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1.
Journal of the American Society of Nephrology ; 33:34, 2022.
Article in English | EMBASE | ID: covidwho-2125037

ABSTRACT

Background: COVID-19-associated nephropathy (COVAN) is a type of collapsing glomerulopathy that leads to acute kidney injury (AKI) and overt proteinuria in individuals with apolipoprotein L1 (APOL1) polymorphism infected with SARS-CoV-2. Although the severity of the acute presentation of COVAN is well described, the long-term renal prognosis has not been clearly established. Method(s): We retrospectively identified native kidney biopsies from patients with diagnosis of COVAN discharged alive between January 2020 and March 2021. Time of biopsy pathological and clinical data were collected. We performed APOL1 genotyping for G1/G2 risk alleles. We examined the rate of end-stage kidney disease (ESKD), de novo or progressive chronic kidney disease (CKD) and death. Factors associated with those outcomes were assessed by logistic regression. Result(s): A total of 43 patients with COVAN with median follow-up at 244 days were included. Mean age was 53 +/- 12 years (range 30-78), 49% women, and 85% were of African descent. High-risk APOL1 genotypes were found in 86%. Most presented with AKI (91%) and nephrotic-range proteinuria (81%). Sixteen patients required dialysis at presentation (AKI-RRT), 8 of which reached ESKD and dialysis dependence at followup. Additionally, 6 patients without AKI-RRT developed ESKD and required dialysis at follow-up. Forty patients (93%) either developed de novo CKD or progressed to advanced stage of CKD [mean serum creatinine (sCr) 3.1 +/- 1.9 mg/dL]. Overall, 35% reached the combined endpoint of ESKD, progressive CKD or death. Predictive factors of ESKD included older age (59.1 +/- 13.9 vs. 50.4 +/- 10.7 years, p=0.03), increased sCr at time of biopsy (9.4 +/- 3.2 vs. 6.0 +/- 4.9, p=0.03), increased glomerular obsolescence (52.8 +/- 21.3 vs. 25.0 +/- 23.2%, p=0.0005), and IFTA [moderate-severe vs. mild, OR 9.8 (CI: 1.1-85.2), p=0.03]. AKI-RRT, sex, proteinuria at the time of biopsy, and absence vs. presence of an APOL1 high-risk genotype were not predictive of ESKD. Conclusion(s): COVAN is associated with ominous long-term renal sequelae. Serum creatinine at time of biopsy, patient age, glomerular obsolescence, and IFTA are associated with greater risk of ESKD.

2.
Libraries, Digital Information, and COVID: Practical Applications and Approaches to Challenge and Change ; : 135-147, 2021.
Article in English | Scopus | ID: covidwho-1787969

ABSTRACT

During the COVID-19 pandemic, schools and exams were shut down globally. The socioeconomic impact of lost learning will have damaging future consequences for recovery, growth, and national security. Despite the rise and scale of the learning technology market, technology-enabled teaching strategies proved ineffective overall at engaging learners with digital information, highlighting a significant deficit in the broader capabilities required to run education remotely for mass cohorts. The inconsistent results of a technology-enabled approach also underlined shortcomings in government ambitions to reform the structure of learning and assessment systems. Some countries proactively “massified” access to digital platforms and assessment technology by centrally coordinating content and development sprints. Across the global south, “low-tech” media and “open-book” assessments enabled learners from the poorest communities to continue studying. Policymakers must now aggregate the best practice that emerged during lockdowns into a collective change programme and plan to deal with future school closures. NGOs and supranational education institutions that transcend national political timescales should be invited play a central role in stewarding radical reform and updating the architecture of teaching and assessment. © 2021 David Baker and Lucy Ellis Published by Elsevier Ltd.

3.
Proc Natl Acad Sci U S A ; 118(32)2021 08 10.
Article in English | MEDLINE | ID: covidwho-1747104
4.
Search-Journal of Media and Communication Research ; 13(1):61-77, 2021.
Article in English | Web of Science | ID: covidwho-1688297

ABSTRACT

Gastronomic tourism is a strong motivator for tourists to visit destinations famous for their cuisine and street food. Street food is a socially and culturally recognised food source that is inexpensive, easy, and appealing for both urban and rural populations worldwide. As a unique destination attractor, street food can be a useful tool in marketing destinations. In Malaysia, the street food sector is one of the many industries that employs many foreign workers to resolve its labour shortage due to Malaysia's rapid economic growth and demand for unskilled workers. Regrettably, foreign workers have contributed considerably towards the total number of COVID-19 cases in Malaysia. This research explores street food traders' perspective regarding the hiring of foreign workers for their stalls during the COVID-19 pandemic and the impact of the pandemic on these workers. Using the theory of planned behaviour as the underlying theory, researchers obtained qualitative data from in-depth interviews with eight street food traders and five foreign workers from October to December 2020. The thematic analysis of the interview data was done using NVivo 12 Pro. The findings provide some insights on the motivations for recruiting foreign workers in terms of attitude, perceived social pressure and perceived behavioural control. In light of the findings, the government should review its foreign workforce and design nuanced policies to accommodate the labour needs of specific economic sectors while striving towards reducing foreign labour dependence.

5.
Journal of the Academy of Nutrition and Dietetics ; 121(9, Supplement):A29, 2021.
Article in English | ScienceDirect | ID: covidwho-1364158
6.
Journal of Asian Finance Economics and Business ; 8(5):951-959, 2021.
Article in English | Web of Science | ID: covidwho-1266973

ABSTRACT

The study investigated the effect of food safety knowledge, food safety trust and the factors influencing organic food purchase intention in the 'new normal' of the COVID-19 pandemic. The study employed non-contrived and cross-sectional methods. The data was collected in Malaysia using convenience sampling. A total of 330 valid questionnaires were analyzed using Structural Equation Modelling (SEM) and PROCESS for hypothesis testing. The study revealed a significant relationship involving food safety knowledge on personal attitude, perceived social pressure, and perceived autonomy. Moreover, organic food purchase intention was found to be influenced by personal attitude, perceived social pressure, and perceived autonomy. Interestingly, trust in organic food safety moderated the relationship between perceived autonomy and organic food purchase intention. The study proved valuable for stakeholders and organic food producers to understand the 'new normal' COVID-19 market scenario for a sound understanding of the market and the sustainability of the organic food industry. A new research framework is proposed and validated, related to individual purchase decision in global health issues which is limited in current literature. Hence, the study contributed to a better comprehension of green consumerism mainly in the Asian market.

8.
Proc Natl Acad Sci U S A ; 118(2)2021 01 12.
Article in English | MEDLINE | ID: covidwho-1015064
9.
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