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1.
Hepatology ; 76(Supplement 1):S1479, 2022.
Article in English | EMBASE | ID: covidwho-2157796

ABSTRACT

Background: Evolution toward remote lifestyles, including healthcare access, has accelerated due to the COVID-19 pandemic. Challenges related to participant recruitment and retention mean clinical trial design is also evolving toward a remote model where trials use digital health technologies and services to improve patient experience. A Decentralized Clinical Trial (DCT) is an emerging model where assessment of patients can occur outside of a traditional site, including at a patient's own home. Hybrid trials which incorporate some DCT components increase convenience and enhance accessibility to patients. Several professional organizations including the Clinical Trials Transformation Initiative and Decentralized Trials and Research Alliance advocate DCT design in clinical studies. Draft guidance on the use of digital health technology for remote data acquisition from participants in clinical trials has been recently issued by the FDA. They recognize that to improve participant recruitment and retention, and increase patient diversity, remote data collection can allow more frequent or even continuous data collection that may better represent real-world experience with the study drug. DCTs are particularly relevant for rare diseases such as PBC where patients may not be in close proximity to a specialist. In fact, 70% of patients with PBC surveyed indicated they would be more likely to participate in a clinical trial if remote options were available. Method(s): The Phase 3 GLISTEN trial (NCT04950127) is investigating the efficacy and safety of linerixibat for the treatment of cholestatic pruritus in patients with PBC. Several operating models are in place, including a fully decentralized option (Figure). DCT elements included in GLISTEN include digital recruitment of patients via social media/patient groups, remote completion of informed consent, telemedicine, electronic clinical and patient-reported outcome (PRO) assessments, home health visits, and direct shipment of study drug/placebo to the patient's home. The primary endpoint in GLISTEN is a PRO, making it compatible with a DCT approach. Result(s): Patient recruitment is ongoing;the study is active at physical study sites worldwide and as a fully remote DCT in the USA. Conclusion(s): Incorporation of DCT design elements into GLISTEN is expected to address the issues of limited numbers and diversity of patients recruited, which is particularly important for a rare disease such as PBC.

2.
12th Annual IEEE Global Humanitarian Technology Conference, GHTC 2022 ; : 23-29, 2022.
Article in English | Scopus | ID: covidwho-2136176

ABSTRACT

Work-induced stress is a large problem that has only been exacerbated by the coronavirus pandemic. Nature has beneficial effects on psychological and physiological well-being, with an abundance of scientific literature demonstrating the ability of greenery to reduce stress. As such, the fusion of nature-based design into the work and academic environments has the potential to greatly decrease student and employee stress. Primary methods of incorporating greenery indoors include living walls and potted plants. However, these methods fall short of creating an immersive environment that maximizes the positive impact on worker well-being, and additionally, barriers such as maintenance, costs, and extensive construction limit implementation. This paper outlines a new method to integrate nature into the work environment through 'EcoRealms,' which are immersive, natural spaces created by modular and self-maintaining 'living partitions.' These low-cost, easy-to-install partitions act as design elements to create a flexible space that serves worker well-being and enhances productivity. Discussed are prototypes that demonstrate the design's technical feasibility and results from a self-reported questionnaire that validate the positive impacts of the EcoRealm on wellbeing. © 2022 IEEE.

3.
Monthly Notices of the Royal Astronomical Society ; 509(2):1929-1939, 2022.
Article in English | Web of Science | ID: covidwho-1584216

ABSTRACT

We conducted a drift-scan observation campaign using the 305-m Arecibo telescope in 2020 January and March when the observatory was temporarily closed during the intense earthquakes and the initial outbreak of the COVID-19 pandemic, respectively. The primary objective of the survey was to search for fast radio transients, including fast radio bursts (FRBs) and rotating radio transients (RRATs). We used the seven-beam ALFA receiver to observe different sections of the sky within the declination region similar to(10 degrees-20 degrees) on 23 nights and collected 160 h of data in total. We searched our data for single-pulse transients, of covering up to a maximum dispersion measure of 11 000 pc cm(-3) at which the dispersion delay across the entire bandwidth is equal to the 13-s transit length of our observations. The analysis produced more than 18 million candidates. Machine learning techniques sorted the radio frequency interference and possibly astrophysical candidates, allowing us to visually inspect and confirm the candidate transients. We found no evidence for new astrophysical transients in our data. We also searched for emission from repeated transient signals, but found no evidence for such sources. We detected single pulses from two known pulsars in our observations and their measured flux densities are consistent with the expected values. Based on our observations and sensitivity, we estimated the upper limit for the FRB rate to be <2.8 x 10(5) sky(-1) d(-1) above a fluence of 0.16 Jy ms at 1.4 GHz, which is consistent with the rates from other telescopes and surveys.

4.
Investigative Ophthalmology and Visual Science ; 62(8), 2021.
Article in English | EMBASE | ID: covidwho-1378839

ABSTRACT

Purpose : Humphrey Visual Field (HVF) testing presents challenges for patients with limited mobility. Virtual reality-based visual field testing could provide a practical and portable alternative for visual field testing. This study examines the agreement between Virtual Field (VF), a virtual reality-based visual field test, and HVF. Methods : HVF SITA-Fast and VF BOLT Threshold were performed on both eyes of 40 normal subjects (age 23-66), right eye tested first. The test strategies were randomized. Subjects wore surgical masks in accordance with COVID-19 protocol. Outcome measures included mean deviation (MD), test time and visual field index (VFI). Each patient completed a survey about their experience. Eight eyes were excluded due to unreliable results (FL >20%, FP> 15%). Results : There was not a statistical difference between the right and left eye data on a paired t-test. P-values for HVF were 0.0824, 0.7206, and 0.5663 for MD, VFI and time respectively. P-values for VF were 0.3743, 0.9821, and 0.9872 for MD, VFI and time respectively. The right and left eyes were pooled for analysis. Average MD values were-0.19 dB for HVF and-2.38 dB for VF. Average VFI values were 99.4% for HVF and 96.2% for VF. Average test times were 176.5 sec for HVF and 194.0 sec for VF. When comparing VF to HVF, VF had mean differences (SD) of-2.18 dB (3.36),-3.2% (7.1) and 17.6 sec (39.7) in MD, VFI and time respectively. 95% CIs [-2.98,-1.40], [-4.89,-1.53], and [8.25, 26.89] respectively. All parameters were level dependent on Bland-Altman analysis with greater bias as the results deviated from normal. The bias in MD (mean difference ±SD) was lower for the 29 eyes that did not require trial lenses (-1.0±2.5 dB) than for the 43 eyes that required trial lenses (-3.1± 4.1 dB). 95% CI [-1.90, -0.04], [-4.33, -1.80] respectively. The difference in bias between the two groups was statistically significant (p=0.0163). There was a statistically significant difference (p = 0.0011) between subjects who reported some level of fogging on VF (61.6%) compared to the subjects who reported some level of fogging on HVF (19.4%). Conclusions : VF results did not agree with HVF results. There was more bias between the two tests when a trial lens was required. More subjects experienced fogging of the trial lens on VF than HVF.

5.
MMWR Morb Mortal Wkly Rep ; 69(early release), 2020.
Article | Centers for Disease Control and Prevention | ID: grc-740482

ABSTRACT

This report describes confirmed coronavirus disease 2019 cases among incarcerated or detained persons or staff members across 420 correctional and detention facilities in the United States.

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