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1.
Journal of Cystic Fibrosis ; 21:S65, 2022.
Article in English | EMBASE | ID: covidwho-1996771

ABSTRACT

Objectives: People with CF (PwCF) are at increased risk of respiratory infections and chronic inflammation.We sought to determine whether the inflammatory response is different in nasal epithelium of PwCF compared to healthy volunteers (HV). Since Interferons can increase ACE2 expression, a protein required for SARS-CoV-2 entry,we focused our analysis on the the focusing on the interferon-response signature. Methods: We reanalysed nasal curettage sample bulk RNA-seq signatures of pilot and validation datasets for which the study methods and demographics of the recruited cohort have already been reported. For this analysis, we performed in-silico deconvolution of bulk RNA-seq data using publicly available single-cell RNA-seq data from nasal epitheliumas a reference to determine the abundance of the specific cell types in each sample. Results: Hierarchical clustering of the pilot and validation cohorts revealed 3 clusters. Analysis of the larger validation cohort revealed that Cluster A included HV (11 out of 11 subjects) and both homozygous (7 out of 13 subjects) and heterozygous (3 out of 10 subjects) PwCF. Subject cluster A was characterised by increased expression of genes related to secretory and ciliated epithelial cells, whereas Clusters B and C contained both homozygous and heterozygous PwCF only and were characterised by genes restricted to neutrophils and involved in immune responses. We then compared samples from cluster A that contained samples from HV (n = 11), PwCF homozygous (n = 7) and heterozygous (n = 3) for F508del. This analysis identified 379 genes upregulated in HV and 146 genes upregulated in PwCF homozygous for F508del and only 44 and 6 genes upregulated in HV and PwCF heterozygous for F508del, respectively (FDR q < 0.05). ACE2, TMPRS2 or other interferon-response genes were not deferentially expressed in either comparison of cluster A. Conclusion: PwCF do not have higher expression of interferon-response genes in nasal epithelial cells

3.
Journal of Mountain Agriculture on the Balkans ; 24(6):113-125, 2021.
Article in Bulgarian, English | CAB Abstracts | ID: covidwho-1871346

ABSTRACT

Coronavirus infections rank first in the pathology of the gastrointestinal tract and respiratory system in large and small ruminants. The paper analyzes the occurrence, spread, development, trends and prevention of coronavirus infections in ruminants in Bulgaria, Europe and around the world. Retrospective, descriptive and statistical methods were used. The experience and the specifics of the coronavirus diseases encountered so far in large and small ruminants - cattle, buffaloes, camels, deer, sheep and goats and their epizootic character are summarized.

4.
Journal of Cystic Fibrosis ; 20:S195-S196, 2021.
Article in English | ScienceDirect | ID: covidwho-1466981
5.
Russian Journal of Cardiology ; 25(S4):32-37, 2020.
Article in Russian | Russian Science Citation Index | ID: covidwho-1094456

ABSTRACT

We present a case report of a patient with a previously identified cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), who was admitted due to coronavirus disease 2019 (COVID-19), confirmed by polymerase chain reaction and computed tomography. Examination and treatment of these patients presents certain difficulties due to the large number of thromboembolic complications caused by a combination of congenital and infectious angiopathies. CADASIL syndrome and COVID-19 were manifested by the progression of neurological symptoms and increasing cognitive impairment. During therapy, there was a positive change with a gradual regression of these disorders. Представлен клинический пример пациентки с выявленной ранее доминантной артериопатией с субкортикальными инфарктами и лейкоэнцефалопатией (CADASIL - cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy), поступившей в клинику с новой коронавирусной инфекцией (COVID-19), подтвержденной данными ПЦР и компьютерной томографии. Обследование и терапевтическое лечение этих пациентов представляет определенные трудности в связи с большим числом тромбоэмболических осложнений, обусловленных сочетанием врожденной и инфекционно-обусловленной ангиопатий. CADASIL-синдром и новая коронавирусная инфекция, вызванная вирусом SARS-CoV-2, проявлялись прогрессией неврологической симптоматики и нарастающими когнитивными нарушениями. На фоне терапии отмечалась положительная динамика в виде постепенного регресса данных нарушений.

6.
Trakia Journal of Sciences ; 18(Suppl. 1):442-450, 2020.
Article in English | GIM | ID: covidwho-1000674

ABSTRACT

The aim of the present study is to establish the extent to which natural resources are used and how traditional livelihood practices are exercised at a regional level. The object of this study is a region with developed mass tourism - Bansko Municipality. The subject addresses traditional livelihood practices and the opportunities for expanding alternative forms of tourism. The revival of traditional livelihood models, which directly corresponds to current trends in bioeconomy, can make alternative forms of tourism an important part of the local development strategies in the forthcoming programming period after 2020, including regions established as mass tourism ones. The study has been conducted by applying the survey method in the municipality of Bansko in the period of February-March 2020 coinciding with the onset of the epidemic situation related to COVID-19 in Bulgaria. Taking into account the results from the survey, it is possible to draw conclusions about the extent to which certain conditions for the development of alternative forms of tourism have been created when facing new challenges.

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