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1.
Wellcome Open Research ; 6:127, 2021.
Article in English | MEDLINE | ID: covidwho-2164250

ABSTRACT

Policymakers in Africa need robust estimates of the current and future spread of SARS-CoV-2. We used national surveillance PCR test, serological survey and mobility data to develop and fit a county-specific transmission model for Kenya up to the end of September 2020, which encompasses the first wave of SARS-CoV-2 transmission in the country. We estimate that the first wave of the SARS-CoV-2 pandemic peaked before the end of July 2020 in the major urban counties, with 30-50% of residents infected. Our analysis suggests, first, that the reported low COVID-19 disease burden in Kenya cannot be explained solely by limited spread of the virus, and second, that a 30-50% attack rate was not sufficient to avoid a further wave of transmission.

2.
Am J Trop Med Hyg ; 2022.
Article in English | PubMed | ID: covidwho-2163942

ABSTRACT

Zambia instituted prevention behavior guidelines for social gatherings before the first case of COVID-19 was confirmed on March 18, 2020. Guidelines included nonpharmaceutical interventions (NPIs) including mask wearing, social distancing, and reducing sizes of gatherings. Within a larger cluster randomized trial of community-based parenting groups in four rural districts (three in Southern Province, one in Eastern Province), we collected 5,711 questionnaires from intervention participants between August 2020 and September 2021, during which the country saw two COVID-19 waves. Questionnaires asked about participation and behaviors at community gatherings. Generally, perception of risk of contracting COVID-19 was low for respondents in districts in Southern Province but higher for those in Eastern Province. The highest compliance to mask wearing was reported at clinics (84%) and church services (81%), which were the most frequently attended gatherings. Many funerals were attended by 200 to 300 people, but individuals were 30% less likely to report wearing masks (odds ratio [OR] = 0.71, 95% confidence ratio [CI]: 0.6-0.8) than those attending a clinic visit. After controlling for other variables, the odds of self-reported mask wearing at events were higher in January to March 2021 (adjusted OR = 1.5, 95% CI: 1.3, 1.7) and July and September of 2021 (adjusted OR = 3.0, 95% CI: 2.5-3.5), timepoints that broadly overlay with two COVID-19 peaks observed in Zambia. Results suggest guideline dissemination penetrated the rural areas. However, there is need to optimize the messaging to increase compliance to NPIs at high-risk gatherings, including funerals. The findings from this analysis should be considered as the COVID-19 pandemic continues to evolve.

4.
Engenharia Sanitaria e Ambiental ; 27(6):1113-1122, 2022.
Article in Portuguese | Scopus | ID: covidwho-2162709

ABSTRACT

The transmission of respiratory infections has an important role on human health, especially in the current context of the COVID-19 pandemic. In this work, we present the assessment of an air purifier that uses ultraviolet-C (UVC) radiation and a "High Efficiency Particulate Air” (HEPA) filter as mechanisms to decontaminate indoor environments with low air circulation. To assess the physicochemical and microbicidal characteristics of the equipment, the irradiance produced by the lamp, the flow rate at the entrance and exit of the device, possible changes in the ozone concentration and the equipment's decontamination potential for Staphylococcus aureus, Escherichia coli and Candida albicans. The total dose of UVC radiation that the air receives when passing through the equipment was 801.4 μJ cm-2, which would represent an inactivation of up to 80% of SARS-CoV-2 in the air. Furthermore, the filtration efficiency dropped with smaller particle diameter, and reduced to around 60% for particles with less than 1 μm and remained above 90% for PM2.5 and PM10 . In microbiological tests, there was a reduction of 99.4%, 99.9% and 99.5% for S aureus, E. coli and C. albicans, respectively, in 11 minutes. © 2022 Associação Brasileira de Engenharia Sanitária e Ambiental Este é um artigo de acesso aberto distribuído nos termos de licença Creative Commons.

