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1.
Journal of Wealth Management ; 25(3):72-89, 2022.
Article in English | Scopus | ID: covidwho-2163787

ABSTRACT

The link between the uncertainty of stock markets and the emotional stress of the COVID-19 pandemic has been studied by numerous researchers. For example, a few studies have provided mixed evidence about the behavioral responses of individual retail investors and their financial risk tolerance and stock trading. To the best of the authors' knowledge, however, this study is the first to analyze the influence of the psychological aspects of the pandemic on these investors' financial responses. A total of 396 investors from India participated in the study, and a mediational analysis was performed using AMOS to explore whether the perceived financial threat (PFT) was a linkage between personality traits (PTs), trading preferences, and risk tolerance during the pandemic. The results show that the PFT was a mediator between PTs and stock trading and between PTs and risk tolerance. Additionally, investors with various PTs had varying intensities of the PFT, which eventually impacted financial behavior in the form of trading and risk aversion. © 2022 Journal of Structured Finance. All right reserved.

2.
Emerg Infect Dis ; 28(13):105-113, 2022.
Article in English | PubMed | ID: covidwho-2162914

ABSTRACT

The COVID-19 pandemic spread between neighboring countries through land, water, and air travel. Since May 2020, ministries of health for the Democratic Republic of the Congo, Tanzania, and Uganda have sought to clarify population movement patterns to improve their disease surveillance and pandemic response efforts. Ministry of Health-led teams completed focus group discussions with participatory mapping using country-adapted Population Connectivity Across Borders toolkits. They analyzed the qualitative and spatial data to prioritize locations for enhanced COVID-19 surveillance, community outreach, and cross-border collaboration. Each country employed varying toolkit strategies, but all countries applied the results to adapt their national and binational communicable disease response strategies during the pandemic, although the Democratic Republic of the Congo used only the raw data rather than generating datasets and digitized products. This 3-country comparison highlights how governments create preparedness and response strategies adapted to their unique sociocultural and cross-border dynamics to strengthen global health security.

3.
12th Annual IEEE Global Humanitarian Technology Conference, GHTC 2022 ; : 333-340, 2022.
Article in English | Scopus | ID: covidwho-2136177

ABSTRACT

Sierra Leone has one of the highest maternal mortality rates in the world. In 2010, a new initiative was implemented to provide free healthcare to pregnant women, breastfeeding mothers, and children under the age of five. While this well-intentioned initiative strengthened maternal health in some respects, it added additional dynamics to the complex patient-provider relationships at various levels of the referral-based public health infrastructure. The genesis of these observations and the subsequent research into the complexities of these relationships can be traced to the authors' work over the past five years in championing the integration of a low-cost diagnostic device for pregnant women across 56 rural health clinics. Based on a comprehensive review of the literature, this article describes the complexities of the various types of patient-provider relationships and the role that technology innovations might play in strengthening them. There is a specific emphasis on the impact of the Ebola epidemic in 2014-2016 and the COVID-19 pandemic on patient-provider relationships. This article is of particular interest to technology innovators seeking to integrate novel diagnostic and therapeutic interventions in rural settings in low-resource countries such as Sierra Leone. © 2022 IEEE.

4.
12th Annual IEEE Global Humanitarian Technology Conference, GHTC 2022 ; : 23-29, 2022.
Article in English | Scopus | ID: covidwho-2136176

ABSTRACT

Work-induced stress is a large problem that has only been exacerbated by the coronavirus pandemic. Nature has beneficial effects on psychological and physiological well-being, with an abundance of scientific literature demonstrating the ability of greenery to reduce stress. As such, the fusion of nature-based design into the work and academic environments has the potential to greatly decrease student and employee stress. Primary methods of incorporating greenery indoors include living walls and potted plants. However, these methods fall short of creating an immersive environment that maximizes the positive impact on worker well-being, and additionally, barriers such as maintenance, costs, and extensive construction limit implementation. This paper outlines a new method to integrate nature into the work environment through 'EcoRealms,' which are immersive, natural spaces created by modular and self-maintaining 'living partitions.' These low-cost, easy-to-install partitions act as design elements to create a flexible space that serves worker well-being and enhances productivity. Discussed are prototypes that demonstrate the design's technical feasibility and results from a self-reported questionnaire that validate the positive impacts of the EcoRealm on wellbeing. © 2022 IEEE.

