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1.
Journal of Information Science ; 2023.
Article in English | Scopus | ID: covidwho-2214292

ABSTRACT

Information and Communication Technologies (ICTs) are of great importance in today's society and have permeated different aspects of human life. In fact, access to them is now considered a fundamental right. There exists, however, a gap between individuals and populations who have access to these technologies and those who do not, which has led to social exclusion. In addition, the COVID-19 pandemic has exacerbated the effects of this disparity. In this regard, digital inclusion, through ICTs, becomes a strategy to close not only technical but also social gaps, thereby bringing well-being to vulnerable groups and favouring compliance with the Sustainable Development Goals (SDGs). Given the importance and topicality of this matter, we conducted a bibliometric analysis, which aims to answer what are the main trends in digital inclusion and digital divide studies and what are the challenges facing digital inclusion initiatives in the social context? For this purpose, we applied a search equation in Scopus and used VOSviewer. With this analysis, we were able to identify the evolution of publications over time and the main authors, countries and topics in the field, and the trends and challenges in digital inclusion initiatives. Finally, we conclude that this study can be used to address other research topics, such as the role of ICTs in the promotion of the SDGs through digital inclusion initiatives, the psychosocial aspects of technology adoption and the need for public policies that serve as a platform for digital and social inclusion. © The Author(s) 2023.

2.
Heliyon ; 8(12):e12483, 2022.
Article in English | MEDLINE | ID: covidwho-2179031

ABSTRACT

Objective: To analyse the COVID-19-related lockdown impact on University workers, to identify groups based on this information, and to study the factors associated with each group.

3.
International Journal of Diversity in Education ; 23(1):25-34, 2022.
Article in English | Scopus | ID: covidwho-2164427

ABSTRACT

Even before the COVID-19 pandemic, careers in medicine were challenging, and the academic journey could be a lonely one. The pandemic presented both challenges and opportunities in mentoring such as utilizing technology to transform formal mentorship programs into those that are beneficial for women and minorities because these programs can offer critical engagement, opportunities to hear and express multiple perspectives, expand our capacity to understand and talk about complex social issues, and meaning-making frameworks. Medical schools can utilize innovative and creative mentoring programs to support medical students as they enter the medical profession. © Common Ground Research Networks, Joseph Muñoz et al., All Rights Reserved.

4.
Educatio Siglo Xxi ; 40(3):179-198, 2022.
Article in English | Web of Science | ID: covidwho-2110730

ABSTRACT

The lockdown caused by COVID-19 led to the adoption of new virtual methodo-logies using digital tools. The aim of this study was to design and validate a ques-tionnaire on the use of digital media in the virtual teaching of STEM subjects in Foundation Courses. For this purpose, a descriptive non-experimental quantitative design was used and, with the administra-tion of the designed questionnaire, data were collected from 61 students enrolled in these courses during the academic year 2021/2022 at Northumbria University (United Kingdom). The results showed that the reliability and internal consistency of the implemented questionnaire were good (Cronbach's Alpha = .78;Composite Reliability = .79;Mean Extracted Varian-ce = .48;Omega = .95;KMO = .64) and that in general the student body stated that they had good access to and use of digital media and smooth communication with lecturers during the placement. In addition, they stated that they had adap-ted favourably to virtual teaching and that they had successfully acquired subject competences. The pandemic has brought about the implementation of these new methodologies and has meant a renewal and implementation of new resources, with the consequent acquisition of digital competences by both teaching staff and students.

