Your browser doesn't support javascript.
Show: 20 | 50 | 100
Results 1 - 15 de 15
Filter
1.
International Management Conference, IMC 2021 ; : 199-209, 2022.
Article in English | Scopus | ID: covidwho-1826314

ABSTRACT

COVID-19, or the novel coronavirus, was first detected in Hubei, a province in China in a wet market way back in November 2019. After that, it has spread all over the world like a bonfire. One of the hugely affected sectors during this pandemic is tourism industry. It was all of a sudden tourists were barred to come in and go out of their country by the government. All major tourist and religious places were closed in most of the countries, for months together, even for their own nationals. Ecotourism has been one of the most important tourism patterns as it focuses on enhancing the principles of sustainable tourism by ensuring the satisfaction of the traveler's and hosting communities while enhancing the appreciation and conservation of natural resources, trying to adopt its tourism offerings to suit the updates of the tourism sector during and after COVID-19;all the tourism destinations around the world have given too much attention to ecotourism as it is expected that ecotourism will flourish because of the major changes that has been caused by COVID-19 as it is expected that the tourism preference patterns will change to less crowded and nature-oriented ones. India and Egypt are the two countries which have similarities in culture and are situated in Asia. They share nearly similar cultures, history and ethnicity. Both countries faced the first wave of COVID-19 at a similar time, and the havoc caused was more or less comparable. The study was conducted in both countries on the basis of the common questionnaire that was asked to the participants in written as well as in oral form who comprised of population of different profession and sphere. The main objectives of this paper are to analyze the impact of COVID-19 on ecotourism in India and Egypt. Face-to-face interviews were conducted with the governmental and private tourism professionals in both countries to explore the current status of ecotourism in both India and Egypt and know their opinion about to which extent ecotourism could be used as a very effective tool to overcome the challenges that have been created by COVID-19. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

2.
Acm Transactions on Management Information Systems ; 12(4):24, 2021.
Article in English | Web of Science | ID: covidwho-1691227

ABSTRACT

During the COVID-19 pandemic, authorities have been asking for social distancing to prevent transmission of the virus. However, enforcing such distancing has been challenging in tight spaces such as elevators and unmonitored commercial settings such as offices. This article addresses this gap by proposing a low-cost and non-intrusive method for monitoring social distancing within a given space, using Channel State Information (CSI) from passive WiFi sensing. By exploiting the frequency selective behavior of CSI with a Support Vector Machine (SVM) classifier, we achieve an improvement in accuracy over existing crowd counting works. Our system counts the number of occupants with a 93% accuracy rate in an elevator setting and predicts whether the COVID-Safe limit is breached with a 97% accuracy rate. We also demonstrate the occupant counting capability of the system in a commercial office setting, achieving 97% accuracy. Our proposed occupancy monitoring outperforms existing methods by at least 7%. Overall, the proposed framework is inexpensive, requiring only one device that passively collects data and a lightweight supervised learning algorithm for prediction. Our lightweight model and accuracy improvements are necessary contributions for WiFi-based counting to be suitable for COVID-specific applications.(1)

3.
5th World Conference on Smart Trends in Systems, Security and Sustainability, WS4 2021 ; 334:785-800, 2022.
Article in English | Scopus | ID: covidwho-1611372

ABSTRACT

The COVID pandemic has opened the eyes of numerous nations about their medical services framework. The short blast and uncontrolled overall spread of COVID-19 show the constraints of existing medical services frameworks to handle general wellbeing crises conveniently. The disease and demise numbers detailed by World Health Organization (WHO) about this pandemic is an expanding danger to the lives of individuals and the financial matters of nations. The greatest challenge that most governments are experiencing is the absence of a precise mechanism to recognize obscure contaminated cases and anticipate the disease danger of COVID-19 infection. Numerous countries have been utilizing a scope of devices to battle the pandemic, looking for data about development, checking just as the releasing the private data of the occupants. This research paper plans to help tainted individuals with care utilizing the Internet of Things (IoT) and blockchain innovations. From one viewpoint, blockchain can battle pandemics by empowering early discovery of the cases, securing client protection, and guaranteeing a compacted clinical flexibly chain during the pandemic attack. Then again, IoT-based medical services accumulate valuable data, give advanced knowledge through indications and practices, permit far-off checking, and essentially give individuals better self-assurance and medical services. A proposed layer consists of four-layer architecture utilizing IoT and blockchain to identify and predict people to be COVID-19. This idea provides a framework for patients with COVID-19 irresistible infection and perceives medical problems and determinations. The proposed approach is anticipated to deliver a robust framework ready to help governments, healthcare specialists, and residents make basic choices concerning disease recognition, disease forecast, and disease avoidance. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.

