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1.
Blood Cancer Journal ; 13(1):8, 2023.
Article in English | MEDLINE | ID: covidwho-2185781

ABSTRACT

The long-term clinical efficacy of SARS-CoV-2 vaccines according to antibody response in immunosuppressed patients such as hematological patients has been little explored. A prospective multicenter registry-based cohort study conducted from December 2020 to July 2022 by the Spanish Transplant and Cell Therapy group, was used to analyze the relationship of antibody response over time after full vaccination (at 3-6 weeks, 3, 6 and 12 months) (2 doses) and of booster doses with breakthrough SARS-CoV-2 infection in 1551 patients with hematological disorders. At a median follow-up of 388 days after complete immunization, 266 out of 1551 (17%) developed breakthrough SARS-CoV-2 infection at median of 86 days (range 7-391) after full vaccination. The cumulative incidence was 18% [95% confidence interval (C.I.), 16-20%]. Multivariate analysis identified higher incidence in chronic lymphocytic leukemia patients (29%) and with the use of corticosteroids (24.5%), whereas female sex (15.5%) and more than 1 year after last therapy (14%) were associated with a lower incidence (p < 0.05 for all comparisons). Median antibody titers at different time points were significantly lower in breakthrough cases than in non-cases. A serological titer cut-off of 250 BAU/mL was predictive of breakthrough infection and its severity. SARS-CoV-2 infection-related mortality was encouragingly low (1.9%) in our series. Our study describes the incidence of and risk factors for COVID-19 breakthrough infections during the initial vaccination and booster doses in the 2021 to mid-2022 period. The level of antibody titers at any time after 2-dose vaccination is strongly linked with protection against both breakthrough infection and severe disease, even with the Omicron SARS-CoV-2 variant.

2.
J Clin Epidemiol ; 2023.
Article in English | PubMed | ID: covidwho-2180257

ABSTRACT

OBJECTIVE: To introduce methods for living guidelines based in practical experiences by the Australian Living Evidence Consortium (ALEC), the National Institute of Health and Care Excellence (NICE) and the Infectious Diseases Society of America (IDSA), with methodological support from the United States (US) Grading of Recommendations, Assessment, Development and Evaluations (GRADE) Network. STUDY DESIGN AND SETTING: Members of ALEC, NICE, and the US GRADE Network, convened a working group to share experiences of the methods used to develop living guidelines and outline the key differences between traditional and living guidelines methods. RESULTS: The guidance includes the following steps: 1) deciding if the guideline is a priority for a living approach, 2) preparing for living guideline development, 3) literature surveillance and frequency of searching, 4) assessment and synthesis of the evidence, 5) publication and dissemination, and 6) transitioning recommendations out of living mode. CONCLUSION: This paper introduces methods for living guidelines and provides examples of the similarities and differences in approach across multiple organizations conducting living guidelines. It also introduces a series of papers exploring methods living guidelines based on our practical experiences, including: consumer involvement, selecting and prioritising questions, search decisions, and methods decisions.

3.
J Clin Epidemiol ; 2023.
Article in English | PubMed | ID: covidwho-2180256

ABSTRACT

OBJECTIVE: To describe the key features of a continual evidence surveillance process that can be implemented for living guidelines and to outline the considerations and trade-offs in adopting different approaches. STUDY DESIGN AND SETTING: Members of the Australian Living Evidence Consortium (ALEC), National Institute of Health and Care Excellence (NICE) and the US GRADE Network shared their practical experiences of and approaches to establishing surveillance systems for living guidelines. We identified several common components of evidence surveillance and listed the key features and considerations for each component drawn from case studies, highlighting differences with standard guidelines. RESULTS: We developed guidance that covers the initial information needed to support decisions around suitability for living mode, and the practical considerations in setting up continual search surveillance systems (search frequency, sources to search, use of automation, reporting the search, ongoing resources, and evaluation). The case studies draw on our experiences with developing guidelines for COVID-19, as well as other conditions such as stroke and diabetes, and cover a range of practical approaches, including the use of automation. CONCLUSION: This paper highlights different approaches to continual evidence surveillance that can be implemented in living guidelines.

