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1.
Comparative Federalism and Covid-19: Combating the Pandemic ; : 239-257, 2021.
Article in English | Scopus | ID: covidwho-1924489

ABSTRACT

This chapter discusses the dual nature of Brazilian federalism and the strengthening of subnational autonomy, as evidenced during the Covid-19 pandemic. On one hand, the crisis highlighted the importance of the federal government in the institutional arrangement of Brazilian federalism, which is highly centralised;on the other, it has provided greater scope for action by state governments, whose political power has gradually diminished over the 30 years since the 1988 Constitution came into being. Municipalities have also played a stronger role based on their local interest. To analyse those aspects, the chapter presents the constitutional design of the Brazilian federation and the public policies in health and disaster management to contain the pandemic, demonstrating that the intergovernmental relations generated by the very nature of federalism were indispensable in enabling Brazil to address the pandemic and so prevent worse outcomes in terms of public health. Additionally, the expanded autonomy of states and municipalities during the pandemic, due to a Supreme Court decision, was fundamental to the struggle against the denialism of the President Jair Bolsonaro, who neglected his federal responsibilities. © 2022 selection and editorial matter, Nico Steytler.

2.
Applied Sciences-Basel ; 12(12):21, 2022.
Article in English | Web of Science | ID: covidwho-1917265

ABSTRACT

Featured Application A new device to support oxygen therapy for patients diagnosed with severe COVID-19. The need for mechanical ventilation is one of the main concerns related to the care of patients with COVID-19. The aim of this study is to evaluate the efficacy of a bubble device for oxygen supplementation. This device was implemented for the selected patients hospitalized with severe COVID-19 pneumonia with persistent low oxygen saturation. Patients were selected in three major COVID-19 hospitals of Bahia state in Brazil from July to November 2020, where they remained with the device for seven days and were monitored for different factors, such as vital signs, oximetry evaluation, and arterial blood gasometry. Among the 51 patients included in the study, 68.63% successfully overcame hypoxemia without the necessity to be transferred to mechanical ventilation, whereas 31.37% required tracheal intubation (p value < 0.05). There was no difference of note on the analysis of the clinical data, chemistry, and hematological evaluation, with the exception of the SpO(2) on follow-up days. Multivariate analysis revealed that the independent variable, male sex, SpO(2), and non-inhaled mask, was associated with the necessity of requiring early mechanical ventilation. We concluded that this bubble device should be a prior step to be utilized before indication of mechanical ventilation in patients with persistent hypoxemia of severe COVID-19 pneumonia.

3.
Index de Enfermeria ; 30(3):219-223, 2021.
Article in Spanish | EMBASE | ID: covidwho-1865902

ABSTRACT

Objective: The objective was to analyze the health conditions of people living on the streets, in the COVID-19 scenario, based on the contributions of the Environ-mental Theory. Methods: This is a theoretical-reflexive analysis. Results: Two cate-gories were developed: The dichotomy between living on the street and the Night-ingalian assumptions and;The reality of people living on the street in times of pan-demic by COVID-19. The first category addressed the difference between what is experienced by people on the street and what the Nightingalian assumptions say about health conditions. The second category showed the insertion of these people in the context of prevention measures. Final considerations: It is of fundamental importance to discuss the access to prevention and health promotion strategies by these people and to promote specific actions for the reality in which they live.