5.
BMC Public Health ; 22(1):2318, 2022.
Article in English | PubMed | ID: covidwho-2162349

ABSTRACT

BACKGROUND: Non-pharmaceutical interventions (NPIs), such as travel restrictions, social distancing and isolation policies, aimed at controlling the spread of COVID-19 may have reduced transmission of other endemic communicable diseases, such as measles, mumps and meningitis in England. METHODS: An interrupted time series analysis was conducted to examine whether NPIs was associated with trends in endemic communicable diseases, using weekly reported cases of seven notifiable communicable diseases (food poisoning, measles, meningitis, mumps, scarlet fever and pertussis) between 02/01/2017 to 02/01/2021 for England. RESULTS: Following the introduction of COVID-19 restrictions, there was an 81.1% (95% CI;77.2-84.4) adjusted percentage reduction in the total number of notifiable diseases recorded per week in England. The greatest decrease was observed for measles, with a 90.5% percentage reduction (95% CI;86.8-93.1) from 42 to 5 cases per week. The smallest decrease was observed for food poisoning, with a 56.4% (95%CI;42.5-54.2) decrease from 191 to 83 cases per week. CONCLUSIONS: A total reduction in the incidence of endemic notifiable diseases was observed in England following the implementation of public health measures aimed at reducing transmission of SARS-COV-2 on March 23, 2020. The greatest reductions were observed in diseases most frequently observed during childhood that are transmitted via close human-to-human contact, such as measles and pertussis. A less substantive reduction was observed in reported cases of food poisoning, likely due to dining services (i.e., home deliveries and takeaways) remaining open and providing a potential route of transmission. This study provides further evidence of the effectiveness of non-pharmaceutical public health interventions in reducing the transmission of both respiratory and food-borne communicable diseases.

6.
Mol Med ; 28(1):153, 2022.
Article in English | PubMed | ID: covidwho-2162292

ABSTRACT

BACKGROUND: Multisystem Inflammatory Syndrome in Children (MIS-C) is a life-threatening complication of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, which manifests as a hyper inflammatory process with multiorgan involvement in predominantly healthy children in the weeks following mild or asymptomatic coronavirus disease 2019 (COVID-19). However, host monogenic predisposing factors to MIS-C remain elusive. METHODS: Herein, we used whole exome sequencing (WES) on 16 MIS-C Brazilian patients to identify single nucleotide/InDels variants as predisposition factors associated with MIS-C. RESULTS: We identified ten very rare variants in eight genes (FREM1, MPO, POLG, C6, C9, ABCA4, ABCC6, and BSCL2) as the most promising candidates to be related to a higher risk of MIS-C development. These variants may propitiate a less effective immune response to infection or trigger the inflammatory response or yet a delayed hyperimmune response to SARS-CoV-2. Protein-Protein Interactions (PPIs) among the products of the mutated genes revealed an integrated network, enriched for immune and inflammatory response mechanisms with some of the direct partners representing gene products previously associated with MIS-C and Kawasaki disease (KD). In addition, the PPIs direct partners are also enriched for COVID-19-related gene sets. HLA alleles prediction from WES data allowed the identification of at least one risk allele in 100% of the MIS-C patients. CONCLUSIONS: This study is the first to explore host MIS-C-associated variants in a Latin American admixed population. Besides expanding the spectrum of MIS-C-associated variants, our findings highlight the relevance of using WES for characterising the genetic interindividual variability associated with COVID-19 complications and ratify the presence of overlapping/convergent mechanisms among MIS-C, KD and COVID-19, crucial for future therapeutic management.

7.
15th International Conference on Advanced Computer Theory and Engineering, ICACTE 2022 ; : 78-82, 2022.
Article in English | Scopus | ID: covidwho-2161397

ABSTRACT

The world was put in disarray when the novel coronavirus first began. Furthermore, when the World Health Organization (WHO) declared the novel coronavirus outbreak a public health emergency of international concern (PHEIC), people prepared safety protocols to minimize the effect of the virus. One of these is the implementation of e-learning in countries, including the Philippines. As this contactless learning began, students' motivation decreased due to a lack of private space/classroom and face-to-face communication with their teachers. Learners' motivation is as crucial as this influences their pace to learn. The researchers developed a tool to help students with their studies and motivate them. LINYA is a web-based text annotation tool in machine learning. The tool was developed using an NLP method in machine learning. The researchers used automated Agile testing with four phases in testing the web tool. It began with component testing and progressed to integration, system, and acceptance testing. Based on the results from simulated data, the tests showed favorable results, with mean scores ranging from 3.8 to 4.6, for all areas of a usability test. It further shows that the developed system is ready for implementation. © 2022 IEEE.