5.
Journal of the Scientific Society ; 49(2):180-185, 2022.
Article in English | Web of Science | ID: covidwho-2072004

ABSTRACT

Background: The novel severe acute respiratory syndrome-coronavirus-2 virus has undoubtedly disrupted the life of every individual and created a global health and economic crisis. Health-care systems, including dental clinics, were affected and patients with dental pain suffered since they were unable to seek dental care at the right time. It has since become relevant to examine and understand the outlook and views of patients toward seeking routine dental services and their acceptance of alternative methods of dental practice through the COVID-19 pandemic. Hence, this cross-sectional questionnaire study was conducted to assess the knowledge, attitude, and opinion of patients visiting a dentist for routine dental services during the COVID-19 pandemic Methodology: A cross-sectional questionnaire-based survey was conducted among 200 patients who visited the dental college for their treatment. Their responses were recorded and descriptive analysis, Chi-square test, and multiple logistic regression analysis were carried out to evaluate their responses. Results: The participants were aware of the transmission of COVID-19 (91%), 64% believed it was safe to visit a dentist and 99.5% believed it necessary to take proper precautions before visiting the dentist. Participants (84%) preferred having dental consultations over phone/email/video calls compared to regular in-person consultations during the pandemic. Conclusion: Teledentistry has the potential to emerge as an effective mode of managing patients with dental needs to reduce the burden on dental clinics and hospitals. It can ensure the accessibility to dental care even in the remotest area by allowing patients to connect with dentists through appropriate digital and social media.

6.
Industry 4.0 and Intelligent Business Analytics for Healthcare ; : 253-269, 2022.
Article in English | Scopus | ID: covidwho-2058180

ABSTRACT

COVID-19 is causing turmoil across the world’s healthcare systems, aiming to contain the spread of pandemics and develop the basis for global economic productivity. A professional healthcare infrastructure would depend on the country’s commitment to ethical principles, a prerequisite for effective anti-corruption governance. It serves as the creative growth accelerator for healthcare. COVID is a global threat to not all human health but also to the country’s economic balance. The chapter has initiated to evaluate the relationship of the variables such as the Artificial Intelligence (AI) techniques, Global Connectivity levels, Corruption levels, and the health care systems. The research has been conducted using secondary data collected from various published online and offline sources. Our study’s sample covers the various indexesrecorded by 71 countries from all over the globe. The chapter exhibits a clear and positive impact of all the variables on each other. The indexes calculated also showed that the country having a robust AI framework will have good governance resulting in an anticorruption healthcare system. © 2022 Nova Science Publishers, Inc.

7.
Journal of Clinical and Diagnostic Research ; 16(9):XD01-XD03, 2022.
Article in English | EMBASE | ID: covidwho-2033408

ABSTRACT

Chronic lymphocytic leukaemia is a haematological malignancy that occurs due to an increased proliferation of mature B lymphocytes. It is considered to be the most common leukaemia in adults. Hyponatremia is commonly seen in such patients. This case report is about a 75-year-old male, who presented with giddiness, followed by altered sensorium. However, the patient had no motor weakness or sensory loss. Initially, a diagnosis of posterior circulation stroke was made but Magnetic Resonance Imaging (MRI) brain did not show associated signs. The routine investigations showed highly elevated total leukocyte count and hyponatremia. The patient was worked up for malignancy and diagnosed with Chronic lymphocytic leukaemia. Oncology reference was taken and treated with tablet Ibrutinib. On discharge, the patient's mentation improved, and he is on regular follow-up.