6.
Journal of Clinical Oncology ; 40(16), 2022.
Article in English | EMBASE | ID: covidwho-2009641

ABSTRACT

Background: Prognosis of COVID-19 is poor in the setting of immunosuppression. Casirivimab/imdevimab (REGEN-COV), bamlanivimab, and sotrovimab are investigational monoclonal antibodies (MoAbs) authorized for treatment of mild/moderate COVID-19 for patients (pts) 12 years or older and who are at high-risk for progression to severe COVID-19. These neutralizing antibodies, against SARS-CoV-2 spike proteins, have been shown to decrease risk of progression to severe disease. Recipients of allogeneic stem cell transplants (allo-SCT) or chimeric antigen T cell therapy (CAR T cell) represent a high risk population. However, treatment outcomes with these MoAbs in these pts are not well described. Methods: This retrospective study included 33 consecutive adult pts who developed mild/moderate COVID-19 and received anti-spike SARS-CoV-2 MoAbs between December 2020 and November 2021. Allo-SCT (N=27) or CAR T cell (N=6) recipients were included, and outcomes were analyzed separately. Pts received REGEN-COV (N=19), bamlanivimab (N=11), or sotrovimab (N=1), missing (N=2). Results: In the allo-SCT cohort (N=27), median age at time of COVID-19 was 55 (23-76) years. Median time from allo-SCT to COVID-19 was 31 (22-64) months. Two pts received CAR T-cell therapy prior to allo-SCT. Diagnoses included leukemia or myeloid diseases (82%), lymphoma (11%), or myeloma (7%). Transplant characteristics are summarized (Table). Thirteen pts were vaccinated against SARS-CoV-2 prior to breakthrough COVID-19. Events considered included hospitalization due to COVID- 19, disease progression, or death from any cause. The 6-month event-free and overall survivals were 81% and 91%, respectively. In the CAR T cell recipients cohort (N=6), 4 pts received axicabtagene ciloleucel for diffuse large B-cell or follicular lymphoma and 2 received brexucabtagene autoleucel for mantle cell lymphoma. The median follow-up was 8 (1-11) months. Two pts received autologous SCT prior to COVID-19. Median time from CAR T cell therapy to COVID-19 was 10 (3-24) months. Three pts were vaccinated prior to COVID-19. Only 1 pt was hospitalized due to severe COVID- 19 requiring mechanical ventilation leading to death. Conclusions: These results show a potential benefit of MoAbs in high-risk pts, namely allo-SCT or CAR T cell recipients. Future studies should evaluate the role of prophylactic use MoAbs in these populations. A comparative analysis with a matched control cohort (who did not receive MoAbs) will be provided at the meeting.

7.
Pediatrics ; 149, 2022.
Article in English | EMBASE | ID: covidwho-2003273

ABSTRACT

Background: Fractures are a common cause of pediatric injury. The coronavirus disease 2019 (COVID-19) pandemic resulted in significant changes in daily life including social distancing, partial cessation of youth sports, and school closings, all of which could have a major impact on the incidence of pediatric fractures. Prior work has demonstrated a significant reduction in fracture burden during the early pandemic;however, few have examined pediatric fractures in the period after lifted restrictions or on a national level. The purpose of this study was to compare pediatric fracture rates in the United States during the COVID-19 pandemic to previous seasonally-adjusted injury rates using the National Electronic Injury Surveillance System (NEISS) database. Methods: The NEISS database was queried from 2016 to 2020 for fractures occurring in pediatric (0-17yo) patients. Studied demographic variables included age, sex, body region injured, disposition, and location of injury. Using a quasi-experimental, interrupted time series design, we constructed linear regression models for number of fractures per month that included a linear time trend, month of injury, a binary variable representing whether the fracture occurred after February 2020, and number of months post-March 2020 to allow the effect of restrictions to change over time. The differential impact of COVID-19 on fracture rate by each demographic variable was then tested using interaction terms. Results: Our sample consisted of 121,803 cases representing 2,959,421±372,337 fractures nationally. Monthly incidences (Figure 1) identified a 32% decrease in fractures per month after February of 2020 (Overall B=-11,400 fractures 95% Credible Interval[-17,600, -5,200]), and the decay of this effect did not reach significance. We found significant effect modification by age, body region, location, and disposition (p<0.05, Table 1). Children (6-11yo) experienced 44% fewer fractures (-5,070 [-7,590, -2,570]) while adolescent injuries declined 34% (-5,300 [-7,760, -3,020]). A 93% reduction in fractures at school (-5,050 [-6,870, -3,250]) and a 69% decrease in those during sports (-7,570 [-9,380, -5,750]) was identified. Fractures that did not require hospitalization decreased by 35% (-11,200 [-16,890, -5,630]). Conclusion: A nationally representative injury database demonstrated a 32% decline in monthly pediatric fractures during the COVID-19 pandemic that persisted into the latter half of 2020. These trends were identified to be most attributable to a reduction in less severe, extremity fractures among older children sustained at school and in sports. In contrast, more severe injuries or those in younger children remained relatively unaffected. Our findings provide unique insight into the epidemiology of pediatric fractures and demonstrate a baseline need for musculoskeletal care among young children and orthopaedic injuries necessitating hospitalization, even in the setting of a national shutdown. (Table Presented).