4.
Journal of Medical Virology ; 12:12, 2022.
Article in English | MEDLINE | ID: covidwho-2157850

ABSTRACT

The information provided by SARS-CoV-2 Spike (S)-targeting immunoassays can be instrumental in clinical-decision making. We compared the performance of the Elecsys R Anti-SARS-CoV-2 S assay (Roche Diagnostics) and the LIAISON R SARS-CoV-2 TrimericS IgG assay (DiaSorin) using a total of 1,176 sera from 797 individuals, of which 286 were from vaccinated-SARS-CoV-2/experienced (Vac-Ex), 581 from vaccinated/naive (Vac-N), 147 from unvaccinated/experienced (Unvac-Ex) and 162 from unvaccinated/naive (Unvac-N) individuals. The Roche assay returned a higher number of positive results (907 vs. 790;P=0.45;overall sensitivity: 89.3% vs. 77.6%). The concordance between results provided by the two immunoassays was higher for sera from Vac-N (Kappa: 0.58;IQR, 0.50-0.65) than for sera from Vac-Ex (Kappa: 0.19;IQR, -0.14-0.52) or Unvac-Ex (Kappa: 0.18;IQR, 0.06-0.30). Discordant results occurred more frequently among sera from Unvac-Ex (34.7%) followed by Vac-N (14.6%) and Vac-Ex (2.7%). Antibody levels quantified by both immunoassays were not significantly different when <250 (P=0.87) or <1,000 BAU/ml (P=0.13);in contrast, for sera >=1,000 BAU/ml, the Roche assay returned significantly higher values than the DiaSorin assay (P<0.008). Neutralizing antibody titers (NtAb) were measured in 127 sera from Vac-Ex or Vac-N using a S-pseudotyped virus neutralization assay of Wuhan-Hu-1, Omicron BA.1 and Omicron BA.2. The correlation between antibody levels and NtAb titers was higher for sera from Vac-N than those from Vac-Ex, irrespective of the (sub)variant considered. In conclusion, neither qualitative nor quantitative results returned by both immunoassays are interchangeable. The performance of both assays was found to be greatly influenced by the vaccination and SARS-CoV-2 infection status of individuals. This article is protected by copyright. All rights reserved.

5.
Plastic and Aesthetic Nursing ; 42(4):190-196, 2022.
Article in English | MEDLINE | ID: covidwho-2152271

ABSTRACT

Coronavirus disease was first described as an identified syndrome in December 2019 (COVID-19). Since then, a global pandemic has taken place and the disease has repeatedly been associated with thromboembolic complications, most of which are venous, but may also occur at the arterial level, even in patients receiving thromboprophylaxis. To date, only medium- and large-caliber vessels have been affected by arterial thrombosis secondary to COVID-19. This article describes the case of a 60-year-old woman with a prior severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection who developed multiple bone infarcts, complicated by secondary osteomyelitis. The patient underwent multiple surgical debridements and received a variety of antibiotics before the correct diagnosis was made and a multidisciplinary surgery was planned that provided coverage with a medial gastrocnemius flap. At 5-months follow-up, the patient had recovered well without any clinical evidence of infection or other complications. To the best of our knowledge, this is the first known case of a bone infarct complicated with a secondary osteomyelitis occurring in a patient having suffered a previous SARS-CoV-2 infection. We postulate as our main hypothesis that the prothrombogenic state secondary to SARS-CoV-2 infection may have contributed to thrombosis of small-caliber vessels, in our patient the arteria nutricia tibialis, triggering bone infarcts and a secondary infection with Staphylococcus aureus.