9.
8th International Conference on Advanced Computing and Communication Systems, ICACCS 2022 ; : 1550-1553, 2022.
Article in English | Scopus | ID: covidwho-1922643

ABSTRACT

In the recent times, digital financial services have seen exponential growth with expanded opportunities to individuals, especially women. In 2020, more than 240 million women, as compared to data of the year 2014, have a bank account and access to mobile payment services. However, compared to men, women are more likely to be poor and have less participation in the formal economy. They mostly find jobs in the informal economy. Therefore, there is a need to support women's financial status by providing them with appropriate infrastructure and resources and removing barriers to digital financial inclusion. In addition, the policymakers need to address the challenges in access to financial services for women, different laws and regulations, and limited access to technology. The study explores the challenges to women's access to online banking and policy options to strengthen women's participation in digital financial services. © 2022 IEEE.

10.
CSR, Sustainability, Ethics and Governance ; : 155-170, 2022.
Article in English | Scopus | ID: covidwho-1877771

ABSTRACT

Trafficking in persons (TIP) has become ‘an issue without borders’, where worldwide, 24.9 million people are prey to this act of human rights violation. India has been combatting this issue as a source, transit and destination country for both sex-based and non-sex-based exploitation. This is because, India, despite much development in the socio-economic sector in recent times, remains an emerging nation with dismal social indicators and porous international borders that nurtures unsafe migration. To make matters worse, the COVID-19 pandemic has further increased the vulnerability of certain sections of the people to trafficking. While the government has taken certain steps to tackle the issue of trafficking in persons, but the business sector, has remained oblivious to such pressing social matters. However, only recently, the Companies Act, 2013 was passed and the new statute incorporated Section 135 and Schedule VII within its purview that deals with mandated Corporate Social Responsibility (CSR) for certain large, stable companies. Section 135 lays down the requirement of the law for conducting CSR and Section VII lays down a list of broad areas in which the CSR resources need to be spent. Interestingly, much of the Schedule VII corresponds to the 17 broader goals of the Sustainable Development Goals (SDGs) as laid down by the United Nations in the year 2015, that became effective from 2016. This paper aims to document some of the causes of trafficking in persons in India as well as map the various ways in which the corporate sector can do its part in combatting such a social problem through its CSR interventions. © 2022, Springer Nature Singapore Pte Ltd.

11.
Clinical Cancer Research ; 27(6 SUPPL 1), 2021.
Article in English | EMBASE | ID: covidwho-1816883

ABSTRACT

Background The SARS-CoV-2 pandemic has assaulted all aspects of daily life. Medical professionals in oncology face additional challenges with balancing prompt cancer diagnosis and urgent treatment against potential COVID-19 exposure risk in these high-risk patients. We designed this prospective freewill study to offer testing for SAR2-CoV-2 viral RNA and/or anti-COVID-19, respectively in asymptomatic medical and research staff who work in direct contact with cancer patients. The overall goal was to evaluate the prevalence of infection in this group of asymptomatic healthcare providers to reduce exposure of cancer patients to asymptomatic staff. Methods Asymptomatic medical and research staff who work in direct contact with cancer patients were asked to voluntarily be tested for either SARS-CoV-2 viral RNA or antibodies or both. Either NP swabs and/or blood samples (EDTA tube) were collected. Tests are performed at Sinochips Kansas LLC, Sinochips Diagnostics (CLIA number:17D2176068, CAP number: 8709463). The PCR test is performed with FDA authorized 2019-Novel Coronavirus (2019-nCoV) Real-Time RT-PCR Diagnostic Panel EUA. The Elecsys® Anti-SARS-CoV-2 (Roche Diagnostics) immunoassay was used to qualitative detection of antibodies to SARS-CoV-2 in human plasma. Results From 06/18/2020 to 12/18/2020, 861 participated in the study. 1095 tests were completed for SAR2-CoV-2 virus infection, and 918 were completed for antibody. Amount participants, 530 had both virus and antibody tested. 235 were tested more than once for viral infection and 166 were tested more than once for the antibody. Median age of participants was 39 years (IQR 32-51 years). Among these 84.7% were females, 84.4% white, 6.7% African American, 4.8% Asian and 84.7% non-Hispanic. The cumulative incidence of a positive test for the virus was 2.2% (16/712), and for the antibody test was 3.8% (26/679). 5 had both viral and antibody tests positive, with an average time of 4.1 weeks from viral testing positivity to detectable antibody among 3 cases and 2 cases with both viral infection and antibody detected at same time. There were 3 cases virus was detected more than once after turning positive. 2 remained positive at 16 and 22 days after initial test and one turned negative at 36 days as of last follow up. There were 7 cases where the antibody was tested more than once after turning positive and all 7 remained positive as of last follow up (range 7-103 days). Conclusion Prospective voluntary testing in asymptomatic medical and research staff who work in direct contact with cancer patients was feasible and resulted in identification of asymptomatic carriers who then placed in quarantine, thereby limiting exposure to cancer patients. Medical and research staff who work with cancer patients are general very cautious and the frequency of infections were significantly lower than general society. In addition, it seems that 1) virus and antibody may co-exist in the same person after exposure, and 2) the antibody may last for a relatively long time.