4.
Hematology, Transfusion and Cell Therapy ; 43:S367-S368, 2021.
Article in Portuguese | EMBASE | ID: covidwho-1859660

ABSTRACT

A Acreditação é a mais impactante estratégia de melhoria que prioriza a segurança e que busca o aprimoramento contínuo. O Programa QMentum Internacional teve início em novembro de 2019 com aplicação de visitas preparatórias, inicialmente presenciais, promovendo o desenvolvimento educacional em 08 Bancos de Sangue e mais de 140 agências transfusionais de 240 hospitais e clínicas, totalizando mais de 220 mil pacientes atendidos anualmente em 16 Estados brasileiros. A proposta desafiadora diante da amplitude do Grupo se tornaria ainda mais complexa, pois, com apenas três meses de projeto, tivemos o surgimento da pandemia do coronavírus. Mesmo diante das adversidades a Alta Gestão do Grupo entendeu a necessidade de fortalecer a Cultura de Segurança na Instituição. Objetivo: Descrever estratégias para obtenção da Certificação, bem como, a Cultura de Segurança, enraizada e cultivada em todas as esferas dos processos. Método: Utilizados os dados do projeto da Acreditação e da Pesquisa de Cultura de Segurança. Resultados: O Grupo conquistou a Certificação Internacional QMentum Diamond, o mais alto nível de excelência. Esse passo traz a consolidação da Cultura de Segurança Institucional além do nivelamento demonstrado nos resultados sistêmicos de excelência. Discussão: Após as visitas de diagnóstico, foram selecionadas as ROPs (Required Organizational Pratices), são práticas organizacionais obrigatórias respaldadas em evidências. Com as 14 ROPs, a Qualidade traçou o plano de ação para disseminar os conceitos e engajar os profissionais (cerca de 1700) com a proposta de assimilar que não teriam novas atividades, mas apenas uma forma nova de nomear as rotinas já executadas, solidificando a Cultura de Segurança. O planejamento conteve, por exemplo: 1. Vídeos Institucionais: de curta duração, vinculados por via whatsapp e e-mails, contendo exemplos de aplicação dos testes de conformidades e suas evidências, favorecendo assimilação das boas práticas. 2. Cartilha do Programa QMentum Internacional: distribuída de forma impressa e individual, contextualizando e correlacionando a identidade organizacional e planejamento estratégico do Grupo com o processo de Acreditação. 3. Auditorias Internas: o checklist desenvolvido especificamente para cada setor, com teste de conformidade de 75% por ROP, desta maneira, foram desenvolvidos crachás para os colaboradores, colecionarem os 14 bottons, diante da performance obtida gerando um clima competitivo, amistoso e emponderando os colaboradores como identificadores e condutores das melhorias. 4. Pesquisa de Cultura de Segurança: avalia as percepções dos profissionais sobre as práticas de segurança e o compromisso da gestão, bem como, a concretização desta como estratégia institucional, fortalecendo o clima organizacional, obtendo média de 87% de conformidade na primeira aplicação. O projeto foi realizado de forma robusta, com demais ações. Conclusão: Uma trajetória brilhante, com interação corporativa, focado nas diretrizes e padrões globais com consolidação da Cultura de Segurança, a Certificação apenas reflete as boas práticas vivenciadas todos os dias pelos colaboradores do Grupo GSH.

5.
Hematology, Transfusion and Cell Therapy ; 43:S362-S363, 2021.
Article in Portuguese | EMBASE | ID: covidwho-1859656

ABSTRACT

O Grupo GSH, para garantir o cumprimento de sua missão: “Prover Soluções em Hemoterapia com Excelência, Segurança e Inovação”, adotou como estratégia a aquisição do Selo COVID FREE por meio da implantação e adequação de práticas preventivas para o enfrentamento do Coronavírus. O Grupo encontra-se atualmente em 16 Estados, com 06 Centros de Produção certificados com o Selo COVID FREE e mais de 120 Agências Transfusionais que prestam assistência hemoterápica para mais de 240 hospitais e clínicas. Diante do crescimento do Grupo, entende-se que a Equipe de Qualidade é de suma importância à medida que oferece suporte contínuo durante o processo de certificação e manutenção das diretrizes e boas práticas de gerenciamento de riscos e gestão. Objetivo: O principal objetivo deste artigo é demonstrar quantitativamente e qualitativamente os benefícios da implantação e acompanhamento das boas práticas preventivas para o enfrentamento do Coronavírus pela Certificação COVID FREE. Material e método: Para desenvolvimento deste artigo, utilizamos dados coletados da plataforma BE SOLUTIONS-COVID FREE, Sistema de Gestão da Qualidade AS – Strategic Adviser, treinamentos, Pesquisa de Cultura de Segurança/Clima Organizacional e Auditorias Internas realizadas pela equipe da Qualidade. Resultados: Após implantação da Certificação COVID FREE nos Centros de Produção, foi evidenciado mesmo durante os períodos mais críticos da Pandemia COVID-19 a manutenção dos níveis de satisfação dos doadores com média de 98, 33% e em relação aos pacientes a média foi de 99,72%. É importante ressaltar que para avaliar a satisfação dos colaboradores foi realizada uma Pesquisa de Cultura de Segurança/Clima Organizacional com média de satisfação de 93%. Discussão: No segundo semestre de 2021 foi iniciado o processo de implantação e adequação das boas práticas de segurança para o enfrentamento do Coronavírus nos Centros de Produção do Grupo GSH, conforme os padrões estabelecidos no Manual de Certificação COVID FREE. Durante a implantação seguimos as seguintes etapas: 1. Diagnóstico: Autoavaliação das unidades. 2. Implantação: Sensibilização dos colaboradores e adequação das práticas de segurança através do distanciamento físico, higienização e limpeza, utilização de equipamentos de proteção, monitoramento de saúde física e mental dos colaboradores, elaboração de informativos específicos de prevenção e controle, treinamentos, fortalecimento da comunicação efetiva elaboração de planos de contingência, dentre outros. Posteriormente foi realizado o upload das evidências, conforme requisitos do manual na Plataforma IBES Digital. 3. Certificação: Os avaliadores validaram as evidências, por meio da análise de documentos, entrevistas e fotos. Após avaliação emitiram o certificado aos Centros de Produção contemplados no escopo da Certificação. Conclusão: A implantação da Certificação foi de grande valia para o Grupo GSH, pois auxiliou na manutenção de um ambiente seguro conferindo credibilidade em relação as boas práticas de segurança na produção, operação e atendimento aos clientes. É importante salientar que o suporte da Equipe da Qualidade foi fundamental na disseminação e acompanhamento das diretrizes estabelecidas pela Certificação.

