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1.
Cogent Public Health ; 9(1), 2022.
Article in English | EMBASE | ID: covidwho-2062798

ABSTRACT

: Africa serves as a rich research mine due to its significant contribution to the global burden of diseases. This study sought to analyze the trends in African journals as a means to further characterize the research landscape on the continent. The African Journals Online (AJOL) database was searched from inception to 17 October 2021 and 173 journals were identified. Journal titles were then used to search nine databases via the Web of Science core collection on 16 December 2021. Journal metadata was analysed using summary descriptive statistics. 58,952 articles published by 40 journals between 1972 and 2021 were found. 62.4% (n = 36,806) were original articles with 66.4% (n = 39,118) focused on general internal medicine and 44.5% (n = 26,251) were published by the South African Medical Journal. Most authors were located in South Africa, Nigeria, China, Morocco and the United States. Top 5 author-assigned keywords were Nigeria, COVID-19, HIV, Children and Prevalence. Most popular database-assigned keywords were Prevalence, Management, Risk, Children and Disease. The African research community makes significant contributions to the literature. However, the continued ability of researchers to embark on critical scientific investigations can be further improved by increased investment and collaborations.

2.
Infectious Disorders - Drug Targets ; 21(8):5-14, 2021.
Article in English | MEDLINE | ID: covidwho-1625155

ABSTRACT

Coronavirus Disease (COVID-19) pandemic has affected more than seven million individuals in 213 countries worldwide with a basic reproduction number ranging from 1.5 to 3.5 and an estimated case fatality rate ranging from 2% to 7%. A substantial proportion of COVID-19 patients are asymptomatic;however, symptomatic cases might present with fever, cough, and dyspnoea or severe symptoms up to acute respiratory distress syndrome. Currently, RNA RT-PCR is the screening tool, while bilateral chest CT is the confirmatory clinical diagnostic test. Several drugs have been repurposed to treat COVID-19, including chloroquine or hydroxychloroquine with or without azithromycin, lopinavir/ritonavir combination, remdesivir, favipiravir, tocilizumab, and EIDD-1931. Recently, Remdesivir gained FDA emergency approval based on promising early findings from the interim analysis of 1063 patients. The recently developed serology testing for SARSCoV-2 antibodies opened the door to evaluate the actual burden of the disease and to determine the rate of the population who have been previously infected (or developed immunity). This review article summarizes current data on the COVID-19 pandemic starting from the early outbreak, viral structure and origin, pathogenesis, diagnosis, treatment, discharge criteria, and future research.

3.
British Journal of Surgery ; 108:1, 2021.
Article in English | Web of Science | ID: covidwho-1537488
4.
Biointerface Research in Applied Chemistry ; 12(3):3357-3371, 2022.
Article in English | Scopus | ID: covidwho-1365969

ABSTRACT

The novel coronavirus pandemic (COVID-19) caused by SARS-CoV-2 has affected more than 53 million individuals worldwide. Currently, there is a dire need to develop or find potential drugs that can treat SARS-CoV-2 infection. One of the standard methods to accelerate drug discovery and development in pandemics is to screen currently available medications against the critical therapeutic targets to find potential therapeutic agents. The literature has pointed out the 3CLpro and RdRp proteins as the most important proteins involved in viral replications. In the present study, we used an in-silico modeling approach to examine the affinity of six tyrosine kinases inhibitors (TKIs), Imatinib, Ponatinib, Nilotinib, Gefitinib, Erlotinib, and Dasatinibagainst the 3CLpro and RdRp by calculating the energy balance. The six tested TKIs had more than-7 Kcal/mol energy balance values for both viral target proteins. Nilotinib and Ponatinib showed the highest affinity for 3CLpro (-8.32,-8.16, respectively) while Dasatinib, Ponatinib, and Imatinib presented the strongest binding toRdRp(-14.50,-10.57,-9.46, respectively). Based on these findings, we recommend future evaluations of TKIs for SARs-CoV-2 infection in-vitro and further testing in clinical trials. © 2021 by the authors.

5.
Infect Disord Drug Targets ; 2020.
Article in English | PubMed | ID: covidwho-983624

ABSTRACT

Coronavirus Disease (COVID-19) pandemic has affected more than seven million individuals in 213 countries worldwide with a basic reproduction number ranging from 1.5 to 3.5 and an estimated case fatality rate ranging from 2% to 7%. A substantial proportion of COVID-19 patients are asymptomatic;however, symptomatic cases might present with fever, cough, and dyspnoea or severe symptoms up to acute respiratory distress syndrome. Currently, RNA RT-PCR is the screening tool, while bilateral chest CT is the confirmatory clinical diagnostic test. Several drugs have been repurposed to treat COVID-19, including chloroquine or hydroxychloroquine with or without azithromycin, lopinavir/ritonavir combination, remdesivir, favipiravir, tocilizumab, and EIDD-1931. Recently, Remdesivir gained FDA emergency approval based on promising early findings from the interim analysis of 1063 patients. The recently developed serology testing for SARSCoV-2 antibodies opened the door to evaluate the actual burden of the disease and to determine the rate of the population who have been previously infected (or developed immunity). This review article summarizes current data on the COVID-19 pandemic starting from the early outbreak, viral structure and origin, pathogenesis, diagnosis, treatment, discharge criteria, and future research.

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