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1.
Matematika ; JOUR(2):69-82, 38.
Article in English | Web of Science | ID: covidwho-2081699

ABSTRACT

Coronavirus (COVID-19) pandemic has a massive impact on economic growth and the stock market. Due to COVID-19's high transmission rate, a movement control order (MCO) was enforced by the Malaysian government in four stages. Consequently, this situation has affected the stability and the relationship of stocks listed on Bursa Malaysia. Thus, this study is motivated to investigate and visualize a correlation of securities listed on FTSE Bursa Malaysia KLCI by employing a network analysis approach. The limitation of correlation analysis is that it only provides the strength and direction of the association, which is not visually shown in the graph. As a result, the network analysis technique is used to highlight the correlations between the stocks. The input of the network is based on the rate of return of each stock. The data is divided into two parts. The first duration is the period before implementation of MCO which is from 17th December 2020 to 17th March 2020. The second duration is during four stages of MCO which cover from 18th March 2020 to 3rd May 2020. There are changes in the interconnection between stocks in which seventeen stocks increased in the correlation measure during MCO. The importance of stocks is determined by applying centrality measures to disclose a topological structure of a network. This study finds that the stock with the highest connectivity based on the degree centrality before the MCO was unable to maintain the status as the central hub during the MCO. The results can assist the market participant to strategize the asset allocation to obtain well diversified portfolio. selection.

3.
Cureus ; 14(9), 2022.
Article in English | EuropePMC | ID: covidwho-2058198

ABSTRACT

Introduction The Rothman Index (RI, PeraHealth, Inc. Charlotte, NC, USA) is a predictive model intended to provide continuous monitoring of a patient's clinical status. There is limited data to support its use in the risk stratification of patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). We hypothesized that low admission RI scores would correlate with higher rates of adverse outcomes in patients hospitalized for coronavirus disease 2019 (COVID-19). Methods Medical records of adult patients admitted to a single 1,200-bed tertiary academic center were retrospectively reviewed for demographic data, baseline characteristics, RI scores, admission to intensive care unit (ICU), need for mechanical ventilation, and inpatient mortality. Statistical analyses were performed using STATA statistical software, version 17 (Stata Corp LLC, College Station, TX, USA). Continuous variables were analyzed using the Mann-Whitney test, and categorical variables were analyzed using Fisher’s exact test. Both univariate and multivariate analyses were performed. A p-value <0.05 was considered statistically significant. Results Median admission RI score for the entire cohort was 63.0 (IQR 45.0 - 77.1). The cohort was divided by admission RI into a low-risk group (RI ≥70;n=70) and a high-risk group (RI <70;n=107). Compared to patients with low-risk RI, patients with high-risk RI had higher mortality (95.2%, 95% CI: 85.8 - 105 vs 4.8%, 95% CI: -5 - 14.2, p < 0.01), were more likely to require ICU admission (90.2%, 95% CI: 81.9 - 98.5 vs 9.8%, 95% CI: 1.5 - 18.1, p < 0.01) and mechanical ventilation (89.7%, 95% CI: 78.3 - 101 vs 10.3%, 95% CI: -1 - 21.7, p < 0.01), and had a longer median hospital length of stay (12 days, 95% CI: 9 - 14 vs 5 days, 95% CI: 4 - 7, p < 0.01). Conclusions High-risk RI was associated with increased admission to the ICU, mechanical ventilation, and mortality. These results suggest that it may be used as a tool to aid provider judgment in the setting of COVID-19.

