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1.
Radiother Oncol ; 169: 140, 2022 04.
Article in English | MEDLINE | ID: covidwho-1586758
2.
Int J Radiat Oncol Biol Phys ; 110(5): 1551, 2021 08 01.
Article in English | MEDLINE | ID: covidwho-1549840
3.
Int J Radiat Oncol Biol Phys ; 110(5): 1274-1282, 2021 08 01.
Article in English | MEDLINE | ID: covidwho-1116867

ABSTRACT

PURPOSE: The morbidity and mortality of patients requiring mechanical ventilation for coronavirus disease 2019 (COVID-19) pneumonia is considerable. We studied the use of whole-lung low-dose radiation therapy (LDRT) in this patient cohort. METHODS AND MATERIALS: Patients admitted to the intensive care unit and requiring mechanical ventilation for COVID-19 pneumonia were included in this randomized double-blind study. Patients were randomized to 1 Gy whole-lung LDRT or sham irradiation (sham-RT). Treatment group allocation was concealed from patients and intensive care unit clinicians, who treated patients according to the current standard of care. Patients were followed for the primary endpoint of ventilator-free days at day 15 postintervention. Secondary endpoints included overall survival, as well as changes in oxygenation and inflammatory markers. RESULTS: Twenty-two patients were randomized to either whole-lung LDRT or sham-RT between November and December 2020. Patients were generally elderly and comorbid, with a median age of 75 years in both arms. No difference in 15-day ventilator-free days was observed between groups (P = 1.00), with a median of 0 days (range, 0-9) in the LDRT arm and 0 days (range, 0-13) in the sham-RT arm. Overall survival at 28 days was identical at 63.6% (95% confidence interval, 40.7%-99.5%) in both arms (P = .69). Apart from a more pronounced reduction in lymphocyte counts after LDRT (P < .01), analyses of secondary endpoints revealed no significant differences between the groups. CONCLUSIONS: Whole-lung LDRT failed to improve clinical outcomes in critically ill patients requiring mechanical ventilation for COVID-19 pneumonia.


Subject(s)
COVID-19/radiotherapy , Aged , Aged, 80 and over , COVID-19/diagnostic imaging , COVID-19/drug therapy , COVID-19/mortality , Confidence Intervals , Double-Blind Method , Female , Humans , Intensive Care Units , Kaplan-Meier Estimate , Lung/radiation effects , Lymphocyte Count , Male , Middle Aged , Oxygen Consumption , Patient Positioning , Radiotherapy Dosage , Respiration, Artificial/statistics & numerical data , Time Factors , Treatment Outcome , Ventilator Weaning
4.
InFo Hämatologie + Onkologie ; 23(4):12-16, 2020.
Article in German | PMC | ID: covidwho-829653
5.
Strahlenther Onkol ; 196(12): 1068-1079, 2020 12.
Article in English | MEDLINE | ID: covidwho-754691

ABSTRACT

PURPOSE: COVID-19 infection has manifested as a major threat to both patients and healthcare providers around the world. Radiation oncology institutions (ROI) deliver a major component of cancer treatment, with protocols that might span over several weeks, with the result of increasing susceptibility to COVID-19 infection and presenting with a more severe clinical course when compared with the general population. The aim of this manuscript is to investigate the impact of ROI protocols and performance on daily practice in the high-risk cancer patients during this pandemic. METHODS: We addressed the incidence of positive COVID-19 cases in both patients and health care workers (HCW), in addition to the protective measures adopted in ROIs in Germany, Austria and Switzerland using a specific questionnaire. RESULTS: The results of the questionnaire showed that a noteworthy number of ROIs were able to complete treatment in SARS-CoV­2 positive cancer patients, with only a short interruption. The ROIs reported a significant decrease in patient volume that was not impacted by the circumambient disease incidence, the type of ROI or the occurrence of positive cases. Of the ROIs 16.5% also reported infected HCWs. About half of the ROIs (50.5%) adopted a screening program for patients whereas only 23.3% also screened their HCWs. The range of protective measures included the creation of working groups, instituting home office work and protection with face masks. Regarding the therapeutic options offered, curative procedures were performed with either unchanged or moderately decreased schedules, whereas palliative or benign radiotherapy procedures were more often shortened. Most ROIs postponed or cancelled radiation treatment for benign indications (88.1%). The occurrence of SARS-CoV­2 infections did not affect the treatment options for curative procedures. Non-university-based ROIs seemed to be more willing to change their treatment options for curative and palliative cases than university-based ROIs. CONCLUSION: Most ROIs reported a deep impact of SARS-CoV­2 infections on their work routine. Modification and prioritization of treatment regimens and the application of protective measures preserved a well-functioning radiation oncology service and patient care.


Subject(s)
COVID-19/prevention & control , Cross Infection/prevention & control , Infection Control/methods , Neoplasms/radiotherapy , Pandemics , Personnel, Hospital/statistics & numerical data , SARS-CoV-2/isolation & purification , Appointments and Schedules , Austria/epidemiology , COVID-19/diagnosis , COVID-19/epidemiology , COVID-19 Testing/statistics & numerical data , Cancer Care Facilities/statistics & numerical data , Comorbidity , Cross Infection/epidemiology , Cross-Sectional Studies , Germany/epidemiology , Hospitals, Community , Hospitals, University/statistics & numerical data , Humans , Incidence , Infection Control/organization & administration , Masks/statistics & numerical data , Masks/supply & distribution , Neoplasms/epidemiology , Palliative Care/statistics & numerical data , Procedures and Techniques Utilization , Risk , Surveys and Questionnaires , Switzerland/epidemiology , Telemedicine/statistics & numerical data , Teleworking/statistics & numerical data
7.
Adv Radiat Oncol ; 5(4): 577-581, 2020.
Article in English | MEDLINE | ID: covidwho-143095

ABSTRACT

The ongoing novel coronavirus (2019-nCoV) pandemic is expected to develop into an unprecedented stress test for health care systems worldwide. This brief report, written from a radiation oncology perspective during the developing outbreak of 2019-nCoV in Switzerland, highlights the challenges identified and measures taken in our department to mitigate risks and ensure continued operations during the outbreak.

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