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1.
BMC Chemistry ; 16(1), 2022.
Article in English | ProQuest Central | ID: covidwho-2153660

ABSTRACT

Etoricoxib (ETO), Paracetamol (PCM), and two toxic impurities for Paracetamol impurity K (4-aminophenol (PAP)) and impurity E (para-hydroxy acetophenone (PHA)) were separated using a simple and selective HPLC method that was tested for the first time. PCM is a commonly used analgesic and antipyretic medication that has recently been incorporated into COVID-19 supportive treatment. Pharmaceuticals containing PCM in combination with other analgesic-antipyretic drugs like ETO help to improve patient compliance. The studied drugs and impurities were separated on a GL Sciences Inertsil ODS-3 (250 × 4.6) mm, 5.0 µm column, and linear gradient elution was performed using 50 mM potassium dihydrogen phosphate adjusted to pH 4.0 with ortho-phosphoric acid and acetonitrile as mobile phase at 2.0 mL/min flow rate at 25 °C and UV detection at 220 nm. The linearity range was 1.5–30.0 µg/mL for ETO and PCM while 0.5–10.0 µg/mL for PAP and PHA, with correlation coefficients (r) for ETO, PCM, PAP, and PHA of 0.9999, 0.9993, 0.9996, and 0.9998, respectively. The proposed method could be used well for routine analysis in quality control laboratory.

2.
International Journal of Advanced Computer Science and Applications ; 13(10):224-230, 2022.
Article in English | Scopus | ID: covidwho-2145462

ABSTRACT

Mobile devices such as mobile phones are becoming more important to school students today. This is due to the COVID-19 pandemic, mostly traditional face-to-face learning has shifted to online learning such as learning via a mobile platform. Mobile learning also known as m-learning, is defined as learning in numerous situations through social and content interaction utilizing personal electronic devices. M-learning applications not only need to have efficient functions, but it also has to attract students to learn by providing an attractive interface. An aesthetic of a mobile interface is essential since it could influence the user's learning experiences, but vice versa for non-aesthetic interfaces. User experience (UX) encompasses an extensive range of outcomes of the user-device interaction, including cognitions, attitudes, beliefs, behaviour, behavioural intentions, and affect. However, this study focuses on UX in terms of learnability, satisfaction, and efficiency since most previous studies were not explicitly focused on examining these three (3) UX components. Thus, this study aims to investigate the effect of aesthetically mobile interfaces on the learnability, satisfaction, and efficiency of primary school students, specifically, for Kelas Al-Quran and Fardu Ain (KAFA) students. This study found that aesthetically mobile interfaces significantly affected students’ learning experiences regarding learnability, satisfaction, and efficiency. In conclusion, the findings of this study could serve as guidelines for future research in the field of mobile interface design. © 2022, International Journal of Advanced Computer Science and Applications. All Rights Reserved. All Rights Reserved.

3.
Molecules ; 27(21)2022 Oct 29.
Article in English | MEDLINE | ID: covidwho-2090288

ABSTRACT

Chemical investigation of the total extract of the Egyptian soft coral Heteroxenia fuscescens, led to the isolation of eight compounds, including two new metabolites, sesquiterpene fusceterpene A (1) and a sterol fuscesterol A (4), along with six known compounds. The structures of 1-8 were elucidated via intensive studies of their 1D, 2D-NMR, and HR-MS analyses, as well as a comparison of their spectral data with those mentioned in the literature. Subsequent comprehensive in-silico-based investigations against almost all viral proteins, including those of the new variants, e.g., Omicron, revealed the most probable target for these isolated compounds, which was found to be Mpro. Additionally, the dynamic modes of interaction of the putatively active compounds were highlighted, depending on 50-ns-long MDS. In conclusion, the structural information provided in the current investigation highlights the antiviral potential of H. fuscescens metabolites with 3ß,5α,6ß-trihydroxy steroids with different nuclei against SARS-CoV-2, including newly widespread variants.


