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1.
J Investig Med High Impact Case Rep ; 9: 23247096211013215, 2021.
Article in English | MEDLINE | ID: covidwho-1598539

ABSTRACT

Bronchopleural fistula (BPF) is associated with high morbidity if left untreated. Although rare, the frequency of BPF in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is becoming recognized in medical literature. We present a case of a 64-year-old male with BPF with persistent air leak due to SARS-CoV-2 pneumonia treated with Spiration Valve System endobronchial valve (EBV). An EBV was placed in the right middle lobe with successful cessation of air leak. In conclusion, the use of EBVs for BPF with persistent air leaks in SARS-CoV-2 patients who are poor surgical candidates is effective and safe.


Subject(s)
Bronchial Fistula/surgery , Bronchoscopy , COVID-19/complications , Empyema, Pleural/surgery , Pleural Diseases/surgery , Surgical Instruments , Bronchial Fistula/etiology , Chest Tubes , Empyema, Pleural/etiology , Humans , Male , Middle Aged , Pleural Diseases/etiology , SARS-CoV-2 , Thoracostomy
2.
Journal of Hospitality and Tourism Technology ; 12(4):762-776, 2021.
Article in English | ProQuest Central | ID: covidwho-1546143

ABSTRACT

PurposeThis study aims to explore the factors affecting customers’ attitudes to the adoption of robots in hotels and travel agencies.Design/methodology/approachStructural equation modelling was used to test the extended technology acceptance model based on data collected from 570 customers of hotels and travel agencies.FindingsThe findings revealed that hotel customers have more positive attitudes to service robots than their peers in travel agencies.Originality/valueThis research contributes to the literature on robots in tourism and responds to the call to investigate customers’ attitudes to the adoption of robots in developing countries.

4.
Transpl Infect Dis ; 23(2): e13480, 2021 Apr.
Article in English | MEDLINE | ID: covidwho-804849

ABSTRACT

Exosomes isolated from plasma of lung transplant recipients with allograft injury contain donor-derived lung self-antigens (collagen V and Kα1 tubulin) and human leukocyte antigen (HLA) molecules. We present a case of a 76-year-old, female lung transplant recipient treated for acute cellular rejection with methylprednisolone and anti-thymocyte globulin, who subsequently contracted SARS-CoV-2 and developed a sharp increase in the mean fluorescent intensity of anti-HLA antibodies. Analysis of circulating exosomes during rejection, but before SARS-CoV-2 infection, revealed the presence of lung self-antigens and HLA class II molecules. After the patient contracted SARS-CoV-2, exosomes with the SARS-CoV-2 spike protein were also found. After resolution of infectious symptoms, exosomes with SARS-CoV-2 spike protein were no longer detected; however, exosomes with lung self-antigens and HLA class II molecules persisted, which coincided with a progressive decline in spirometric flows, suggesting chronic lung allograft dysfunction. We propose that the analysis of circulating exosomes may be used to detect allograft injury mediated by both rejection and infection. Furthermore, the detection of exosomes containing viral proteins may be helpful in identifying allograft injury driven by viral pathogens.


Subject(s)
COVID-19/metabolism , Exosomes/metabolism , Graft Rejection/drug therapy , Histocompatibility Antigens Class II/metabolism , Immunosuppressive Agents/adverse effects , Lung Transplantation , Spike Glycoprotein, Coronavirus/metabolism , Aged , Antilymphocyte Serum/therapeutic use , Autoantigens/immunology , Autoantigens/metabolism , Bronchiolitis Obliterans , COVID-19/immunology , Collagen Type V/immunology , Collagen Type V/metabolism , Disease Progression , Female , Glucocorticoids/adverse effects , Glucocorticoids/therapeutic use , HLA Antigens/immunology , HLA Antigens/metabolism , Histocompatibility Antigens Class II/immunology , Humans , Immunosuppressive Agents/therapeutic use , Methylprednisolone/adverse effects , Methylprednisolone/therapeutic use , SARS-CoV-2/immunology , SARS-CoV-2/metabolism , Spike Glycoprotein, Coronavirus/immunology , Tubulin/immunology , Tubulin/metabolism
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