8.
Pulmonology ; 2022 Aug 01.
Article in English | MEDLINE | ID: covidwho-1967025

ABSTRACT

BACKGROUND: In coronavirus disease (COVID-19), physical capacity is one of the most impaired sequelae. Due to their simplicity and low cost, field tests such as the six-minute walk test (6MWT) are widely used However, in many places it is difficult to perform them and alternatives can be used such as the 1 min sit-to-stand test (1min-STST) or the Chester step test (CST). Therefore, our objective was to compare the 6MWT, 1min-STST and the CST in post-COVID-19 patients. METHODS: We conducted a cross-sectional analysis in post-COVID-19 patients, compared with matched controls (CG). Demographic characteristics and comorbidities were collected. We analysed oxygen saturation (SpO2), heart rate (HR), and the modified Borg scale in the 6MWT, 1min-STST, and CST. Additionally, the correlations between tests were analysed. RESULTS: We recruited 27 post-COVID-19 patients and 27 matched controls. The median age was 48 (IQR 43-59) years old (44% female). The median distance walked in 6MWT was 461 (IQR 415-506) m in post-COVID-patients and 517 (IQR 461-560) m in CG (p = 0.001). In 1min-STST, the repetitions were 21.9 ± 6.7 and 28.3 ± 7.1 in the post-COVID-19 group and CG, respectively (p = 0.001). In the CST, the post-COVID-19 group performed 150 (86-204) steps vs the CG with 250 (250-250) steps (p < 0.001). We found correlations between the 6MWT with the 1min-STST in COVID-19 patients (r = 0.681, p < 0.001) and CG (r = 0.668, p < 0.001), and between the 6MWT and the CST in COVID-19 patients (r = 0.692, p < 0.001). CONCLUSION: The 1min-STST and the CST correlated significantly with the 6MWT in patients post-COVID-19 being alternatives if the 6MWT cannot be performed.

9.
Revista Venezolana de Gerencia ; 27(99):1008-1026, 2022.
Article in Spanish | Scopus | ID: covidwho-1935069

ABSTRACT

This article is a response to the need for economic reactivation because of the crisis resulting from the context of COVID-19. The purpose of the research was to elaborate a theoretical construct through the application of Confirmatory Factor Analysis that gathers observable variables around dimensions or factors. The study begins with a review of the literature that approximates the causal relationship of the phenomenon. The research has a quantitative approach with exploratory, descriptive and correlational designs. The following factors such as associativity, sustainable tourism, competitive advantage, market orientation, digital inclusion, agricultural innovation and knowledge transfer were found and they are linked with the economic reactivation. The Confirmatory Factorial Analysis was used in this study which helped to reduce from 117 to 47 items in the measurement instrument for the research of economic reactivation in the province of Cañar in Ecuador with factor loadings higher than 0.6. As a conclusion, it is said that it is possible to study the phenomenon with a validated questionnaire on the bivariate association of the researching variables. © 2022, Universidad del Zulia. All rights reserved.

10.
European Journal of Preventive Cardiology ; 29(SUPPL 1):i412-i414, 2022.
Article in English | EMBASE | ID: covidwho-1915608

