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J Infect Public Health ; 15(7): 746-751, 2022 Jul.
Article in English | MEDLINE | ID: covidwho-1885926


BACKGROUND: This study aims to assess the neonatal outcomes related to maternal SARS-COV-2 infection. METHODS: In this study, we identified newborns born between May 14 and August 31, 2020, to mothers who were PCR-SRAS-CoV-2 positive at the time of delivery. From the cohort of 974 infants, we performed a nested case-control study. RESULTS: During the study period, 133 (13.7%) mothers were positive for SARS-CoV-2. Among the 35 pregnant women with COVID-19 symptoms (26.3%), cough was the most common symptom, present in half of the cases. Four of them have progressed to critical pneumonia requiring transfer to intensive care unit. The neonates from mothers with positive SARS-CoV-2-RT-PCR, were routinely tested for COVID-19 within the first 24 h after labor, and 3 other newborns tested in the presence of symptoms. There was no significant difference between the two groups with respect to preterm birth, meconium-stained amniotic fluid distress, and neonatal asphyxia. Most infants were breastfed at birth, regardless of their mothers' COVID-19 status. In COVID-19-positive pregnant women admitted to intensive care unit, the proportion of preterm births (OR=12.5 [1.7-90.5]), fetal death in utero (OR=25.9 [2.2-305]) and admission in neonatal intensive care unit admission (OR=13.4 [3.0-60]), appeared higher than the controls. No maternal deaths were recorded. CONCLUSIONS: Our data suggest little neonatal morbidity associated with maternal COVID-19, except for those born to mothers admitted to intensive care unit. However, under breastfeeding conditions with rigorous hygiene precautions and parental education, the risk of transmission of SARS-COV-2 virus to the newborn was very low.

COVID-19 , Pregnancy Complications, Infectious , Premature Birth , COVID-19/epidemiology , Case-Control Studies , Female , French Guiana/epidemiology , Humans , Infant , Infant, Newborn , Infectious Disease Transmission, Vertical/prevention & control , Pregnancy , Pregnancy Complications, Infectious/diagnosis , Pregnancy Complications, Infectious/epidemiology , Pregnancy Outcome , Premature Birth/epidemiology , SARS-CoV-2
Bulletin Hebdomadaire ; 2022.
Article in French | GIM | ID: covidwho-1743817


Background - In the context of the global COVID-19 pandemic and the expansion of the more transmissible 20J/501Y.V3 (P1) variant of concern (VOC), mRNA vaccines were made available in French Guiana, an overseas French territory in South America, from mid-January 2021. This study aimes to estimate the willingness to be vaccinated and the socio-demographic and motivational correlates among Health Care Workers (HCWs) in French Guiana. Methods - A cross-sectional survey was conducted from January 22 to March 26, 2021, among a sample of HCWs in French Guiana based on an anonymous online questionnaire. Results - A total of 579 HCWs were interviewed, including 220 physicians and 200 nurses most often working in hospital (54%) or in the liberal sector (22%). Overall, 65.6% of respondents reported that they were willing to be or had already been vaccinated against COVID-19, while 24.3% of respondents reported that they did not want to get vaccinated against COVID-19 and 11.2% were unsure. In multivariate analysis, factors associated with vaccination willingness were older age, level of concern about COVID-19, confidence in vaccine information, and having been vaccinated against influenza in the previous year. Conversely, reluctance to certain vaccinations in general (adjusted OR=0.23, CI95%: [0.13-0.41]) and being from the West Indies or French Guiana (aOR=0.39 [0.21-0.73]) were associated with greater vaccine distrust. Conclusion - Negative opinions and attitudes toward vaccines are a major public health concern among HCWs in French Guiana when considering the current active epidemic with P1 VOC. Territorial specificities, general vaccine hesitancy and concerns about future side effects in particular represent important barriers and/or issues. Low confidence in government and science are important for COVID-19 vaccine refusal among non-medical staff. Public health messages with information on vaccine safety should be tailored to address these concerns.