12.
Open Forum Infectious Diseases ; 8(SUPPL 1):S685-S686, 2021.
Article in English | EMBASE | ID: covidwho-1746320

ABSTRACT

Background. The COVID-19 pandemic resulted in unprecedented implementation of wide-ranging public health measures globally. During the pandemic, dramatic decreases in seasonal influenza virus detection have been reported worldwide. Information on pediatric influenza-related hospitalizations is limited. We describe influenza-related hospitalization in Canadian children during the 2020/2021 influenza season compared to ten previous seasons. Methods. Data on influenza-related hospitalizations, intensive care unit (ICU) admissions and in-hospital deaths in children across Canada were obtained from the Canadian Immunization Monitoring Program, ACTive (IMPACT). This national surveillance initiative comprises 90% of all tertiary care pediatric beds in Canada. The total study period included eleven influenza seasons from September 2010 to April 2021 inclusive. Time series modelling was used to compare trends in influenza-related hospitalizations during the 2020/2021 season (September 2020 to April 2021 inclusive) with the ten previous seasons. Results. During the 2020/2021 influenza season there were no pediatric influenza infection-related hospitalizations. This was a significant decrease compared to the predicted total influenza-related hospitalizations for this period (p< 0.001). No pediatric ICU admission or deaths were reported for the 2020/2021 influenza season. Conclusion. We show complete absence of influenza infection-related hospitalization in children in Canada during the 2020/2021 season. This significant decrease is likely related in large part to non-pharmacological public health interventions implemented during the COVID-19 pandemic, although the potential role of viral interference is unknown. Our findings suggest measures such as use of facemasks, hand-washing, distancing and school closures may be beneficial for influenza control and mitigation of future influenza epidemics.

13.
Journal of Clinical and Diagnostic Research ; 15(11):EC11-EC14, 2021.
Article in English | Web of Science | ID: covidwho-1572931

ABSTRACT

Introduction: The pandemic Coronavirus Disease 2019 (COVID-19) continues to be a significant problem worldwide. The disease pattern ranges from mild to life threatening pneumonia. Association of COVID-19 with mucormycosis is rare but an increase in this association has been observed recently, particularly in a background of immunocompromised state with rhino-orbital-cerebral region being the most common site of involvement. Aim: To study the site and presentation of mucormycosis in COVID-19 patients with histopathological association. Materials and Methods: A descriptive study was conducted at American International Institute of Medical Sciences, Udaipur, Rajasthan, India, in which 1st 20 patients of COVID-19 with mucormycosis of rhino-orbital region were included in the study. The study was conducted for a period of two months (April-May 2021). Detailed clinical history and associated co-morbidities were noted for each patient. Histopathological examination of all the specimens resected for fungal infection was done along with special stain. Statistical analysis was done using Chi-square test. Results: COVID-19 association with mucormycosis was observed in all 20 cases. Maximum number of cases (11) was present in the age group of 20-40 years. Diabetes Mellitus (DM) had a strong association with mucormycosis. Maxillary sinus was most commonly associated site. Preoperative Potassium Hydroxide (KOH) was positive in all 20 cases, detailed histopathology study along with Periodic Acid Schiff (PAS) stain was performed in all cases. Additional microscopic findings like angioinvasion (03), granuloma (01) and giant cell reaction (13) were also recorded. Conclusion: COVID-19 has emerged as a global threat to mankind. In the present scenario the entire medical fraternity should have a prompt and team approach towards the management of this pandemic, in terms of, early detection of the infection, meticulous use of corticosteroids and screening of comorbidities to safeguard patients from such life threatening fungal infections.