4.
Indian Journal of Medical and Paediatric Oncology ; : 5, 2021.
Article in English | Web of Science | ID: covidwho-1585684

ABSTRACT

Blood is a very important resource for healthcare-based services and there has been a consistently increasing demand for it in most parts of the world. Poor volunteer-based collection system, high-risk of transfusion-transmitted infections, and emergence of new pathogens as evident from the ongoing Coronavirus Disease 2019 (COVID-19) pandemic are potential challenges to the global healthcare systems. It is imperative to explore safe and reliable alternatives to red cell transfusions. Ex vivo culture of red cells (cRBCs) from different sources such as hematopoietic stem cells (HSCs), pluripotent stem cells, and immortalized progenitors (e.g., BELA-2 cells) could revolutionize transfusion medicine. cRBC could be of great diagnostic and therapeutic utility. It may provide a backup in times of acute shortages in patients with rare blood groups, and in cases with multiple antibodies or sickle cell anemia. The CRISP-Cas9 system has been used to develop personalized, multi-compatible RBCs for diagnostic reagents and patients with multiple allo-antibodies. cRBC could be practically feasible for pediatric patients, who require small quantities of red cell transfusions. cRBC produced under good manufacturing practice (GMP) conditions has been reported to survive in human blood circulation for more than 26 days. Recently, a phase I randomized controlled clinical trial called RESTORE was initiated to assess the survival and recovery of cRBCs. However, feasible technological advancement is required to produce enough cRBCs for clinical use. It is crucial to identify sustainable sources for large-scale production of clinically useful cRBCs. Although the potential cost of one unit of cRBC is extrapolated to be around US$ 8000, it is a life-saving product for patients having rare blood groups and is a "ready to use" source of phenotype-matched, homogenous young red cells in emergency situations.

5.
Blood ; 138:2752, 2021.
Article in English | EMBASE | ID: covidwho-1582239

ABSTRACT

Introduction: Pomalidomide is a third-generation immunomodulatory drug approved for relapsed and/or refractory Multiple Myeloma (RRMM). In the phase 3 OPTIMISMM trial, pomalidomide, bortezomib, and dexamethasone demonstrated superior efficacy in patients with RRMM. PRIME study (CTRI/2019/10/021618) is testing this combination in Newly Diagnosed Multiple Myeloma (NDMM) Aim: To determine safety of Pomalidomide in combination with Bortezomib and dexamethasone (VPD) in NDMM Study design: A prospective, single arm, phase II study from a tertiary center. Both transplant eligible and ineligible patients with NDMM aged between 18-70 years are being recruited in the study. Patients with Plasma cell leukemia, POEMS and amyloidosis were excluded. The regimen consists of weekly Bortezomib 1.3mg/sq.m (subcutaneous), Tab. Pomalidomide 2-4mg once daily for 21days, and Tab Dexamethasone 20mg twice weekly, with the cycle repeating every 28 days, 9-12 cycles. Here we report the adverse events (AE) by NCI CTCAE v5.0, upon recruiting 26 patients, as predetermined in the study. Results: Of the proposed 45-50 patients, 26 patients were enrolled in the study between April 2020 to May 2021 and 23 (88.4%) have completed 4 cycles of VPD. The median age is 55years (18-70), and gender ratio 1:1. At disease presentation, bone lesions were the commonest (96.2%, n=25), IMWG high risk cytogenetics were seen in 42.4% (n=11), RISS-2 in 69.3% (n=18), IgG kappa paraproteinemia in 54% (n=14) patients and ECOG performance score 2-3 in 57.6%(n=15). Ten (38.5%) patients have completed 9 cycles, and 3 underwent auto-transplant (between Cycle 4 & 6). Protocol adherence was 96.1% (25/26 patients). Table-1 shows drug-induced toxicity, hematological toxicities were the commonest. Two patients withdrew consent in view of bortezomib-induced peripheral neuropathy. Serious adverse events (SAE) were reported in 9 (34.6%) patients and were considered unrelated to the regimen by the safety committee (PSVT=1, Bony pain=2, dyspnea=1, pneumonia=1, constipation=1, diarrhea=1, hypotension=1) and one death due to SARS-CoV2 pneumonia. Treatment delays of 2 weeks in 4 patients (SARS-CoV2 = 3, Syncope = 1) After 4 cycles (n=23), 6 (26%) patients were in stringent Complete Response (sCR), 17(74%) in Very Good partial response (VGPR) and 13 (56.5%) are Measurable Residual Disease (MRD) negative. Of 10 patients who completed cycle 9, 9 were MRD negative and 1 showed disease progression. Conclusion: Safety data from the PRIME study demonstrates that VPD regimen has a favorable tolerance profile in patients with NDMM. Early efficacy signals are encouraging, and recruitment continues. [Formula presented] Disclosures: Radhakrishnan: Dr Reddy's Laboratories: Honoraria, Membership on an entity's Board of Directors or advisory committees;Emcure Pharmaceuticals: Research Funding;Intas Pharmaceuticals: Research Funding;Janssen India: Honoraria;NATCO Pharmaceuticals: Research Funding;Novartis India: Membership on an entity's Board of Directors or advisory committees;Roche India: Honoraria, Membership on an entity's Board of Directors or advisory committees, Research Funding;AstraZeneca India: Honoraria, Speakers Bureau;Bristol-Myers-Squibb India: Membership on an entity's Board of Directors or advisory committees, Research Funding;Cipla Pharmaceuticals India: Research Funding;Aurigene: Speakers Bureau. Garg: Dr Reddys Laboratories: Honoraria, Speakers Bureau. Nair: Dr Reddy's Laboratories: Honoraria, Membership on an entity's Board of Directors or advisory committees, Speakers Bureau;Intas pharmaceuticals: Honoraria, Speakers Bureau;Mylan pharmaceuticals: Honoraria;Novartis India: Honoraria;Fresenius Kabi India: Honoraria;Cipla Pharmaceuticals: Honoraria, Speakers Bureau;Janssen India: Honoraria, Speakers Bureau. Chandy: Janssen: Honoraria;Pfizer: Honoraria;Intas Pharmaceuticals: Research Funding.

