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1.
Malaysian Journal of Pathology ; 44(1):83-92, 2022.
Article in English | EMBASE | ID: covidwho-2102504

ABSTRACT

Introduction: Data on pathological changes in COVID-19 are scarce. The aim of this study was to describe the histopathological and virological findings of postmortem biopsies, and the existing clinical correlations, in people who died of COVID-19. Material(s) and Method(s): We performed postmortem needle core biopsies of the chest in 11 people who died of COVID-19 pneumonia. Tissue examination was done by light microscopy and real-time polymerase chain reaction (RT-PCR). Result(s): The age of the patients were between 61 to 94 years. Of the 11 postmortem chest biopsies, lung tissue was obtained in 8, myocardium tissue in 7, and liver tissue in 5. Histologically of lung, the main findings pertaining to the lung were diffuse alveolar damage in proliferative phase (n = 4, 50%), diffuse alveolar damage in exudative and proliferative phase (n = 3, 37.5%), diffuse alveolar damage in exudative (n=1;12.5%) and acute pneumonia (n = 2, 25%). Necrotising pneumonia, acute fibrinous and organising pneumonia, and neutrophils were detected in one sample each (12.5%). Another case presented myocarditis. RT-PCR showed RNA of SARS-CoV-2 in 7 of the 8 lung samples (87.5%), 2 of the 7 myocardial tissue samples (28.6%), and 1 of the 5 liver tissue samples (20%). Conclusion(s): The postmortem examinations show diffuse alveolar damage, as well as acute or necrotising pneumonia. RT-PCR of SARS-CoV-2 was positive in most lung samples. Copyright © 2022, Malaysian Society of Pathologists. All rights reserved.

2.
Universidad y Sociedad ; 14(5):465-471, 2022.
Article in Spanish | Scopus | ID: covidwho-2092203

ABSTRACT

Life satisfaction is a cognitive component of well-being that arises from the subject’s evaluation of his life quality based on multiple criteria. Dealing with new problems involve making decisions that draw upon the development of skills and competencies that help students res-pond to the demands of the university stage. The objective of this study was to determine life satisfaction in times of pandemic in university students in Lima. The population consisted of 6,400 students, from which a sample of 764 subjects was drawn from five (5) universities in the city of Metropolitan Lima. The instrument applied was the Satisfaction With Life Scale (SWLS). The psychometric analysis of the scale has an acceptable reliability, as well as excellent construct validity. Regarding the descriptive analysis of the variable, the results show that there is a medium level of life satisfaction, and this is a rather worrying result when considering that the respondents are young people who should have a higher or high level of satisfaction. It is suggested to prioritize greater attention to this problem, as well as to develop research on this variable with other groups equally vulnerable as the university sector. © 2022, University of Cienfuegos, Carlos Rafael Rodriguez. All rights reserved.

3.
Revista Ciencias de la Salud ; 20(2), 2022.
Article in English | CAB Abstracts | ID: covidwho-2080961

ABSTRACT

Introduction: The objective of this article was to explore, from an anthropological perspective, the social representations that doctors who treat covid-19 in specialized hospitals in Mexico City have, regarding the relationship between their professional performance and the deterioration of their mental health;as well as their social representations of the existing institutional resources to provide them mental health attention and their care-seeking and self-care strategies. Materials and Methods: For this, a qualitative investigation was carried out with semi-structured interviews with 35 doctors who treat covid-19.

4.
12th International Conference on Human-Computer Interaction, INTERACCION 2022 ; 2022.
Article in English | Scopus | ID: covidwho-2053369

ABSTRACT

This research analyzes the announcements issued by Spanish universities during the COVID-19 pandemic relating to students with special needs, to offer a new vision, complementary to existing audits conducted on university websites about technical accessibility compliance. The study approaches the evaluation of accessibility from the point of view of organizational support. The identified measures are mapped onto Universal Design Learning guidelines to give them context and to analyze their coverage. The research shows a landscape with an uncoordinated and uncollaborative approach, with negative consequences in the tackling of remote emergency teaching.. © 2022 ACM.