Subject(s)
Anthozoa , COVID-19 , Animals , SARS-CoV-2 , COVID-19/drug therapy , Antiviral Agents/pharmacology , Antiviral Agents/chemistry , Anthozoa/chemistry , Sterols , Molecular Docking Simulation , Molecular Dynamics Simulation
4.
Engineering Analysis with Boundary Elements ; 2022.
Article in English | ScienceDirect | ID: covidwho-2086162

ABSTRACT

In this study, the nonlinear mathematical model of COVID-19 is investigated by stochastic solver using the scaled conjugate gradient neural networks (SCGNNs). The nonlinear mathematical model of COVID-19 is represented by coupled system of ordinary differential equations and is studied for three different cases of initial conditions with suitable parametric values. This model is studied subject to seven class of human population N(t) and individuals are categorized as: susceptible S(t), exposed E(t), quarantined Q(t), asymptotically diseased IA(t), symptomatic diseased IS(t) and finally the persons removed from COVID-19 and are denoted by R(t). The stochastic numerical computing SCGNNs approach will be used to examine the numerical performance of nonlinear mathematical model of COVID-19. The stochastic SCGNNs approach is based on three factors by using procedure of verification, sample statistics, testing and training. For this purpose, large portion of data is considered, i.e., 70%, 16%, 14% for training, testing and validation, respectively. The efficiency, reliability and authenticity of stochastic numerical SCGNNs approach are analysed graphically in terms of error histograms, mean square error, correlation, regression and finally further endorsed by graphical illustrations for absolute errors in the range of 10−05 to 10−07 for each scenario of the system model.

5.
Inform Med Unlocked ; 33: 101081, 2022.
Article in English | MEDLINE | ID: covidwho-2041834

ABSTRACT

The task of this work is to present the solutions of the mathematical robot system (MRS) to examine the positive coronavirus cases through the artificial intelligence (AI) based Morlet wavelet neural network (MWNN). The MRS is divided into two classes, infected I ( θ ) and Robots R ( θ ) . The design of the fitness function is presented by using the differential MRS and then optimized by the hybrid of the global swarming computational particle swarm optimization (PSO) and local active set procedure (ASP). For the exactness of the AI based MWNN-PSOIPS, the comparison of the results is presented by using the proposed and reference solutions. The reliability of the MWNN-PSOASP is authenticated by extending the data into 20 trials to check the performance of the scheme by using the statistical operators with 10 hidden numbers of neurons to solve the MRS.

6.
Inform Med Unlocked ; 32: 101028, 2022.
Article in English | MEDLINE | ID: covidwho-2041833

ABSTRACT

The current work aims to design a computational framework based on artificial neural networks (ANNs) and the optimization procedures of global and local search approach to solve the nonlinear dynamics of the spread of COVID-19, i.e., the SEIR-NDC model. The combination of the Genetic algorithm (GA) and active-set approach (ASA), i.e., GA-ASA, works as a global-local search scheme to solve the SEIR-NDC model. An error-based fitness function is optimized through the hybrid combination of the GA-ASA by using the differential SEIR-NDC model and its initial conditions. The numerical performances of the SEIR-NDC nonlinear model are presented through the procedures of ANNs along with GA-ASA by taking ten neurons. The correctness of the designed scheme is observed by comparing the obtained results based on the SEIR-NDC model and the reference Adams method. The absolute error performances are performed in suitable ranges for each dynamic of the SEIR-NDC model. The statistical analysis is provided to authenticate the reliability of the proposed scheme. Moreover, performance indices graphs and convergence measures are provided to authenticate the exactness and constancy of the proposed stochastic scheme.