8.
Analytical Chemistry ; 13:13, 2022.
Article in English | MEDLINE | ID: covidwho-2160134

ABSTRACT

Addressing the spread of coronavirus disease 2019 (COVID-19) has highlighted the need for rapid, accurate, and low-cost diagnostic methods that detect specific antigens for SARS-CoV-2 infection. Tests for COVID-19 are based on reverse transcription PCR (RT-PCR), which requires laboratory services and is time-consuming. Here, by targeting the SARS-CoV-2 spike protein, we present a point-of-care SERS detection platform that specifically detects SARS-CoV-2 antigen in one step by captureing substrates and detection probes based on aptamer-specific recognition. Using the pseudovirus, without any pretreatment, the SARS-CoV-2 virus and its variants were detected by a handheld Raman spectrometer within 5 min. The limit of detection (LoD) for the pseudovirus was 124 TU muL-1 (18 fM spike protein), with a linear range of 250-10,000 TU muL-1. Moreover, this assay can specifically recognize the SARS-CoV-2 antigen without cross reacting with specific antigens of other coronaviruses or influenza A. Therefore, the platform has great potential for application in rapid point-of-care diagnostic assays for SARS-CoV-2.

9.
Anal Chem ; 2022.
Article in English | PubMed | ID: covidwho-2160132

ABSTRACT

The pandemic readiness toolbox needs to be extended, targeting different biomolecules, using orthogonal experimental set-ups. Here, we build on our Cov-MS effort using LC-MS, adding SISCAPA technology to enrich proteotypic peptides of the SARS-CoV-2 nucleocapsid (N) protein from trypsin-digested patient samples. The Cov(2)MS assay is compatible with most matrices including nasopharyngeal swabs, saliva, and plasma and has increased sensitivity into the attomole range, a 1000-fold improvement compared to direct detection in a matrix. A strong positive correlation was observed with qPCR detection beyond a quantification cycle of 30-31, the level where no live virus can be cultured. The automatable sample preparation and reduced LC dependency allow analysis of up to 500 samples per day per instrument. Importantly, peptide enrichment allows detection of the N protein in pooled samples without sensitivity loss. Easily multiplexed, we detect variants and propose targets for Influenza A and B detection. Thus, the Cov(2)MS assay can be adapted to test for many different pathogens in pooled samples, providing longitudinal epidemiological monitoring of large numbers of pathogens within a population as an early warning system.

10.
Microscopy Today ; 29(6):42-48, 2021.
Article in English | MEDLINE | ID: covidwho-2160126

ABSTRACT

In response to the requirements imposed by the COVID-19 pandemic in 2020, we developed a remote learning undergraduate workshop for 44 students at the University of Newcastle by embedding scanning electron microscope (SEM) images of Maratus (Peacock) spiders into the MyScope Explore environment. The workshop session had two main components: 1) to use the online MyScope Explore tool to virtually image scales with structural color and pigmented color on Maratus spiders;2) to join a live SEM session via Zoom to image an actual Maratus spider. In previous years, the undergraduate university students attending this annual workshop would enter the Microscopy Facility at the University of Newcastle to image specimens with SEM;however, in 2020 the Microscopy Facility was closed to student visitors, and this virtual activity was developed in order to proceed with the educational event. The program was highly successful and constitutes a platform that can be used in the future by universities for teaching microscopy remotely.