6.
Embase; 2022.
Preprint in English | EMBASE | ID: ppcovidwho-337460

ABSTRACT

Hybrid immunity (infection plus vaccination) provided high protection against infection and severe disease in the periods of delta and gamma variants of concern. However, the protection of hybrid immunity in the Omicron era remains unknown. We performed a test-negative study using Brazilian national databases between January 01 and March 22, 2022, a period of predominant circulation of the Omicron variant in Brazil. Hybrid immunity offered low protection against infection, with rapid waning, compared to unvaccinated with or without previous infection. For severe illness (hospitalisation or death), the protection, although already high for unvaccinated pre-infected increased regardless of the type of vaccine (Ad26.COV2.S, BNT162b2, ChAdOx-1 or CoronaVac). In conclusion, during the Omicron-dominant period in Brazil, hybrid immunity offered high protection against severe illness and low protection against infection.

7.
27th Brazilian Congress on Biomedical Engineering, CBEB 2020 ; 83:1183-1187, 2022.
Article in English | Scopus | ID: covidwho-1826143

ABSTRACT

The present work describes the technological development of a low-cost and miniaturized instrument to Polymerase Chain Reaction (PCR) for detection of Sars-CoV-2 ribonucleic acid (RNA) and, potentially, an open platform for detection of other microorganisms. Most devices use a big aluminum bar coupled to a peltier to heat and cool the reaction tube;however, a lot of energy is wasted in the process. To take advantage of the energy and reduce cost–benefit of the device, we introduced the Joule Effect in the printed circuit board for heating samples, and a computer fan for cooling. Other improvements such as a precise heating sample spot, and a LM35 thermal sensor with a PID (proportional integral-derivative) algorithm to control the circuit temperature, have also been included. The processes were carried out based on cost–benefit and performance to bring to the market a robust detection platform for in vitro diagnostic tests. © 2022, Springer Nature Switzerland AG.

8.
Humanidades & Inovacao ; 8(62):186-198, 2021.
Article in Portuguese | Web of Science | ID: covidwho-1790160

ABSTRACT

The imposition of corporal isolation and the physical closure of schools required adaptations and transformations in basic education institutions with regard to forms of contact and teaching-learning actions. The aim of this study was to describe and reflect on the tactics and strategies of the UFRGS College of Application in the face of the need for social isolation and maintenance of teaching activities. Certeau's theory was used to analyze the tactics and strategies used by the school in this period. As methodological procedures, public documents were used, in which content analysis resulted in three analytical categories: remote directed studies, digital inclusion, and the food kit. The results showed the transformation of counter-hegemonic tactics to combat social inequality and access to education into power strategies for maintaining remote studies.

9.
Current Psychology ; : 12, 2022.
Article in English | Web of Science | ID: covidwho-1694291

ABSTRACT

Learning, leisure, social, and movement activities are essential facets of children ' s development affecting their physical, mental, and social well-being. During the first Covid-19 lockdown and post-lockdown period, children ' s everyday lives were disrupted and altered in significant ways for an extended period, raising several concerns regarding its negative effects. This study investigated children ' s daily activities during the lockdown and post-lockdown period, considering child and family factors that influenced their participation, and the effects of daily activities on child well-being. Cross-sectional data were collected during June and July 2020 from a sample of 3(rd) and 4(th) graders (n = 110) and their parents. Participants reported the intensity of children ' s weekly participation in various learning, leisure, socializing, and movement activities, child and family characteristics, and child well-being outcomes. Findings indicate an overall pattern characterized by a higher prevalence of sedentary behaviors (screen time) and a lower prevalence of active leisure and playing activities, particularly among socioeconomically vulnerable children. Compared to boys, girls were less physically active but engaged more in play and social activities. In addition, sleep, active leisure, playing and learning activities, and family coping strategies were linked to better overall child well-being. These findings help identify promising avenues for effective intervention strategies, at the family and community levels, aimed at promoting child well-being and mitigating harm during the present and future crises.

