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1.
Annals of Movement Disorders ; 5(2):112-117, 2022.
Article in English | Scopus | ID: covidwho-2040101

ABSTRACT

Introduction: The coronavirus disease-19 (COVID-19) pandemic is a global health crisis that has directly and indirectly impacted almost all populations globally. In this study, we aimed to study the impact of the COVID-19 pandemic on motor and nonmotor symptoms in patients with various movement disorders who visited our outpatient department. Materials and Methods: We conducted a prospective study using a structured questionnaire involving patients who visited our outpatient department during the COVID-19 pandemic from May 2020 to April 2021. The study was conducted at the Department of Neurology at the National Institute of Mental Health and Neuro Sciences, Bangalore. Results: A total of 208 patients with the following disorders were assessed: Parkinson's disease (n = 141), atypical parkinsonism (n = 31), dystonia (n = 15), Wilson's disease (n = 5), and other disorders (n = 16). Approximately, 3.5% of the patients had acquired the COVID-19 infection. Almost 80% of the patients had missed scheduled appointments with their physicians during this study period due to travel restrictions or the fear of traveling. Approximately, 50% of the patients experienced worsening of their motor and nonmotor symptoms. Approximately, 25% of patients availed teleconsultation facilities, and majority of them found it to be equivalent to or better than in-person consultation. Almost 80% of the patients were eager to receive the COVID-19 vaccination. Conclusion: The COVID-19 pandemic resulted in worsening of both motor and nonmotor symptoms in patients with movement disorders. Teleconsultation is a helpful option in managing the patients' symptoms during the pandemic. © 2022 Wolters Kluwer Medknow Publications. All rights reserved.

2.
Economic Affairs ; 67(2):37-42, 2022.
Article in English | CAB Abstracts | ID: covidwho-2026767

ABSTRACT

The COVID-19 pandemic has caused unprecedented stresses on food supply chain in the country, with bottlenecks in processing, transportation and logistics, as well as momentous shifts in consumption pattern and demand for fish and other meat. In this study, the impact of COVID-19 pandemic on consumption pattern of fish, chicken, egg, mutton, beef and pork, market availability and as well as prices in North Eastern Region of India was analysed in this study. The study based on primary data collected through online survey method for which a questionnaire framed in Google Form. The sample comprises of total 104 respondents. The Wilcoxon signed-rank test for repeated measure differences between before COVID-19 and during COVID-19 levels of consumption of fish and other non vegetarian food items and quality of fishes supplied during two periods were analysed. It was found that the reduction in consumption of fishes, chicken and beef, during COVID-19 pandemic, were statistically significant. Whereas, the Wilcoxon signed rank test statistics for mutton and pork turned out to be insignificant. During COVID-19 the consumption of local fishes increased due non availability and distortion of fish supply chain. The quality of fishes in terms of freshness, size and odour were also impacted. Due poor availability of fishes, prices of fish increased during COVID-19. The increase in fish prices and poor availability of fishes resulted to shift in purchase of processed fish products in the North Eastern Region in India. The disruption in transportation, logistics, lockdown, etc during COVID-19 impacted trade of fishes as well as its consumption in the region. Hence, efforts for increasing of local supply of fishes as well as the development of resilient supply chain with sufficient storage facilities is needed to cope up under such unprecedented situation.

