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1.
Carbon N Y ; 194: 34-41, 2022 Jul.
Article in English | MEDLINE | ID: covidwho-1739589

ABSTRACT

Additive manufacturing has played a crucial role in the COVID-19 global emergency allowing for rapid production of medical devices, indispensable tools for hospitals, or personal protection equipment. However, medical devices, especially in nosocomial environments, represent high touch surfaces prone to viral infection and currently used filaments for 3D printing can't inhibit transmission of virus [1]. Graphene-family materials are capable of reinforcing mechanical, optical and thermal properties of 3D printed constructs. In particular, graphene can adsorb near-infrared light with high efficiency. Here we demonstrate that the addition of graphene nanoplatelets to PLA filaments (PLA-G) allows the creation of 3D-printed devices that can be sterilized by near-infrared light exposure at power density analog to sunlight. This method has been used to kill SARS-CoV-2 viral particles on the surface of 3D printed PLA-G by 3 min of exposure. 3D-printed PLA-G is highly biocompatible and can represent the ideal material for the production of sterilizable personal protective equipment and daily life objects intended for multiple users.

2.
Nano Today ; 43: 101403, 2022 Apr.
Article in English | MEDLINE | ID: covidwho-1636284

ABSTRACT

BioNTech/Pfizer's Comirnaty and Moderna's SpikeVax vaccines consist in mRNA encapsulated in lipid nanoparticles (LNPs). The modularity of the delivery platform and the manufacturing possibilities provided by microfluidics let them look like an instant success, but they are the product of decades of intense research. There is a multitude of considerations to be made when designing an optimal mRNA-LNPs vaccine. Herein, we provide a brief overview of what is presently known and what still requires investigation to optimize mRNA LNPs vaccines. Lastly, we give our perspective on the engineering of 3D bioprinted validation systems that will allow faster, cheaper, and more predictive vaccine testing in the future compared with animal models.

3.
iScience ; 24(7): 102788, 2021 Jul 23.
Article in English | MEDLINE | ID: covidwho-1284161

ABSTRACT

Recent advancements in bidimensional nanoparticles production such as graphene (G) and graphene oxide (GO) have the potential to meet the need for highly functional personal protective equipment (PPE) against SARS-CoV-2 infection. The ability of G and GO to interact with microorganisms provides an opportunity to develop engineered textiles for use in PPE and limit the spread of COVID-19. PPE in current use in high-risk settings for COVID transmission provides only a physical barrier that decreases infection likelihood and does not inactivate the virus. Here, we show that virus pre-incubation with soluble GO inhibits SARS-CoV-2 infection of VERO cells. Furthermore, when G/GO-functionalized polyurethane or cotton was in contact SARS-CoV-2, the infectivity of the fabric was nearly completely inhibited. The findings presented here constitute an important innovative nanomaterial-based strategy to significantly increase PPE efficacy in protection against the SARS-CoV-2 virus that may implement water filtration, air purification, and diagnostics methods.

4.
Nano Today ; 37: 101077, 2021 Apr.
Article in English | MEDLINE | ID: covidwho-1026396

ABSTRACT

Coronavirus Disease 2019 (COVID-19) is one of the biggest challenges of the 21st century. While researchers are working on vaccine development and elucidating the mechanism of action and evolution of the harmful SARS-CoV-2, the current most important public health measure, second only to social distancing, is the obligatory wearing of facial protection. The Centers for Disease Control and Prevention recommended in April 2020 that the public wear face coverings in areas with high rates of transmission based on epidemiological evidence on the strong relationship between mask wearing and pandemic control. This protection against SARS-CoV-2 and other airborne pathogens, boost the design and production of innovative solutions by industry stakeholders. Nanoparticles, nanofibers, and other pioneering technologies based on nanomaterials have been introduced in mask production chains to improve performance and confer antiviral properties. During an emergency like COVID-19, these products directly available to the public should be carefully analyzed in terms of efficacy and possible long-term effects on the wearers' skin and lungs as well as on the environment. This opinion paper provides a wealth of information on the role of nanotechnologies in improving the performance of facial masks and on possible future consequences caused by a poorly regulated use of nanotechnology in textiles.

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