5.
European psychiatry : the journal of the Association of European Psychiatrists ; 64(Suppl 1):S668-S668, 2021.
Article in English | EuropePMC | ID: covidwho-2046130

ABSTRACT

Introduction Electroconvulsive therapy is a highly effective treatment for severe psychopharmacological resistant patients but it is also a procedure that involves open airway management and has been considered as an aerosol generating procedure. The COVID-19 pandemic, has resulted in reduction in ECT services internationally. The COVID-19 pandemic has dramatically and rapidly transformed hospitals in heavily affected areas, decreasing mental health services. The need to locate critical patients in spaces intended for anesthesia, where we usually administered ECT, has forced us to decrease the number of procedures and be highly selective. In the same way, continuation and maintenance ECT (m-ECT) have also been dramatically reduced. The risk of contagion urged us to develop a protocol involving other areas of the hospital Objectives To create a safe circuit from admission to the hospital to the ECT including emergency room and psychiatric Ward Methods Review of the tliterature and published protocols Workshops with Preventive Medicine, Anaesthesia and Emergency Service to elaborate a protocol Submission of the protocol to Management of the Hospital Results The protocol (Figure 1) began with the screening for COVID-19 in every patient. If the PCR was (+) the patient was not excluded. We moved treatment from the PACU into the OR and if a patient tested positive It was determined that the ECT was administered in the OR That was provided with negative pressure. Circuits were established within the Psychiatric Ward and in the areas of the hospital involved to reduce risks and patients remained isolated until negative test was confirmed The number of persons present in the treatment room was kept to the absolute minimum required and appropriate personal protective equipment was used, as prescribed by the WHO Conclusions We must keep in mind treating the most vulnerable of our patients. ECT should be seen as an essential medical procedure and made available Disclosure No significant relationships.

7.
Annals of the Rheumatic Diseases ; 81:1707-1708, 2022.
Article in English | EMBASE | ID: covidwho-2009195

ABSTRACT

Background: The most common etiology of acute pericarditis is usually infectious, especially viral. When its cause is infammatory (up to 7% of cases), it can be presented as an isolated process or be a clinical manifestation in the context of multiple systemic autoimmune diseases (SAD), therefore it is necessary to make a broad differential diagnosis. Nowadays, an increased incidence has been described in relation to SARS-CoV-2 infection, and especially in global vaccination against this one. This represents a clinical challenge when we have to identify the cause of this pathology with a not insignifcant comorbidity. Objectives: To describe the characteristics of a series of patients with acute pericarditis and its association with SAD. Methods: Retrospective and descriptive observational study. Digitalised records of patients with acute pericarditis evaluated in the Rheumatology unit of a tertiary hospital in Seville during 2021 were reviewed. Demographic, epidemiological, clinical and therapeutic variables were analysed. Results: Eight cases of acute pericarditis were detected. The average age of the patients was 51.50 ± 18.601 years. 62.5% were women. 50% had previous rheumatological pathology: two rheumatoid arthritis (RA), one systemic lupus erythematosus (SLE) and one limited systemic sclerosis (LSS);with an average disease duration of 8.63 ± 2.387 months. Of these, 3 were on treatment with steroids and DMARDs (lefunomide or hydroxychloroquine) and 1 had previously received rituximab. Pericardial effusion was moderate in 50% of cases, severe in 33.3% and mild in 16.7%. One patient had cardiac tamponade. Five patients had pleural effusion, which was moderate in 80%, and in one case associated with pneumonia. As complications, one patient developed heart failure and the patient with ESL was diagnosed with pulmonary arterial hypertension. Two patients had previous COVID19 and 7 were vaccinated against Sars-CoV2. Treatment was colchicine in 57.15% of cases, steroids in 85.7%, DMARDsc in 85.8% (3 hydroxychloroquine and 3 azathioprine) and DMARDsb in 42.9% (1 anakinra, 1 tocilizumab and 1 rituximab). Pericarditis resolved in all patients. Table 1. Conclusion: In the previous year, an increase in consultations from other departments for acute pericarditis with suspected infammatory origin was observed. The possibility of a correlation with COVID19 or vaccination against COVID was initially considered, but it could not be demonstrated, since vaccination was later in vaccinated patients, and in those who had been infected, the time interval until the development of pericarditis was too long for it in order to be attributed to COVID19. Finally, in 5 of the 8 patients, pericarditis was related to SAD, in particular with the rheumatic pathologies most associated with this clinical manifestation (RA and SLE). Therefore, in the middle of the COVID pandemic, in addition to considering COVID19 or its vaccine in the differential diagnosis of acute pericarditis, we must not forget to include SAD in this diagnosis.