3.
Journal of Clinical Oncology ; 40(16), 2022.
Article in English | EMBASE | ID: covidwho-2009527

ABSTRACT

Background: Molecular profiling of tumor tissue is the gold standard for treatment decision making in advanced non-small cell lung cancer. Results may be delayed or unavailable due to insufficient tissue samples or prolonged wait times for biopsy, pathology assessment and testing. We piloted the use of plasma molecular testing as part of the initial diagnostic work-up for patients with suspected advanced lung cancer (NCT04863924). Methods: Patients with radiologic evidence of advanced lung cancer referred to the lung rapid diagnostic program underwent plasma circulating tumor DNA (ctDNA) testing using InVisionFirst-Lung, a next-generation sequencing (NGS) assay targeting 37 genes. Standard tissue testing was performed with comprehensive NGS (Oncomine). The primary endpoint was time to treatment in stage IV NSCLC patients compared to an historical pre-COVID-19 cohort (2018-9). Secondary endpoints included actionable targets identified in plasma, % of patients starting targeted therapy based on liquid biopsy and result turnaround time (TAT). Results: Between July 1 to December 31, 2021, 60 patients were enrolled. Median age was 70 years (range 33-91), 52% were female, 57% Caucasian, 48% never smokers. Of these, 73% had NSCLC, 12% small cell, 10% non-lung pathology and 5% declined tissue biopsy. Of 44 NSCLC patients, 5 (11%) had early-stage disease and underwent curative therapy. Most stage IV patients (79%) had systemic treatment. Median time to treatment initiation in the study cohort was 34 days (n = 31, range 10-90) versus 62 days (n = 101, range 13- 159) in the historical cohort (p<0.0001). Two thirds (N = 23) of stage IV NSCLC patients had actionable alterations identified, (30% in current/ex-smokers);18 started targeted therapy including 10 based on plasma results before tissue results were available. Median TAT was 7 days for plasma from blood draw to reporting (range 4-14) and 26 days for tissue molecular testing (range 11-42), p<0.0001. Concordance was high between plasma and tissue testing (70%). Liquid biopsy identified actionable alterations for 3 patients not identified by tissue NGS. In 4 cases, plasma testing failed to identify actionable alterations detected in tissue, due to undetectable plasma ctDNA. Conclusions: Liquid biopsy in the initial diagnostic workup of patients with suspected advanced NSCLC leads to faster molecular results and shortens time to treatment compared to tissue testing alone. Supplementing the current standard of tissue molecular testing with a plasma-first approach during the diagnostic work up of patients with suspected advanced lung cancer may increase access to precision medicine and improve patient outcomes. (Table Presented).

4.
Defence Life Science Journal ; 7(2):63-70, 2022.
Article in English | Scopus | ID: covidwho-1924726

ABSTRACT

The COVID-19 outbreak has caused an impervious financial and psychological burden. Health care professionals, including oral health care workers, have been risking fighting the pandemic. The chief objective of the current study was to estimate the rates of prevalence of depression, stress, and anxiety among the oral health care professionals in Jammu and Udaipur city. The study was delineated as an online cross-sectional questionnaire-based research. It was mailed to different practitioners between May and July 2020, particularly those offered their services in COVID centers. The participants were to fill the self report questionnaires. Then, the parameters were measured using depression, anxiety, and stress scale 21(DASS 21) and Hamilton anxiety rating scale (HARS) to measure the degrees of depression, stress, and fear among the volunteers. The target population was divided into age groups between 23 to 28 years and over 28 years. Four hundred ninety responses were received and were considered for the study. The acquired data were analysed using IBM SPSSsoftware (windows version 23). The mean and standard deviations were calculated for stress, anxiety, depression using mentioned scale. The results were compared based on gender and age group. A statistically significant variance in stress level was found between male and female groups (p=0.002) and for the two age groups (p=0.001). Using the Hamilton anxiety rating scale, no statistically significant divergence could be seen among male and female participants. The current study showed stress, anxiety, and depressions were prevalent among health care workers working in COVID pandemic situations. Therefore, mental health status must be addressed, and issues must be resolved. © 2022, DESIDOC.

5.
Economic and Political Weekly ; 57(20):49-57, 2022.
Article in English | Scopus | ID: covidwho-1898086

ABSTRACT

During the COVID-19 pandemic, expansionary economic policies played an important role in reviving the floundering global economy. In this context, the present paper looks at the effectiveness of monetary policy in the global North in stimulating real economic activity. In an ultra-low interest rate regime, the traditional monetary policy ceases to be effective. Therefore, many developed country central banks adopted a slew of unconventional monetary policy tools to tackle the recession. This paper analyses the unconventional monetary policy tools pursued by the global North with special reference to the United States and argues that the transmission channels of unconventional monetary policy tools to increase effective demand are not always automatic and straightforward. There is strong evidence that while these expansionary measures may have helped during the initial crisis, their effectiveness in reviving sustained economic activity in the medium run is doubtful. On the other hand, there are routes through which increased liquidity created by unconventional monetary policy tools has ended up in the financial sector, thereby leading to an asset price inflation that may not have a net beneficial impact on the real economy. © 2022 Economic and Political Weekly. All rights reserved.