14.
Journal of Clinical Oncology ; 39(15):3, 2021.
Article in English | Web of Science | ID: covidwho-1538147
15.
Journal of Clinical Oncology ; 39(15 SUPPL), 2021.
Article in English | EMBASE | ID: covidwho-1339379

ABSTRACT

Background: Obesity is a bona fide risk factor for ICU admission, mechanical ventilation, and mortality in patients (pts) with COVID-19 in the general population. However, whether obesity is a risk factor in cancer pts remains unknown. Herein, we have conducted a systematic review/meta-analysis of obesity and all-cause mortality in cancer pts with COVID-19. Methods: Following PRISMA guidelines,a systematic search of PubMed and Embase as well as major conference proceedings (ASCO/ESMO/AACR) was conducted for publications from inception to 14 January 2020. Observational studies that reported all-cause mortality in cancer pts with lab confirmation or clinical diagnosis of COVID19 and BMI (obese (>30 kg/m2 ) vs. non-obese) were included in the analysis. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated with the fixed-effects model based on low heterogeneity. Small sample publication bias was evaluated using the Begg's Funnel Plot and Egger's test. Results: After reviewing 3387 studies,3 retrospective cohort studies of 419 obese and 1694 non-obese cancer pts (N=2117) with COVID-19 in both inpatient/outpatient settings that reported outcomes based on obesity were found. The 3 studies were conducted multi-nationally in North America, in France, and in the Netherlands respectively. The median ages of the cohorts ranged 66-68. All studies included various cancers of various stages and were of high quality per Newcastle Ottawa scale (scores 7-9). Fixed effects metaanalysis showed no association between obesity and all-cause mortality (OR 0.95, 95% CI 0.74- 1.23) in cancer pts with COVID-19. Heterogeneity was low (I2= 33%). No significant funnel plot asymmetry was detected per Egger's test (P=0.2273). The reported OR of each study is outlined in the table. Conclusions: In contrast to the general population, our analysis reveals that obesity is not associated with increased all-cause mortality in cancer pts with COVID-19. Limitations of this study include a limited number of included studies, reliance on retrospective studies, non-use of ethnicityspecific WHO BMI criteria, and limited granularity of the study-reported BMI. Future prospective studies are warranted to assess the complex interplay among anthropomorphic measures, cachexia/sarcopenia, comorbidities associated with the metabolic syndrome, and COVID-19 outcomes in the cancer pt population. (Table Presented).

17.
Journal of the Indian Medical Association ; 119(1):16-23, 2021.
Article in English | EMBASE | ID: covidwho-1106848

ABSTRACT

With the growing understanding of coronavirus disease-2019 (COVID-19) pathogenesis, different therapeutic targets are being considered for the management of COVID-19. The development of new drugs is a time-consuming process;hence, many drugs acting on similar therapeutic targets/sites in the COVID-19 treatment are repurposed in COVID-19. In this article, an expert panel deliberated on the existing evidence on the immunopathogenesis, therapeutic targets under consideration for treatment of COVID-19, and the place of mefenamic acid in the therapy landscape of COVID-19. The expert panel has also provided recommendations regarding the dose and regimen of mefenamic acid in different phases of the COVID-19 disease.

