Colorectal cancer care in the COVID-19 era: outcomes from a 'mixed site' model.

INTRODUCTION: The COVID-19 pandemic has presented many challenges to colorectal cancer (CRC) care. Many organisations opted to perform CRC resections in 'cold' sites. Infrastructure in Northumbria Healthcare NHS Foundation Trust (NHCT) necessitated co-locating CRC care with 'hot' COVID streams but with additional precautions. This study aimed to evaluate that approach for a consecutive series of CRC cases, diagnosed before and during the COVID-19 pandemic. METHODS: A prospectively populated data set of CRC patients diagnosed between 1 April 2019 and 30 September 2020 was used. Patients presenting before 1 April 2020 were considered 'pre-COVID' and those presenting subsequently as 'COVID era'. RESULTS: Some 344 cases were diagnosed in the 12 months 'pre-COVID' and 166 in the 6 months of the 'COVID era'. The median numbers of days from referral to diagnosis (21 vs 20, p=0.373) and operation (63 vs 61, p=0.208) were unchanged. The 'COVID era' saw an increase in the proportion of radiological diagnoses (39.5% vs 53.0%, p=0.004) with an associated decrease in endoscopic diagnoses (56.7% vs 45.8%, p=0.021). Rates of inoperable (1.5% vs 1.2%, p=0.821), obstructing (11.0% vs 16.2%, p=0.272) and perforated tumours (0.6% vs 1.5%, p=0.492) remained the same. One patient developed COVID-19 perioperatively. Rates of laparoscopic operation (59.5% vs 61.8%, p=0.751), anastomotic leak (6.4% vs 5.9%, p=0.891), re-operative surgery (10.4% vs 4.4%, p=0.138), primary stoma (40.5% vs 32.4%, p=0.244) and 90-day mortality (0.6% vs 1.5%, p=0.492) did not change. CONCLUSIONS: With appropriate infection control measures, it may be safe to continue providing standard elective and urgent CRC care without access to a 'COVID clean' site.

Colorectal Cancer Care in the COVID-19 Era;Keep Calm and Carry On?

Background: The COVID-19 pandemic has presented many challenges to Colorectal Cancer (CRC) care. Many organisations opted to perform CRC resections in “cold” sites. Trust infra-structure necessitated co-locating CRC care with “hot” COVID streams, but additional precautions were used (self-isolating pre-operatively, PCR testing of patients and staff and suspension of visiting). Aims: To compare the process of, and outcomes from, care for a consecutive series of newly diagnosed CRC cases before and during the COVID-19 pandemic. Methods: A prospectively populated dataset of CRC patients diagnosed between 01/04/2019 to 30/09/2020. Patients presenting before 01/04/2020 were considered “Pre-COVID” and those on or after that date “COVID era”. Results: Three hundred and forty-four cases were diagnosed in the 12 months “Pre-COVID” and 166 in the 6 months of the “COVID era”. Time to diagnosis and surgical resection were unchanged. The “COVID era” saw an increase in the proportion of radiologically diagnosed CRCs (39.5% vs 53.0% P = 0.004) but a decrease in the proportion of those diagnosed endoscopically (56.7% vs 45.8%, P = 0.021). Rates of inoperable (1.5% vs 1.2%, P = 0.821), obstructing (11.0% vs 16.2%, P = 0.272) and perforated tumours (0.6% vs 1.5%, P = 0.492) remained the same. One patient developed COVID-19 peri-operatively. Rates of laparoscopically completed operation (59.5% vs 61.8%, P = 0.751), anastomotic leak (6.4% vs 5.9%, P = 0.891), re-operative surgery (10.4% vs 4.4%, P = 0.138), primary stoma (40.5% vs 32.4%, P = 0.244) and 90-day mortality (0.6% vs 1.5%, P = 0.492) did not change. Conclusions: With appropriate infection control measures, it may be safe to continue providing standard elective and urgent CRC care.