6.
High Contrast Metastructures XI 2022 ; 12011, 2022.
Article in English | Scopus | ID: covidwho-1891710

ABSTRACT

The COVID-19 pandemic attributed to the SARs-Cov-2 virus has disrupted the lives of individuals in every corner of the world, causing millions of infections and numerous deaths worldwide. Identifying and isolating infected people is very crucial to slow down the spread of the disease. In this paper, we report a design of highly sensitive, graphene-metasurface based biosensor for detecting the S1 spike protein expressed on the surface of the SARSCoV-2 virus in the terahertz band. Our structure consists of a silicon dioxide substrate sandwiched between a complete gold layer at the bottom, and a graphene monolayer on top etched with a phi-shaped slot tilted at 45 degree, which performs a wideband reflective-type cross-polarization conversion of the incident electromagnetic (EM) wave. The optimized polarization conversion ratio (PCR) has been achieved at 0.75eV chemical potential value of the graphene layer. When samples of Sars-CoV-2 virus contained in a phosphate buffer saline (PBS) solvent is put on top of proposed design of the sensing surface, the spike proteins of the virus interact with the spike antibody grown on the sensing surface;and it changes the refractive index of the overall system (Biosensor + Analyte), which in turn changes the PCR and the corresponding frequency of the reflected wave. The biosensor response has been computed using the Finite Integration Technique (FIT) in the terahertz region. The sensitivity of the biosensor is found to be 354 GHz/RIU at the PCR of 0.9. © COPYRIGHT SPIE. Downloading of the is permitted for personal use only.

7.
Economic Affairs ; 67(2):37-42, 2022.
Article in English | ProQuest Central | ID: covidwho-1877409

ABSTRACT

The COVID-19 pandemic has caused unprecedented stresses on food supply chain in the country, with bottlenecks in processing, transportation and logistics, as well as momentous shifts in consumption pattern and demand for fish and other meat. In this study, the impact of COVID-19 pandemic on consumption pattern of fish, chicken, egg, mutton, beef and pork, market availability and as well as prices in North Eastern Region of India was analysed in this study. The study based on primary data collected through online survey method for which a questionnaire framed in Google Form. The sample comprises of total 104 respondents. The Wilcoxon signed-rank test for repeated measure differences between before COVID-19 and during COVID-19 levels of consumption of fish and other non vegetarian food items and quality of fishes supplied during two periods were analysed. It was found that the reduction in consumption of fishes, chicken and beef, during COVID-19 pandemic, were statistically significant. Whereas, the Wilcoxon signed rank test statistics for mutton and pork turned out to be insignificant. During COVID-19 the consumption of local fishes increased due non availability and distortion of fish supply chain. The quality of fishes in terms of freshness, size and odour were also impacted. Due poor availability of fishes, prices of fish increased during COVID-19. The increase in fish prices and poor availability of fishes resulted to shift in purchase of processed fish products in the North Eastern Region in India. The disruption in transportation, logistics, lockdown, etc during COVID-19 impacted trade of fishes as well as its consumption in the region. Hence, efforts for increasing of local supply of fishes as well as the development of resilient supply chain with sufficient storage facilities is needed to cope up under such unprecedented situation.

8.
IEEE Sensors Journal ; : 1-1, 2022.
Article in English | Scopus | ID: covidwho-1874326

ABSTRACT

We present the design and analysis of a graphene metasurface-based cross polarization converter operating within the terahertz gap for detecting biomolecules over a broad spectral range, taking the SARS-CoV-2 virus as a specific example. To the best of our knowledge, our design reports the widest band of operation in the THz region of a graphene-based metasensor. Each meta-atom comprises a graphene pattern on silicon dioxide atop a continuous gold layer and exhibits near-unity cross polarization conversion ratio (PCR) and a 90% PCR bandwidth of 0.926 THz within the desired band (1.88 THz-2.81 THz). The proposed device demonstrates additional benefits which include a thin configuration (λ/7.84) and compact lattice size (λ/10.66), which are significantly better than other recently reported graphene metasurface biosensors. The device provides a sensitivity up to 490 GHz/RIU and a figure of merit (FoM) of 0.377 over a wide span of 0.926 THz within the terahertz gap. The electromagnetic response of this device has been validated via rigorous numerical analyses of simulated outputs as well as by developing a detailed circuit model representation of the same. The device demonstrates angular stability of nearly 40°under oblique incidence of the incident wave. IEEE