11.
Hepatology ; 76(Supplement 1):S1161-S1163, 2022.
Article in English | EMBASE | ID: covidwho-2157801

ABSTRACT

Background: MELD and Child-Pugh scores have traditionally been used as prognostic indicators in patients with cirrhosis. Albumin infusions in outpatients have been associated with improved outcomes, but not in transplant waitlisted patients or inpatients. This aim of this study was to assess whether low serum albumin (sAlb) on admission alone is a poor prognostic indicator among cirrhotic inpatients from a new multi-national cohort. Method(s): The CLEARED study is a global study that enrolled consecutive non-electively admitted inpatients without organ transplant or COVID-19 from 6 continents. Admission demographics, medical history, laboratory data, inpatient course, death/hospice transfer and mortality at 30 days post-discharge were recorded. Patients were divided into 3 groups: sAlb <28gm/L(A), sAlb >=28 but <35gm/L (B), and sAlb>=35gm/L (C) were compared. Multi-variable logistic regression was performed using inpatient mortality and overall 30-day mortality as outcomes. Result(s): 2429 patients were enrolled from 21 countries worldwide. The distribution was A:49%, B:39%, C:12%. Gp A patients were significantly younger (54yrs vs. 57yrs vs 58yrs p<0.0001) but with similar gender distribution, and higher MELD-Na score of 25 vs. 20 vs. 17 (p<0.0001). Gp A patients were more likely to have alcohol as etiology of cirrhosis (49% vs. 45% vs 38%, p=0.004), and were more likely to have either infection (27% vs. 18% vs. 13%, p<0.0001), HE (39% vs. 33% vs. 23%, p=0.005) or fluid related issues as a reason for admission (p<0.0001). More patients in Gp A received albumin infusion during their hospital stay (120gm vs. 100gm vs. 100gm p=0.0004), mostly for the indications of AKI (47% vs. 49% vs. 47%, p=0.79) and performance of large volume paracentesis (44% vs. 42% vs. 41%, p=0.80), followed by bacterial peritonitis indication (22% vs. 17% vs. 11%, p=0.01). Group A patients had longer hospital stays (9 days vs. 8 days vs. 7 days (p<0.001), but similar ICU transfer (23% vs. 22% vs. 20%, p=0.55). group A patients were more likely to die while inpatients (19% vs. 11% vs. 5%, p<0.0001), or by 30 days post-discharge (29% vs. 20% vs. 9%, p<0.0001). Table shows the admission variables associated with a poor outcome. Conclusion(s): Hypoalbuminemia is extremely common among admitted cirrhotic patients, with sAlb of <28gm/L occurring in almost half. Together with MELD-Na score and infection at admission, a low sAlb is associated with a poor outcome in these patients. Future studies will need to validate these findings and to assess whether albumin infusions will improve the outcome of these patients. (Figure Presented).

12.
Hepatology ; 76(Supplement 1):S126-S128, 2022.
Article in English | EMBASE | ID: covidwho-2157771

ABSTRACT

Background: Although cirrhosis is a major cause of mortality worldwide, there could be disparities in outcomes. This needs a global consortium to study disparities in inpatient cirrhosis care Aim: Define the impact of location in prediction of outcomes in inpts with cirrhosis. Method(s): CLEARED prospectively enrolled non-electively admitted cirrhosis pts without COVID from all continents. To ensure equity, we allowed only 50 pts/site. Admission details, cirrhosis history, inpatient & 30-day course were recorded. World bank classification of low/low middle income (LMI), upper middle (UMI) & High income (HI) were used. Cirrhosis details, inpatient & 30-day outcomes were compared between groups. Multi-variable regression was performed using inpatient & 30-day mortality as outcomes. Result(s): 2758 pts from 21 countries from all continents, including Africa & Australia, were included.727 were L/LMI, 1050 UMI & 981 pts were from HICs. More men & younger pts were in LMI. Cirrhosis details: More pts in HI gp had 6M hospitalizations & infections, HE & ascites while prior variceal bleeding was higher in LMI . Prior HCC & transplant listings were lower in LMI but similar in UMI/HI. Alcohol & NASH was highest in HI. Viral hepatitis & cryptogenic were highest in UMI.Admissions: Admission MELD was highest in LMI. LMI pts were admitted more for GI Bleed, HE, & DILI, while anasarca & HBV flares were higher in UMI. Higher SBP (36% vs 24% vs 21% p<0.0001) & lowest skin/soft-tissue infections were in LMI (5% vs 5% vs 10% p=0.008);rest were similar. Nosocomial infections, driven by UTI were highest in LMI & HI pts (15% vs 14% vs 11% UMI, p=0.03). Admission diuretics, PPIs, Lactulose & statins were highest & antivirals lower in HI. SBP prophylaxis & rifaximin were highest in LMI pts. Outcome(s): More LMI pts needed ICU & had more organ failures (Fig B). Discharge MELD was highest in LMI. In-hospital mortality was highest & transplant lowest in LMI. This extended to 30-day mortality & transplant in LMI patients vs HI pts.Regression: In-hospital mortality was linked with age, infections, MELD & being in a LMI/UMI vs HIC while being on a transplant list, diabetes, & SBP prophylaxis were protective (Fig C). 30-day mortality predicted by age, ascites, HCC, discharge MELD, organ failures, LMI/UMI vs HIC but rifaximin was protective(Fig D). In-hospital transplant was higher with high MELD, admission rifaximin & listed pts &lower in LMI (OR 0.26) & UMI (OR 0.22) & age. 30-day transplant was higher in those with hyponatremia, ascites & HRS, on the list & on rifaximin and lower in LMI (OR 0.24) & UMI (OR 0.59) vs HI. Conclusion(s): In a global study of inpatients with cirrhosis, there were major differences in outcomes. Not being in a high-income country significantly increased the risk of inpatient and 30-day mortality independent of demographics, medications, in-hospital course, and cirrhosis severity likely due to disparities in access to transplant, which should be accounted for in global models. (Figure Presented).

