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1.
Journal of Gastroenterology and Hepatology ; 37(Supplement 1):216, 2022.
Article in English | EMBASE | ID: covidwho-2088263

ABSTRACT

Background and Aim: The prevalence of celiac disease (CD) in Australia is about 1 in 70, and it is estimated about 80% of people remain undiagnosed. To date, the only treatment is a strict lifelong gluten-free diet. At Logan Hospital, lengthy delays to diagnosis and limited dietetic support for adult patients with newly diagnosed CD were observed. A CD dietitian-led clinic (ACDC) was implemented in 2019, reflecting the National Institute for Health and Care Excellence (NICE) and British Society of Gastroenterology guidelines to improve both concerns. Under ACDC, a dietitian with extended scope of practice removes potential CD patients from the gastroenterology waitlist and orders appropriate pathology tests and endoscopy. Those with confirmed CD are given dietetic education within 2-4 weeks, with follow-up at 3, 6, and 12 months. This 24-month pretest-posttest study therefore aimed to compare time to patient CD diagnosis and nutrition education between the previous (pre-ACDC) and ACDC expanded-scope (post-ACDC) models of care. Method(s): Demographic, medical, and appointment data were sourced from medical records. Chi-squared and t-tests were used to assess differences between pre-ACDC and post-ACDC groups. Result(s): A total of 61 patients (31 post-ACDC;66% female;age, 43 +/- 16 years;anti-tissue transglutaminase >20, 41/49 [84%]) were eligible. Time from specialist referral to CD diagnosis (endoscopy date) improved from 140 (10-749) days before ACDC to 90 (11-213) days after ACDC (P = 0.002). Time from specialist referral to first CD-related nutrition education improved from 247 (29-1364) days before ACDC to 112 (34-245) days after ACDC (P < 0.001). These are conservative improvements, given that COVID-19 delayed services, after ACDC only, for most post-ACDC patients (27/31). While most pre-ACDC patients (93%) had gastroenterologist appointments over 12 months (3 [0-6] appointments), preliminary review suggests fewer patients required fewer gastroenterologist appointments after ACDC. Conclusion(s): An ACDC expanded-scope model of care may provide more timely diagnosis and require fewer gastroenterologist appointments for adult patients with newly diagnosed CD. Longer-term follow-up will determine if ACDC resulted in reduction of patient-reported symptoms and fewer gastroenterologist appointments overall.

2.
2021 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies: Demonstrations (Naacl-Hlt 2021) ; : 66-77, 2021.
Article in English | Web of Science | ID: covidwho-2068449

ABSTRACT

To combat COVID-19, both clinicians and scientists need to digest vast amounts of relevant biomedical knowledge in scientific literature to understand the disease mechanism and related biological functions. We have developed a novel and comprehensive knowledge discovery framework, COVID-KG to extract fine-grained multimedia knowledge elements (entities and their visual chemical structures, relations and events) from scientific literature. We then exploit the constructed multimedia knowledge graphs (KGs) for question answering and report generation, using drug repurposing as a case study. Our framework also provides detailed contextual sentences, subfigures, and knowledge subgraphs as evidence. All of the data, KGs, reports(1), resources, and shared services are publicly available(2).

3.
Revista Espanola De Salud Publica ; 95:12, 2021.
Article in Spanish | Web of Science | ID: covidwho-1321163

ABSTRACT

Background: A first protective dose of vaccine may allow delaying the second dose in a context of low supply. The objective is to assess the effectiveness of a single dose of vaccine against SARS-CoV-2 (BNT162b2) after twelve days of its administration in healthcare personnel (HCP) of a Health Department. Methods: A case-control study was made. HCP with suspected COVID-19 and HCP close contacts of COVID-19 cases were included between January 27 and February 7, 2021. They were PCR tested for SARS-CoV-2;those with positive PCR were considered cases and those with negative PCR were considered controls. The crude (VE) and adjusted (VEa) vaccine effectiveness to prevent COVID-19 cases and their 95% confidence interval were calculated using the formula VE = (1-Odds ratio) x 100. Results: 268 HCP were included, of which 70 (26.1%) were considered cases and 198 (73.9%) controls. The frequency of vaccine exposure in cases was 55.7% vs. 69.7% in controls (p=0.035). The VEa of the first vaccine dose was 52.6% (95%CI: 1.1-77.3). The VEa in the subgroup of HCP studied for suspected disease was 74.6% (CI95%: 38.4-89.5). Conclusions: One dose of BNT162b2 vaccine against SARS-CoV-2 offers early protection after twelve days of administration. These data could be considered to adapt strategies and consider postponing the second dose in situations of limited vaccine supply in order to achieve the maximum number of people covered with a first dose.

4.
BMJ Sexual & Reproductive Health ; 29:29, 2021.
Article in English | MEDLINE | ID: covidwho-1208872
5.
Revista Espanola de Salud Publica ; 95:29, 2021.
Article in Spanish | MEDLINE | ID: covidwho-1206672

ABSTRACT

OBJECTIVE: A first protective dose of vaccine may allow delaying the second dose in a context of low supply. The objective is to assess the effectiveness of a single dose of vaccine against SARS-CoV-2 (BNT162b2) after twelve days of its administration in healthcare personnel (HCP) of a Health Department. METHODS: A case-control study was made. HCP with suspected COVID-19 and HCP close contacts of COVID-19 cases were included between January 27 and February 7, 2021. They were PCR tested for SARS-CoV-2;those with positive PCR were considered cases and those with negative PCR were considered controls. The crude (VE) and adjusted (VEa) vaccine effectiveness to prevent COVID-19 cases and their 95% confidence interval were calculated using the formula VE = (1-Odds ratio) x 100. RESULTS: 268 HCP were included, of which 70 (26.1%) were considered cases and 198 (73.9%) controls. The frequency of vaccine exposure in cases was 55.7% vs. 69.7% in controls (p=0.035). The VEa of the first vaccine dose was 52.6% (95%CI: 1.1-77.3). The VEa in the subgroup of HCP studied for suspected disease was 74.6% (CI95%: 38.4-89.5). CONCLUSIONS: One dose of BNT162b2 vaccine against SARS-CoV-2 offers early protection after twelve days of administration. These data could be considered to adapt strategies and consider postponing the second dose in situations of limited vaccine supply in order to achieve the maximum number of people covered with a first dose.

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