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1.
Journal of the American College of Surgeons ; JOUR(5):S28-S28, 235.
Article in English | Web of Science | ID: covidwho-2083987
2.
Personality and Individual Differences ; 201, 2023.
Article in English | Scopus | ID: covidwho-2076575

ABSTRACT

Dramatic social changes brought about by the COVID-19 pandemic shifted the dating scene and the likelihood of people starting new relationships. What factors make individuals more or less likely to start a new relationship during this period? In a sample of 2285 college students (Mage = 19.36, SD = 1.44;69.2% women;66.7% White) collected from October 2020 to April 2021, anxiously attached and extraverted people were 10–26% more likely to start a new relationship. Avoidantly attached and conscientious people were 15–17% less likely to start a new relationship. How people pursued (or avoided) new romantic relationships closely mirrored their broader patterns of health and interpersonal behavior during the global pandemic. © 2022 Elsevier Ltd

3.
EWHA Medical Journal ; 45(2):46-54, 2022.
Article in Korean | EMBASE | ID: covidwho-2067252

ABSTRACT

Objectives: Public health risks and anxiety have been increasing since the outbreak of Coronavirus disease 19 (COVID-19). The public expresses questions related to the COVID-19 issue through the web base. The aim of this study was to analyze public perception and sentiments of COVID-19 Pandemic in South Korea. Methods: We collected the text data (questions: 252, 181) related to COVID-19 from Naver Knowledge-iN during January 1, 2020 to December 31, 2020. The search keywords included related to COVID-19 using Korean words for “SARS-Cov-2”, “COVID19”, “COVID-19”, “Wuhan pneumonia”, “Coronavirus”, “Corona”. A topic modeling analysis was used to investigate and search trends of public perception. The sentiment analysis was conducted to analyze of public emotions in the questions related to COVID-19. We performed the Pearson's correlation analysis between daily number of COVID-19 cases and daily proportion of negative sentiment in documents related to COVID-19 by COVID-19 outbreak period. Results: A total of 241, 776 documents used in this study. The most frequent words in the documents to appear cough, symptoms, tests, confirmed patients, mask and etc. Twenty topics (COVID-test, Economy, School, Hospital/Diagnose, Travel/Overseas, Health, Social issue, Symptom 1 (respiratory), Relationships, Symptom 2 (e.g., fever), Workplace, Mask/Social distancing, infection/Vaccine, Stimulus Package, Family, Delivery Service, Unclassified, Region, Study/Exam, Worry, Anxiety) were extracted using the topic modeling. There was a positive association between the daily counts of COVID-19 patients and proportion of negative sentiment. By COVID-19 period, Stage 4 had the highest correlation. Conclusion: This study identified the South Korean public's interest and emotions about COVID-19 during the prolonged pandemic crisis.

