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Disaster Med Public Health Prep ; 17: e410, 2023 05 08.
Article in English | MEDLINE | ID: covidwho-2316717


OBJECTIVE: Frontline healthcare workers (FHCWs) exposed to COVID-19 patients are at an increased risk of developing psychological burden. This study aims to determine the prevalence of mental health symptoms and associated factors among Mexican FHCWs attending COVID-19 patients. METHODS: FHCWs, including attending physicians, residents/fellows, and nurses providing care to COVID-19 patients at a private hospital in Monterrey, Mexico, were invited to answer an online survey between August 28, and November 30, 2020. Symptoms of depression, anxiety, post-traumatic stress, and insomnia were evaluated with the Patient Health Questionnaire (PHQ)-9, Generalized Anxiety Disorder (GAD)-7, Impact of Event Scale-Revised (IES-R), and Insomnia Severity Index (ISI). Multivariate analysis was performed to identify variables associated with each outcome. RESULTS: 131 FHCWs, 43.5% attending physicians, 19.8% residents/fellows, and 36.6% nurses were included. The overall prevalence of depression, anxiety, post-traumatic stress, and insomnia was 36%, 21%, 23%, and 24% respectively. Multivariate analysis revealed that residents/fellows and nurses reported more depression and insomnia than attending physicians. Although not significant, residents/fellows were more likely to experience all symptoms than nurses. CONCLUSIONS: Mexican FHCWs, especially nurses and residents/fellows, experienced a significant psychological burden while attending to COVID-19 patients. Tailored interventions providing support to FHCWs during future outbreaks are required.

COVID-19 , Sleep Initiation and Maintenance Disorders , Stress Disorders, Post-Traumatic , Humans , COVID-19/epidemiology , Sleep Initiation and Maintenance Disorders/epidemiology , Sleep Initiation and Maintenance Disorders/etiology , Stress Disorders, Post-Traumatic/epidemiology , Stress Disorders, Post-Traumatic/etiology , Depression/epidemiology , Depression/etiology , Depression/psychology , Prevalence , Mexico/epidemiology , SARS-CoV-2 , Anxiety/epidemiology , Anxiety/etiology , Anxiety/psychology , Anxiety Disorders/epidemiology , Health Personnel/psychology , Hospitals
Infect Dis (Lond) ; 54(11): 810-818, 2022 11.
Article in English | MEDLINE | ID: covidwho-1937614


BACKGROUND: COVID-19 may trigger an acute hyperinflammatory syndrome characterised by heightened levels of acute phase reactants and is associated with adverse outcomes among hospitalised individuals. The relationship between 48-hour changes in acute phase reactants and adverse outcomes is unclear. This study evaluated the relationship between change in four acute phase reactants (interleukin-6, procalcitonin, ferritin, and C-reactive protein), and the risk for in-hospital death and invasive mechanical ventilation. METHODS: A retrospective cohort among 2,523 adult patients hospitalised with COVID-19 pneumonia was conducted. Changes in IL-6, procalcitonin, ferritin, and CRP from admission to 48 h after admission were recorded. Delta was calculated using the difference in each acute phase reactant at admission and at 48-hours. Delta in acute phase reactants and the risk for in-hospital death and invasive mechanical ventilation was assessed using logistic regression models adjusting for demographics and comorbidities. RESULTS: Patients with both admission and 48-hour measurement for interleukin-6 (IL-6) (n = 541), procalcitonin (n = 828), ferritin (n = 1022), and C-reactive protein (CRP) (n = 1919) were included. Baseline characteristics were similar across all four populations. Increases in ferritin associated with a heightened risk of in-hospital death (OR 1.00032; 95%CI 1.00007- 1.00056; p < .001) and invasive mechanical ventilation (OR 1.00035; 95%CI 1.00014- 1.00055; p = .001). Therefore, for every 100 ng/mL increase in ferritin, the odds for in-hospital death and invasive mechanical ventilation increase by 3.2% and 3.5%, respectively. CONCLUSIONS: Delta in ferritin is associated with in-hospital death and invasive mechanical ventilation. Other acute phase reactants were not associated with these outcomes among COVID-19 inpatients.

COVID-19 , Adult , C-Reactive Protein , COVID-19/therapy , Ferritins , Hospital Mortality , Humans , Interleukin-6 , Procalcitonin , Respiration, Artificial , Retrospective Studies , SARS-CoV-2
Non-conventional in Times Cited: 0 0 | WHO COVID | ID: covidwho-732602


The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly pathogenic virus that causes severe pneumonia and acute respiratory distress syndrome. On March 11, 2020, this novel coronavirus was declared a pandemic by the World Health Organization. To date, millions of patients have been infected. Recent reports indicate that a substantial proportion of cases present with neurological symptoms. However, it remains to be elucidated whether these manifestations are secondary to direct nervous system invasion, indirect damage mediated by a systemic inflammatory response, or a combination of both. In this review, we explore the potential routes for central nervous system involvement, the possible pathogenic mechanisms in the nervous system and the conceivable neurological long-term sequoia of infection by SARS-CoV-2 infection. Future efforts should concentrate on clarifying the pathophysiology of the neurological component of COVID-19.