4.
JEADV Clinical Practice ; 2022.
Article in English | EuropePMC | ID: covidwho-2057452

ABSTRACT

Background In Saudi Arabia, three approved vaccines against severe acute respiratory syndrome coronavirus 2 (AstraZeneca [AZD1222], Pfizer‐BioNTech [BNT162b2] and [Ad26. COV 2‐S] Moderna vaccine) have been administered to the population. Objective To characterise cutaneous adverse events associated with COVID‐19 vaccines. Methodology We collected information on 26 patients presented to two secondary health care facilities, over the period extending from mid of December 2020 to the 1st of January 2022 with cutaneous reactions after COVID‐19 vaccine administration. Data were descriptively analysed using Statistical Package for the Social Sciences, SPSS 23rd version. Results A total of 53.8% of the patients were male;31% of the patients reported having at least one chronic illness. Reactions were most frequent after the first dose (57.6% of the patients). Messenger RNA‐based vaccines were the most frequently noted vaccines associated with the reactions (76.9% of the cases). The most common reactions were cutaneous small‐vessel vasculitis (19.2%), interface/lichenoid reactions (19.2%), psoriasis (15.4%), and acute urticaria (11.5%). Only 11.5% patients required admission to the hospital for their clinical presentation. Conclusion Most of our patients had mild reactions and were successfully managed with supportive treatments. However, still some patients may experience severe or long‐lasting reactions requiring systemic therapies.

5.
PLoS One ; 17(10): e0269864, 2022.
Article in English | MEDLINE | ID: covidwho-2054309

ABSTRACT

Till now the exact mechanism and effect of biogenic silver nanoparticles on fungus is an indefinable question. To focus on this issue, the first time we prepared hydrothermal assisted thyme coated silver nanoparticles (T/AgNPs) and their toxic effect on Candida isolates were determined. The role of thyme (Thymus Vulgaris) in the reduction of silver ions and stabilization of T/AgNPs was estimated by Fourier transforms infrared spectroscopy, structure and size of present silver nanoparticles were detected via atomic force microscopy as well as high-resolution transmission electron microscopy. The biological activity of T/AgNPs was observed against Candida isolates from COVID-19 Patients. Testing of virulence of Candida species using Multiplex PCR. T/AgNPs proved highly effective against Candida albicans, Candida kruzei, Candida glabrata and MIC values ranging from 156.25 to 1,250 µg/mL and MFC values ranging from 312.5 to 5,000 µg/mL. The structural and morphological modifications due to T/AgNPs on Candida albicans were detected by TEM. It was highly observed that when Candida albicans cells were subjected to 50 and 100 µg/mL T/AgNPs, a remarkable change in the cell wall and cell membrane was observed.


Subject(s)
COVID-19 , Metal Nanoparticles , Anti-Bacterial Agents/pharmacology , Antifungal Agents/chemistry , Antifungal Agents/pharmacology , Candida , Candida albicans , Humans , Metal Nanoparticles/chemistry , Microbial Sensitivity Tests , Silver/chemistry
6.
BMC Chem ; 16(1): 72, 2022 Sep 27.
Article in English | MEDLINE | ID: covidwho-2053957

ABSTRACT

Pharmaceutical quality control products (QC) demand quick, sensitive, and cost-effective methods to ensure high production at a low cost. Green analytical methods are also becoming more common in pharmaceutical research to cut down on the amount of waste that goes into the environment. Meclizine hydrochloride (MZH) and pyridoxine hydrochloride (PYH) are reported to be excellent for calming down COVID-19. As a result, the amount of MZH and PYH manufactured by multinational pharmaceutical organizations has increased considerably during the last several months. The present work proposes three environmentally friendly, straightforward, and sensitive spectrophotometric procedures for quantification of MZH in the presence of PYH in a pure and marketable formulations. The approaches under examination include ratio subtraction (RSM), induced dual wavelength (IDW), and Fourier self-deconvolution (FSD). PYH, on the other hand, was directly quantified at 290 nm. For both drugs, the procedures follow Beer's law in the range of (5-50 µg/mL). The RSM, IDW, and FSD methods, as well as the zero-order approach for PYH, have all been verified in accordance with ICH standards. The ecological value of established methodologies was determined using four distinct ways: the national environmental methods index (NEMI), the analytical Eco-scale, the Analytical Greenness Metric (AGREE), and the green analytical process index (GAPI). Comparing the findings to those of the previously described spectrophotometric technique, no major changes were identified.