ABSTRACT

Introduction: Although the effects of SARS-CoV-2 infection on the cardiovascular system are well known in the acute phase, the cardiovascular impact in the elderly population surviving respiratory COVID-19 infection after 1-year follow-up has not been sufficiently studied. Methods: Observational registry of 240 elderly patients (75 years or older) consecutively admitted for and surviving COVID-19 respiratory infection between March 1 and April 30, 2020. The incidence of major cardiovascular events [MACE] (cardiovascular death [CD], acute coronary syndrome [ACS], cerebrovascular disease [CVD], venous thromboembolic disease [VTE], and heart failure [HF]) was prospectively analyzed. Results: The mean age was 83.8 ± 5.6 years (range 75-103 years). A total of 54.2% were women. Most patients had a personal history of cardiovascular risk factors: hypertension (83.3%), diabetes mellitus (27.9%), dyslipidemia (43.8%). Among the main cardiological comorbidities, a history of atrial fibrillation was the most frequent (18.8%). Of note was the high percentage of institutionalized patients (37.1%) and those with moderate-severe dementia (16.7%). After a mean follow-up of 352.2±70.4 days, 13.8% of patients died and 9.6% had MACE, the most frequent being heart failure (7.5%), with no differences in the severity or overall evolution of the acute disease. Of the 33 patients who developed HF, only 3 died of cardiovascular causes. Only 2 patients suffered a stroke, in both cases without a history of AF or anticoagulants. Only 2 patients had a thromboembolic event (0.8%). The low incidence of thrombotic events may be due in part to the high rate of anticoagulation and chronic antiplatelet therapy and the high percentage of prophylactic heparin prescription at discharge, as well as the fact that only cases with clinical repercussions. COPD, CKD, institutionalization and moderate-severe dementia are associated with an increased risk of MACE, although only COPD and prescription of loop diuretics were identified as independent risk markers in the multivariate analysis. Conclusions: In elderly COVID-19 survivors, the incidence of MACE after one year of follow-up is high, the main manifestation being heart failure. COPD and the prescription of loop diuretics were identified as independent risk markers for the development of MACE in the multivariate analysis. Baseline clinical characteristics Cox survival analysis.Predictors of MACE.

11.
European Journal of Preventive Cardiology ; 29(SUPPL 1):i117-i118, 2022.
Article in English | EMBASE | ID: covidwho-1915578

ABSTRACT

Introduction: The management of antihypertensive drugs and especially ACEI/ARA2 during the first wave of the SARS-CoV-2 pandemic was a matter of debate. The change in antihypertensive treatment during the pandemic and its repercussions have not been sufficiently studied. Methods: Observational and prospective study that analyzed consecutive patients admitted for respiratory infection and positive polymerase chain reaction (PCR) between March 1 and April 30, 2020. During the period analyzed, 921 patients were registered, of whom 673 patients were discharged;among them 359 were patients with a diagnosis of arterial hypertension and pharmacological treatment. These patients were followed up in days, from the time of discharge to data analysis, with a mean of 352±70.4 days. Results: The mean age was 74.4±12.9 years, and 50.7% were male. A total of 28.7% were diabetic patients, 49% were dyslipidemic, 17.8% were smokers, and 19.8% were obese. Of the patients analyzed, 13.4% had a previous diagnosis of ischemic heart disease, a similar percentage, 13.1% had heart failure, and 13.6% had atrial fibrillation. The antihypertensive drugs analyzed were ACE inhibitors (angiotensin-converting enzyme inhibitors), ARA-2 (angiotensin II receptor antagonists), calcium antagonists, thiazide diuretics, loop diuretics, aldosterone antagonists, beta-blockers and alpha-blockers. At discharge, 75.8% of the patients maintained their antihypertensive treatment, and the remaining 24.2% were modified. Prior to admission, 77.2% were taking ACE inhibitors or ARA-2;however, in 16.4% of the patients they were discontinued after admission. In contrast, treatment with calcium antagonists increased from 27.6% to 34.1% after hospitalization. In both cases there were statistically significant differences in the bivariate analysis in the McNemar test (p < 0.05 in both cases), with no differences in the other antihypertensive drugs analyzed. After follow-up, the combined event occurred in 28 patients, with the most frequent event being the development of HF;in contrast, only 0.8% presented ACS. Overall mortality was 8.9%. Picture 1 shows the events recorded according to the change in antihypertensive treatment and the maintenance or discontinuation of ACEI/ARA-2 in those patients who were already taking it on admission. Similarly, a survival analysis was performed in which no differences were observed in terms of all-cause mortality or major cardiovascular events between patients who maintained their antihypertensive treatment and those who modified it. Conclusions: In the population surviving SARS-CoV-2 respiratory infection, maintaining or discontinuing treatment with ACEI/ARA-2 did not influence mortality or the appearance of major cardiovascular events after the first year of follow-up. (Table Presented).