9.
Journal of Natural Remedies ; 22(2):261-267, 2022.
Article in English | Scopus | ID: covidwho-1847911

ABSTRACT

In the middle of April 2021, the infection rate due to 2nd wave of COVID-19 attained a peak alarming level. Total COVID-19 hospital accommodation became inadequate with respect to the demand of COVID-19 patients. Several unused schools, community halls and auditoriums were converted to safe-homes for COVID-19 patients and home isolated accommodations. Two local clubs at Salt Lake, Sector 4, Kolkata was collaborated to run a COVID-19 Safe-home at Basanti Devi Vidyapith, Basanti Devi colony, at the beginning of May 2021. On behalf of the coordinators, a few Electro-Homeopathy (EH) practitioners were voluntarily engaged themselves to look after the patients. A complete report on the successful management of COVID-19 patients using Electro-Homeopathy treatment has been presented here in details. The efficacy of Electro-Homeopathy for COVID-19 treatment and in-depth details of the philosophy of EH along with EH treatment methodology has been discussed. © 2022, Informatics Publishing Limited. All rights reserved.

10.
Mult Scler Relat Disord ; 60: 103739, 2022 Apr.
Article in English | MEDLINE | ID: covidwho-1747671

ABSTRACT

BACKGROUND: ChAdOx1-S (Covishield™/Vaxzervria, AstraZeneca) and BBV152 (Covaxin) SARS-CoV-2 vaccines are proven to be safe and effective, but rare complications have been reported. OBJECTIVE: To describe reports of central nervous system (CNS) demyelination following ChAdOx1-S and BBV152 vaccinations. METHODS & RESULTS: We report 29 (17 female; mean 38 years) cases of CNS demyelination; twenty-seven occurred in temporal association with ChAdOx1-S vaccine; two in association with BBV152 vaccine. Eleven patients had presentation with myelitis, six patients developed optic neuritis, five had acute demyelinating encephalomyelitis, three presented with brainstem demyelination, and four had multiaxial involvement. Myelin oligodendrocyte glycoprotein (MOG) antibodies were positive in ten patients. One patient with ADEM and tumefactive demyelinating lesions died after a prolonged intensive care unit stay and superimposed infection. As compared to the control group (87); the postvaccinial cases were found to have a significantly higher mean age, presence of encephalopathy (p value:0.0007), CSF pleocytosis (p value: 0.0094) and raised CSF protein (p value: 0.0062). CONCLUSIONS: It is difficult to establish a causal relationship between vaccination and neurological adverse events such as demyelination. The temporal association with the vaccination and the presence of MOG antibodies raises the possibility of an immunogenic process triggered by the vaccine in susceptible individuals.


Subject(s)
COVID-19 , Demyelinating Diseases , Autoantibodies , COVID-19/prevention & control , COVID-19 Vaccines/adverse effects , Demyelinating Diseases/chemically induced , Female , Humans , Myelin-Oligodendrocyte Glycoprotein , SARS-CoV-2
11.
Annals of Indian Academy of Neurology ; 24(6):1001-1002, 2021.
Article in English | EMBASE | ID: covidwho-1596385
12.
Journal of Endourology ; 35(SUPPL 1):A178, 2021.
Article in English | EMBASE | ID: covidwho-1569554