7.
Vaccines (Basel) ; 10(9)2022 Sep 15.
Article in English | MEDLINE | ID: covidwho-2044009

ABSTRACT

BACKGROUND: We conducted a longitudinal study to estimate immunity produced in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection among university students over seven months. METHODS: All participants were attending a public university and resided in Pitt County, North Carolina. University students enrolled weekly for 10 weeks between 26 August 2020 and 28 October 2020, resulting in 136 young adults completing at least one study visit by 17 November 2020. Enrolled students completed an online survey and nasal swab collection at two-week intervals and monthly blood collection between 26 August 2020 and 31 March 2021. RESULTS: Amongst 695 serum samples tested during follow-up, the prevalence of a positive result for anti-nucleocapsid antibodies (N-IgG) was 9.78%. In 22 students with more than one positive N-IgG serum sample, 68.1% of the group lost persistence of N-IgG below the positive threshold over 140 days. Anti-spike IgG antibodies were significantly higher among 11 vaccinated compared to 10 unvaccinated. CONCLUSIONS: In healthy young adults, N-IgG wanes below the detectable threshold within five months. S-IgG titer remained consistently elevated months after infection, and significantly increased after vaccination.

8.
Rev Med Virol ; : e2395, 2022 Sep 03.
Article in English | MEDLINE | ID: covidwho-2013778

ABSTRACT

There is overwhelming evidence to suggest that male gender is at a higher risk of developing more severe Covid-19 disease and thus having poorer clinical outcomes. However, the relationship between testosterone (T) and Covid-19 remains unclear with both protective and deleterious effects on different aspects of the disease suggested. Here, we review the current epidemiological and biological evidence on the role of testosterone in the process of SARS-CoV-2 infection and in mediating Covid-19 severity, its potential to serve as a biomarker for risk stratification and discuss the possibility of T supplementation as a treatment or preventative therapy for Covid-19.

9.
Health Sci Rep ; 5(4): e740, 2022 Jul.
Article in English | MEDLINE | ID: covidwho-1935685

ABSTRACT

Background & Aims: The BioNTech-Pfizer vaccine is the only vaccine offered to children among all available vaccines. However, limited evidence is available about the clinical outcomes of COVID-19 vaccines, especially among children and adolescents. This review offers a comprehensive and up-to-date overview of the BioNTech-Pfizer vaccine's current information on children and adolescents. Methods: The review was conducted following the PRISMA guidelines; a comprehensive search was performed in PubMed, Scopus, MEDLINE, and EMBASE databases for research publications COVID-19 published between December 2019 and October 2021. All studies reporting on the outcomes of vaccinating children in their respective institutes were included. Results: A total of 78 vaccinated children and adolescents from six studies were included. The majority of symptomatic vaccinated pediatrics were males (71%). The mean age was 15.6 years, and the BMI was 24.1. The most common clinical symptoms were found in chest pain (35%), fever (32%), and myalgia (17%). The most common cardiac symptom in the EKG results was ST elevation, and 35% of vaccinated pediatrics had elevated serum troponin. The hospitalization, including ICU admission, was lower than in unvaccinated groups. Statistically significant associations (p ≤ 0.05) were found in two symptoms (fever and headache) between the vaccinated and nonvaccinated pediatric groups. Conclusions: Although we found better outcomes in the vaccinated group versus the nonvaccinated pediatric group, more studies are still crucial to further understand the specific etiology underlying postvaccination, particularly myocarditis, psychological impact, and other cardiac clinical symptoms in children and adolescents after receiving the BioNTech-Pfizer vaccine.