4.
Gynecologic Oncology ; 166:S156, 2022.
Article in English | EMBASE | ID: covidwho-2031755

ABSTRACT

Objectives: In light of the COVID-19 pandemic, the Society of Gynecologic Oncology (SGO), National Cancer Institute, and Food and Drug Administration published clinical practice statements encouraging the use of telemedicine in clinical trials, which had previously been prohibited. Our study aimed to assess the feasibility and safety of telehealth utilization in clinical trials for gynecologic malignancies. Methods: A retrospective cohort study was performed. Patients who were enrolled in a gynecologic oncology clinical trial at the University of Pennsylvania Health System from March 16, 2020, to August 30, 2020, were included. Receipt of care during the telehealth period (March 16, 2020, to August 30, 2020) was compared to the pre-telehealth period (September 30, 2019, to March 15, 2020). Pairwise comparisons of clinical trial outcomes were performed between the two time periods, using paired t-test, Wilcoxon signed-rank test, simple linear regression, Chi-square, and ANOVA. Results: Thirty-one patients met the inclusion criteria. The mean age was 63.7 years (SD 10.3);84% were non-Hispanic White. The median distance from home zip code to study center was 25.2 miles (IQR: 16-46, range: 1.9-170). Most patients had high-grade serous ovarian carcinoma (84%) and had the disease at an advanced stage (Stage III 48%, Stage IV 38.7%). Trial drugs included 22.6% (n=7) intravenous only, 29% (n=9) oral only, and 48.4% (n=15) combination oral/intravenous therapies. The median duration of enrollment was similar between pre-telehealth (5.2 months, IQR: 3.2-5.6) and telehealth periods (5.6 months, IQR: 3.8-5.6), (p=0.682). During the TELEHEALTH period, significantly more virtual provider visits (p <0.001) and remote laboratory testing (p=0.015) occurred, with similar rates of remote imaging (p=0.551). Delayed provider visits (p = 0.965), laboratory testing (p = 0.989) and imaging (p = 0.999) occurred infrequently in both timeframes. The number of patient touchpoints (portal messages and phone calls) per month did not increase (p = 0.147). Patients who lived farther from the study center were more likely to use remote imaging (p = 0.013);however, the distance was not associated with the use of virtual provider visits (p = 0.309) or remote laboratory testing (p = 0.821). Number of dose reductions (p = 0.112) and toxicity-related treatment delays (p = 0.888) were similar. Increased need for extra imaging was noted in the telehealth period (p=0.007) and was not associated with disease progression (p=0.614). Extra provider visits, emergency department visits, and hospital admissions were infrequent and similar in both timeframes (Table 1). The total number of deviations was increased (p=0.010);however, when adjusted for minor deviations documenting telehealth use or deferment of research-related laboratory testing given the pandemic precautions, there was no difference between timeframes (p = 0.468). The total number of adverse events and severe adverse events did not increase in the telehealth period (p=0.494 and p=0.601, respectively). Conclusions: Utilizing telehealth in clinical trials for gynecologic oncology patients did not increase clinical workload or adverse patient outcomes. Documentation of telehealth use and pause of research-related laboratory collections resulted in a higher number of protocol deviations during the telehealth period. Telehealth should be incorporated into future clinical trials as it appears safe and feasible and may facilitate access for remote, rural, and under-served populations.

5.
Journal of the Architectural Institute of Korea ; 38(7):139-150, 2022.
Article in Korean | Scopus | ID: covidwho-2030267

ABSTRACT

The long-term pandemic caused by COVID-19 has changed many aspects of the work environment. Companies stalled to seriously consider telework and many have actually adopted it as an alternative way to work, hi fact 73.9% of overseas architect firms are using the telework while domestic architect firms shows no signs of introducing it yet. Various causes are suggested as to why the telework is not yet implemented in architectural practice even with the necessity of introduction, they are only unverified speculations and in order to understand the causes and solve the problems, a sophisticated analysis of the cause is required, hi addition, telework is not just a temporary option in pandemic situation but it needs to be established as another type of work in arcliitectiiral industiy in preparation for similar situation that may occur in the future. Therefore, this study aims to derive the impediments recognized by architect in introducing telework into domestic architect offices, and based on the results of the analysis from the derived factors, it was attempted to find a way to activate telework. Through the literature review, it is conformed that the research regarding the telework of architect office was insufficient and for this reason, telework consideration factors were derived from related studies targeting general companies. The questionnaire was prepared in consideration of the derived factors and the characteristics of the design work, and it was conducted at a time when the government's social distancing guidelines and telework recommendations were made. The study was conducted using the responses of 103 persons working in architect offices of the metropolitan area. As a result, it was confirmed that the cause of hindrace for teleworking perceived by the workers in the architect office was due to the specific characteristics of the design work, and it was confimed that the communication of visual information was the biggest hindrance factor ill the design work, hi addition, as a result of ANOVA on the questionnaire results, it was confirmed that there was a difference in the perceptions of architects about telework, and the main difference came from the work position and project experience. Afterwards. through factor analysis, specific directions were presented for three aspects: communication of design work when working from home, support within the organization, and establishment of IT infrastructure as a way to revitalize it. © 2022 Architectural Institute of Korea

6.
Innovation in Aging ; 5:310-310, 2021.
Article in English | Web of Science | ID: covidwho-2011106
7.
Annals of the Rheumatic Diseases ; 81:957-958, 2022.
Article in English | EMBASE | ID: covidwho-2009039