ABSTRACT

Introduction & Objective: The management of patients with ureteric stones can be logistically challenging in large volume centres with long waits for outpatient clinics and definitive interventions. Many units in publicly funded health systems resort to temporising obstructed kidneys with stent insertion and a subsequent plan for elective ureteroscopy at a later date. This can result in unnecessary stent insertions, repeated attendances to the emergency department and an overall poor experience for patients. We aimed to reorganise resources to improve waiting times for definitive intervention, reduce the need for pre-stenting, reduce emergency department re-attendance and improve the overall patient experience. Methods: All patients diagnosed with ureteric stones between March-September 2017 were collected as baseline data. Time to clinic review and definitive treatment were measured. By collaborating with the emergency department, radiology and operation schedulers, our intervention for improvement where a consultant led acute stone clinic (ASC) with a pathway for primary ureteroscopy was implemented and a second cycle was performed June 2018-January 2019. Further data was collected January-October 2020 to assess performance during the COVID-19 pandemic. Results: After implementing the ASC model, median time from diagnosis to clinic consultation reduced from 77 to 9 days. Median time to definitive procedure reduced from 56 to 25 days. Emergency ureteric stent insertion reduced from 69.1% to 27.9%. Reattendance to the emergency department reduced from 3.0 to 1.6 episodes/month. Primary definitive treatment increased from 31.0% to 72.1%. Patients receiving definitive treatment within 4 weeks improved from 26.2% to 51.2% post intervention and sustained at 54.5% during the pandemic period. Conclusions: Implementation of the ASC model has led to a reduced time from diagnosis to clinic review and from diagnosis to definitive treatment. Further improvement is limited by the lack of extra operating lists to reduce the waiting times for ureteroscopy. The ASC model can provide a blueprint for other hospitals to improve outcomes and care of patients with acute ureteric stones.

13.
Advances in Pharmacology and Pharmacy ; 9(4):127-138, 2021.
Article in English | Web of Science | ID: covidwho-1513226

ABSTRACT

The novel coronavirus disease is a rapidly spreading infection caused by recently discovered different variants of SARS CoV-2 viruses, causing mild to severe respiratory symptoms in the majority of people. The Coronavirus disease 2019 pandemic has spread almost all the nooks and corners of the world. There are significant possible approaches pharmaceutically to fight against COVID-19. Original full-text research articles were searched online in PubMed, ScienceDirect, ResearchGate, Google Scholar, Core and Wiley Online Library. Scientists throughout the world are working on different platforms and targeting certain proteins moieties against SARS CoV-2 for the development of methods of safety, efficacy and potential vaccine candidates. Many candidates showed efficacy in In-vitro studies but relatively few clinical studies proceeded through different vaccine development platforms, such as entire virus vaccines, plant-based and nucleic acid vaccines, recombinant protein subunit vaccines. This review study provides a short description of SARS-CoV-2 characteristics and deals with recent developments in the design of attempts to produce vaccines to combat COVID-19.

14.
Journal of Association of Physicians of India ; 69(10):17-23, 2021.
Article in English | Scopus | ID: covidwho-1469268

ABSTRACT

Background: There is more than twofold rise in prevalence of mucormycosis cases in India during the COVID-19 pandemic which needs to be evaluated. Aims: The study aimed to document the spectrum of cases of mucormycosis seen at our Institute during COVID-19 times. Methods: The study is a retrospective observational study carried out at our Institute from May 2021 to mid-June 2021. All patients with biopsy-proven mucormycosis were enrolled in the study. The patients were subjected to complete history taking, ophthalmological examination, and imaging studies. The patients were treated with a multidisciplinary approach with antifungal therapy as well as surgical intervention when needed. Results: Ten patients (n=10) were seen, with a mean age of 50.3 years. The major risk factors included recent use of steroids, uncontrolled diabetes, and CKD. The most common presentation was swelling of unilateral eye and ptosis, followed by loss of vision. Inflammatory marker (CRP) and d-dimer were raised at presentation in all cases. Imaging showed the spread of infection from paranasal sinus to orbit and brain via cavernous sinus, which was a poor prognostic factor. Intravenous Amphotericin-B was given to all patients for at least 4 weeks. Two patients were discharged after completion of treatment and mortality was seen in three patients. Conclusion: We present an array of COVID-associated-mucormycosis (CAM) cases from Eastern India. CAM is presenting with rhino-orbito-cerebral involvement. There is poor outcome with cerebral involvement and high incidence of adverse effects with deoxycholate formulation of amphotericin-B. The causal association of COVID-19 with mucormycosis needs to be unearthed but possible preventive role of anticoagulation should be evaluated. © 2021 Journal of Association of Physicians of India. All rights reserved.