6.
Multiple Sclerosis Journal ; 28(3 Supplement):756-757, 2022.
Article in English | EMBASE | ID: covidwho-2138786

ABSTRACT

Objective: The objective of the study was to evaluate the incidence of COVID-19 infections after vaccination in NMOSD patients included in RELACOEM, a LATAM registry of MS and NMOSD patients infected and vaccinated for COVID-19. Method(s): Retrospective cohort study developed between May 2021 to December 2021. The primary outcome was the appearance of infection during the follow up time (at least three months after complete vaccination (second dose)). Data was collected through the contact between the treating physician and the patient. Specific information was requested (vaccine received, dose, date, symptoms, COVID-19 infection, need for hospitalization, ventilatory assistance, treatment, and evolution). The primary objective of the analysis was to compare the incidence of breakthrough SARS-CoV-2 19 infections among the vaccinated pwMS in each DMT group. These conditions entail a PCR-confirmed test, and a time lag of at least 14 days from a full vaccination cycle (after the second vaccination dose). Cumulative incidence was reported by Kaplan Meier survival curves as well as incidence density. Result(s): A total of 49 NMOSD patients from eight countries in LATAM were included. Mean age was 43.8 +/-13 years. The most frequent treatment use was rituximab in 29 (59.2%). The mean follow up after the second dose was 149 +/- 32 days. Most frequent first and second dose received was Pfizer (28.6%), followed by Sinopharm (24.5%). During follow up a total of 2 COVID-19 cases were observed for a total exposure time of 8627 days. Cumulative incidence was 4.1% (SE 0.87%) with an overall incidence density of 2.31 x 10.000 patients/day (95%CI 1.13-3.71). Both cases occurred in patients under rituximab (2/29, exposure time 4208, IR 4.7 x 10,000 patients/day 95%CI 3.5-5.1). No hospitalizations were reported for both cases. Conclusion(s): We observed an ID of COVID-19 infection after vaccination of 2.31 x 10.000 patients/day in NMOSD patients.

7.
Apuntes-Revista De Ciencias Sociales ; 49(92):151-182, 2022.
Article in Spanish | Web of Science | ID: covidwho-2082365

ABSTRACT

One of the main challenges that the COVID-19 pandemic brought was the continuity of education. In this context, this work focuses on analyzing the practice of higher education in the discipline of Engineering and its related academic programs with a future perspective, motivated by the limitations and challenges imposed by the pandemic. To ensure high-quality education, it was relevant to give continuity to the education of students, maintaining active, experiential, student-centered learning experiences that are relevant to developing their skills, despite their remote interaction and frequent technological deficiencies. and educational resources. Thus, this work proposes a conceptual scheme to guide the design and reflection of learning experiences with a post-pandemic perspective. This scheme is composed of six dimensions of innovation and educational leadership for higher education: environment, impact and linkage, educational models and value chain, educational strategies, teaching formats, infrastructure and learning resources, accreditations and learning evaluation. Additionally, this document presents initiatives that exemplify this effort within the MIT Supply Chain And Logistics Excellence network for Latin America and the Caribbean (MIT SCALE LAC), led by the Center for Transportation and Logistics from the Massachusetts Institute of Technology. These initiatives refer to learning experiences in universities in Bolivia, Mexico, and Peru that have sought to maintain active learning in the context of the pandemic, with a link to the contemporary challenges of organizations, communities, and the society in general in which they live. students immersed.

8.
Edunine2022 - Vi Ieee World Engineering Education Conference (Edunine): Rethinking Engineering Education after Covid-19: A Path to the New Normal ; 2022.
Article in English | Web of Science | ID: covidwho-2018715

ABSTRACT

The COVID-19 pandemic has set instructional barriers to engineering courses because of the limited access to learning resources and infrastructure. However, there is still the need for active alternatives for high-impact learning. This work explores the transformation of laboratory courses for Industrial Engineering education using Experiential Learning under remote learning spaces. The authors explore the current alternative efforts and propose a framework to face disruptive circumstances. These ideas were further implemented in two application cases over the last year. This work contributes to the enrichment of engineering learning experiences by considering novel learning situations and contextual conditions in labwork.

9.
Nephrology Dialysis Transplantation ; 37(SUPPL 3):i633-i634, 2022.
Article in English | EMBASE | ID: covidwho-1915766

ABSTRACT

BACKGROUND AND AIMS: Little is known regarding the dynamics of antibody and T-cell responses in chronic kidney disease (CKD) following COVID-19 vaccination. METHOD: Prospective observational cohort study including 144 participants on haemodialysis (HD) (n = 52), peritoneal dialysis (PD) (n = 14), kidney transplantation (KT) (n = 30) or advanced chronic kidney disease not on dialysis (ACKD), and healthy controls (n = 18). Anti-Spike(S) antibody and T-cell responses were assessed at 15 days (15D) and 3 months (3M) after vaccination. RESULTS: Anti-S antibodies at 15D and 3M were detectable in 95% (48/50)/98% (49/50) of HD patients, 93% (13/14)/100% of PD patients, 67% (17/26)/75% (21/28) of KT patients and 96% (25/26)/100% (24/24) of ACKD patients. Rates for healthy controls were 81% (13/16)/100% (17/17). Antibody levels decreased at 3M in HD (P = 0.04), PD (P = 0.008) and ACKD patients (P = 0.0009). In KT, patients levels increased (P = 0.04) between 15D and 3M, although they were low at both time points. Detectable T-cell responses notably increased at 3M in HD patients (P < 0.022). In PD, patients response increased by 15D (13/14;93%) and 3M (9/9;100%), while they were present in KT patients at 41% (12/27), 84% (22/26) and 96% (25/26) at baseline. Detectable T-cell responses in ACKD patients reached 80% (20/25) and 89% (17/19) at 15D and 3M, respectively. whereas in healthy controls it was 67% and 89% at 15D and 3M. CONCLUSION: Most HD, PD and ACKD patients develop SARS-CoV-2-S antibody responses comparable to that of healthy controls, in contrast to KT recipients. Antibody waning at 3M was faster in HD, PD, ACKD patients. No differences in SARS-CoV-2 T-cell immunity responses were noticed across study groups.