ABSTRACT

Background: There is still controversy about the efficacy of COVID-19 vaccination and its extent in lowering immunogenicity of Rheumatoid Arthritis (RA) patients. The guideline in whether immunosuppressive agents need to be discontinued before the vaccination is continuously updated because it is considered to lower immunogenicity. Furthermore, there is great discussion on the effectiveness of the COVID-19 booster vaccine and interest in antibody generation in different types of vaccine, as in South Korea there are many patients who were prescribed the mRNA booster vaccine after two doses of ChAdOx1-S nCoV-19 vaccine. Objectives: Thus, we investigated the differences of antibody production between patients who received only two doses of ChAdOx1-S nCoV-19 and those who received the mRNA booster vaccine. Also, antibody production under different types of immunosuppressive agents was analyzed. Methods: From October 14, 2021 to January 21, 2022 at a tertiary referral center, two patient groups diagnosed with RA were studied prospectively;one group that completed 1st and 2nd doses of ChAdOx1-S nCoV-19 vaccine, second group that completed mRNA booster vaccine as well as two doses of ChAdOx1-S nCoV-19 vaccine. SARS-CoV-2 antibody testing on the semiquantitative anti-SARS-CoV-2 S enzyme immunoassay was done, and differences in antibody titers were analyzed in patients who received different immunosup-pressive agents such as csDMARD, TNF inhibitor, JAK inhibitor, Tocilizumab, Abatacept and Corticosteroid. Statistical analysis with a multivariate logistic regression model was performed. Results: In a total of 261 patients, 153 patients had completed two doses of ChAdOx1-S nCoV-19, 108 patients had completed third mRNA booster vaccine. Anti-SARS-CoV-2 RBD antibody positive rate (titer>0.8U/mL) was 97%(149/153) and 99%(107/108) respectively, and only 5 patients showed negative result. In the aspect of high antibody titer(>250U/mL), which is the upper limit of the RBD antibody immunoassay, the result showed rate of 31% (47/153) in the non-booster group and 94%(102/108) in the booster group respectively. Among the different immunosuppressive agents and other clinical aspects, multivariate analysis revealed that corticosteroid use (OR 0.91;95% CI: 0.86-0.98), older age(OR 4.33;95% CI: 1.34-13.91), and male gender(OR 0.35;95% CI 0.16-0.75) were signifcantly associated with low rate of high antibody titer. Furthermore, out of 14 patients who underwent antibody test twice before and after the mRNA booster vaccine, other than four patients who already showed high titer of >250U/mL before the mRNA booster vaccine, 10 patients showed an increase in titer after the booster vaccine and 7 patients were acquired high titer of >250U/mL. Conclusion: Anti-SARS-CoV-2 RBD antibody positive rate was 97% or more regardless of the mRNA booster vaccination. However, patients who received the mRNA booster vaccine after two doses of ChAdOx1-S nCoV-19 vaccine showed high antibody titer (>250U/mL) three times more than those who did not receive the booster shot. Our fndings also showed that corticosteroid use, old age, and male gender is signifcantly associated with low rate of acquiring high antibody titer.