13.
Obesity ; 30:266-267, 2022.
Article in English | ProQuest Central | ID: covidwho-2157115

ABSTRACT

Background: COVID-19 stay-at-home orders required healthcare providers to adopt new strategies to deliver patient care. Pediatric weight management programs (PWMP) shifted to telemedicine. The objectives of this study were to assess the implementation of telemedicine during the initial COVID-19 period and compare patients during COVID-19 to those pre-COVID in order to investigate potential disparities in accessing care. Methods: This retrospective chart review of 6 US PWMP compared program and patient-level variables during the initial COVID-19 period (spring 2020) and an equivalent pre-COVID period (spring 2019). The COVID-19 period was specific to each PWMP starting when all in-person clinics were closed and ending when any aspect of in-person care resumed. Patients were stratified by visit completion status. Comparisons were made between pre-COVID vs. COVID-19 periods using Fisher's exact tests for proportions and Wilcoxon rank sums tests for continuous variables. Results: Data were analyzed from 3,297 unique patients. Mean duration for the COVID-19 time-period was 9 weeks (range 5-13 weeks). The volume and show rates were lower during COVID-19 (596 completed, show rate 35%) vs. pre-COVID (1,004 completed, show rate 60%). Reimbursement was higher pre-COVID (16.7% vs. 33.3% not reimbursed). During COVID-19, a smaller proportion of patients who completed visits were male, Hispanic, or non-English speaking, and a higher proportion were Black or lived > 20 miles from the program (all values <0.05). For completed visits during COVID-19 vs. pre-COVID periods, insurance status, age and BMI percentile were not significant. Conclusions: Telemedicine was essential during COVID-19 closures. Although reimbursement and patient volumes were lower, telemedicine improved access to those living farther away from a PWMP and those who were Black. Additional strategies are needed to identify and address barriers to telemedicine for those who are Hispanic and non-English speaking.

14.
PLoS ONE [Electronic Resource] ; 17(12):e0268145, 2022.
Article in English | MEDLINE | ID: covidwho-2154226

ABSTRACT

The COVID-19 pandemic has caused a public health emergency in all sectors of society, including universities and other academic institutions. This study determined the seroprevalence of SARS-CoV-2 antibodies among administrators, faculty, staff, and students of a private tertiary academic institution in the Philippines over a 7 month period. It employed a serial cross-sectional method using qualitative and quantitative COVID-19 antibody test kits. A total of 1,318 participants were tested, showing 47.80% of the study population yielding IgG antibodies to SARS-CoV-2 virus. A general increase in seroprevalence was observed from June to December 2021, which coincided with the vaccine roll-out of the country. All brands yielded positive antibody formation, with mRNA vaccines having higher levels than other types of vaccines. A decreasing trend in IgG reactivity was found in vaccinated individuals after 1 to 6 months of completion of the 2 doses of the COVID-19 vaccine. Where possible, IgG and T-cell reactivity and/or neutralizing capacity against SAR-CoV-2 need to be monitored regardless of vaccine brand. Together with uptake of COVID-19 vaccines and boosters, other public health interventions such as wearing of masks and regular testing need to be continued for better protection. Effective communication is also needed to inform risks associated with activities across different settings. Investments in long-term measures such as air filtration and ventilation systems, and wastewater surveillance need to be made.