12.
Topics in Antiviral Medicine ; 30(1 SUPPL):251, 2022.
Article in English | EMBASE | ID: covidwho-1880248

ABSTRACT

Background: Although SARS-CoV-2 has mainly respiratory manifestations, gastrointestinal symptoms are observed in 30% of cases. The ACE-2 receptor used by SARS-CoV-2 to infect cells is highly expressed in the brush border of enterocytes. However, studying the small intestine in live patients is a challenge in the field of clinical research. A minimally invasive alternative for studying the small intestine is the use of capsule endoscopy, which could be useful in the context of COVID-19. Here, we describe endoscopic changes in the mucosa of the small intestine secondary to severe SARS-CoV-2 infection in hospitalized patients. Methods: We performed a prospective observational study in hospitalized patients with a severe COVID-19 according to NIH guidelines. Participants with a positive COVID-19 PCR from nasopharyngeal swab, hemodynamically stable, able to swallow, and without additional respiratory co-infections, were enrolled between January 27th and May 17th, 2021 at the largest tertiary COVID-19 referral center in Mexico City. Demographic and clinical characteristics were collected for each participant from clinical files. A PillCam capsule from Medtronic® was used for Capsule Endoscopy (CE). Each capsule study was reviewed separately by two trained endoscopists. Detection of SARS-CoV-2 RNA in stool samples was performed according to CDC guidelines for all participants. Results: Twenty volunteers were enrolled in the study. Diarrhea was the most common gastrointestinal symptom (78%). CE study was normal in 6 participants, while the rest showed at least one intestinal finding. The most frequent finding was shortening or atrophy of villi and hyperemia (45%);followed by red spots (40%), and ulcers (15%). Two participants with shortening or atrophy of villi also presented denuded mucosa. CE findings were observed mainly in duodenum and jejunum. Participants showing changes in villi also presented positive SARS-CoV-2 RNA in stool. Conclusion: We observed that macroscopic changes in the small intestine mucosa, specifically in villi, occurred frequently in severe COVID-19 patients. These changes were accompanied by the presence of SARS-CoV-2 RNA in stool. We proposed the term COVID-19 Enteropathy to encompass these findings. Further studies are warranted to establish mechanisms of SARS-CoV-2-associated gastrointestinal disease.

14.
Psicoperspectivas ; 20(3), 2021.
Article in Spanish | Scopus | ID: covidwho-1847528

ABSTRACT

The restrictions of the current pandemic (COVID-19) on daily life, linked to social distancing and increased time at home, considerably affect people's physical and emotional health. This quantitative evaluative study was conducted at the national level with the aim of assessing how confinement affected family leisure activities, collecting information from 763 families. An online instrument composed of 61 items was used to measure, among other dimensions, the benefits, characteristics and changes experienced in family leisure. The results indicate that there were significant differences in the variables of family type, the person completing the questionnaire and the mother's level of education. This suggests, in conclusion, that family leisure has undergone a positive change, although the burden of its development continues to fall on the mother. © 2021 Pontificia Universidad Catolica de Valparaiso. All rights reserved.

