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1.
EuropePMC; 2020.
Preprint in English | EuropePMC | ID: ppcovidwho-310426

ABSTRACT

Background. Although the ongoing coronavirus disease 2019 (COVID-19) pandemics is directly contributing to derange global health and fitness, the restrictive measures applied for containing the outbreaks are also impacting detection and management of many diseases, including cancers. This study aimed to establish if and how the COVID-19 outbreak may have impacted the practice of routine prostate cancer screening in Verona, Italy.Methods. We searched the laboratory information system of the Service of Laboratory Medicine of the University Hospitals of Verona to identify all test requests for prostate-specific antigen (PSA) and vitamin D (Vit D;i.e., the most locally requested immunochemical test) for outpatients during the last five years (December 10, 2016, to December 10, 2020). The weekly requests for these tests placed between February 25 and December 9, 2020, was compared to those placed during the period of the previous four years (i.e., 2016-2019).Results. The volume of test requests for both Vit D and PSA did not differ in 2020 compared to the previous four years. However, a dramatic decline was observed during the local lockdown period (between March 10 and May 17, 2020), with a median decrease of 76% for Vit D and 62% for PSA, respectively. This reduction was compensated by 13% increase for Vit D and 43% increase for PSA in the post-lockdown period. Conclusion. These results show that the lockdown period established during the first peak of the COVID-19 outbreak in Italy’s Verona province was associated with a dramatic decrease in routine prostate cancer screening.

2.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-295434

ABSTRACT

Background: Nationwide COVID-19 (coronavirus disease 2019) vaccination campaigns have been effective to avert as many as 51% deaths in people aged ≥60 years in the European region between December 2020 and November 2021, though broad heterogeneity has been observed in the percentage of averted deaths across the different European countries. Methods: : We downloaded data of vaccine uptake and efficacy into an Excel Worksheet, and we then performed univariate (Spearman’s correlation) and multivariate (multiple linear regression analysis) correlations. Results: : A significant linear association was found between the percentage of averted deaths of older people and percentage of vaccine uptake in each corresponding European country (Spearman’s correlation: r=0.872;p<0.001), though such relationship was even better fitted by using an exponential curve (r=0.881;p<0.001). In multiple linear regression analysis, the percentage of deaths averted by COVID-19 vaccination remained independently associated with vaccine uptake (p<0.001), but not with the type of vaccine administered (p=0.264). Conclusions: : The results of analysis support the foremost importance of reinforcing nationwide COVID-19 vaccination campaigns, especially in those countries where vaccination programmes have been less successful.

3.
EuropePMC; 2021.
Preprint in English | EuropePMC | ID: ppcovidwho-293371

ABSTRACT

Background: Nationwide COVID-19 (coronavirus disease 2019) vaccination campaigns have been effective to avert as many as 51% deaths in people aged ≥60 years in the European region between December 2020 and November 2021, though broad heterogeneity has been observed in the percentage of averted deaths across the different European countries. Methods: : We downloaded data of vaccine uptake and efficacy into an Excel Worksheet, and we then performed univariate (Spearman’s correlation) and multivariate (multiple linear regression analysis) correlations. Results: : A significant linear association was found between the percentage of averted deaths of older people and percentage of vaccine uptake in each corresponding European country (Spearman’s correlation: r=0.872;p<0.001), though such relationship was even better fitted by using an exponential curve (r=0.881;p<0.001). In multiple linear regression analysis, the percentage of deaths averted by COVID-19 vaccination remained independently associated with vaccine uptake (p<0.001), but not with the type of vaccine administered (p=0.264). Conclusions: : The results of analysis support the foremost importance of reinforcing nationwide COVID-19 vaccination campaigns, especially in those countries where vaccination programmes have been less successful.

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