8.
Annals of the Rheumatic Diseases ; 81:1827-1828, 2022.
Article in English | EMBASE | ID: covidwho-2008990

ABSTRACT

Background: In Korea, it has been reported that the incidence of some respiratory diseases and Kawasaki diseases has decreased compared to the previous year along with active non-pharmaceutical interventions in the early stages of the COVID-19 pandemic. Autoimmune infammatory rheumatic disease (AIIRD) is mainly affected musculoskeletal organs and connective tissues due to impaired immune regulation. Although gout and osteoarthritis are rheumatic diseases, they are not a disease of the immune system, and are not included in the AIIRD. Objectives: In this study, we investigated the change and difference in the incidence rate of various rheumatic diseases during the COVID-19 pandemic after 2020. Methods: The number of patients for each disease from January 2016 to December 2020 was obtained from the Korea Health Insurance Review and Assessment Service database. We compared the incidence of 9 rheumatic diseases [systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), ankylosing spondylitis (AS), Sjogren syndrome (SJS), Behcet's disease (BD), infammatory myositis (IIM), scleroderma, polymyalgia rheumatica (PMR), and gout] and hypertension before and after the COVID-19 outbreak. The incidence rates of patients before and after the COVID-19 outbreak were compared using the Poisson test. Results: From 2016 to 2019, the prevalence of rheumatic diseases showed gradually increased. In 2020, the incidence of SLE, AS, SJS, BD, and IIM were signif-cantly decreased compared to the previous 4 years. In contrast, the incidences of gout and hypertension during the COVID-19 pandemic period were signifcantly increased from the predicted values. Conclusion: In conclusion, we found that the incidence of many AIIRDs, including SLE, AS, SJS, BD, and IIM decreased despite the increased incidence of hypertension and gout during the COVID-19 pandemic.

9.
Frontiers in Immunology ; 13:867577, 2022.
Article in English | MEDLINE | ID: covidwho-1974654

ABSTRACT

SARS-CoV-2 is still a major burden for global health despite effective vaccines. With the reduction of social distancing measures, infection rates are increasing in children, while data on the pediatric immune response to SARS-CoV-2 infection is still lacking. Although the typical disease course in children has been mild, emerging variants may present new challenges in this age group. Peripheral blood mononuclear cells (PBMC) from 51 convalescent children, 24 seronegative siblings from early 2020, and 51 unexposed controls were stimulated with SARS-CoV-2-derived peptide MegaPools from the ancestral and beta variants. Flow cytometric determination of activation-induced markers and secreted cytokines were used to quantify the CD4+ T cell response. The average time after infection was over 80 days. CD4+ T cell responses were detected in 61% of convalescent children and were markedly reduced in preschool children. Cross-reactive T cells for the SARS-CoV-2 beta variant were identified in 45% of cases after infection with an ancestral SARS-CoV-2 variant. The CD4+ T cell response was accompanied most predominantly by IFN-gamma and Granzyme B secretion. An antiviral CD4+ T cell response was present in children after ancestral SARS-CoV-2 infection, which was reduced in the youngest age group. We detected significant cross-reactivity of CD4+ T cell responses to the more recently evolved immune-escaping beta variant. Our findings have epidemiologic relevance for children regarding novel viral variants of concern and vaccination efforts.

10.
Neurology ; 98(18 SUPPL), 2022.
Article in English | EMBASE | ID: covidwho-1925423

ABSTRACT

Objective: To describe safety and efficacy of tolebrutinib in patients with relapsing multiple sclerosis at Week 72 (Month 18) in the long-term safety (LTS) extension of the phase 2b trial. Background: In the phase 2b trial (NCT03889639), tolebrutinib, a CNS-penetrant Bruton's tyrosine kinase inhibitor, was well tolerated over 12 weeks with dose-dependent reduction in new gadolinium-enhancing T1 and new/enlarging T2 lesions. Design/Methods: The LTS extension (NCT03996291) consists of 2 parts: patients continued their core study tolebrutinib dose (5, 15, 30, or 60 mg/day) double-blind until the phase 3 study dose was selected (Part A), and currently receive tolebrutinib 60 mg/day open-label (Part B). Long-term safety and tolerability is the primary objective. Secondary endpoints include annualized relapse rate (ARR) and change from baseline in Expanded Disability Status Scale (EDSS) score. Results: 124 of 125 patients treated in the extension completed Part A and transitioned to Part B. One patient (on 5 mg/day) discontinued Part A due to progressive disease and 6 discontinued Part B due to a variety of reasons, including adverse event (AE;n=2), lack of efficacy (n=1), progressive disease (n=1), and emigration (n=2). To date, no new safety signals have been observed. The most common treatment-emergent AEs (TEAEs) were headache (12.8% [16/125]), COVID-19 (12.8% [16/125]), nasopharyngitis (10.4% [13/125]), upper respiratory tract infection (8.0% [10/125]), and arthralgia (5.6% [7/125]). There was no suggestion of a dose effect for TEAE or serious AE in Part A and no emergence of new safety signals for patients switching to 60 mg in Part B. ARR on tolebrutinib 60 mg was 0.17 (95% CI: 0.11, 0.27);84.7% of patients were relapse-free at the LTS Week 72 cut-off. Mean EDSS scores remained stable to LTS Week 72. Conclusions: Through LTS Week 72, tolebrutinib 60 mg continues to show favorable safety and tolerability, and low ARR.