8.
International Journal of Neutrosophic Science ; 18(4):313-322, 2022.
Article in English | Scopus | ID: covidwho-1995102

ABSTRACT

The globe has been coping with the COVID-19 epidemic, eagerly awaiting the completion of the vaccine process. Despite the Internet of Things (IoT) and its effect on supply networks, the recent epidemic has brought unprecedented supply chain disruptions. To assess the relevance of these issues, we speak with leading specialists. A novel distance-based similarity metric based on neutrosophic set theory is being used in this research to examine IoT challenges in the supply chain. The proofs for each of the properties are provided straightforwardly. © 2022, American Scientific Publishing Group (ASPG). All rights reserved.

9.
Gastroenterology ; 162(7):S-1253, 2022.
Article in English | EMBASE | ID: covidwho-1967443

ABSTRACT

Introduction. Solid organ transplant recipients were excluded from the pivotal clinical trials of COVID-19 vaccines. Therefore, the safety and efficacy data of the different types of available vaccines in this susceptible population is scarce. The goal of the present analysis was to evaluate the humoral response to the COVID-19 vaccines in orthotopic liver transplant (OLT) recipients. Methods. Participants were included from February to September 2021. No prioritized vaccination was performed for OLT patients, and they were included in the regular schedule according to age and place of residency. Controls were otherwise healthy people, mainly family members of patients. All subjects completed the full vaccination schemes, and blood samples were taken after at least 15 days of the complete vaccine doses. The samples were analyzed according to the manufacturer instructions using Liaison XL platform from DiaSorin, LIAISON® SARS-CoV-2 S1/S2 IgG (DiaSorin S.p.A., Italy), and SARS-COV-2 IgG II Quant (COV-2 IgG II) (Abbott Diagnostics, IL, USA). Results. In all, 187 participants (133 OLT, 54 controls, median age: 60 years, 58.8% women) were included for the analysis;74.3% had at least one comorbidity (31.6% had hypertension, 32.6% diabetes, 7% neoplasia, and 23% obesity). By vaccine brands, 50.3% received Pfizer-BioNTech, 13.9% received Oxford-AstraZeneca, 10.7% received Sinovac, 7.0% Cansino;16% Sputnik-V and 2.1% received Moderna. The serologic response in OLT patients was lower than in controls (median 549 AU/mL vs. 3450 AU/mL, respectively;p 0.001). A positive humoral response was found in 133 OLT individuals: 89.2% with Pfizer-BioNTech, 60% Oxford-AstraZeneca, 76.9% Sinovac, 55.6% Cansino, 68.2% Sputnik-V, and 100% with Moderna. In controls, only Cansino had a 75% humoral response;all other vaccines had a 100% response. In a multivariable model adjusted for relevant confounders, the antecedent of COVID-19 and Pfizer-BioNTech inoculation were associated positively with the serologic response, while the use of prednisone (compared with other immunosuppressants) interfere with this response. Conclusion. The serologic response to COVID-19 vaccines in OLT patients is lower than otherwise healthy controls. In these patients, the Pfizer-BioNTech vaccine was associated with a higher serologic response. Other variables significantly associated with the humoral response were the COVID-19 antecedent (positively) and prednisone exposure (negatively). At the moment, further analysis is necessary to determine whether this serological response is associated with SARS-COV2 infection or reinfection. (Figure Presented)