7.
Journal of the Canadian Association of Gastroenterology ; 4, 2021.
Article in English | EMBASE | ID: covidwho-2032054

ABSTRACT

Background: Given the COVID-19 pandemic, international travel restrictions have been in effect since March 2020 in Canada. As a result, some patients requiring international travel for medical care have experienced delays. Therefore, innovative techniques were required to provide care that would not routinely be performed in Canada, as in the case of Orbera® gastric balloon retrieval. Aims: To describe an approach to gastric balloon retrieval amidst COVID-19 related travel restrictions Methods: Case review of three cases of gastric balloon retrieval was performed Results: 1: A 41-year-old (yo) woman had an Orbera® gastric balloon placement in Washington state in September 2019. She lost 42lbs. Retrieval was scheduled for March 2020, but was delayed due to COVID-19 restrictions. In May 2020, she developed symptoms of balloon dysfunction. The patient was referred to a Canadian tertiary care centre. Gastroscopy was performed under conscious sedation. The Orbera® balloon was in the distal gastric body. The balloon was punctured with a 19G EUS FNA needle;600cc of blue tinted liquid was aspirated. The emptied balloon was retrieved successfully using rat tooth forceps. 2: A 35-yo woman had an Orbera® gastric balloon placed in October 2019 in Toronto at a private health facility. She lost 20lbs. Retrieval of the balloon was scheduled for March 2020, but due to COVID-19 restrictions, it was not possible at the original facility. She did not have symptoms related to the balloon. Gastroscopy was performed under general anesthesia (GA) on October 8, 2020. The balloon was intact in the distal gastric body. The balloon was punctured with a 19G Cook Echotip Needle and vacuum suction applied;400cc of blue tinted fluid was removed. Alligator forceps were used to create holes in the underside of the balloon, allowing excess fluid to be expelled as the balloon was pulled up against the GEJ. Once the balloon was deflated, it was removed successfully through the mouth. 3: A 38-yo man had an Orbera® gastric balloon placed in his native Columbia in March 2020. He did not achieve weight loss. Due to COVID-19 restrictions, he was unable to return for planned removal. He did not have symptoms related to the balloon. Gastroscopy was performed under GA on October 8, 2020. The balloon was intact in the distal gastric body. The balloon was punctured with a 19G Cook Echotip Needle and vacuum suction applied;600cc of blue tinted fluid was removed. Alligator forceps were used in retroflexion to tear the underside of the flattened balloon to ensure all liquid and air had escaped from the balloon. Once the balloon was deflated, it was removed successfully through the mouth. Conclusions: Although Orbera® gastric balloon retrieval is not routinely performed in Canada, we demonstrate that gastroscopy with balloon puncture and forcepsretrieval is a safe option.

8.
Pediatr Res ; 2022 Sep 09.
Article in English | MEDLINE | ID: covidwho-2016652

ABSTRACT

BACKGROUND: Given the sparse data on vitamin D status in pediatric COVID-19, we investigated whether vitamin D deficiency could be a risk factor for susceptibility to COVID-19 in Egyptian children and adolescents. We also investigated whether vitamin D receptor (VDR) FokI polymorphism could be a genetic marker for COVID-19 susceptibility. METHODS: One hundred and eighty patients diagnosed to have COVID-19 and 200 matched control children and adolescents were recruited. Patients were laboratory confirmed as SARS-CoV-2 positive by real-time RT-PCR. All participants were genotyped for VDR Fok1 polymorphism by RT-PCR. Vitamin D status was defined as sufficient for serum 25(OH) D at least 30 ng/mL, insufficient at 21-29 ng/mL, deficient at <20 ng/mL. RESULTS: Ninety-four patients (52%) had low vitamin D levels with 74 (41%) being deficient and 20 (11%) had vitamin D insufficiency. Vitamin D deficiency was associated with 2.6-fold increased risk for COVID-19 (OR = 2.6; [95% CI 1.96-4.9]; P = 0.002. The FokI FF genotype was significantly more represented in patients compared to control group (OR = 4.05; [95% CI: 1.95-8.55]; P < 0.001). CONCLUSIONS: Vitamin D deficiency and VDR Fok I polymorphism may constitute independent risk factors for susceptibility to COVID-19 in Egyptian children and adolescents. IMPACT: Vitamin D deficiency could be a modifiable risk factor for COVID-19 in children and adolescents because of its immune-modulatory action. To our knowledge, ours is the first such study to investigate the VDR Fok I polymorphism in Caucasian children and adolescents with COVID-19. Vitamin D deficiency and the VDR Fok I polymorphism may constitute independent risk factors for susceptibility to COVID-19 in Egyptian children and adolescents. Clinical trials should be urgently conducted to test for causality and to evaluate the efficacy of vitamin D supplementation for prophylaxis and treatment of COVID-19 taking into account the VDR polymorphisms.