11.
Nieren- und Hochdruckkrankheiten ; 51(4):134, 2022.
Article in English | EMBASE | ID: covidwho-1897058

ABSTRACT

Objectives: The COVID-19 pandemic has led to widespread change of lifestyle, restrictions of social relations and activities. The required lockdowns caused modifications in eating habits, physical activities and psychological distress. This not only has consequences for adults, but also for children and adolescents. The COVID-19 pandemic has been linked to significant weight gain in the general population, but its impact on children and adolescents after kidney transplantation (KTx) is unknown. Methods: We retrospectively evaluated body mass index SD scores (BMI-SDS) between September 2019 and September 2021 in 132 pediatric KTx patients followed up at three German pediatric nephrology centers. The patients were categorized according to age (0 - 11.9 y vs. 12 - 18 y) and sex (female vs. male) in four groups. Data were assessed by a linear mixed model approach. Results: There was no significant change in BMI-SDS in children (0 - 11.9 y), irrespectively of sex (boys -0.11 SDS, p = 0.22;girls 0.05 SDS, p = 0.49). By contrast, a significant increase in BMI-SDS was noted in both male (0.24 SDS) and female (0.20 SDS) teenagers (each p < 0.05). In addition, the proportion of obese teenagers tended to increase from 12 to 19% (p = 0.08). Conclusion: The COVID19 pandemic was associated with a significant increase in standardized BMI values in adolescents but not in children after KTx. This may further increase the cardiovascular risk in the former population.

12.
Multiple Sclerosis Journal ; 28(1_SUPPL):77-77, 2022.
Article in English | Web of Science | ID: covidwho-1865932
13.
Journal of the American College of Cardiology ; 79(9):1485-1485, 2022.
Article in English | Web of Science | ID: covidwho-1848569
14.
Journal of Applied Arts and Health ; 12(3):383-392, 2021.
Article in English | Scopus | ID: covidwho-1793475

ABSTRACT

The Iris Music Project is a non-profit dedicated to reimagining residential and healthcare communities as spaces of creative exchange. By February 2020, our chamber music group, the Iris Piano Trio, had developed a model for music programming at Charles E. Smith Life Communities (CESLC) in Rockville, Maryland (United States), that emphasized collaborative relationships between professional musicians and community members. The COVID-19 pandemic severely disrupted the Trio’s work and tested its model. In this article, we describe how the Trio remained connected and relevant to CESLC residents by experiment-ing with virtual programmes that adapted our model to a digital setting. We argue that our prior relationships with residents and staff enabled us to impact their lives throughout the pandemic despite the isolation created by COVID-19 closures. The pandemic strained, but did not fundamentally change, the Trio’s ensemble-in-resi-dence model, suggesting its potential as a generalized model in the field of music and health. © 2021 Intellect Ltd Notes from the Field. English language.