10.
DIGITAL EDUCATION REVIEW ; - (41):195-223, 2022.
Article in Spanish | Web of Science | ID: covidwho-1965483

ABSTRACT

Since the appearance of the Covid-19 pandemic, teachers are updating the school activities of the courses with the support of Information and Communication Technologies (ICTs). The aim of this mixed research is to analyze the students' perceptions about the use of technology in the Clinical Method course considering data science (machine learning) through linear regression and decision tree techniques. The participants are 77 students from the Faculty of Psychology who took the Clinical Method course at the National Autonomous University of Mexico during the 2020 school year. The results of the machine learning technique indicate that the use of Zoom, Moodie, audios and Padlet during the educational process about observation and inquiry in Clinical Psychology positively influence the assimilation of knowledge and motivation of the students. Likewise, data science identifies 8 predictive models about the use of these technological tools in the educational process through the decision tree technique. In conclusion, ICTs allow the construction of new educational spaces that facilitate the learning process from anywhere, allow the active participation of the students at any time and satisfy the educational demand during the Covid-19 pandemic.

11.
Update in Anaesthesia ; 36, 2022.
Article in English | Scopus | ID: covidwho-1960259

ABSTRACT

Simulation-based education (SBE) has a long history in medical education. SBE is now widely used to train individuals and teams in technical as well as social and cognitive skills. Much of the simulation literature is developed in well-resourced universities and hospitals with a dedicated simulation center, staff, consumables, and other assets. Looking at simulation from a global viewpoint, simulation centers are very hard to establish since the opportunity cost of investing in simulators, mannequins, equipment, a physical space and staff to run the center, is high. There also exists other barriers, for example time and training opportunities needed to develop expertise amongst simulation educators in the institution. Understanding that fidelity is not equal to benefit and that scenarios can be conducted in actual clinical settings, such as using in-situ simulation, rather than specialist simulation facilities, can help anesthesiologists begin to train using simulation without the need for significant financial investment. We provide practical tips for getting started with SBE and argue that the most important investment is in faculty development and engagement of the team. We also discuss the impact of the COVID-19 pandemic in necessitating the simulation world to be creative and develop new ways to train, for example through remote simulation. © World Federation of Societies of Anaesthesiologists 2022.

12.
Oftalmologicheskii Zhurnal ; 97(3):63-64, 2022.
Article in English | Scopus | ID: covidwho-1955440

ABSTRACT

Background. The COVID-19 virus infection can develop ocular manifestations. Purpose. To report a case of a coats disease patient who was evaluated one week before as part of a routine retinal consultation and later had COVID-19 with sudden loss of vision in one eye. Material and Methods. The affected eye had a visual acuity of 20/400. At fundus examination abnormal tortuous vasculature, hemorrhages, branch retinal vein occlusion and macular edema were found. It was confirmed with fluorescein angiography and optical coherence tomography. Results. With a combined therapy of intravitreal Aflibercept, periocular triamcinolone and focal laser was recovery the visual acuity to 20/20. Conclusion. There are few cases described in literature, but a sudden loss of vision during a COVID-19 infection must be early detected and treated to achieve a better visual acuity recovery. © Leopoldo Garduño Vieyra, Raúl Rúa Martínez, Bruno Flores Escobar, 2022.