15.
Blood ; 138(SUPPL 1):3826, 2021.
Article in English | EMBASE | ID: covidwho-1770242

ABSTRACT

Introduction: Axicabtagene ciloleucel (axi-cel) is an autologous anti-CD19 Chimeric Antigen Receptor (CAR) T-cell therapy that induces durable responses in patients with relapsed or refractory large B-cell lymphoma. At a median of 27.1 months follow-up on the ZUMA-1 trial, median overall survival (OS) was 25.8 months with 39% progression free survival (PFS) at 2 years post-infusion (Locke, Lancet Onc 2019). We previously reported outcomes of axi-cel patients treated with standard of care therapy at a median follow up of 12.9 months, including 42% who did not meet eligibility criteria for ZUMA-1 based on co-morbidities (Nastoupil, JCO 2020). Here we report results from this cohort at a median follow up of 32.4 months, as well as late outcomes of interest including cytopenias, infections and secondary malignancies. Methods and Results: The US Lymphoma CAR-T Consortium comprised of 17 US academic centers who contributed data independent of the manufacturer. Two hundred and ninety-eight patients underwent leukapheresis with intent to manufacture standard of care axi-cel as of September 30, 2018. In infused patients (n=275), OS and PFS were calculated from date of infusion. After median follow-up of 32.4 months (95% CI 31.1 - 34.3), median OS was not reached (95% CI 25.6 - not evaluable) (Figure 1A) with 1-, 2- and 3-year OS of 68.5% (95% CI 62.6-73.7), 56.4% (95% CI 50.1-62.2) and 52.2% (95% CI 45.7-58.2%), respectively. Median PFS was 9 months (95% CI 5.9-19.6) (Figure 1B);1-, 2- and 3-year PFS was 47.4% (95% CI 41.4-53.2), 41.6% (95% CI 35.6-47.5) and 37.3% (95% CI 31.3-43.2), respectively. Twenty-seven PFS events occurred at or after 1 year post infusion;19 events were progressive lymphoma, with the latest relapse observed 28 months after axi-cel infusion. Eight patients died while in remission from their lymphoma: 4 from secondary malignancy, 3 from infection, and 1 from unknown causes. Results of multivariable modeling were similar to our prior analysis: factors associated with both a shorter PFS and shorter OS included male sex, elevated pre-lymphodepletion LDH, and poor ECOG status. Complete blood count and B- and T-cell recovery data were collected at 1 and 2-years post-infusion, excluding patients who had relapsed or been treated for secondary malignancy at time of collection (Table 1). Rates of neutropenia (absolute neutrophil count ≤1000) at 1- and 2- years were 9.2% (10/109) and 11.2% (9/80) and rates of CD4 count ≤200/ul were 62% (23/37) and 27% (7/26). Recovery of B cells was seen in 54% (15/28) and 57% (13/23) at 1-and 2-years post infusion. Infections were reported in 31.2% (34/109) patients between 6- and 12-months post infusion, and 17% (18/109) were severe, requiring either hospitalization and/or IV antibiotics. Twenty-one patients (24%, 21/89) had an infection between 1- and 2- years, 11% of which were severe. Twenty percent (10/49) of patients between 2- and 3-years had an infection and 4 (8%) were severe. Neutropenia, low CD4 counts, and IgG levels were not associated with infection, though patients with infection between 6-12 months were more likely to have received IVIG (p<0.001). No patient in this cohort died of COVID-19. Twenty-two of 275 (8%) patients were diagnosed with subsequent malignancy after axi-cel treatment: 14/275 (5%) patients were diagnosed with myeloid malignancies (MDS (n=12), AML (n=1), CMML (n=1));other malignancies included squamous cell carcinoma of skin (n=3);sarcoma (n=1);endometrial (n=1);lung (n=1);mesothelioma (n=1) and AITL (n=1). Patients with myeloid malignancy had a median age of 62 at axi-cel apheresis (IQR 56-67), 64% were male and median lines of prior therapy was 4 (IQR 3-6), including 36% with a prior autologous stem cell transplant. Eleven patients were in remission from lymphoma at myeloid malignancy diagnosis, while 3 were diagnosed after progression and interval therapy. Conclusion: This multi-center retrospective study showed similar long-term results to the ZUMA-1 trial, despite including patients who did not meet ZUMA-1 eligibility criteria ba ed on comorbidities. Sixteen percent of PFS events were seen after 1 year, largely due to disease progression. Late infection was common but was not explained by persistent neutropenia or low CD4 counts. Subsequent malignancy, including MDS, occurred in 8% of patients and require further study to better identify patients at risk. (Figure Presented).

16.
Reidocrea-Revista Eectronica De Investigacion Y Docencia Creativa ; 11:1-13, 2022.
Article in Spanish | Web of Science | ID: covidwho-1743674

ABSTRACT

We are in a pandemic situation in which knowing the perception of risk of the virus, and the intention of conduct before the vaccine against it, can provide valuable knowledge to make decisions both in the educational context of the school and in other areas. To advance knowledge on the subject, a quantitative study has been developed in which the responses of 308 ESO and Baccalaureate students, from all over Spain, have been analysed, by means of a previously validated questionnaire. This reinforces the epistemological knowledge of the students' perception of current socio-scientific issues that are present in the public debate at all its scales, also within the classroom. In turn, it seeks to open the door to future studies, which, in comparison with the results of this work and other similar ones, allow to establish what factors affect students' attitudes towards science and to what extent, especially those who allow shedding light on the influence of teaching-learning in science in the classroom compared to learning by other untested means. The results show a distribution of the risk perception and the vaccination intention according to age and gender.