10.
Embase;
Preprint in English | EMBASE | ID: ppcovidwho-326947

ABSTRACT

Background. COVID-19 vaccines have proven highly effective among SARS-CoV-2 naive individuals, but their effectiveness in preventing symptomatic infection and severe outcomes among individuals with prior infection is less clear. Methods. Utilizing national COVID-19 notification, hospitalization, and vaccination datasets from Brazil, we performed a case-control study using a test-negative design to assess the effectiveness of four vaccines (CoronaVac, ChAdOx1, Ad26.COV2.S and BNT162b2) among individuals with laboratory-confirmed prior SARS-CoV-2 infection. We matched RT-PCR positive, symptomatic COVID-19 cases with RT-PCR-negative controls presenting with symptomatic illnesses, restricting both groups to tests performed at least 90 days after an initial infection. We used multivariable conditional logistic regression to compare the odds of test positivity, and the odds of hospitalization or death due to COVID-19, according to vaccination status and time since first or second dose of vaccines. Findings. Among individuals with prior SARS-CoV-2 infection, vaccine effectiveness against symptomatic infection ≥ 14 days from vaccine series completion was 39.4% (95% CI 36.1-42.6) for CoronaVac, 56.0% (95% CI 51.4-60.2) for ChAdOx1, 44.0% (95% CI 31.5-54.2) for Ad26.COV2.S, and 64.8% (95% CI 54.9-72.4) for BNT162b2. For the two-dose vaccine series (CoronaVac, ChAdOx1, and BNT162b2), effectiveness against symptomatic infection was significantly greater after the second dose compared with the first dose. Effectiveness against hospitalization or death ≥ 14 days from vaccine series completion was 81.3% (95% CI 75.3-85.8) for CoronaVac, 89.9% (95% CI 83.5-93.8) for ChAdOx1, 57.7% (95% CI -2.6-82.5) for Ad26.COV2.S, and 89.7% (95% CI 54.3-97.7) for BNT162b2. Interpretation. All four vaccines conferred additional protection against symptomatic infections and severe outcomes among individuals with previous SARS-CoV-2 infection. Provision of a full vaccine series to individuals following recovery from COVID-19 may reduce morbidity and mortality. Funding. Brazilian National Research Council, Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro, Oswaldo Cruz Foundation, JBS S.A., Instituto de Salud Carlos III, Spanish Ministry of Science and Innovation, Generalitat de Catalunya.

12.
Journal of the Indian Chemical Society ; 98(10):6, 2021.
Article in English | Web of Science | ID: covidwho-1510017

ABSTRACT

COVID-19 pandemic is the biggest public health problem of the century so far.The main protease (Mpro) is one of the main enzymes studied as a pharmacological target. In this context, the present work aimed to perform a virtual screening of possible inhibitors against the enzyme Mpro, having limonoids as the main object of research as supposed inhibitors. Molecular docking simulations indicated that limonoids have an affinity to complex with M-pro.However, Limonine and Nimoliciol showed nonspecific and low affinity interactions. In conclusion, Limonoids are substances of natural origin that can be used in the study of new pharmacological tools designed to combat and understand COVID-19.

13.
Sociologia e Antropologia ; 11(Special Issue):32-65, 2021.
Article in English, Portuguese | Scopus | ID: covidwho-1502155

ABSTRACT

The purpose of this text is to analyze the consequences of the covid-19 pandemic in the academic work routines of Social Sciences in Brazil. The study is based on the results of a survey disseminated with the support of professional associations in Anthropology, Political Science, Sociology and International Relations. The article presents the profile of the 1,073 participants and their perceptions about the effects of the crisis on training, teaching and research activities, as well as on the division of tasks in the private sphere. Although most respondents said they felt negative impacts of the pandemic, there are disparities by discipline, gender and race. The data reinforce the importance of discussing productivity evaluation parameters sensitive to inequalities. © 2021. All Rights Reserved.