10.
Heart International ; 16(1):1, 2022.
Article in English | EMBASE | ID: covidwho-1938574
12.
J Card Surg ; 37(7): 1946, 2022 07.
Article in English | MEDLINE | ID: covidwho-1883217
13.
J Obstet Gynaecol ; 42(6): 1868-1873, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-1815727

ABSTRACT

This study was conducted to evaluate the rate of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and immunity among asymptomatic non-immunised low-risk parturient women and their newborns. A cross-sectional study conducted in a tertiary hospital during the nadir period of new cases in Egypt. All asymptomatic pregnant, low risk and non-immunised women were included. All eligible participants had been subjected to SARS-CoV-2 nasopharyngeal swabs according to CDC and sampling of maternal and umbilical blood to evaluate the presence of coronavirus disease 2019 (COVID-19) IgM and IgG antibodies by immunochromatographic assay. Two cases out of 171 (1.2%) parturient women were tested positive for PCR swab to COVID-19 infection. Furthermore, COVID-19 IgG and IgM antibodies testing showed that 67.8% of women were negative for both IgG and IGM, 24.6% were positive for IgG only, 4.1% were positive for IgM only, while 3.5% were positive for both IgG and IgM. Regarding neonatal testing for immunity, 28.1% of the neonates were positive to IgG only and none for IgM.The rate of positive PCR patients among asymptomatic low-risk parturient women was 1.2%. About quarter of women had got herd immunity as evident by positive IgG antibodies. IgG antibodies transferred to the neonates in almost all cases.Impact StatementWhat is already known on this subject? Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global public health emergency. Asymptomatic pregnant women with coronavirus disease can transmit their infection to their newborn, family members and the health care providers.What do the results of this study add? The study showed very low (1.2%) prevalence of COVID positive cases among asymptomatic pregnant women admitted to our facility. Only two cases out of 171 parturient women tested PCR positive for COVID-19 infection (1.2%). SARS-Cov-2 IgG and IgM antibodies testing showed, about a quarter (24.6%) were positive for IgG antibodies, 4.1% were positive for IgM antibodies, while 3.5% were positive for both IgG and IgM. On the other hand, 28.1% of the neonates were positive to IgG only and none of the newborns had had IgM antibodies in their cord blood.What are the implications of these findings for clinical practice and/or further research? The first wave of COVID-19 pandemic in Egypt left behind at least a quarter of pregnant women with a positive antibody denoting some immunity. This immunity is usually transmitted to the neonates in almost all cases.


Subject(s)
COVID-19 , SARS-CoV-2 , COVID-19/diagnosis , COVID-19/epidemiology , Cross-Sectional Studies , Female , Humans , Immunoglobulin G , Immunoglobulin M , Infant, Newborn , Pandemics , Pregnancy
14.
RSC Adv ; 11(22): 13537-13544, 2021 Apr 07.
Article in English | MEDLINE | ID: covidwho-1795651

ABSTRACT

Several studies are now underway as a worldwide response for the containment of the COVID-19 outbreak; unfortunately, none of them have resulted in an effective treatment. Salvadora persica L. (Salvadoraceae), commonly known as meswak, is one of the popular plants used by Muslims as an oral hygiene tool. It is documented that the meswak possesses antiviral activity, but no report discusses its use for coronavirus treatment. Herein, a mixture of 11 flavonoids prepared from the aqueous plant extract and its liposomal formulation were shown to inhibit SARS-CoV-2 in an in vitro A549 cell line culture and a RT-PCR test almost as well as the FDA-approved anti-COVID-19 agent, remdesivir. Encapsulation within liposomal formulation led to a highly significant increase in the percentage of inhibition of viral replication from 38.09 ± 0.83 to 85.56 ± 1.12% in a flavonoid mixture and its liposomal preparation, respectively, and this figure approached that obtained for remdesivir (91.20 ± 1.71%). Preliminary tests were also performed, including a total flavonoid assay, a molecular docking study, a 3CL-protease inhibition assay and a cytotoxicity study. It was worthy to find a cheap, readily available, safe natural source for promising anti-SARS-CoV-2 agents, that leak their phytochemicals into the aqueous saliva during regular use as a brushing agent.