18.
Clinical Cancer Research ; 26(18 SUPPL), 2020.
Article in English | EMBASE | ID: covidwho-992067

ABSTRACT

Importance: There is strong evidence that COVID-19 is associated with higher morbidity and mortality in malescompared to females in the general population. However, whether the same sex bias exists in the cancer patientpopulation is unknown. Several published studies have examined this question, but the results are inconclusive andinconsistent and the association remains unclear. Objective: To evaluate the sex differences in the risk of severe illness and mortality attributable to COVID-19 in thecancer patient population. Data Sources: Published articles that evaluated clinical outcomes associated with severe illness or deathattributable to COVID-19 in the cancer patient population from inception to June 1, 2020, were identified bysearching PubMed and EMBASE, as well as the ASCO 2020 Virtual Annual Conference, ESMO conferences heldfrom January 2020 to June 1, 2020, and the preprint databases medRxiv and bioRxiv. Study Selection: Prospective or retrospective analyses, studies published in English, providing clinical outcomesdata with sex differences in the cancer patient population. Data Extraction and Synthesis: Author, date of publication, country, type of studies, median and range of age, cancer types included in the studies, definitions of clinical outcomes, and the odds ratios (OR) for severe illness ordeath attributable to COVID-19 were retrieved. Where OR data were not available, raw data were used to calculatethe OR in a univariate analysis model and included in the meta-analysis. Main Outcome(s) and Measure(s): The primary outcome of interest was OR of (1) severe illness, (2) death, and(3) composite outcome of severe illness and death attributable to COVID-19 in males versus females. Results: Overall, 2,764 patients (9 studies) were analyzed in retrospective study settings. Of the included studies, two studies were multinational whereas the rest were conducted in China (4), France (1), United Kingdom (1), andUnited States (1). Median ages were similar across studies (range 62-70). Three studies reported outcomes fordeath and six studies reported outcomes for severe illness. Of the seven studies, all but one defined severe illnessas illness requiring ICU admission or leading to death and attributable to COVID-19. Pooled ORs for the compositeoutcome was 1.68 (95% CI, 1.27-2.24), death was 1.98 (95% CI, 1.21-3.26), and severe illness was 1.48 (95% CI,1.05-2.10), all disfavoring males. Random effects model was used with the Dersimonian-Laird Model throughoutanalyses and significant heterogeneity was subsequently confirmed (I2, 48.1%;tau2, 0.0816). No significantbetween-study bias was detected per Begg's funnel plot. Conclusions and Relevance: The male sex was associated with higher risk of severe illness, death, and thecomposite outcome of both attributable to COVID-19. This finding has implications in informing the clinical prognosisand decision making regarding oncologic patients.