10.
Revista De Comunicacion De La Seeci ; - (55):1-+, 2022.
Article in Spanish | Web of Science | ID: covidwho-1897204

ABSTRACT

In March 2020, the new SARS-CoV-2 virus arrived to stay amongst us, bringing the most important global pandemic known up to now. The entire world was affected by a health crisis that spread to all sectors of society, leading to company clousures, rises in unemployment rates and many changes in ordinary lifestyle. This pandemic has also had an impact on changes in society's consumption habits and a relevant increase in the use of social networks due to the months of lockdown, which has leaded to important changes in various areas and, specifically, in the fashion and influencers sector. In addition to the pandemic problem, there is the trouble of adapting to the new Spanish regulation, code of conduct on social networks, from January 2021. This research aims to analyze, using a mixed methodology, the changes produced in fashion influencers jobs before, during and after the pandemic, the evolution of fashion brands in digital media and new trends in influencer marketing that have been caused by this new situation. To do so, we have performed a content analysis and interviews with professionals from the fashion sector. Conclusions show a greater control of content, an increase in number of followers and a closer link with brands. Comparisons with the dynamic in other international markets, as well as the future adaptation of the professional activity to current regulations, are the most relevant questions to be addressed in order to be able to expand the study in the future.

11.
IISE Annual Conference and Expo 2021 ; : 495-500, 2021.
Article in English | Scopus | ID: covidwho-1589778

ABSTRACT

The COVID-19 pandemic changed education by disrupting activities and interactions among all stakeholders. However, this event also opened new possibilities, as in higher education, to explore the future implications of the pandemic for learning purposes. One possibility is about the study of supply chains where delivery times and product quality were affected during the sanitary emergency. One essential category of goods strongly affected is food concerning availability, accessibility, and affordability because of physical limitations, mandatory ordinances, or deficient infrastructure. This situation interrupted supply chains affecting food provision and procurement across different social groups and locations, especially in disadvantaged or poor communities or countries. Accordingly, this work explores, from the perspective of Industrial Engineering education, the effects of the pandemic on food supply as relevant learning experiences about relevant contemporary issues. Learning experiences can refer to present difficulties in food supply during the pandemic;however, other possibilities might exist to improve food security in the future. Thus, a study of the pandemic situation in Latin America has been implemented about food supply. An online survey using internet social networks helped to collect data about people's profiles, consumption preferences, and shifts in food demand and supply over the pandemic in the two main conurbations of Mexico and Bolivia. Data analysis studied the impact on distinct age groups, locations, and income levels. Results explore consequences in the food provision because of increasing delivery times, shortages, and price rises. These findings can help to conceptualize learning experiences to strengthen food security in urban areas. © 2021 IISE Annual Conference and Expo 2021. All rights reserved.

12.
Bioactive Compounds in Health and Disease ; 4(9):189-200, 2021.
Article in English | Scopus | ID: covidwho-1552124

ABSTRACT

Obesity has been associated with adverse Coronavirus disease [COVID-19] outcomes;obesity is associated with sub-optimal immune function, including vitamin D and zinc deficiencies, two micronutrients essential for immune function, including anti-viral activity. The co-occurrence of vitamin D and zinc deficiencies have been documented. These exposures have been widely discussed in both scientific and popular literature. Thus, a critical review of the association between obesity, vitamin D and zinc, in relation to the COVID pandemic, is appropriate. Evidence strongly associates obesity and adverse COVID outcomes including hospitalization, intensive care hospitalization, need for mechanical ventilation and death. While the mechanisms associating vitamin D and zinc to immune function are well-delineated, clinical trials of these nutrients fail to identify efficacy in the prevention or treatment of COVID. Further studies are warranted in susceptible populations. It is important that healthcare professionals practice evidence-based care;thus at this point, neither vitamin D nor zinc can be recommended as a preventive or cure for COVID. © FFC 2021.