14.
Advances in Laboratory Medicine ; 2(3):390-398, 2021.
Article in English | Scopus | ID: covidwho-1846966

ABSTRACT

Objectives: The strain the SARS-COV-2 pandemic is putting on hospitals requires that predictive values are identified for a rapid triage and management of patients at a higher risk of developing severe COVID-19. We developed and validated a prognostic model of COVID-19 severity. Methods: A descriptive, comparative study of patients with positive vs. negative PCR-RT for SARS-COV-2 and of patients who developed moderate vs. severe COVID-19 was conducted. The model was built based on analytical and demographic data and comorbidities of patients seen in an Emergency Department with symptoms consistent with COVID-19. A logistic regression model was designed from data of the COVID-19-positive cohort. Results: The sample was composed of 410 COVID-positive patients (303 with moderate disease and 107 with severe disease) and 81 COVID-negative patients. The predictive variables identified included lactate dehydrogenase, C-reactive protein, total proteins, urea, and platelets. Internal calibration showed an area under the ROC curve (AUC) of 0.88 (CI 95%: 0.85-0.92), with a rate of correct classifications of 85.2% for a cut-off value of 0.5. External validation (100 patients) yielded an AUC of 0.79 (95% CI: 0.71-0.89), with a rate of correct classifications of 73%. Conclusions: The predictive model identifies patients at a higher risk of developing severe COVID-19 at Emergency Department, with a first blood test and common parameters used in a clinical laboratory. This model may be a valuable tool for clinical planning and decision-making. © 2021 Yolanda Villena-Ortiz et al., published by De Gruyter, Berlin/Boston.

15.
Universidad y Sociedad ; 14(1):655-662, 2022.
Article in Spanish | Scopus | ID: covidwho-1837550

ABSTRACT

This paper focuses on describing the impact of the application of public policies on student access to the tele-training platform of the University of Cienfuegos and the level of student satisfaction with tele-training services from UCF. Two instruments were applied in the study, the review of documents based on the possibilities offered by the Moodle Reports to analyze the behavior in the access to tele-training resources before and after the measures were applied by ETECSA. An online questionnaire allowed obtaining information about how students access the different services and the level of satisfaction. The main results are that the measure to free up access costs has managed to exponentially increase access to available platforms and resources. The survey allowed to know the tools and main contents that the students use for the development of the activities and to determine the main deficiencies on which to project improvement actions. Finally, the level of satisfaction that students have with the process is recognized as adequate. © 2022, University of Cienfuegos, Carlos Rafael Rodriguez. All rights reserved.

16.
Malays J Pathol ; 44(1): 83-92, 2022 Apr.
Article in English | MEDLINE | ID: covidwho-1812960

ABSTRACT

INTRODUCTION: Data on pathological changes in COVID-19 are scarce. The aim of this study was to describe the histopathological and virological findings of postmortem biopsies, and the existing clinical correlations, in people who died of COVID-19. MATERIALS AND METHODS: We performed postmortem needle core biopsies of the chest in 11 people who died of COVID-19 pneumonia. Tissue examination was done by light microscopy and real-time polymerase chain reaction (RTPCR). RESULTS: The age of the patients were between 61 to 94 years. Of the 11 postmortem chest biopsies, lung tissue was obtained in 8, myocardium tissue in 7, and liver tissue in 5. Histologically of lung, the main findings pertaining to the lung were diffuse alveolar damage in proliferative phase (n = 4, 50%), diffuse alveolar damage in exudative and proliferative phase (n = 3, 37.5%), diffuse alveolar damage in exudative (n=1; 12.5%) and acute pneumonia (n = 2, 25%). Necrotising pneumonia, acute fibrinous and organising pneumonia, and neutrophils were detected in one sample each (12.5%). Another case presented myocarditis. RT-PCR showed RNA of SARS-CoV-2 in 7 of the 8 lung samples (87.5%), 2 of the 7 myocardial tissue samples (28.6%), and 1 of the 5 liver tissue samples (20%). CONCLUSION: The postmortem examinations show diffuse alveolar damage, as well as acute or necrotising pneumonia. RT-PCR of SARS-CoV-2 was positive in most lung samples.