19.
Clinical Cancer Research ; 26(18 SUPPL), 2020.
Article in English | EMBASE | ID: covidwho-992065

ABSTRACT

Background: There is insufficient evidence to support clinical decision-making for oncology patients diagnosed withCOVID-19 due to the limited studies focusing on factors affecting COVID-19-associated disease severity/death incancer patients. Methods: We retrospectively analyzed data from KU Cancer Center to assess demographic/clinical characteristicsand ferritin levels of 40 cancer patients with a confirmed COVID19 diagnosis by viral RNA detection in anasopharyngeal swab between 3/1/20 through 6/9/20. Chi square test and Mann-Whitney U test were used toidentify whether demographic/clinical characteristics and ferritin were associated with COVID-19 severity/death. Results: Median age was 59.5 years, 16 (40%) were aged 65 years or older, and 18 (45%) patients were male. 31(77.5%) were non-Hispanic, 21 (52%) were Caucasians, 11 (27%) were African Americans, and 21 (52.5%) werecurrent/former smokers. 14 (35%) were obese. Breast cancer n=9 (22.5%) was the most prevalent malignancy. 28(70%) had ECOG of 0/1. 27 (67.5%) were on active anticancer treatment, and 13 (32.5%) had active (measurable)cancer. 12 (30%) had recent surgery. 6 (15%) were asymptomatic and 34 (85%) were symptomatic. Fever (47.5%), cough (57.5%), productive cough (50%), and shortness of breath (47.5%) were the most common symptoms. Atanalysis (June 9, 2020), 3 (7.5%) patients had died. 8 (38.1%) had mild/moderate COVID-19 illness and 13 (61.9%)had severe illness (ICU admission, intubation, death). Patients with mild/moderate illness were significantly younger(median age 56.5 years) vs. those with severe illness (median age 67.5 years), p=0.02. Sex, race and ethnicity, obesity, ECOG, cancer type, active cancer treatment, and recent surgery were not associated with COVID-19severity. However, productive cough (p=0.01) and shortness of breath (p=0.006) were associated with COVID-19severity. In 19 patients with available ferritin levels, asymptomatic patients (n=2) had a significantly lower ferritin(median 68.5 NG/ML) vs. symptomatic (n=17), who had higher ferritin (median 422 NG/ML) p=0.04. Conclusions: Age was associated with an increased risk of COVID-19-related disease severity/death in cancerpatients. This may possibly reflect the effects of more advanced malignant disease, anticancer treatment, andcomorbidities on the impact of this infection. Ferritin levels appear to have a role in screening and monitoring forCOVID-19 infection in cancer patients. Hence, our findings warrant validation in a larger cohort. A prospective studyis under way at the University of Kansas Cancer Center to validate the factors associated with COVID-19-relateddisease severity/death in cancer patients.

20.
Clinical Cancer Research ; 26(18 SUPPL), 2020.
Article in English | EMBASE | ID: covidwho-992035

ABSTRACT

Background: The oncology community faces unprecedented challenges in balancing a delay in cancer treatmentagainst the risk for a potential COVID-19 infection and associated complications. An early retrospective analysisreported that cancer patients with COVID-19 infection have a much higher death rate than those infected but withouta cancer diagnosis, likely because of their immunocompromised disease from cancer and treatment. Even thoughCOVID-19 is known to have a long incubation period (∼14 days), there were no clear guidelines for screeningasymptomatic cancer patients who are planning to have and having antitumor treatment as of April 2020. Methods: We developed a protocol to screen asymptomatic cancer patients for COVID-19 who are scheduled toreceive cancer-directed treatment (i.e., chemotherapy, targeted therapy, immunotherapy, anticancer monoclonalantibody, endocrine therapy, or investigational agent). The protocol was developed and activated within 2 weeksthrough the Cancer Center Investigator Initiated Trial Program. FDA-authorized CDC 2019-Novel Coronavirus(2019-nCoV) Real-Time RT-PCR Diagnostic Panel EUA kit was performed at Sinochips Diagnostics. The primaryobjective was to determine COVID-19 status in participants prior to initiating anticancer treatment. The secondaryobjective was to evaluate COVID-19 related adverse events (AEs) in recovered COVID-19-positive participants for30 days after initiation of anticancer therapy. Results: We enrolled 507 patients and tested for COVID-19 from 4/28/20 to 5/8/20 through coordinated efforts within the CTO and Biospecimen Repository Core Facility. The research study was stopped when the KU HealthSystem was able to test this population as standard of care. Median age was 65 years, 110 patients (22%) wereaged 75 years or older, and 274 (54%) patients were female. 387 patients (76.3%) were Caucasians, 35 (6.9%)African American, 7 (1.4%) Asian, and 437 (86.2%) non-Hispanic. Based on the catchment of zip codes, 7% oftested patients came from more than 60 miles and 1.6% from more than 100 miles. Zero patients had a positiveCOVID-19 test. Conclusions: The prevalence of COVID19 in asymptomatic cancer patients is low, likely because of goodcompliance with the social distance policy. Screening for COVID19 may help reduce AEs related to COVID-19 inpatients receiving cancer-directed treatment. Studying COVID-19 test results in a larger patient pool is warranted. Asimilar study to test asymptomatic patient-facing oncology staff is pending.

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