications were obtained with a 45% rate of electronic notification. The most clinically relevant events reported were:tachycardia (n = 19), dyspnea (n = 7), chest pain (n = 6), facial/labial edema (n = 6), lipothymia (n = 5), bronchospasm (n = 2), herpetic infection (n = 2), vasculitis (n = 2), arrhythmia (n = 1), difficult to control arterial hypertension (n = 1), gastritis (n = 1), and spontaneous abortion (n = 1). Regarding the intensity of symptoms (n = 2928), 70.0% were reported as mild, 25.8% as moderate, and 4.27% as severe, with higher intensity in the second dose compared to first dose. The highest frequency of severe events were reported in the groups from 40 to 59 years in both vaccination periods. During the vaccination process, no hospitalizations and no deaths were notified and/or recorded. Conclusion: In this real world study, comparing with Comirnaty clinical trials program, it was observed a higher frequency of adenomegaly and gastrointestinal disorders. Noteworthy, the notification of a case of miscarriage. The use of hospital pharmacy pharmacovigilance electronic forms, seemed to be relevant to notification adherence and to obtain a greater and faster knowledge of COVID-19 vaccine safety profile.

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