Subject(s)
COVID-19 , Pneumonia, Necrotizing , Pneumonia , Aged , Aged, 80 and over , Biopsy, Needle , Humans , Liver/pathology , Lung/pathology , Middle Aged , Pneumonia/pathology , Pneumonia, Necrotizing/pathology , SARS-CoV-2
17.
Revista de Educacion y Derecho ; - (1):484-513, 2021.
Article in Spanish | Scopus | ID: covidwho-1759816

ABSTRACT

The aim of this research is to summarise thoughts, feelings and demands of lecturers, students and support staff in relation to special needs education, within the context of a legal framework with stated compromises and legal duties. The research is contextualized in the COVID-19 pandemics online or hybrid teaching, and it compares the statements of stakeholders with the recommendations issued by universities during this period and with existing best practices. The article aims to give an answer to the following questions: Which are the most important measures for students with special needs in this situation? Which are the most important for lecturers? How can we get ready for similar emergency situations? The methodology consisted in a review of the legal and standard framework, and a thematic analysis of 45 semi-structured interviews to students (27), lecturers (10), and support staff (8). The most problematic areas for students,lecturers and support staff are the inaccessibility of online teaching, virtual classrooms, teaching material, exams and assessment exercises. Students also emphasize the need for emotional/social support and the lack of it. © 2021 University of Barcelona. All Rights Reserved.

18.
Texto Livre-Linguagem E Tecnologia ; 15:19, 2022.
Article in Spanish | Web of Science | ID: covidwho-1754287

ABSTRACT

The SARS-CoV-2 virus has caused universities to search for new technological alternatives in order to im-prove the teaching and learning in distance modality. This quantitative and qualitative research analyzes the perception of educators about web games and mobile devices during the COVID-19 pandemic considering the machine learning technique and decision tree technique (data science). The participants are 60 teachers of higher education who taught courses at the National Autonomous University of Mexico in 2021 and took the "Innovation in University Teaching 2021" Diploma. The machine learning technique indicates that the use of web games and mobile devices positively influence the teaching work and participation of the students during the teaching-learning process. In addition, data science establishes 4 predictive models about these technological tools through the decision tree technique. Finally, web games and mobile devices allow the creation of new virtual spaces that favor the teaching in the distance modality and facilitate the learning from anywhere.

19.
Gaceta Medica Boliviana ; 44(2):187-197, 2021.
Article in Spanish | Scopus | ID: covidwho-1743249

ABSTRACT

The lack of drugs against COVID-19 and the health crisis prompted to evaluate ivermectin plus anticoagulation (ANCO) versus ANCO in non-ventilated critically ill patients with COVID-19, and the effect on clinical outcome, complications and survival. Objectives: To evaluate ivermectin vs anticoagulation in non-ventilated critical patients with COVID-19, and its effect on the patient's clinical condition, laboratory parameters, evolution and complications in 2nd and 3rd level hospitals (Hospital Sud and Hospital Obrero No. 2 of the Caja Nacional de Salud-CNS). Material and methods: Randomized clinical trial, from July 2020 to January 2021, ivermectin (0.2 mg/k) + ANCO arm and ANCO arm;with two variable groups and three assessments. Results: 44 patients enrolled, 27 at Hospital Sud and 17 CNS;64% to the ivermectin+ANCO group, 57% male. Average age 57.3 years;of hospitalization 13 days;obesity 40%;possibility of recovery with ivermectin 10 days and ANCO> 20 days. The mean initial oxygen saturation (SatO2) 79% (PaO2/FiO2=60) in the group with ivermectin + ANCO and 75% (55) in the ANCO group;in a final measurement 86% (138) and 83% (120) respectively. The first evaluation showed Rho Spearman=-0.7 between SatO2 and respiratory rate (FR) and a Rho=-0.7 between pH and FiO2 in the third evaluation. 26-day survival, RR = 0.98, 95% CI (0.49-1.98), with no differences in both arms (p = 0.94);27% intubated with ivermectin + ANCO and 21% ANCO;>60% were admitted to intensive care;probability of needing intubation, with RR of 0.76, 95% CI (0.42-1.40), (p = 0.4). Conclusions: Ivermectin does not reduce mortality or possibility of intubation. Evolution depends on severity, whether patients are polymedicated, days of progression and use of oxygen. It is necessary to standardise combinations, doses, large and homogeneous samples;for the moment we cannot recommend the use of ivermectin. © 2021 Facultad de Medicina Dr. Aurelio Melean. All right reserved.

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