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1.
NeuroQuantology ; 20(8):2194-2200, 2022.
Article in English | EMBASE | ID: covidwho-2033459

ABSTRACT

Education around the world is facing a setback due to the onset of the pandemic from the year 2019. The field of education and the academicians around the world working hard to provide uninterrupted education to their wards and the only option left with them is the online mode of education. Shifting their mode of delivery from face-to-face conventional classroom education to an entirely new system requires a lot of effort. This study intends to understand the challenges and opportunities before the teaching community to deliver quality education to their students through online mode.

2.
Journal of the International Aids Society ; 25:17-18, 2022.
Article in English | Web of Science | ID: covidwho-1980277
3.
Frontiers in Sustainable Food Systems ; 6:27, 2022.
Article in English | Web of Science | ID: covidwho-1798914

ABSTRACT

Literatures on social innovation, collective agency and multi-actor collaboration stress the importance of action research and joint problematization to research ongoing processes of collaboration and transformation to advance both theory and practice in these fields. In this paper we analyze our experience building a transdisciplinary action research (TAR) trajectory between 2020 and 2021 to investigate socially innovative multi-actor collaborations (IMACs) and urban governance innovation trajectories in the city of Leuven (Belgium). We specifically focus on (1) how we involved a wide array of researchers, stakeholders and practitioners in the TAR trajectory;(2) how we enacted joint problematization and action, ensuring that all facilitative leadership roles were taken care of;(3) the challenges that the specific COVID context posed on TAR and the innovative tools and approaches we took to adapt under such circumstances;and (4) how our TAR contributed to the ongoing IMACs in Leuven. Discussing our experience in relation to issues raised in action research literature, we summarize key dimensions, roles and tasks necessary in TAR to enable facilitative leadership and multi-actor collaboration and successfully drive joint problematization and transformative change. We conclude that our TAR trajectory in Leuven became a case study of IMAC in itself, and so learnings from our TAR directly dialogue with and inform our empirical analysis of the performance of IMACs too. Through this realization and the analysis of our experience, we get to broader question the role of action research and researchers in urban governance innovation.

4.
Indian Journal of Traditional Knowledge ; 20(4):885-890, 2021.
Article in English | Web of Science | ID: covidwho-1535617

ABSTRACT

Medicinal herbs play an important role in the primary health care system of developing countries and always uphold the importance of ethnomedicinal studies in the drug discovery process. Indian Siddha practitioners urged people to consume a polyherbal formulation named 'Kaba Sura kudineer (KSK)' as a prophylactic measure against COVID-19. To validate the presence of anti-COVID 19 agents if any in KSK, virtual screening of 80 phytochemicals was done by blind docking, fixing the RBD-ACE2 complex as the target using PyRx software. The binding energy of the compounds was calculated using Autodock Vina. The SWISSADME server was used to identify the phytochemicals that obey the Lipinski rule and the blood-brain barrier permeability of the compounds. The outcome of the study revealed that phytochemicals such as diosgenin, diosgenone, coumaperine, bisdemethoxycurcumin, tinocordifolin, isovanillinand 1,8-Cineole displayed hydrogen bond interactions with the complex residues in the interacting site (-8.9 to -5.1 kcal/mol) and were found to obey the Lipinski rule as well as possess blood-brain barrier (BBB) permeability. Based on the highest docking score and the more number of interacting residues at the active site herein we suggest diosgenin and bisdemethoxycurcumin as potential inhibitors of SARS-Co-V-2.

5.
Journal of Biomolecular Structure & Dynamics ; : 1-15, 2020.
Article in English | MEDLINE | ID: covidwho-1246547

ABSTRACT

SARS-CoV-2 cause fatal infection in 213 countries accounting for the death of millions of people globally. In the present study, phytochemicals from spices were assessed for their ability to interact with SARS-CoV-2 MPro. Structure based virtual screening was performed with 146 phytochemicals from spices using Autodock Vina. Phytochemicals with binding energy >= -8.0 kcal/mol were selected to understand their interaction with MPro. Virtual screening was further validated by performing molecular docking to generate favorable docked poses and the participation of important amino acid residues. Molecular dynamics simulation for the docked poses was performed to study thermodynamic properties of the protein, ligand and protein-ligand complexes. The finding shows that cinnamtannin B2 and cyanin showed favorable binding affinity values with SARS-CoV-2 MPro. The results are comparable in terms of docked poses, important amino acid participation and thermodynamic properties with the standard control drugs remdesivir, benazepril and hydroxychloroquine diphosphate. Prime MM-GBSA was employed for end-point binding energy calculation. Binding to domain I and II of MPro were mediated through the OH, SH, NH2 and non-polar side chain of amino acids. Cinnamtannin B2 and cyanin binds to MPro with many sub sites within the active site with RMSD and RMSF within 4 A. The results computed using Prime MM-GBSA show that cinnamtannin B2 (-68.54940214 kcal/mol) and cyanin (-62.1902835 kcal/mol) have better binding affinity in comparison to hydroxychloroquine diphosphate (-54.00912412 kcal/mol) and benazepril (-53.70242369 kcal/mol). The results provide a basis for exploiting cinnamtannin B2 and cyanin as a starting point potential candidate for the development of drug against SARS-CoV-2.Communicated by Ramaswamy H. Sarma.

6.
IEEE Conf. Inf. Commun. Technol., CICT ; 2020.
Article in English | Scopus | ID: covidwho-1066541

ABSTRACT

Corona Virus Disease (COVID-19) is a new disease that is spreading worldwide. It easily spreads from the contaminated individual to others through beads of salivation or release from the nose. This pandemic situation proved that doctors, nurses, and front line workers are real-life heroes. The patients affected due to COVID-19 is increasing regularly. Doctors and nurses who treat the patients wear all their personal protective equipment and clothes, yet, they get influenced as well. Doctors and nurses can't be in direct contact with the patients frequently since the probability of spread is high. The patients need to be served with food, medicines, and other required things on a regular time basis. To reduce the spread, human force, and to maintain a strategic distance from COVID-19 affected patients, the best way is to utilize an automated guided vehicle (AGV) to carry the essentials and transport it to the patient's room as per the line map given. A hospital environment that depicts the isolated ward with the COVID-19 affected patients is created using Webots. Four mobile robots are left inside the environment with a map that navigates it to the patient's room. The robots are simulated with the environment as such two robots take care of the left half and the other two robots take care of the right half of the isolated ward. © 2020 IEEE.

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