9.
Archives of Pharmacy Practice ; 13(3):11-15, 2022.
Article in English | Web of Science | ID: covidwho-2006745

ABSTRACT

SARS-CoV-2 is a systemic infection that has a significant impact on the hemostasis and hematopoietic system. Lymphopenia may be considered a cardinal laboratory finding, with prognostic potential. The study aimed to determine the differential leukocyte count in SARS-CoV-2 among Sudanese patients, during the period from March to December 2020. A total of 787 subjects were enrolled 487 patients with COVID-19 and 300 healthy volunteers as a control group;their ages ranged from 29 to 89 years. 3 ml of EDTA venous blood samples were collected from each participant standard for CBC investigation and then analyzed by SPSS version 21 (Mean and Standard deviation). A significant association between leukocyte count among ICU, ER group, and control with (P. value 0.000), in addition, a significant association was revealed among mild group and control group in differential neutrophil count, differential lymphocyte count, and absolute neutrophil count (p. value 0.000), however non-significant in TWBC absolute mixed cell count, absolute lymphocyte count, and differential mixed cells count (value 0.7,0.2, 0.19) respectively. The study concluded that leukocytosis with neutrophilia and lymphopenia is associated with the severity of SARS-CoV-2 infection, and should be implicated as predict for a serious course of the disease as well as mortality.

10.
Life (Basel) ; 12(9)2022 Aug 29.
Article in English | MEDLINE | ID: covidwho-2006124

ABSTRACT

SARS-CoV-2 and its variants, especially the Omicron variant, remain a great threat to human health. The need to discover potent compounds that may control the SARS-CoV-2 virus pandemic and the emerged mutants is rising. A set of 1,2,3-triazole and/or 1,2,4-triazole was synthesized either from benzimidazole or isatin precursors. Molecular docking studies and in vitro enzyme activity revealed that most of the investigated compounds demonstrated promising binding scores against the SARS-CoV-2 and Omicron spike proteins, in comparison to the reference drugs. In particular, compound 9 has the highest scoring affinity against the SARS-CoV-2 and Omicron spike proteins in vitro with its IC50 reaching 75.98 nM against the Omicron spike protein and 74.51 nM against the SARS-CoV-2 spike protein. The possible interaction between the synthesized triazoles and the viral spike proteins was by the prevention of the viral entry into the host cells, which led to a reduction in viral reproduction and infection. A cytopathic inhibition assay in the human airway epithelial cell line (Vero E6) infected with SARS-CoV-2 revealed the effectiveness and safety of the synthesized compound (compound 9) (EC50 and CC50 reached 80.4 and 1028.28 µg/mL, respectively, with a selectivity index of 12.78). Moreover, the antiinflammatory effect of the tested compound may pave the way to reduce the reported SARS-CoV-2-induced hyperinflammation.

11.
Cureus ; 14(7): e26611, 2022 Jul.
Article in English | MEDLINE | ID: covidwho-1979634

ABSTRACT

Information and communication technology has left a print on all fields of life, including medicine and the health care system. Telemedicine is the perfect way to ensure adequate healthcare delivery to all people at any time, particularly during pandemics, regardless of any geographic or economic considerations. This article investigates the different types, categories, and benefits in addition to the barriers to telemedicine implementation, especially in the Middle East and North Africa (MENA) region. After a thorough review of medical literature related to telemedicine using PubMed, Google Scholar, and some other gray literature, it has been found that telemedicine has been involved in almost all medical specialties with a positive influence on healthcare delivery and medical education and research. It had a major role during the COVID-19 pandemic. However, many obstacles prevent its proper application and need to be addressed carefully by the government and relevant authorities. Due to the rapidly growing population, unequal distribution of healthcare services, and social distancing of the COVID-19 pandemic, the role of telemedicine has become increasingly essential. Regarding medical education and research, telemedicine facilitates the exchange of information and ideas between physicians and professionals from all over the world, bringing these various minds together on a single platform.

