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Indian Journal of Hematology and Blood Transfusion ; 37(SUPPL 1):S121, 2021.
Article in English | EMBASE | ID: covidwho-1638488


Introduction: COVID-19, caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has spread across the globe,causing > 100,000 deaths in India in the first wave. The second wavewith its atypical undetected genetic mutation brings new trends indisease morbidity and significant variation in target organs, blood andblood components, especially new and some significant trends in thecoagulation parameters. The coagulopathy associated with COVID-19is characterized by thrombocytopenia, prolongation of the prothrombin time, high levels of D-dimer, elevated levels of fibrinogenand APTT. The levels of D-dimer correlate with disease severity andpredict the risk of thrombosis.Aims &Objectives: Predicting the severity and prognosis ofCOVID-19 patients in the Second Wave of the Pandemic by evaluating the coagulation markers like D-dimer (DD), Prothrombin Time(PT), Activated Partial Thromboplastin Time (APTT), and Fibrinogen(Fb) in them.Materials &Methods: A total of 110 confirmed COVID 19 patientsduring the Second wave who were admitted at DR PRABHAKARKORE HOSPITAL, JNMC, BELAGAVI between March 2021 andJuly 2021 were categorized into mild, moderate and severe based onCO-RADS SCORE. The dynamic changes of DD, PT, APTT, and Fbwere studied and correlated with clinical findings and prognosis.Result: Coagulation variations occurred at the early stage of COVID-19 infection, with 79(71.81%) patients having significant increase inDD, 70(63.63%) patients having significant Fb increase, 53(48.18%)in PT and 57(51.81%) in APTT. In mild to moderate cases significantvariation of coagulation parameters was found in the first week ofadmission whereas in severe and critically ill cases the variationswere more in the last week of their hospital stay. Gender variation isnot significant in the study population. The above 50 yrs age grouphad poorer prognosis with higher variation and higher levels of all theparameters studied as compared to the age group below 50 yrs.Conclusions: Coagulation parameters could be used as significantindicators in predicting the severity and prognosis of COVID-19patients in the Second Wave.

Indian Journal of Hematology and Blood Transfusion ; 37(SUPPL 1):S83, 2021.
Article in English | EMBASE | ID: covidwho-1635857


Introduction: Coronavirus Disease 2019(COVID-19) has beendeclared by World Health Organization (WHO) as a global emergency due to its pandemicity. Since its first emergence in Wuhan,China number of new cases and deaths are still increasing by the day.While most patient have mild influenza and may be asymptomatic, aminority of patients will develop severe pneumonia, acute respiratorydistress syndrome, multi organ failure and death. Clinical and Laboratory biomarkers to predict the mortality and severity of COVID-19are essential in this pandemic. According to studies and data Neutrophil Lymphocyte Ratio is the first and the most importantparameter that is found to be associated with the course of the disease.Following SARS-COV 2 infection, most of the patients presentedwith Lymphopenia and elevated levels of infection related biomarkers, more interestingly, a higher number of Neutrophils and lowernumber of Lymphocytes, the increase of Neutrophil LymphocyteRatio were found in non-survivors with COVID-19 compared tosurvivors along with monocyte lymphocyte ratio, platelet lymphocyteratio, D-Dimer level. These changes showed the degree of inflammation in the body was further intensified, triggering an inflammatorystorm and leading to increased tissue and cell damage.Aims &Objectives: Predicting the severity of COVID-19 patients byevaluating the blood parameters like neutrophils, lymphocyte, neutrophil lymphocyte ratio, monocyte lymphocyte ratio, plateletlymphocyte ratio, D-Dimer.Materials &Methods: A total of 100 confirmed COVID 19 patientsat DR PRABHAKAR KORE HOSPITAL OF JNMC, BELAGAVIbetween March 2021 and July 2021 were studied.Result: At hospital admission, the median leukocyte count was 5900cell/mm3. The median neutrophil count was 4240 cell/mm3 and themedian lymphocyte count was 925 cell/mm3. The median platelet-tolymphocyte ratio (PLR) was 191.7 while the median NLR was 4.5.Conclusions: Blood parameters could be used as significant indicators in predicting the severity of COVID-19 patients.