6.
International Journal of Sociotechnology and Knowledge Development ; 14(2):92-113, 2022.
Article in English | Scopus | ID: covidwho-1448998

ABSTRACT

COVID-19 has been primarily regarded as a respiratory disease, and until a safer and effective treatment or vaccine becomes available, the prevention of COVID-19 may continue through interventions based on non-pharmaceutical measures such as maintaining of physical distances and use of personal protective equipment like facemasks, etc. Therefore, an attempt was made in this study to explore the drawbacks with the presently available facemasks for protection from COVID-19 viruses in the state of Odisha in India, and also to explore the possible opportunities for further development of these facemasks. The associated discomforts;strength, weaknesses, opportunities, and threats (SWOT) analysis of existing facemasks in Odisha;possible opportunities for "Make in India"of these facemasks;along with safer use have been analyzed with the help of interpretive structural modelling (ISM) approach followed by MICMAC analysis. Copyright © 2022, IGI Global.

7.
Applied Mathematics and Computation ; 410, 2021.
Article in English | Scopus | ID: covidwho-1326904

ABSTRACT

Monotone matrices play a key role in the convergence theory of regular splittings and different types of weak regular splittings. If monotonicity fails, then it is difficult to guarantee the convergence of the above-mentioned classes of matrices. In such a case, K-monotonicity is sufficient for the convergence of K-regular and K-weak regular splittings, where K is a proper cone in Rn. However, the convergence theory of a two-stage iteration scheme in a general proper cone setting is a gap in the literature. Especially, the same study for weak regular splittings of type II (even if in standard proper cone setting, i.e., K=R+n), is open. To this end, we propose convergence theory of two-stage iterative scheme for K-weak regular splittings of both types in the proper cone setting. We provide some sufficient conditions which guarantee that the induced splitting from a two-stage iterative scheme is a K-regular splitting and then establish some comparison theorems. We also study K-monotone convergence theory of the stationary two-stage iterative method in case of a K-weak regular splitting of type II. The most interesting and important part of this work is on M-matrices appearing in the Covid-19 pandemic model. Finally, numerical computations are performed using the proposed technique to compute the next generation matrix involved in the pandemic model. The computation of large PageRank matrices shows that the two-stage Gauss-Seidel method performs better than the Gauss-Seidel methods. © 2021 Elsevier Inc.