12.
NeuroQuantology ; 20(6):6430-6446, 2022.
Article in English | EMBASE | ID: covidwho-1939459

ABSTRACT

Background: healthcare workers (HCWs) are on the front lines of SARS-Cov-2 Omicron pandemic defense. Inadequate knowledge and inappropriate attitudes among HCWs can have a direct impact on practices, resulting in delayed diagnosis, reduced infection control practice and disease extent. Aim: The purpose of this study was to assess healthcare workers' knowledge and attitudes toward Sars-Cov-2 Omicron. Materials and Methods: A descriptive cross-sectional study was directed in Aseer Province at Kingdom of Saudi Arabia and Cairo, Egypt, among 450 HCWs developing a self-limited questionnaire for data collection. The questionnaire concealed the following parts: (I) Demographic characteristics: age, sex and source of information about SARS-Cov-2 Omicron. (II) Knowledge of Sars-Cov-2 Omicron: the important basic information, method of transmission, and disease prevention measures (III) Attitude regarding Sars-Cov-2 Omicron: such as a preventable and manageable disease and their guidelines to overcome SARS-Cov-2 Omicron pandemic situation. Results: The most of HCWs (99.4%) agreed that infection control precautions can protect against Omicron. Overall knowledge and attitude level across subgroup were highly statistical significant differences (p< 0.001). Conclusion: This study discovered that HCWs had a high level of knowledge and attitude toward actions to prevent and control the spread of the SARS-CoV-2 Omicron. Recommendations: Continuous providing of personal protective equipment (PPE) and teaching of all HCWs on correct infection prevention actions.

13.
Critical Care ; 26(SUPPL 1), 2022.
Article in English | EMBASE | ID: covidwho-1793890

ABSTRACT

Introduction: The aim of this study was to improve treatment of corticosteroid induced hyperglycaemia in patients critically unwell with COVID-19. Management with high dose steroids reduces mortality and has become standard practice. However, high dose glucocorticoid therapy impairs glucose metabolism in patients already at risk of insulin resistance and impaired insulin production, resulting in increased incidence of hyperglycaemia [1]. Methods: A retrospective audit was undertaken, collecting data on steroid use, glycaemic control, and insulin treatment in 100 patients admitted to the Royal Cornwall Hospital Intensive Care Unit with COVID-19. A standard operating procedure (SOP) for the treatment of steroid induced hyperglycaemia was created, based on guidelines from the National Inpatient Diabetes COVID-19 Response Group [1]. Results: Of 100 patients, 91 received high dose steroids. The majority (64.8%) experienced glycaemic control issues, defined as one episode of blood sugar > 12 mmol/l. Of the patients treated with 6 mg dexamethasone 52% experienced hyperglycaemia, compared to 71% of those treated with higher steroid doses. There was no significant difference in the highest blood sugar level of either cohort (t54 = - 0.450, p = 0.654). The average time between first episode of hyperglycaemia and commensal of insulin was 76 h. There was a lack of consensus in management of steroid-induced hyperglycaemia-no treatment was administered in 37% of patients. In those who were treated, 19 different combinations of insulin were given. Sliding scale insulin was administered in most patients who experienced no further hyperglycaemia. Conclusions: These results highlight a necessity for consensus management of steroid induced hyperglycaemia. In line with these findings, the devised SOP recommends initial therapy with rapid acting insulin and administration of a sliding scale if hyperglycaemia persists.

14.
Indian Journal of Pharmaceutical Sciences ; 84:235-245, 2022.
Article in English | Scopus | ID: covidwho-1789981

ABSTRACT

The severe acute respiratory syndrome coronavirus 2 which is the source of pandemic coronavirus disease 2019 has engulfed almost whole world. This virus was first reported in Wuhan city (China) in December 2019. Since the discovery of the virus, till today the researchers and scientists have been working to develop new vaccines or therapeutic agents against severe acute respiratory syndrome coronavirus 2. However, thus far no vaccine has emerged that can be approved to treat or prevent coronavirus disease 2019. Due to lack of specific preventative and therapeutic options for the treatment of coronavirus disease 2019, the use of convalescent plasma therapy may be of great benefit in the current situation. Previous use of immune plasma has resulted in successful treatment of hemagglutinin type 1 and neuraminidase type 1 influenza virus, Middle East respiratory syndrome coronavirus and severe acute respiratory syndrome coronavirus 1 epidemics. In the current scenario raised by coronavirus disease 2019, the convalescent plasma therapy has been applied successfully among many patients across various regions. This article presents an up-to-date review of existing literature on recovery through convalescent plasma as a treatment of choice, safety and its efficacy, possibility and its challenges for the treatment of coronavirus disease 2019. © 2022 Indian Pharmaceutical Association. All rights reserved.

