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1.
Developmental Medicine and Child Neurology ; 63(SUPPL 3):89-90, 2021.
Article in English | EMBASE | ID: covidwho-1518022

ABSTRACT

Background and Objective(s): The coronavirus disease (COVID-19) global pandemic has resulted in social distancing measures and stay-at-home orders, affecting the capacity to carry out in-person research related to cerebral palsy (CP). As researchers maneuver re-initiation of in-person research during the current phase of the pandemic with a demographic that is historically difficult to recruit, they need information from stakeholders about the considerations that affect their decision to participate in research. The purpose of this study was to explore the comfort levels surrounding and perceptions towards participation in CP research using survey-based qualitative methods. Study Design: Qualitative Research (Consecutive and Purposive Sampling). Study Participants & Setting: A voluntary sample of 187 (129 GMFCS I-III and 57 GMFCS IV-V) parents of children with CP (n=105) or adults with CP (n=81) completed this qualitative online survey. Materials/Methods: Participants were asked about the impact of the COVID-19 pandemic on feelings towards participation in CP research. Responses were organized into a spectrum of perceptions using keywords. Initial categorization grouped impact responses into 'yes,' 'no,' and 'maybe.' Responses were further categorized using additional qualifying reasons;several responses fell into multiple categories. Results: There was a wide range in attitudes surrounding in-person research participation, with 36% stating that COVID-19 had no impact, 30% stating that it did have an impact, and 41% somewhere in the middle. Individuals who felt that COVID-19 had a strong impact stated being immunocompromised or needing a vaccination as influencing their feelings towards participating. In contrast, those who felt there was little to no impact of COVID-19 indicated a value for CP research, or willingness to participate if certain measures were in place (ie. safety precautions at the study site or potential direct benefits offered). Health concerns, transportation to and location of study site, and mitigation of COVID-19 risk at study site were the most commonly cited factors of respondents regardless of their overall feelings towards participation. One participant stated that they "have more time now, so [they] might be more apt to participate as long as safety protocols are in place and strictly followed," while another indicated that they were "somewhat more anxious about exposing [their] child and [themselves]." Conclusions/Significance: In the evolving era of COVID-19, the results of this survey provide insights into the feelings of potential participants when deliberating and planning for re-initiation of in-person CP research. If researchers are aware of general participant concerns regarding transportation, location, precautionary measures, and underlying medical conditions when planning to re-initiate CP research, they can proactively work to address concerns. The large number of respondents shows a commitment to navigating the new normal of COVID-19 by both scientists and participants.

2.
Atherosclerosis ; 331:e140, 2021.
Article in English | EMBASE | ID: covidwho-1401206

ABSTRACT

Background and Aims: Hypolipidaemia is a known consequence of sepsis, predominantly from HDL-C (HDL-cholesterol) lowering. The dynamic of lipoprotein responses is in COVID-19 is not yet elucidated. We aim to describe a lipoprotein response pattern in patients with severe COVID-19 admitted to Intensive Care Department (ICU) at TUH during the first wave of the pandemic in Ireland. Methods: A multidisciplinary team extracted the clinical data and laboratory results of all patients diagnosed with COVID-19 by RT-PCR and admitted to the ICU department in March and April 2020. Data are presented as means, apart from laboratory data where patients had more than one set of results in 24 hours, when median results were calculated for each 24-h period. Results: Twenty-five patients were admitted to ICU (table 1). Presenting comorbidities included hypertension in 10, cardiovascular disease in 5 and diabetes mellitus in 8 patients. Lipoprotein median concentrations demonstrated initial reduction at admission to ICU, followed by rise in concentration during ICU stay (table 1 and figure 1). A significant negative correlation was observed between ICU outcome and HDL-C area under the curve (AUC) (R=-0.506, p=0.004) and LDL-AUC (R=-0.575, p=0.003). Delta LDL-AUC had the strongest correlation with ICU length of stay (LOS) (R=0.455, p=0.02), hospital LOS (R=0.484, p=0.02) and ICU outcomes (R=-0.454, p=0.02). Individual lipoprotein parameters did not demonstrate significant correlation. [Formula presented] [Formula presented] Conclusions: Lipoprotein concentrations (HDL-C and LDL-C) upon ICU admission are low in severe COVID-19 pneumonia patients and subsequent changes in concentrations may be associated with patient outcomes.

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