15.
Infect Dis Poverty ; 11(1):118, 2022.
Article in English | PubMed | ID: covidwho-2153684

ABSTRACT

BACKGROUND: From May 2018 to September 2022, the Democratic Republic of Congo (DRC) experienced seven Ebola virus disease (EVD) outbreaks within its borders. During the 10th EVD outbreak (2018-2020), the largest experienced in the DRC and the second largest and most prolonged EVD outbreak recorded globally, a WHO risk assessment identified nine countries bordering the DRC as moderate to high risk from cross border importation. These countries implemented varying levels of Ebola virus disease preparedness interventions. This case study highlights the gains and shortfalls with the Ebola virus disease preparedness interventions within the various contexts of these countries against the background of a renewed and growing commitment for global epidemic preparedness highlighted during recent World Health Assembly events. MAIN TEXT: Several positive impacts from preparedness support to countries bordering the affected provinces in the DRC were identified, including development of sustained capacities which were leveraged upon to respond to the subsequent coronavirus disease 2019 (COVID-19) pandemic. Shortfalls such as lost opportunities for operationalizing cross-border regional preparedness collaboration and better integration of multidisciplinary perspectives, vertical approaches to response pillars such as surveillance, over dependence on external support and duplication of efforts especially in areas of capacity building were also identified. A recurrent theme that emerged from this case study is the propensity towards implementing short-term interventions during active Ebola virus disease outbreaks for preparedness rather than sustainable investment into strengthening systems for improved health security in alignment with IHR obligations, the Sustainable Development Goals and advocating global policy for addressing the larger structural determinants underscoring these outbreaks. CONCLUSIONS: Despite several international frameworks established at the global level for emergency preparedness, a shortfall exists between global policy and practice in countries at high risk of cross border transmission from persistent Ebola virus disease outbreaks in the Democratic Republic of Congo. With renewed global health commitment for country emergency preparedness resulting from the COVID-19 pandemic and cumulating in a resolution for a pandemic preparedness treaty, the time to review and address these gaps and provide recommendations for more sustainable and integrative approaches to emergency preparedness towards achieving global health security is now.

16.
Respir Res ; 23(1):327, 2022.
Article in English | PubMed | ID: covidwho-2153589

ABSTRACT

BACKGROUND: Acute respiratory distress syndrome (ARDS) is one of the most severe complications of SARS-CoV-2 infection. Non-Invasive Respiratory Support (NRS) as Continuous Positive Airway Pressure (CPAP) and/or Non-Invasive Ventilation (NIV) has been proven as effective in the management of SARS-CoV-2-related ARDS. However, the most appropriate timing for start NRS is unknown. METHODS: We conducted a prospective pilot study including all consecutive patients who developed moderate SARS-CoV-2-related ARDS during hospitalization. Patients were randomly divided into two intervention groups according to ARDS severity (assessed by PaO(2)/FiO(2)-P/F) at NRS beginning: group A started CPAP/NIV when P/F was ≤ 200 and group B started CPAP/NIV when P/F was ≤ 150. Eligible patients who did not give their consent to CPAP/NIV until the severe stage of ARDS and started non-invasive treatment when P/F ≤ 100 (group C) was added. The considered outcomes were in-hospital mortality, oro-tracheal intubation (OTI) and days of hospitalization. RESULTS: Among 146 eligible patients, 29 underwent CPAP/NIV when P/F was ≤ 200 (Group A), 68 when P/F was ≤ 150 (Group B) and 31 patients agreed to non-invasive treatment only when P/F was ≤ 100 (Group C). Starting NRS at P/F level between 151 and 200 did not results in significant differences in the outcomes as compared to treatment starting with P/F ranging 101-150. Conversely, patients undergone CPAP/NIV in a moderate stage (P/F 101-200) had a significantly lower in-hospital mortality rate (13.4 vs. 29.0%, p = 0.044) and hospitalization length (14 vs. 15 days, p = 0.038) than those in the severe stage (P/F ≤ 100). Age and need for continuous ventilation were independent predictors of CPAP/NIV failure. CONCLUSIONS: Starting CPAP/NIV in patients with SARS-CoV-2-related ARDS in moderate stage (100 > P/F ≤ 200) is associated to a reduction of both in-hospital mortality and hospitalization length compared to the severe stage (P/F ≤ 100). Starting CPAP/NIV with a P/F > 150 does not appear to be of clinical utility.