15.
Int J Mol Sci ; 23(7)2022 Apr 03.
Article in English | MEDLINE | ID: covidwho-1776251

ABSTRACT

Two tetradentate dibasic chelating Schiff base iron (III) chelates were prepared from the reaction of 2,2'-((1E,1'E)-(1,2-phenylenebis(azanylylidene))bis(methanylylidene))bis(4-bromophenol) (PDBS) and 2,2'-((1E,1'E)-((4-chloro-1,2-phenylene)bis(azanylylidene))-bis(methanylylidene))bis(4-bromophenol) (CPBS) with Fe3+ ions. The prepared complexes were fully characterized with spectral and physicochemical tools such as IR, NMR, CHN analysis, TGA, UV-visible spectra, and magnetic moment measurements. Moreover, geometry optimizations for the synthesized ligands and complexes were conducted using the Gaussian09 program through the DFT approach, to find the best structures and key parameters. The prepared compounds were tested as antimicrobial agents against selected strains of bacteria and fungi. The results suggests that the CPBSFe complex has the highest activity, which is close to the reference. An MTT assay was used to screen the newly synthesized compounds against a variety of cell lines, including colon cancer cells, hepatic cellular carcinoma cells, and breast carcinoma cells. The results are expressed by IC50 value, in which the 48 µg/mL value of the CPBSFe complex indicates its success as a potential anticancer agent. The antioxidant behavior of the two imine chelates was studied by DPPH assay. All the tested imine complexes show potent antioxidant activity compared to the standard Vitamin C. Furthermore, the in vitro assay and the mechanism of binding and interaction efficiency of the tested samples with the receptor of COVID-19 core protease viral protein (PDB ID: 6lu7) and the receptor of Gram-negative bacteria (Escherichia coli, PDB ID: 1fj4) were investigated using molecular docking experiments.


Subject(s)
COVID-19 , Imines , COVID-19/drug therapy , Chelating Agents/chemistry , Chelating Agents/pharmacology , DNA/chemistry , Density Functional Theory , Ferric Compounds , Humans , Imines/chemistry , Imines/pharmacology , Molecular Docking Simulation , Pharmaceutical Preparations
16.
Computers & Operations Research ; : 105776, 2022.
Article in English | ScienceDirect | ID: covidwho-1748101

ABSTRACT

The risk of infection in a pandemic increases with duration of close contact with an infected person. Since the application of social distancing in public transit vehicles is challenging, minimization of in-vehicle time can help to protect passengers from getting infected. Skip-stop operation is a viable strategy to reduce in-vehicle time as opposed to the conventional all-stop operation, and therefore can provide safer mobility for passengers. In this paper, a mixed integer linear programming model is formulated to minimize the in-vehicle time of passengers while operating an A/B stopping pattern (one of the most popular skip-stop strategies in the literature and in practice). Since the number of direct trips is necessarily decreased when using such a skip-stop operation, this paper quantifies the tradeoff between the in-vehicle time of passengers as a pandemic-based safety measure and the number of direct trips as a measure of passenger satisfaction. In order to efficiently solve problems with a large number of transit stops, a multi-start genetic algorithm is developed. Rigorous numerical experiments indicate that the proposed approach can reduce in-vehicle time by up to 34%. Furthermore, Pareto optimal solutions are obtained to exhibit the tradeoff between in-vehicle time savings and percentage of direct trips.

17.
Journal of Ambient Intelligence and Humanized Computing ; : 1-16, 2022.
Article in English | EuropePMC | ID: covidwho-1728470

ABSTRACT

This paper explores the issue of COVID-19 detection from X-ray images. X-ray images, in general, suffer from low quality and low resolution. That is why the detection of different diseases from X-ray images requires sophisticated algorithms. First of all, machine learning (ML) is adopted on the features extracted manually from the X-ray images. Twelve classifiers are compared for this task. Simulation results reveal the superiority of Gaussian process (GP) and random forest (RF) classifiers. To extend the feasibility of this study, we have modified the feature extraction strategy to give deep features. Four pre-trained models, namely ResNet50, ResNet101, Inception-v3 and InceptionResnet-v2 are adopted in this study. Simulation results prove that InceptionResnet-v2 and ResNet101 with GP classifier achieve the best performance. Moreover, transfer learning (TL) is also introduced in this paper to enhance the COVID-19 detection process. The selected classification hierarchy is also compared with a convolutional neural network (CNN) model built from scratch to prove its quality of classification. Simulation results prove that deep features and TL methods provide the best performance that reached 100% for accuracy.