15.
2021 SPE Symposium: Decommissioning and Abandonment, SM02 2021 ; 2021.
Article in English | Scopus | ID: covidwho-1793398

ABSTRACT

In 2020, PCSB implemented the first permanent Plug & Abandonment (P&A) campaign for three Subsea wells in a gas field offshore Malaysia. The main objective of the campaign was to establish two (2) barriers for every movable hydrocarbon or overpressure bearing sand by placing laterally extended cement plug across impermeable formation with enough formation strength to handle the pressure of the formation to be isolated. The unique case of this operation was the challenges to execute PCSB's first subsea P&A operation in gas field Malaysia during pandemic situation. In March 2020, the Malaysian government imposed Movement Control Order (MCO) to curb the spread of the COVID-19. A semi-submersible rig was on-hired a week after government initiated the MCO, resulted in the rig preparation being badly hampered due to manpower management and material fabrication and delivery. PCSB was exposed to expensive rig daily rate that had to be managed. Four (4) main challenges were encountered during operation: safe protection for workers, expensive standby cost, manpower management and material fabrication and delivery. This paper, from the 'project management' point of view, describes the journey of managing rig operation during PCSB's first subsea wells P&A in Malaysia efficiently amidst the pandemic by reducing the impact of COVID-19 on project cost. With the experience of managing rig for subsea well operation, a complex operation in Malaysia, amidst pandemic, PCSB sharing on the experience is beneficial to provide context setting and benchmark on maintaining the efficiency of operation. Wells successfully met the objective of operation with no incident occurred, negotiated reduction on standby cost and managed to bring critical manpower on time during operation. Copyright © 2021, Society of Petroleum Engineers

16.
13th EAI International Conference on Intelligent Technologies for Interactive Entertainment, INTETAIN 2021 ; 429 LNICST:322-335, 2022.
Article in English | Scopus | ID: covidwho-1787746

ABSTRACT

Technology in teaching and learning is crucial as we are now focusing on 21st Century Learning. Moreover, the Covid-19 pandemic has affected many sectors, including education sectors, where most educators are continuously looking for approach and tools to enhance their teaching deliveries to ensure students can still learn effectively even though most of the classes are currently conducted online. Other than that, students also have problems with their visualization skills when learning engineering drawing, which caused a lack of understanding of the content, thus making it even harder for them to learn in this situation. Technology such as augmented reality is a well-received technology application due to its benefit in enhancing users’ learning experiences, enhancing visualization skills, and supplementing materials more effectively. Thus, this paper aims to describe Augmented Reality Engineering Drawing Apps (AREDApps) development process, a mobile augmented reality apps for orthographic projection topic in engineering drawing subject, highlight the students’ perception when using AREDApps during learning and introduce the engineering drawing learning framework based on AREDApps implementation in the classroom. The result indicates that students were mostly satisfied with augmented reality technology to learn orthographic projection. This is because AREDApps helps them supplement the information that cannot be delivered by using modules or PowerPoint presentation such as the three-dimensional representations of the task given to them. The findings of this paper strengthen the facts that augmented reality is a suitable technology to teach complex technical subjects, which requires supplementary materials that can help students to be able to visualize the task effectively. © 2022, ICST Institute for Computer Sciences, Social Informatics and Telecommunications Engineering.

17.
RSC advances ; 11(22):13537-13544, 2021.
Article in English | EuropePMC | ID: covidwho-1787358

ABSTRACT

Several studies are now underway as a worldwide response for the containment of the COVID-19 outbreak;unfortunately, none of them have resulted in an effective treatment. Salvadora persica L. (Salvadoraceae), commonly known as meswak, is one of the popular plants used by Muslims as an oral hygiene tool. It is documented that the meswak possesses antiviral activity, but no report discusses its use for coronavirus treatment. Herein, a mixture of 11 flavonoids prepared from the aqueous plant extract and its liposomal formulation were shown to inhibit SARS-CoV-2 in an in vitro A549 cell line culture and a RT-PCR test almost as well as the FDA-approved anti-COVID-19 agent, remdesivir. Encapsulation within liposomal formulation led to a highly significant increase in the percentage of inhibition of viral replication from 38.09 ± 0.83 to 85.56 ± 1.12% in a flavonoid mixture and its liposomal preparation, respectively, and this figure approached that obtained for remdesivir (91.20 ± 1.71%). Preliminary tests were also performed, including a total flavonoid assay, a molecular docking study, a 3CL-protease inhibition assay and a cytotoxicity study. It was worthy to find a cheap, readily available, safe natural source for promising anti-SARS-CoV-2 agents, that leak their phytochemicals into the aqueous saliva during regular use as a brushing agent. Several studies are now underway as a worldwide response for the containment of the COVID-19 outbreak;unfortunately, none of them have resulted in an effective treatment.