17.
15th International Conference on Theory and Practice of Electronic Governance, ICEGOV 2022 ; : 588-590, 2022.
Article in English | Scopus | ID: covidwho-2153143

ABSTRACT

The digital revolution has played a decisive role in economic and social development. With Covid-19, the need to maintain services and organizations working, adjusting to the social distancing rules, forced institutions to develop new strategies using technologies. In this context, CapacitAmente Project was developed at Universidade Católica Portuguesa, integrating teachers and students from Social Work and Psychology dedicated to promoting continuous training to employees of social solidarity institutions. Using the Service-Learning methodology to implement this interdisciplinary project, a set of actions were developed anchored in the 2030 Agenda for Sustainable Development, in close collaboration with United Nations University. This project constitutes a potential contribution of good practices for Digital Governance, making theoretical and practical knowledge accessible to all without discrimination, supporting the formulation of policies and the provision of services for the SDGs. © 2022 ACM.

18.
2022 IEEE Learning with MOOCS, LWMOOCS 2022 ; : 227-232, 2022.
Article in English | Scopus | ID: covidwho-2152499

ABSTRACT

This research analyzes the undergraduate student's perceptions and challenges of the mandatory transition of six computer-aided design courses, from a blended modality to a completely remote one, in the context of the coronavirus pandemic. We analyzed a School of Architecture in Peru, which has implemented the blended learning in these six courses since 2015, to acquire technical skills in drawing, design, BIM, visualization, information graphic, video editing, computational design, and digital fabrication. We used an anonymous and self-administered survey between November and December 2021 to 1,045 students and received 435 responses for analysis. The results reveal the different ways in which the student interacts with the CAD software for each course. We concluded that the experience of going through the stages of face-to-face, blended, and online, prepares us to migrate into learning environments in the format of MOOCs. The study allowed us to identify challenges and strengths, such as usage preferences to consider for future transition, taking into account the characteristics of these types of courses as a basis for the creation of MOOCs for the inevitable demand for the technologies of the Fourth Industrial Revolution. © 2022 IEEE.

19.
Med Mycol ; 2022.
Article in English | PubMed | ID: covidwho-2152103

ABSTRACT

Aspergillus spp. isolated from non-BAL cultures of COVID-19-associated pulmonary aspergillosis (CAPA) patients may reflect colonization rather than infection. Sera (n = 181) from 49 adult ICU CAPA patients (24 probable and 25 possible CAPA) with bronchial secretions (BS) culture positive for Aspergillus spp. were collected and tested for Aspergillus DNA detection by species-specific real-time PCR. Overall, 30/49 (61%) patients were PCR positive. BS culture/serum PCR agreement was moderate (21/30;70%). Based on PCR positive patients, all CAPAs were due to A. fumigatus (80%), A. flavus (10%) and A. terreus (10%). No A. niger/A. nidulans or mixed infections were found despite positive BS cultures.

20.
Studies in Computational Intelligence ; 1045:179-190, 2023.
Article in English | Scopus | ID: covidwho-2148522

ABSTRACT

When one feels unwell, it is crucial to arrange a time as soon as possible to meet a doctor for early detection of potential health-related problems. However, a relatively large number of Vietnamese people usually avoid going to the hospital as they are afraid of long waits at such crowded places, while the current COVID-19 pandemic means being at those places poses a higher risk of contracting the disease. For simpler health problems, people would prefer a solution that, given their symptoms, provides a reliable diagnosis in a shorter time. This study presents an approach in building a deep-learning-based disease predictor of health conditions conducted from given symptoms in Vietnamese. The proposed method combines a tokenizer and bi-directional recurrent neural networks and achieved an accuracy of 98.96% (compared to a certified doctor’s diagnosis) in selected test cases, demonstrating its promising capabilities in the task. The application is expected to easily be integrated into a mobile application and open the way for other deep-learning-based solutions which analyze people’s symptoms to help them have their health conditions diagnosed at home. © 2023, The Author(s), under exclusive license to Springer Nature Switzerland AG.

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