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1.
American Journal of Infectious Diseases ; 19(1):13-22, 2023.
Article in English | EMBASE | ID: covidwho-2302943

ABSTRACT

COVID-19 due to SARS-CoV-2 is a global pandemic that presents a serious challenge from many angles for healthcare professionals. The virus causes a potentially fatal disease that is easily transmitted among patients and caregivers, hence specific dead body care is required for such patients. Our study was conducted to identify knowledge, attitude, and practice regarding COVID-19 dead body care among hospital nursing personnel. A cross sectional survey-based study was performed involving 282 nurses who worked in COVID-19 units during data collection from July 2020 to September 2020. The online structured questionnaire was based on world health organization guidelines, institutional infection control protocols, and course material regarding emerging respiratory diseases including COVID-19. We found that work experience in the COVID-19 unit had a significant impact on knowledge and practice regarding COVID-19 dead body care. Similarly, we observed that training improved the knowledge and practice of nursing personnel regarding dead body care. Good knowledge, attitude, and practice were observed in experienced and trained nurses (p-value <0.005). No significant changes were observed with age, gender, and education qualification. Overall knowledge, attitude, and practice regarding COVID-19 dead body care were moderate to good. Adequate training among nurses should prevent the transmission of disease due to occupational exposure.Copyright © 2023, Science Publications. All rights reserved.

2.
Journal of Datta Meghe Institute of Medical Sciences University ; 17(5):S32-S37, 2022.
Article in English | Scopus | ID: covidwho-2040151

ABSTRACT

Context: Effective hand hygiene (HH) is one of the most important measures to prevent the cross-transmission of infectious diseases such as COVID-19, especially among health professionals. There are very limited studies that have aimed at investigating HH practices among medical and dental students in the period of their professional formation. Aims: This study aim's to measure the quality of HH practices, attitudes, and knowledge among the medical and dental students during the corona pandemic in health science institutes of Maharashtra. Settings and Design: A cross-sectional study through Google Form-based closed-ended questionnaires where options were given. Materials and Methods: All students associated with patient clinics during their academic learning were eligible for inclusion in the study. The knowledge, attitudes, and opinions regarding HH practices were collected through an online Google Form questionnaire. Statistical Analysis Used: Chi-square and 't' tests were used to find out the statistical difference between the two groups. Results: Both medical and dental undergraduate students showed a moderate level of HH knowledge, whereas dental students have a lower level of attitudes and practices of HH as compared to the medical undergraduates. Conclusion: Undergraduate health-care students need to be increased emphasis on HH education and improvement in their current primary training and also there is an urgent need for educational and motivational intervention particularly targeted at dental students. © 2022 Wolters Kluwer Medknow Publications. All rights reserved.

3.
Annals of Medical and Health Sciences Research ; 11:84-88, 2021.
Article in English | Web of Science | ID: covidwho-1576165

ABSTRACT

Background: COVID-19 in children normally causes mild infectious illness, but serious repercussions can occur in combination with both acute infection and related phenomena in children, like the Multisystem Inflammatory Syndrome (MIS-C). In rural hospitals, there is less information available on Cardiac abnormality in MIS-C. Objectives: To know the prevalence of cardiac dysfunction of MIS-C children having COVID-19. Methodology: The MIS-C patients in this prospective research will be diagnosed using WHO criteria. On admission, MIS-C patients with cardiac marker positive will have an anomaly in one or more of the following: Electrocardiography, Brain Natriuretic Peptide (BNP), serum troponin, and/or echocardiogram. Results: We will determine the prevalence of cardiac dysfunction in MIS-C when the study is completed. We will compare outcome factors such as hospital stay days, ICU admission, and death based on the therapy received. We all also study the correlation between the inflammatory marker and LV dysfunction. Conclusion: The study will most likely provide information on the prevalence of heart abnormality in MIS-C children. Also, the outcome of the MIS-C with cardiac dysfunction will be revealed.

4.
Biointerface Research in Applied Chemistry ; 11(4):12120-12148, 2021.
Article in English | Web of Science | ID: covidwho-1049303

ABSTRACT

Tridax procumbens is a popular medicinal plant traditionally used for wound healing and bronchial catarrh. In the current study, in silico computational analysis of 22 active phytoconstituents of T. procumbens was performed against SARS-CoV-2. Molecular Docking studies against six key targets of SARS-CoV-2 including PDB ID: 6LU7, a main protease 3CLpro/Mpro;PDB ID: 6NUR, SARS-Coronavirus NSP12 polymerase bound to NSP7 and NSP8 co-factors, PDB ID: 6m71, SARS-Cov-2 RNA-dependent RNA polymerase (RdRp), PDB ID: 6CS2, SARS Spike Glycoprotein - human ACE2 complex a Stabilized variant;PDB ID: 6VXX, spike glycoprotein of SARS-CoV-2 and its receptor Angiotensin-converting enzyme-2 (PDB ID: 1R42) were accomplished. Additionally, in silico prediction studies using pharmacokinetics (ADMET) properties and the protection profile to identify the paramount drug candidates were also done using online SwissADME and pkCSM web servers. Comprehensive docking analyses confirmed that out of 22 screened phytoconstituents, 6 compounds: Bergenin, beta-Sitosterol, Centaurein, Procumbentin, Luteolin, and Puerarin showed a high binding affinity with studied SARS-CoV-2 target proteins. Pharmacokinetics prediction studies further verified that all selected phytoconstituents were safe with good quality ADMET properties and lacking carcinogenic and tumorigenic properties. Thus, these selected drugs can effectively control COVID-19 and improve immunity, which can be confirmed by further studies.

5.
Medical Science ; 24(106):4144-4157, 2020.
Article in English | Web of Science | ID: covidwho-1030635

ABSTRACT

Background: SARS Cov-2 is a newly identified virus which causes respiratory and other systemic illness with the disease being named as COVID-19. It has been declared as a global pandemic by the World Health Organization. The Indian government has taken extraordinary measures like suspending all transports, closing down the public places, increasing the medical facility, strict rules for maintaining hygienic practices. Aims: To study the knowledge and attitude of people regarding COVID-19 and the preventive measures practiced by the rural population who attending a hospital. Study Design: Descriptive cross-sectional study. Study population: The population in this study is residents of Wardha District, Maharashtra State, India, who are living there for at least one year. 322 adults (aged 18 years and above) were interviewed using a pre-tested questionnaire regarding their knowledge, attitude and practices about COVID-19. Results: In our study (n=322), 50.62% were males, with 54.35% in age group of 18-30 years. The mean knowledge score was 12.48 (SD: 2.15, range: 4-15) suggestive a good knowledge score, attitude score was 16 (SD: 3.93, range: 10-32)- suggesting a positive attitude, practice score was 3.77 (SD=0.54, ranged 0-4), suggesting an overall 90% correct rate in the practices test. Regression analysis showed that male gender, unmarried people who had less education, less income and unemployed or unskilled worker had the lowest scores in all three domains. Conclusion: The rural people had a good knowledge about prevention of COVID-19. Most of them had a positive attitude towards covid-19 practicing preventive measures. Preventive strategies are the only means of controlling COVID-19.

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