14.
International Journal of Gynecological Cancer ; 31(Suppl 4):A96, 2021.
Article in English | ProQuest Central | ID: covidwho-1495508

ABSTRACT

ObjectivesThe objective is to assess the impact of COVID-19 pandemic on the care of gynecologic oncology patients.MethodsThis is a retrospective cohort study of all gynecology oncology new patients treated at Brasilia’s University Hospital - Brazil. We compared to periods: pre-COVID-19 (March 2019 to February 2020) and during COVID-19 pandemic (March 2020 to February 2021).ResultsThere was a 53% reduction in patients with gynecological cancer undergoing treatment at our hospital. The total of surgeries performed was 40 pre and 18 during the pandemic period, a reduction in the surgical volume by 55%. The most operated tumor in the pre-pandemic period was cervix and during was an equal number of surgeries for cervix, endometrial and ovarian cancer. Admissions for chemotherapy or radiotherapy also decreased by 52%. A total of 78 patients underwent cancer treatment before and 37 during the pandemic. The most frequently treated tumor is cervical cancer, with 53 cases in the pre and 26 during the pandemic, followed by ovarian cancer with 14 cases before and only two during the same period. The median waiting time between diagnosis and surgery was 4.44 days longer during the pandemic, as well as the median time to start chemo and radiotherapy was also longer during the pandemic period.ConclusionsWe observed a significant decrease in the number of gynecological cancer patients undergoing treatment during the COVID-19 pandemic. Our results will help health professionals to understand the indirect consequences of the pandemic and the role of women’s health care services in minimizing these consequences.

15.
9th IEEE International Conference on Serious Games and Applications for Health, SeGAH 2021 ; 2021.
Article in English | Scopus | ID: covidwho-1483763

ABSTRACT

Currently and as a future trend, many robotic systems are being adapted to allow medical procedures such as surgeries, diagnostics, and monitoring to be conducted remotely. The integration of these systems allows an alternative for traditional procedures in health to be executed more efficiently over distance. Since the coronavirus pandemic (COVID-19) and the worldwide imposed physical distancing restrictions, the use of teleoperation systems became even more relevant. Although this is now a reality, there are still some major drawbacks to teleoperation, mostly due to communication failure, transmission delays, limited bandwidth, and security breaches. To mitigate the communication problems over greater distances, many authors are giving now positive feedback on the integration of the recent 5G cellular technology in their systems. This paper aims to present a review of the relevant literature targeting the communication protocols and frameworks used in teleoperation systems since 2016. It will focus on showing insights and highlight the key technologies used for the current telerobotic communication frameworks for both short and long-distance systems. © 2021 IEEE.

16.
Journal of Control Automation and Electrical Systems ; : 6, 2021.
Article in English | Web of Science | ID: covidwho-1482344

ABSTRACT

The Brazilian Society of Automatics, Sociedade Brasileira de Automatica (SBA) in Portuguese, celebrated its 45th anniversary during the XXIII Congresso Brasileiro de Automatica (CBA) in a virtual platform due to the global pandemic of coronavirus COVID-19. In this paper, the authors have summarized its activities since 2002. The previous activities before 2002 were presented in Revista Controle & Automacao da SBA. This magazine became Journal of Control, Automation and Electrical Systems after 2012 published by Springer.

17.
European Journal of Neurology ; 28(SUPPL 1):291, 2021.
Article in English | EMBASE | ID: covidwho-1307719

ABSTRACT

Background and aims: Neurological symptoms are reported in over 30% of COVID-19 hospitalized patients. However, systematic studies reporting these manifestations in ambulatory patients are still missing. We aim to characterize and compare neurological phenotypes in hospitalized and ambulatory COVID-19 patients. Methods: Retrospective study in patients with laboratory confirmation of SARS-CoV-2 infection in a tertiary hospital in the North of Portugal, between March 1st and April 30th. Data from hospitalized patients was collected through electronic medical records;ambulatory patients' data was collected using a structured telephonic survey. Results: From a total of 283 patients hospitalized in this period with COVID-19, 116 (40.9%) had at least one neurological manifestation. Mean age was 64 years (20- 100) and 58.6% were women (n=68). The most frequent manifestation was headache (24.7%), followed by myalgia (15.5%) and hyposmia (10.6%). Other neurological manifestations were reported in <10%. In this period, from 488 ambulatory patients infected with COVID-19, all but one reported at least one neurological manifestation (n=487). Mean age was 50.3 years (18-93) and 63% were women (n=307). Myalgia was the most frequent symptom (71.1%), followed by anosmia (65.4%), disgeusia (62.9%) and headache (58.4%). EPR302 Sleep disorders and cognitive complaints were also frequent (39.9% and 17.4%). Hypertension, diabetes, cardiovascular, lung and kidney disease were more prevalent in hospitalized patients. Conclusion: In the 1st systematic evaluation of neurological symptoms in outpatient COVID-19 patients we found an extremely high rate of neurological manifestations, suggesting neurological involvement is not dependent on COVID-19 disease severity. Host susceptibility and viral characteristics may drive the neurological phenotype.