18.
Journal of Governance and Regulation ; 11(1):45-54, 2022.
Article in English | Scopus | ID: covidwho-1716361

ABSTRACT

This paper investigates the influence of accounting information systems (AIS) on firms’ performance during the COVID-19 pandemic and how they help enhance employees’ performance and the external auditing process. This paper is qualitative in nature using the inductive approach. In-depth primary data were gathered through semi-structured interviews conducted in the year 2020. Due to the pandemic, the interviews with ten auditors were done online through the Zoom software application. The empirical findings of this paper show a positive impact of AIS on firms’ performance and a more significant influence on employees’ performance and the auditing process. AIS reduces costs and human errors, eases operations, speeds up work tasks, and increases employees’ productivity during the COVID-19 pandemic. The findings also show that there is no direct impact on firms’ overall cash flow/revenues. This paper increases our understanding of how AIS can influence and improve firms’ performance and the significance of implementation factors such as training. It provides practical guidelines for regulators and managers to utilize accounting information systems to perform better. © 2022 The Authors.

19.
Polimery ; 66(11-12):574-583, 2021.
Article in English | Web of Science | ID: covidwho-1701945

ABSTRACT

The Covid-19 pandemic has increased the need for personal protective equipment (PPE), especially for medical personnel: face masks, full protective clothing, gloves and goggles. To date, they are usually made of thermoplastic polymers, such as polypropylene (PP). To reduce the risk of secondary infections it is essential to enhance the antimicrobial (especially antibacterial and antiviral) properties of the materials used in PPE. There are some attempts to modify materials by, for example, silver nanoparticles or zinc oxides. The increasing demand for personal protective equipment, mostly masks, leads to an increase of environmental problem of non-biodegradable wastes. Therefore some researches on use of safer for user's health sustainable antimicrobial and biodegradable biopolymer fibers, such as cellulose, starch, chitosan, poly(lactic acid) (PLA) or poly(glycolic acid) (PGA), have been done. These biopolymers and their properties are discussed in this article.

20.
Indian Journal of Pharmaceutical Education and Research ; 56(1s):S115-S120, 2022.
Article in English | EMBASE | ID: covidwho-1667564

ABSTRACT

Aim/Background: The present study was aimed at investigating the public perceptions about extended services by community pharmacists in Jouf region of Saudi Arabia during COVID-19 pandemic. Design: Institutional based cross sectional prospective survey. The sample size was calculated by an online sample size calculator named Raosoft®️. The calculated sample for this study was 945 with a 5% error margin, confidence interval of 95%, the population size fixed at 200000. Study instrument: A 34-item self-administered questionnaire developed by an in-depth literature review and approved by the subject experts (professor, associate professor, assistant professor and lecturer) after suggestions and modification in the questionnaire, pretested to a small sample of thirty participants. The reliability scale applied to determine the alpha value of pretested sample. Results: Majority of the participants 83.6% were females, the frequency (1-3 times) of visit is highest (52.4%) for the participants with the main reason for visiting a particular pharmacy is close location (52.3%). The participants had positive perceptions towards the role of the pharmacist regarding feeling comfortable asking advice from the pharmacist, getting comprehensive consultation, having sufficient discussion time, communication with the pharmacist, getting answers for their questions, medication labeling and information about medication interactions and side effects. However, the participants had negative attitudes towards the medications prices and the diagnostic services such as lab tests provided by the community pharmacists. Public are of the opinion that the pharmacists are well aware of the COVID-19 pandemic playing a good role in counselling about the COVID-19, without any change in their behavior in the current situation. Conclusion: The study showed that there was positive public perceptions about the role of the community pharmacists and the practices and services offered by them. The study recommended increasing the public awareness about the role of the community pharmacists and the range of the services offered in the community pharmacies.

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