15.
Biomedicine (India) ; 41(2):390-396, 2021.
Article in English | EMBASE | ID: covidwho-1458164

ABSTRACT

Introduction and Aim: Prone positioning has been reported to facilitate oxygenation in patients suffering from COVID-19, and improvement has been observed in cardiorespiratory functions following practice of asanas and pranayamas. We investigated the effects of prone asanas and slow pranayama on recovery from COVID-19 illness. Methods: A study was conducted on six COVID-19 patients of varied age with different pre-existing comorbidities such as asthma, diabetes and hypertension, admitted to COVID-hospital. In addition to routine medical treatment, all the patients practiced the prone asanas and slow pranayamic breathing for a period of four weeks (2 weeks of hospital stay during the illness and two weeks of home quarantine following discharge from the hospital). The intensity of illness, days to recover, level of stress assessed by Perceived Stress Scale (PSS-10), degree of depression assessed by Patient Health Questionnaire (PHQ-9), myocardial work stress determined by rate-pressure product, and complications if any, were recorded. They were advised to continue the asana-pranayama practice for another four weeks during the entire recovery period. Results: All the patients recovered smoothly from COVID-19 illness, their hospital stay was eventless, and the psychological stress, levels of depression and myocardial work stress due to COVID illness were reduced significantly by four-weeks practice of asana-pranayama schedule. Multiple regression demonstrated the association of decreased depression to decreased level of stress following asana-pranayama practice. There were no post-recovery complications during the one-month follow-up in the recovery period. Conclusion: Practice of prone asanas and slow pranayama for four weeks facilitated the healing from COVID-19 illness, alleviated psycho-physical stress and depression, and prevented development of post-recovery complications in all the patients. The reduction in depression could be linked to the reduced stress level following asana-pranayama practice in COVID-19 patients.

16.
Annals of Movement Disorders ; 3(2):71-72, 2020.
Article in English | Scopus | ID: covidwho-1282685
18.
Biomedicine (India) ; 40(4):526-530, 2020.
Article in English | EMBASE | ID: covidwho-1024910

ABSTRACT

Introduction and Aim: It has been observed that recovery from COVID-19 is delayed due to continuation of myalgia, fatigue, headache and some respiratory problems even after the discharge from the hospital. Reports indicate the improvement of sensory, cardiorespiratory and psychological functions following practice of Prone asanas and Pal’s pranayama. Therefore, we conducted a pilot study to assess if practice of asanas in prone posture and slow breathing exercise of Pal’s pranayama schedule can facilitate recovery from the COVID-19 illness and alleviate post-recovery complications in these patients. Materials and Methods: This is an interventional pilot study conducted in COVID positive patients. A structured module of prone asanas and Pal’s pranayama schedule was given to the COVID positive patients in addition to the routine medical treatments and their stress levels were assessed prior to and after the practice. Also, the acute effects of asana-pranayama schedule on the improvement of cardiorespiratory functions and occurrence of other complications in the recovery phase was recorded. Results: Following practice of asana-pranayama schedule, the patients recovered faster from myalgia, fatigue, headache and respiratory problems and they had a feeling of well-being. Further, the complications in the recovery phase of COVID-19 were prevented and the intensity of stress was reduced with the practice of asana-pranayama schedule. Conclusion: This pilot study has shed some light on the early recovery and the prevention of complications in the recovery phase of COVID-19.

19.
Journal of the Indian Medical Association ; 118(5):34-36, 2020.
Article in English | EMBASE | ID: covidwho-681552

ABSTRACT

We present three patients of COVID19 who presented to the emergency with neurological derangements. On admission fever, cough, sorethroat or contact history were notably absent in the first two that led to initial confusion about the diagnosis. We hereby stress on keeping SARSCoV2 infection in the differential diagnosis if patients present during this pandemic with neurological symptoms.

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