18.
European Journal of Neurology ; 28(SUPPL 1):158, 2021.
Article in English | EMBASE | ID: covidwho-1307712

ABSTRACT

Background and aims: COVID-19 related acute neurological phenotypes have been reported in over 30% of hospitalized patients. However, multicentric studies providing a population-based overview are still lacking. Methods: We conducted a retrospective multicentric study in five hospitals in Northern Portugal, between March 1st and June 30th 2020. Patient e-records were systematically revised using a standardized form to identify neurological manifestations stratified by type and severity. Results: From a total of 13,144 persons diagnosed with COVID-19 in the northern region, 2,795 (21.3%) required hospitalization. We reviewed a sample of 1,261 (45.1%) hospitalized patients and found a rate of 362 neurological manifestations per 1000 admitted COVID-19 patients, estimating a total of 1009 hospitalized patients with a neurological manifestation in the Northern Region. Patients with neurologic manifestations were younger (p=0.002), and the most frequent neurological symptoms were headache (13.4%), delirium (10.1%) and impairment of consciousness (9.7%). We observed a rate of 7.8 severe neurological events per every 1000 COVID-19 infected patients, including stroke, seizures, Guillain-Barre syndrome and myelopathy. The fatality among patients with neurological manifestations was 19.8%, and 15.6% had a modified Rankin Scale of 4-5 at hospital discharge. Conclusion: We characterized the population of hospitalized COVID-19 patients from the northern region of Portugal and found that neurological symptoms are common and associated with a high degree of disability. CNS involvement with criteria for in-hospital admission was observed in a significant proportion of patients. Neurology support is highly relevant in the multidisciplinary care of COVID-19 patients.

19.
American Journal of Infectious Diseases ; 17(2):49-54, 2021.
Article in English | EMBASE | ID: covidwho-1234855

ABSTRACT

Solid information on exposure and how to treat COVID-19 in pediatric patients is not yet conclusive in the literature, because of this it is necessary to make a critical analysis of the available data in order to provide common points on the theme in question. This systematic review protocol is registered in PROSPERO (ID: CRD42020181835) and aims through searches in the Databases PubMed, Google Scholar, LILACS and CINAHL, to group the studies published with the theme COVID-19 and pediatric between 2019 and 2020. The MeSH descriptors: COVID-19, child and children will be used in English and Chinese. Observational research, clinical trials and literature reviews will be included, where the study sample was composed of pediatric patients of both sexes aged between 6 and 17 years. The Rayyan QCRI tool® will be used to manage revision data. The analysis of the feasibilities of observational studies will be done by the Loney scale, clinical trials by the Cocharne scale and review studies by the Overview Quality Assessment Questionnaire (OQAQ). The authors intend that the study is completed in the second semester of 2021. The choice of the theme is justified because the results of the future research are useful for the elaboration of public health measures that offer the promotion of effective treatment during the recovery of pediatric patients infected with COVID-19.

20.
Revista Virtual De Quimica ; 12(6):1464-1497, 2020.
Article in Portuguese | Web of Science | ID: covidwho-1129881

ABSTRACT

The pandemic status of COVID-19 was recorded by the World Health Organization (WHO) on March 11, 2020. Since then, more than 10 million cases have been confirmed worldwide, with more than 500,000 reported deaths. Throughout this period, efforts by the global scientific community have focused on understanding the disease process and searching on preventive (e.g. vaccines) or therapeutic (e.g. drugs) alternatives of treatment for COVID-19. The present review portrays the historical aspects associated with the discovery of SARS-CoV-2, the etiological agent of COVID-19, describes the pathophysiological aspects of the disease, the viral replication process and discusses the main molecular targets subject to therapeutic intervention, aiming the design, discovery and development of new drugs to treat COVID-19.

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