15.
Journal of the American College of Cardiology ; 79(9):1485, 2022.
Article in English | EMBASE | ID: covidwho-1768627

ABSTRACT

Background The presence of cardiovascular comorbidities is known to cause increased mortality. However, it is unclear how different cardiovascular comorbidities affect the mortality among patients with SARS-CoV-2. Methods This was a retrospective study of patients 18 years and older with a positive SARS-CoV-2 infection confirmed with polymerase chain reaction test at a public hospital in New York City between March 2020 and April 2021. Different cardiovascular comorbidities, including hypertension, heart failure, and coronary artery disease (CAD), and their effects on the patients with SARS-CoV-2 infection were analyzed. Multivariate logistic regression analyses adjusted for demographics and comorbidities. Results We identified 23,076 patients with a positive SARS-CoV-2 test;The rate of death was 3.0% (703 patients). Of those patients, 631 (89.8%) had hypertension, 266 (37.8%) had CAD, 104 (14.8%) had end-stage renal disease, 74 (10.5%) experienced a myocardial infarction (MI), 442 (62.9%) had diabetes, and 212 (30.2%) had heart failure. The adjusted odds of death was 2.34 (95% Confidence Interval [CI]: 1.59-3.44;p<0.001) for patients with hypertension, 1.43 (95% CI: 1.08-1.88;p<0.013) for patients with heart failure, 0.97 (95% CI: 0.73-1.29;p<0.843) for patients with CAD, 0.227 (95% CI: 0.146-0.351;p<0.001) for patients taking ACE inhibitors, 0.921 (CI: 0.702-1.208;p<0.550) for patients with diabetes, 1.207 (95% CI: 0.724-2.010;p<0.470) for patients with end stage renal disease, and 0.740 (95% CI: 0.431-1.270;<0.274) for patients who experience a MI. Conclusion This retrospective study suggests that cardiovascular comorbidities, specifically hypertension and heart failure, were associated with the increased risk of mortality in patients with SARS-CoV-2, while CAD and MI were not. As with most observational studies, potential residual confounding may not confirm casualty.

16.
Advances in Human Biology ; 11(2):143-146, 2021.
Article in English | Web of Science | ID: covidwho-1744815
19.
Frontiers in Sustainable Cities ; 3:15, 2021.
Article in English | Web of Science | ID: covidwho-1704526

ABSTRACT

The COVID-19 pandemic altered human behavior around the world. To maintain mental and physical health during periods of lockdown and quarantine, people often engaged in outdoor, physically distanced activities such as visits to parks and greenspace. However, research tracking outdoor recreation patterns during the pandemic has yielded inconsistent results, and few studies have explored the impacts of COVID-19 on park use across diverse neighborhoods. We used a mixed methods approach to examine changes in park use patterns in cities across North Carolina, USA, during the COVID-19 pandemic, with an emphasis on impacts in socially vulnerable communities (based on racial/ethnic composition and socioeconomic status). First, we surveyed a demographically representative sample of 611 urban residents during August 2020 to assess their use of outdoor park spaces before and during the pandemic. Second, we used cell phone location (i.e., geo-tracking) data to document changes in park visits within 605 socioeconomically diverse urban census tracts before (July 2019) and during (July 2020) the pandemic. Data from both methods revealed urban park use declined during the pandemic;56% of survey respondents said they stopped or reduced park use, and geo-tracked park visits dropped by 15%. Park users also became more homogenous, with visits increasing the most for past park visitors and declining the most in socially vulnerable communities and among individuals who were BIPOC or lower-income. Our results raise concerns about urban park use during the COVID-19 pandemic and suggest pre-existing health disparities in socially vulnerable communities might be exacerbated by inequitable access and utilization of parks and greenspace.

20.
6th International Conference on Biomedical Imaging, Signal Processing, ICBSP 2021 ; : 24-30, 2021.
Article in English | Scopus | ID: covidwho-1703452

ABSTRACT

The Covid-19 pandemic has caused more then 193 million cases and 4.1 million deaths worldwide as of July 2021. The Fleischner Society reported that Computerized Tomography (CT) is a useful tool for the early identification of Covid-19. Covid-19 disease induces lung changes which can be observed in lung CT predominantly as ground-glass opacification (GGO) and occasional consolidation in the peripheries. Moreover, it was reported that the percentage of lung showing disease correlates with the severity of the disease. Therefore, segmentation of the disease areas in CT images is a logical first step to quantify disease severity. In this paper, we propose g CoviSegNet Enhanced' based on a U-Net with an 813-layer EfficientNetB7 encoder having an attention mechanism to segment the Covid-19 disease area observed in CT images of Covid-19 patients. CoviSegNet Enhanced is an improvement of our previous work g CoviSegNet'. The experiments performed on three public CT datasets and a detailed comparison with recently published work confirms that the proposed CoviNet Enhanced using deep learning approaches is highly effective for Covid-19 segmentation. © 2021 ACM.

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