9.
Pakistan Journal of Medical and Health Sciences ; 15(5):1124-1126, 2021.
Article in English | EMBASE | ID: covidwho-1285772

ABSTRACT

Stage 5 covid-19 case with ground glass effect of lungs is considered as fatal/end stage. An Indian medicine (Ayurvedic\herbal) made of the dermis of the indo native Punica Granatum (dalim) was given. Named AVIR (anti virus india research). Contains ellagic aacid & ellagitannins (e.acid {gallagic group} being the principal therapeutic moiety. X-Ray & HRCT were availed pre to treatment. X-Ray only post recovery. Resulted in eventless smooth swift recovery. The results are presented & discussed. Posits as a possible for home remedy. Rapid Brief Communication.

10.
International Journal of Noncommunicable Diseases ; 5(3):138-142, 2020.
Article in English | Web of Science | ID: covidwho-1273588

ABSTRACT

On March 11, 2020, WHO announced that a novel coronavirus disease 2019 (COVID-19) had transformed into pandemic. Since then, it has challenged health systems and tested the governance of every country. In India, national and sub-national governments have responded by proposing new policies to stop the advance COVID-19 through a slew of measures. Among these was prohibiting smoking and spitting, especially that induced by the use of smokeless tobacco in public places, which could potentially spread the infection further. States and districts were first to propose strict orders, which was followed by advisories and orders at the national level, which supported sub-national implementation. It is premature to estimate the impact of restricting tobacco trade, sale, and use on COVID-19 transmission;however, this early review assesses efforts made which national and sub-national commitment (or lack of it) towards tobacco control.

11.
Journal of Clinical and Diagnostic Research ; 15(4):EE01-EE05, 2021.
Article in English | EMBASE | ID: covidwho-1187140

ABSTRACT

Coronavirus Disease 2019 (COVID-19) is caused by novel Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The disease was first reported from Wuhan, China, in December 2019 and since then it continues to spread worldwide. Although there are rapidly increasing number of studies on epidemiologic characteristics and clinical aspects of COVID-19, its pathology still remains a largely unexplored territory, mainly due to limited autopsy studies. Autopsy studies are essential to demonstrate the spectrum of COVID-19-associated organ changes. This article reviews and highlights the important histopathological findings observed in different organ systems as evident from various published and anecdotal reports from across the world. Major histopathological findings in the lungs include different stages of Diffuse Alveolar Damage (DAD) and microthrombi along with variable degree of inflammation. Microscopic analysis of renal parenchyma may show acute tubular injury and fibrin thrombi in the glomerular capillaries. Heart, liver and brain show no significant inflammation.

12.
Int J Environ Sci Technol (Tehran) ; : 1-8, 2021 Mar 09.
Article in English | MEDLINE | ID: covidwho-1139403

ABSTRACT

Ganges River water quality was assessed to record the changes due to the nation-wide pandemic lockdown. Satellite-based (Sentinel-2) water quality analysis before and during lockdown was performed for seven selected locations spread across the entire stretch of the Ganges (Rishikesh-Dimond Harbour). Results revealed that due to the lockdown, the water quality of the Ganges improved with reference to specific water quality parameters, but the improvements were region specific. Along the entire stretch of Ganges, only the Haridwar site showed improvement to an extent of being potable as per the threshold set by the Central Pollution Control Board, New Delhi, India. A 55% decline in turbidity at that site during the lockdown was attributed to the abrupt halt in pilgrimage activities. Absorption by chromophoric dissolved organic matter which is an indicator of organic pollution declined all along the Ganges stretch with a maximum decline at the downstream location of Diamond Harbour. Restricted discharge of industrial effluent, urban pollution, sewage from hotels, lodges, and spiritual dwellings along the Ganges are some of the reasons behind such declines. No significant change in the geographic trend of chlorophyll-a was observed. The findings of this study highlight the importance of regular monitoring of the changes in the Ganges water quality using Sentinel-2 data to further isolate the anthropogenic impact, as India continues the phase-wise opening amidst the pandemic.