14.
Radiotherapy and Oncology ; 161:S1248-S1249, 2021.
Article in English | EMBASE | ID: covidwho-1492825

ABSTRACT

Purpose or Objective: Cancer diagnostics and surgery have been disrupted by the response of health care services to the coronavirus disease pandemic. With the COVID-19 irruption in 2020, some radiotherapy treatments were omitted, delayed, changed intent or shifted to a hypofractionated scheme. The purpose of this study is to investigate the effect, direct or indirect, that COVID-19 has had on radiotherapy treatments in comparison with previous years. Materials and Methods: All treatments from 2018 (1521), 2019 (1498) and 2020 (1613) were analysed. Treatments were separated into two categories regarding treatment intent: curative or palliative. Moreover curative treatments were classified by site or pathology: H&N, lung, rectum, prostate, breast, central nervous system (CNS), gynaecological, SBRT and other sites. Percentage of hypofractionated treatments per year (for those with curative intent) was also taken into account. Results: Regarding treatment intent, we have found that the number of palliative treatments was similar to previous years: 38% in 2020, 37 % in 2018 and 35% in 2019. Figure I shows the percentage of hypofractionated treatments. During 2020 there were 10% hypofractionated treatments more than 2019, which is more than a threefold increase compared to the growth between 2018 and 2019 (3%). (Figure Presented) Conclusion: On one side, reasons related directly or indirectly with COVID-19 do not had an effect on the treatment intent in our department: similar number of palliative treatments was reported during 2020. On the other side, the use of hypofractionated schemes was accelerated during the pandemic, following national and international recommendations. This has allowed reducing treatment time bringing more comfort to the patients. To resume, it is difficult to assess whether the pandemic had a negative effect on cancer treatments based on treatment intent. Deeper analysis of cancer staging could reveal a different result related to collateral damage to the pandemic.

15.
Statistical Journal of the IAOS ; 37(3):977-995, 2021.
Article in English | Scopus | ID: covidwho-1435944

ABSTRACT

The Sustainable Development Goals (SDGs) Global Indicator Framework (GIF) has multiplied training needs due to the large number of new indicators to be monitored by countries, whereas COVID-19-related social distancing restrictions have provided an unexpected springboard for the proliferation of cutting-edge virtual training tools and modalities. This has exposed a panoply of new data-related skills needed by contemporary statisticians, and therefore the types of training that could be most appropriate for acquiring these skills. This paper analyses the changing context and nature of training, with particular reference to the experience of FAO as a custodian agency for a large share of SDG indicators. The combination of different learning modalities, appropriately blended into a coherent learning programme, is shown to have the greatest impact, with one modality reinforcing the strengths and dampening the limitations of another. © 2021 - The authors. Published by IOS Press.

17.
Revista Habanera de Ciencias Medicas ; 19(2), 2020.
Article in English | Scopus | ID: covidwho-829188

ABSTRACT

Introduction: Dental procedures involve frequent exposure to saliva, blood and other fluids, so there is a risk of nosocomial infection with COVID-19. Objective: To describe the transmission of COVID-19, measurements and current situation in dentistry. Material and methods: A bibliographic review was carried out in April, 2020. Journals from the Web of Sciences were fundamentally evaluated. All publications included were from 2020, in English and Spanish. Descriptors such as: "coronavirus infections" and "transmission" were used. Development: The angiotensin-II converting enzyme has a level of expression in oral tissues that is higher in the tongue. Saliva is a means of transmission. Many health workers have been infected and died during the pandemic. Dental patients and professionals can be exposed to viruses that infect the oral cavity and the respiratory tract;therefore, recommended measures include cessation of elective activities, use of barrier elements, and aerosol control. Conclusions: Saliva is the main means of transmission by COVID-19 in dentistry and the aerosols originated in the care increase the risk of contamination. Recommended measures include using means of protection and carrying out surface disinfection. Many countries suspended dental care, except for urgent care. © 2020 Universidad de Ciencias Medicas de La Hab. All rights reserved.

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