17.
Revista Mexicana de Urologia ; 81(5), 2021.
Article in English | EMBASE | ID: covidwho-1737622

ABSTRACT

Introduction: The COVID-19 pandemics has caused millions of deaths worldwide, has increased the demand for in-hospital beds and has affected in-hospital activities of "non-respiratory patients." There is currently no known effect of the pandemic on the emergency urological care in our region. This study aims to estimate the first - wave COVID-19 pandemics effect on emergency urological care in four tertiary Colombian hospitals. Material and methods: A cross-sectional retrospective multicenter study were made. The emergency urological care activities between April - May 2019 and April - May 2020 were compared. We calculated descriptive statistics and assessed differences during the study periods. We used Stata 13.0. Results: 1570 patients were included. There was a 22.20% decrease in the number of patients who visited the emergency room (ER) for urological disease during the pandemic's initial phase. Urolithiasis and urological infectious were the most common reasons for consulting in the ER. The surgical index for patients who required emergency urological care had a increase of 10.74% (p: 0.0001). There was a decrease of 0.74 days in hospital stay for patients who required urological emergency care in the initial COVID-19 pandemic period. Conclusions: The COVID-19 pandemic has had a significant impact on emergency and elective urological care worldwide. During the initial phase of this emergency, there was a significant decreased in hospital admission and average hospital stays due to urological emergencies in Colombia, however, the surgical index for critical urological diseases increased by 10.74%. According to the pandemićs dynamics, a greater effect on urological care is expected..

18.
International Journal of Radiation Oncology*Biology*Physics ; 112(5):e26, 2022.
Article in English | ScienceDirect | ID: covidwho-1734536

ABSTRACT

Purpose/Objective(s) In Guatemala's Roosevelt Hospital, most patients consult with locally advanced stages of SCCHN. Cisplatin, Docetaxel, and 5FU regimen has shown superiority over Cisplatin plus 5FU during the induction of LA cases, with afew reports supporting the substitution of 5FU with capecitabine for LA SCCHN. During the COVID-19 pandemic, we performed induction therapy with PTC in patients with LA SCCHN to reduce inpatient treatment. Materials/Methods We performed a retrospective analysis of patients with LA SCCHN with preserved swallowing function treated with Cisplatin 75mg/m2, Paclitaxel 175mg/m2, and Capecitabine 1000mg/m2 twice a day for 14 days. RECIST and CTCAE were used to measure response and adverse events. Results A total of 16 LA SCCHN patients were treated with PTC induction. Treated patients were mostly men, smokers, and considered not candidates for surgical resection (Table 1). The mean of cycles administered was 3.5 (SD = 0.97). Regarding the response to the PTC regimen, 93.6% of patients achieved disease control. Only 6.2% of patients stopped capecitabine, whereas 37.5% required dose reduction. The main adverse events were nausea, vomiting, and diarrhea. Conclusion The PTC regimen worked as induction therapy for patients with LA SCCHN. The substitution of 5FU for Capecitabine requires prospective validation.

19.
Discusiones Filosoficas ; 22(38):59-76, 2021.
Article in Spanish | Scopus | ID: covidwho-1732533

ABSTRACT

This work seeks to establish the hypothesis that the COVID-19 pandemic is a symptom of Capital under neoliberal governmentality. To account for this hypothesis, two traditions of contemporary political thought were worked: biopolitics, inaugurated by Michel Foucault, and post-foundational theories, arising from the link between Marxism and psychoanalysis. Finally, an attempt was made to affirm that the idea that the politicization of the pandemic, understood as a situated symptomatic reading, is a critical strategy for addressing social unrest that could open an emancipatory horizon. For this purpose a cartography on certain sensitive points that concern the conditions of symptomatic production of neoliberalism, the role of the State under the laws of the market and its links with the population will be deepened in a limited way © 2021, Discusiones Filosoficas.All Rights Reserved.

20.
Sociedade e Estado ; 36(3):967-988, 2021.
Article in English | Scopus | ID: covidwho-1708834

ABSTRACT

This article proposes a retrospective look at the last year following the World Health Organization’s declaration of Covid-19 as a pandemic, and seeks to reflect the wide diversity of its impact. In reviewing research from around the world, a panorama emerges showing the vast complexity of the phenomenon. This article reviews many of the analyses and debates that have been proposed from the framework of political philosophy, which are drawn almost exclusively from the European context. It shows that the suggested diagnoses, models and concepts can not be universally applied across geographies, such as Latin America, Asia or Africa. It therefore proposes to “deglobalize” the Covid-19 pandemic and invites the reader to consider it through another lens. © 2021, Universidade de Brasilia. All rights reserved.

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