13.
Indian Journal of Hematology and Blood Transfusion ; 36(1 SUPPL):S121-S122, 2020.
Article in English | EMBASE | ID: covidwho-1092839

ABSTRACT

Aims & Objectives: We conducted a clinical audit of patients with hematological disorders and SARS-CoV2 infection. Patients/Materials & Methods: A prospective registry was established in April 2020 for patients from the department of clinical hematology and HCT who were diagnosed to be positive for SARSCoV2 by PCR test. Out patients creening was symptom/contact-exposure driven, and in patients creening was symptomaticorpreemptive. This study is a part of ASHCOVID19 International collaborative and an interim analysis of the institute registry data from April 15, 2020 to October 7, 2020. Results: 1201 new patients were registered and 9539 patient-visits were recorded in the out patient service of the department during this period. 91 (0.08%) patients tested positive for SARS-CoV2. Baseline characteristics of the patients are listed in Table 1. 56 (61.5%) patients needed hospitalization. The median absolute neutrophil count was 3700/cu.mm, while the median absolute lymphocyte count 900/cu.mm. Inflammatory markers (n = 21):median D-dimer was 2845 ng/ml (243-140643) and median CRP level was 14 mg/dl (3.3- 34). Therapy directed against SARS-CoV2 included, Azithromycin (n = 52,60.4%), Dexamethasone (27 patients,29.7%), Remdesivir (n = 10,11.1%) and doxycycline (n = 9,9.9%). 2(2.2%) patients received tocilizumab and 1 patient (1.1%) received convalescent plasma. On univariate analysis, none of the therapies seemed to affect outcomes. The SARS-CoV2 infection mortality was 15% (14/91). 2 patients died due to non-COVID related causes [tumor lysis syndrome (n = 1), leukocytostasis with CVA (n = 1)]. 7/45(15.5%) receiving anti-B-lymphocyte directed therapy died as compared to 7/46(15.21%) not receiving Anti-B-cell therapies. Patients with low grade B-NHL (5/16,31.25%) had the highest mortality rate followed by high grade B-NHL (7/23,30.4%).There was a trend to higher mortality in patients>50 years (12/45,26.6% in those[=50 years age as compared to 4/30,13.33% in those<50 years age). With data available until the date of censoring, most patients were diagnosed in August (n = 32,35.2%) with numbers tailing off in September (n = 20, 22%). Discussion & Conclusion: In our subset of patients with hematological disorders, SARS-COV2 infectivity was found to be low, hospitalization rate was moderate, and mortality was high and commoner in patients>50 yr and a B-cell lymphoma diagnosis. A more aggressive screening approach will potentially improveoutcomes.

14.
Indian Pediatrics ; 57(12):1177-1180, 2020.
Article in English | EMBASE | ID: covidwho-1064630

ABSTRACT

We conducted this online survey to assess the parental perspectives on remote learning, the associated stress, and school reopening during the COVID-19 pandemic. Of 2694 responses, 2032 (75.4%) parents perceived remote learning to be stressful for the child and 1902 (70.6%) for the family. The mean (SD) duration of remote learning was 3.2 (2.1) hours/day and 5.3 (1.0) days/week. Parents from 1637 (61.7%) families reported headaches and eye strain in children. Starting regular school was not acceptable to 1946 (72.2%) parents.

15.
International Journal of Pharmaceutical Sciences Review and Research ; 63(1):200-205, 2020.
Article in English | EMBASE | ID: covidwho-668294

ABSTRACT

In December 2019, there was a flare-up of the unidentified reason for pneumonia that overwhelmed the vast majority of the world. This infection has a place with β-corona virus, an enormous class of infections common in nature. On the 11th of February 2020, W.H.O named this disease as COVID-19 (Corona virus Disease 2019). This novel corona virus is to be believed to get spread from the bat and later on a human to human transmission. These patients gave indications of extreme pneumonia including fever, weakness, dry cough and respiratory trouble. Still, the exact mechanism of its approach has not been cleared yet. But it’s said to be the same as the previous strain of it like SARS-CoV and MERS-CoV. It has been affirmed that the COVID-19 also uses the cell section receptor i.e.;ACE2 as the SARS-CoV. The COVID-19 said to transmit starting with one then onto the next individual, so it is important to totally intrude on human-to-human transmission. Another method to control the spread is to avoid the diligence of corona viruses on inanimate surfaces because of various kinds of materials it can stay irresistible for 2 hours as long as 9 days. The typical standards are keeping up hydration and sustenance and controlling fever and cough. The typical standards are keeping up hydration and sustenance and controlling fever and cough. But still, the previously used antiviral drugs as well as like antibody and convalescent plasma as a potential therapy were used in the treatment.

SELECTION OF CITATIONS
SEARCH DETAIL