18.
International Journal of Evaluation and Research in Education ; 11(1):120-127, 2022.
Article in English | Scopus | ID: covidwho-1776636

ABSTRACT

The integration of mobile technology is not a new thing nowadays. It became increasingly applied after the COVID-19 pandemic hit the world. Teachers need to use mobile technology devices widely to improve teaching effectiveness. This study aimed to explore the elements of teachers' acceptance of mobile technology as a learning alternative. The respondents consisted of 422 teachers in 24 secondary schools around Kedah, Malaysia. The results showed that teachers are impressed to integrate mobile technology based on three dimensions: effort expectancy, hedonic motivation, and habit. This situation reflects teachers' willingness to translate their pedagogical abilities through the medium of technology. It has also recognized that internal motivation and teachers' natural habits are the driving force behind integrating mobile technology as a teaching aid to digital technology. Thus, mobile technology is a trend of daily use and can be utilized as the most advanced pedagogical material to go through learning in the 21st century. © 2022, Institute of Advanced Engineering and Science. All rights reserved.

19.
J Health Psychol ; 27(4): 805-824, 2022 03.
Article in English | MEDLINE | ID: covidwho-1765282

ABSTRACT

A systematic review and a meta-analysis were conducted to examine the overall prevalence of psychological health outcomes during COVID-19. Seven databases were systematically searched to include studies reporting on at least one psychological outcome. The pooled prevalence of primary psychological outcomes was 26% (95%CI: 21-32). Pooled prevalence for symptoms of PTSD was 33% (0-86), anxiety 28% (21-36), stress 27% (14-43), and depression 22% (13-33). The prevalence of psychological outcomes was similar in healthcare workers and in the general population (34% [24-44] and 33% [27-40] respectively). High prevalence figures support the importance of ensuring adequate provision of resources for mental health.


Subject(s)
COVID-19 , Anxiety/psychology , Depression/epidemiology , Humans , Prevalence , SARS-CoV-2
20.
Research Journal of Pharmacy and Technology ; 15(1):305-310, 2022.
Article in English | Scopus | ID: covidwho-1732710

ABSTRACT

Background: The profession of pharmacy nowadays is expanding from dispensing medication to evidence-based, patient-centered approach, in which optimizing pharmacologic therapy is the goal. Community pharmacists can optimize the overall quality of care especially in rural populations where people most of the time can’t afford to visit physician. Pharmacist caring of patients is the new pharmacist’s role. Community pharmacist can motivate patients to adhere to their medications. Medication review and patients’ monitoring contribute to resolve serious problems in health care system. Methods: This study involves four phases. Phase one implies training of community pharmacists. Phase two is quantitative and involves baseline evaluation of recruited patients. Phase three is the interventional phase. It is also quantitative and aims to assess the impact of pharmaceutical care service on elderly patients with polypharmacy in three selected pharmacies in Ajman and Sharjah through Medication Adherence Rating Scale (MARS) questionnaire, and Short Form 36 (SF-36) questionnaire for health status, and quality of life. These two questionnaires will be filled by elderly patients first upon signing consent form, before the pharmacist intervention, and in the two interviews following the intervention. Phase four is qualitative and aims to assess the experience of the participating community pharmacists and explore their perception regarding the pharmaceutical care service through focused group discussion. Discussion: This research is the first to be conducted in United Arab Emirates. Therefore, findings will reveal the possibility and preparedness of pharmacists to perform medication review and patients’ monitoring and follow up. Additionally, due to the unusual circumstances of COVID-19 pandemic, innovative ways will be used to perform such service. © RJPT All right reserved.

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