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J Am Acad Dermatol ; 2022 Jun 25.
Article in English | MEDLINE | ID: covidwho-1907219
Advances in Laboratory Medicine ; 1(4), 2020.
Article in English | Scopus | ID: covidwho-1846959


Background: The pandemic caused by the emergence of the new SARS-CoV-2 virus worldwide has had a major impact at all levels and has forced in-depth research into its behavior, pathogenicity and treatment. Content: This review provides an overview of various aspects of the virus and the immune response it triggers, as well as a description of the different diagnostic and therapeutic approaches adopted. Summary: SARS-COV-2 is a RNA virus with some peculiarities that make it different from its predecessors SARS-CoV and MERS. Given its structural characteristics and pathogenesis, it can cause different clinical manifestations as the disease progresses. The immune system has been proven to play a major role in the response to this virus and, therefore, the study of antibodies and lymphocyte populations during the different stages of the disease is crucial. Outlook: The knowledge of the effect of the virus and the immune response is crucial for the development of good quality vaccines, therapies and diagnostic techniques, which are essential for the control and eradication of the disease. © 2020 Cristina A. López Rodríguez et al., published by De Gruyter, Berlin/Boston.

Advances in Laboratory Medicine ; 1(4), 2020.
Article in Spanish | Scopus | ID: covidwho-1846957
Journal of Clinical Oncology ; 39(15 SUPPL), 2021.
Article in English | EMBASE | ID: covidwho-1339321


Background: The COVID-19 surge in March 2020 resulted in a hiatus placed on screening mammography programs in support of shelter-inplace mandates and diversion of medical resources to pandemic management. The COVIDrelated economic recession and ongoing social distancing policies continued to influence screening practices after the hiatus was lifted. We evaluated the effect of the hiatus on breast cancer stage distribution on the diverse patient population of a health care system in New York City, the first pandemic epicenter in the United States. Methods: Breast cancer patients diagnosed January 1, 2019 to December 31, 2020 were analyzed, with comparisons of stage distribution and mammography screen-detection for three intervals: Pre-Hiatus, During Hiatus (March 15, 2020 to June 15, 2020), and Post- Hiatus. Results were stratified by African American (AA), White American (WA), Asian (As) and Hispanic/Latina (Hisp) self-reported racial/ethnic identity. Results: A total of 894 patients were identified;of these, 549 WA, 100 AA, 104 As, and 93 Hisp comprised the final race/ethnicity-stratified study population. Overall, 588 patients were diagnosed Pre-Hiatus, 61 During-Hiatus, and 245 Post-Hiatus. Nearly two-thirds (65.5%) of the Pre- Hiatus cases were screen-detected versus 49.2% During-Hiatus and 54.7% Post-Hiatus (p = 0.002). Frequency of tumors diagnosed < 1 cm declined from 41.9% Pre-Hiatus to 31.7% Post-Hiatus (p = 0.035). WA patients were more likely to have screen-detected disease compared to AA in the Pre-Hiatus period (69.1% vs. 56.1%;p = 0.05) but non-significantly more likely to have screendetected disease compared to As and Hisp patients (66.2% vs. 56.9%;p = 0.08). In the Post- Hiatus period, the frequency of screen-detected disease was highest among WA patients (63.0%) compared to all other racial/ethnic groups (AA;48.1%, As-33.3%, and Hisp-40%;p = 0.007). Similar patterns were observed for frequency of tumors diagnosed ≤1cm Pre-Hiatus (WA-44.3% vs AA-26%, p = 0.02;and vs. As-41.3%, Hisp-48%;p = 0.09), and Post-Hiatus (WA-37.7% vs. AA- 18.2%, As-30.8%, Hisp-23.5%;p = 0.25). Conclusions: The 3-month pandemicrelated mammography screening hiatus resulted in a more advanced stage distribution for New York City breast cancer patients, and worsened preexisting race/ethnicity-associated disparities, especially for AA pts.

Revue medicale suisse ; 17(724):248-253, 2021.
Article in French | Scopus | ID: covidwho-1102956


The COVID-19 pandemic underlines how vulnerable our societies are to health and economic shocks. It reveals and exacerbates existing inequalities in terms of health status, income, or employment. In Switzerland, as well as globally, most socioeconomically disadvantaged individuals are also the most exposed and vulnerable to the virus, both at work and in their homes. Our aim is to describe the mechanisms through which the pandemic has disproportionally affected some groups of the population. We are particularly interested in the concentration of health and economic risks in specific households and in the public policies implemented to fight the pandemic on the health front while attempting to reduce its economic impact. La pandémie de Covid-19 est un prisme de lecture révélateur de la vulnérabilité de nos sociétés aux chocs sanitaires et économiques. Elle a pour effet non seulement de mettre en lumière mais aussi d’exacerber les inégalités déjà existantes que ce soit en termes d’état de santé, de revenu ou encore d’accès à l’emploi. En Suisse comme ailleurs, les personnes les plus désavantagées socio-économiquement sont également les plus exposées et vulnérables au virus, tant sur leur lieu de travail que dans le cadre privé. Notre objectif ici est de décrire par quels mécanismes la pandémie a touché de façon différenciée certains groupes de la population. Nous nous intéressons en particulier à la concentration des risques sanitaires et économiques pour certains ménages et aux réponses des pouvoirs publics pour combattre cette épidémie sur le plan sanitaire tout en essayant de réduire son impact économique.